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Geneticist's Research Finds His Own Diabetes - NYTimes.com - 0 views

  • The research team monitored the molecular changes closely as the disease developed. The illness was treated successfully while in its early stages, long before it might have been if Dr. Snyder had relied on a conventional visit to the doctor.
  • Currently, the price of human genome sequencing is typically about $4,000, said George M. Church, a genetics professor at Harvard Medical School. But within a year, he said, it could be down to $1,000 or even less.
  • because he typically schedules checkups with his doctor only once every two or three years, the disease would have long remained undiagnosed had it not been for the case study. “Probably no one would have caught my glucose shooting up for at least 18 to 20 months,” he said. “By then, I could have had damage.”
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  • Dr. Church looks forward to the day when current research becomes a routine clinical procedure that combines inherited genomic information with analyses of RNA, proteins, metabolites and microbes in our bodies.
  • the cost to collect molecular data from each blood sample was about $2,500 — which did not include the cost of analysis. But the price for tests similar to Dr. Snyder’s will also decline in the future
  • Dr. Snyder is a co-founder of a company, Personalis, in Palo Alto, Calif., that is developing software and other tools to interpret genomes after sequencing
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New 'Digital Divide' Seen in Wasting Time Online - NYTimes.com - 0 views

  • As access to devices has spread, children in poorer families are spending considerably more time than children from more well-off families using their television and gadgets to watch shows and videos, play games and connect on social networking sites, studies show. This growing time-wasting gap, policy makers and researchers say, is more a reflection of the ability of parents to monitor and limit how children use technology than of access to it.
  • “access is not a panacea,” said Danah Boyd, a senior researcher at Microsoft. “Not only does it not solve problems, it mirrors and magnifies existing problems we’ve been ignoring.”
  • d the initial push to close the digital divide did not anticipate how computers would be used for entertainment.
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  • children and teenagers whose parents do not have a college degree spent 90 minutes more per day exposed to media than children from higher socioeconomic families. In 1999, the difference was just 16 minutes.
  • children of parents who do not have a college degree spend 11.5 hours each day exposed to media from a variety of sources, including television, computer and other gadgets. That is an increase of 4 hours and 40 minutes per day since 1999.
  • Children of more educated parents, generally understood as a proxy for higher socioeconomic status, also largely use their devices for entertainment. In families in which a parent has a college education or an advanced degree, Kaiser found, children use 10 hours of multimedia a day, a 3.5-hour jump since 1999.
  • “Despite the educational potential of computers, the reality is that their use for education or meaningful content creation is minuscule compared to their use for pure entertainment,” said Vicky Rideout, author of the decade-long Kaiser study. “Instead of closing the achievement gap, they’re widening the time-wasting gap.”
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The Myth of the Businessman-President - NYTimes.com - 0 views

  • Romney talked about amending the Constitution to require the president to have business experience. He spoke approvingly of a notion from a store owner who wanted to make anyone who does not have at least three years of business background ineligible to lead the country.“He said, ‘I’d like to have a provision in the Constitution that in addition to the age of the president and the citizenship of the president and the birth place of the president being set by the Constitution, I’d like it also to say that the president has to spend at least three years working in business before he could become president of the United States,’” said Romney, cheerfully summarizing this rewrite of the founders’ governing blueprint.
  • In a scholarly ranking of great presidents, a 2009 survey conducted by C-Span,6 of the 10 best leaders lacked sufficient business experience to be president by Romney’s rumination. This list includes Ronald Reagan, the actor, union activist and corporate spokesman, and John F. Kennedy, the naval officer, writer and politician. There is one failed businessman on the list of great presidents, the haberdasher Harry S. Truman.
  • By contrast, two 20th century businessmen — George W. Bush, whose sweetheart deal with the Texas Rangers made him a multimillionaire, and Herbert Hoover, who came by his mining fortune honestly — were ranked among the worst presidents ever by the same historians. Bush left the country in a sea of debt and an economic crisis rivaled only by the one that engulfed Hoover.
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The Austerity Agenda - NYTimes.com - 0 views

  • why is Britain doing exactly what it shouldn’t? Unlike the governments of, say, Spain or California, the British government can borrow freely, at historically low interest rates. So why is that government sharply reducing investment and eliminating hundreds of thousands of public-sector jobs, rather than waiting until the economy is stronger
  • I’ve posed that question to a number of supporters of the government of Prime Minister David Cameron, sometimes in private, sometimes on TV. And all these conversations followed the same arc: They began with a bad metaphor and ended with the revelation of ulterior motives.
  • The bad metaphor — which you’ve surely heard many times — equates the debt problems of a national economy with the debt problems of an individual family. A family that has run up too much debt, the story goes, must tighten its belt. So if Britain, as a whole, has run up too much debt — which it has, although it’s mostly private rather than public debt — shouldn’t it do the same? What’s wrong with this comparison?
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  • The answer is that an economy is not like an indebted family. Our debt is mostly money we owe to each other; even more important, our income mostly comes from selling things to each other. Your spending is my income, and my spending is your income.
  • So what happens if everyone simultaneously slashes spending in an attempt to pay down debt? The answer is that everyone’s income falls — my income falls because you’re spending less, and your income falls because I’m spending less. And, as our incomes plunge, our debt problem gets worse, not better.
  • these assertions often go along with claims that the economic crisis itself demonstrates the need to shrink government. But that’s manifestly not true. Look at the countries in Europe that have weathered the storm best, and near the top of the list you’ll find big-government nations like Sweden and Austria.
  • there’s a clear moral to this story: When the private sector is frantically trying to pay down debt, the public sector should do the opposite, spending when the private sector can’t or won’t. By all means, let’s balance our budget once the economy has recovered — but not now. The boom, not the slump, is the right time for austerity.
  • when you push “austerians” on the badness of their metaphor, they almost always retreat to assertions along the lines of: “But it’s essential that we shrink the size of the state.”
  • The great American economist Irving Fisher explained it all the way back in 1933, summarizing what he called “debt deflation” with the pithy slogan “the more the debtors pay, the more they owe.
  • So the austerity drive in Britain isn’t really about debt and deficits at all; it’s about using deficit panic as an excuse to dismantle social programs. And this is, of course, exactly the same thing that has been happening in America.
  • The big question here is whether the evident failure of austerity to produce an economic recovery will lead to a “Plan B.” Maybe. But my guess is that even if such a plan is announced, it won’t amount to much. For economic recovery was never the point; the drive for austerity was about using the crisis, not solving it. And it still is.
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Russian Church Opposes Syrian Intervention - NYTimes.com - 0 views

  • It is clear by now that Russia’s government has dug in against outside intervention in Syria, its longtime partner and last firm foothold in the Middle East. Less well known is the position taken by the Russian Orthodox Church, which fears that Christian minorities, many of them Orthodox, will be swept away by a wave of Islamic fundamentalism unleashed by the Arab Spring.
  • This argument for supporting sitting leaders has reached a peak around Syria, whose minority population of Christians, about 10 percent, has been reluctant to join the Sunni Muslim opposition against Mr. Assad, fearing persecution at those same hands if he were to fall. If the church’s advocacy cannot be said to guide Russia’s policy, it is one of the factors that make compromise with the West so elusive, especially at a time of domestic political uncertainty for the Kremlin.
  • The issue of “Christianophobia” shot to the top of the church’s agenda a year ago, with a statement warning that “they are killing our brothers and sisters, driving them from their homes, separating them from their near and dear, stripping them of the right to confess their religious beliefs
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  • The metropolitan asked Mr. Putin to promise to protect Christian minorities in the Middle East. “So it will be,” Mr. Putin said. “There is no doubt at all.”
  • The statements on “Christianophobia” amount to a denunciation of Western intervention, especially in Egypt and Iraq, which lost two-thirds of its 1.5 million Christians after the fall of Saddam Hussein.
  • Western analysts acknowledge the dangers faced by Christians in Syria, but say the church would be wise to distance itself from the Assad government and prepare for a political transition.
  • “If the Christian population and those that support it want a long-term future in the region, they’re going to have to accept that hitching their wagon to this brutal killing machine doesn’t have a long-term future.”
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Obama Ordered Wave of Cyberattacks Against Iran - NYTimes.com - 0 views

  • It appears to be the first time the United States has repeatedly used cyberweapons to cripple another country’s infrastructure, achieving, with computer code, what until then could be accomplished only by bombing a country or sending in agents to plant explosives.
  • If Olympic Games failed, he told aides, there would be no time for sanctions and diplomacy with Iran to work. Israel could carry out a conventional military attack, prompting a conflict that could spread throughout the region.
  • Iran’s president, Mahmoud Ahmadinejad, took reporters on a tour of the plant and described grand ambitions to install upward of 50,000 centrifuges. For a country with only one nuclear power reactor — whose fuel comes from Russia — to say that it needed fuel for its civilian nuclear program seemed dubious to Bush administration officials.
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  • Hawks in the Bush administration like Vice President Dick Cheney urged Mr. Bush to consider a military strike against the Iranian nuclear facilities before they could produce fuel suitable for a weapon. Several times, the administration reviewed military options and concluded that they would only further inflame a region already at war, and would have uncertain results.
  • The first stage in the effort was to develop a bit of computer code called a beacon that could be inserted into the computers, which were made by the German company Siemens and an Iranian manufacturer, to map their operations. The idea was to draw the equivalent of an electrical blueprint of the Natanz plant, to understand how the computers control the giant silvery centrifuges that spin at tremendous speeds. The connections were complex, and unless every circuit was understood, efforts to seize control of the centrifuges could fail.
  • The first attacks were small, and when the centrifuges began spinning out of control in 2008, the Iranians were mystified about the cause, according to intercepts that the United States later picked up.
  • The unusually tight collaboration with Israel was driven by two imperatives. Israel’s Unit 8200, a part of its military, had technical expertise that rivaled the N.S.A.’s, and the Israelis had deep intelligence about operations at Natanz that would be vital to making the cyberattack a success.
  • Soon the two countries had developed a complex worm that the Americans called “the bug.” But the bug needed to be tested. So, under enormous secrecy, the United States began building replicas of Iran’s P-1 centrifuges, an aging, unreliable design that Iran purchased from Abdul Qadeer Khan, the Pakistani nuclear chief who had begun selling fuel-making technology on the black market.
  • “This is the first attack of a major nature in which a cyberattack was used to effect physical destruction,” rather than just slow another computer, or hack into it to steal data.
  • It took months for the beacons to do their work and report home, complete with maps of the electronic directories of the controllers and what amounted to blueprints of how they were connected to the centrifuges deep underground. Then the N.S.A. and a secret Israeli unit respected by American intelligence officials for its cyberskills set to work developing the enormously complex computer worm that would become the attacker from within.
  • the code would lurk inside the plant for weeks, recording normal operations; when it attacked, it sent signals to the Natanz control room indicating that everything downstairs was operating normally. “This may have been the most brilliant part of the code,” one American official said.
  • the Iranians had grown so distrustful of their own instruments that they had assigned people to sit in the plant and radio back what they saw.
  • Mr. Bush urged him to preserve two classified programs, Olympic Games and the drone program in Pakistan. Mr. Obama took Mr. Bush’s advice.
  • Mr. Obama authorized the attacks to continue, and every few weeks — certainly after a major attack — he would get updates and authorize the next step. Sometimes it was a strike riskier and bolder than what had been tried previously. “From his first days in office, he was deep into every step in slowing the Iranian program — the diplomacy, the sanctions, every major decision,” a senior administration official said. “And it’s safe to say that whatever other activity might have been under way was no exception to that rule.”
  • In the summer of 2010, shortly after a new variant of the worm had been sent into Natanz, it became clear that the worm, which was never supposed to leave the Natanz machines, had broken free, like a zoo animal that found the keys to the cage.
  • An error in the code, they said, had led it to spread to an engineer’s computer when it was hooked up to the centrifuges. When the engineer left Natanz and connected the computer to the Internet, the American- and Israeli-made bug failed to recognize that its environment had changed. It began replicating itself all around the world.
  • “We think there was a modification done by the Israelis,” one of the briefers told the president, “and we don’t know if we were part of that activity.”
  • Mr. Obama, according to officials in the room, asked a series of questions, fearful that the code could do damage outside the plant. The answers came back in hedged terms. Mr. Biden fumed. “It’s got to be the Israelis,” he said. “They went too far.”
  • American cyberattacks are not limited to Iran, but the focus of attention, as one administration official put it, “has been overwhelmingly on one country.” There is no reason to believe that will remain the case for long. Some officials question why the same techniques have not been used more aggressively against North Korea. Others see chances to disrupt Chinese military plans, forces in Syria on the way to suppress the uprising there, and Qaeda operations around the world. “We’ve considered a lot more attacks than we have gone ahead with,” one former intelligence official said.
  • In fact, no country’s infrastructure is more dependent on computer systems, and thus more vulnerable to attack, than that of the United States. It is only a matter of time, most experts believe, before it becomes the target of the same kind of weapon that the Americans have used, secretly, against Iran.
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Cyberattack Hits Iranian PCs - WSJ.com - 0 views

  • Flame is the biggest and most high-functioning cyberweapon ever discovered, various cybersecurity experts said. It is comprised of multiple files that are 20 times larger than Stuxnet and carry about 100 times more code than a basic virus, experts said.
  • The most alarming feature, experts said, is that Flame can be highly versatile, depending on instructions by its controller. The malware can steal data and social-network conversations, take snapshots of computer screens, penetrate across networks, turn on a computer's microphone to record audio and scan for Bluetooth-active devices.
  • Experts said they believe Flame reports back the information to a central command-and-control network that has constantly changed location. Analysts found servers in Germany, Vietnam, Turkey, Italy and elsewhere, but haven't located the main server.
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  • U.S. officials draw a distinction between cyber espionage and cyberattacks, which have a destructive or manipulative purpose and could be considered an act of war.
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Business - Derek Thompson - The New Economics of Happiness - The Atlantic - 0 views

  • Happiness is a cake with a million recipes. The same factors that make it so hard for the OECD Better Life Index to compare the "good life" country-by-country make it hard to devise any sort of happiness-centric public policy.
  • Happiness and income might have a controversial relationship. But plenty of evidence suggests that unemployment makes you miserable, no matter where you live
  • " It's conceivable that employment-maximizing policies might be more important, from a happynomics standpoint, than income-egalitarian policies.
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Bruce Bartlett: Republican Keynesians - NYTimes.com - 0 views

  • when push comes to shove, Republicans are happy to fall back on Keynesian theories when it suits them.
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Gandhi's Patrimony Is Misused, Legal Wrangling Over an Institute in Varanasi Shows - NY... - 0 views

  • Beyond nationalism and nonviolence, most people simply don’t know what Gandhi stood for, and his words are open to misinterpretation. Sixty-four years after the Mahatma’s assassination, anyone can claim to be a Gandhian.
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White Roofs May Actually Add to Global Warming | 80beats | Discover Magazine - 0 views

  • in a warm, sunny climate, a white roof almost certainly doesn’t hurt on an individual basis and may help reduce the need for air-conditioning (as inhabitants of sultry climes have known for a long time)
  • While a white roof in the southern states will reduce cooling loads and therefore save energy even some white roof manufacturers agree that the benefits of white roofs in the northern states an especialy in most of Canada are negligible at best and even an energy negative in many areas. In the north the only minor benefit may be a slight reductioin in heat island effect, but that only applies while the roof is clean and in urban areas
  • While programs such as LEED promote white roofs as a blanket policy people need to think the process through, if you have 10 heating degree days for every 1 cooling degree day what is more inportant. In the north most buildings have much higher insulation values negating many of the possibile benefits of the reflective roofing
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  • At the end of the day, having a white roof cannot hurt. It does keep buildings cooler which translates into lower energy costs
  • white roofs aren’t always practical, especially because many people have ordinary shingle roofs and while shingles come in very light colors, I’ve never seen any that are white. That, and as has been mentioned, keeping them clean!
  • white roofs may reduce cooling costs. What about 75 percent of the US where there are more heating degree days (HDD) than cooling degree days (CDD) and a dark colored roof actually provides more benefits by reducing the heating costs…
  • We have found that white roofs do provide a low-cost solution that can help buildings reduce energy costs, in a wide variety of climates, as well as cool the atmosphere regionally and globally. We have also found disadvantages. The reflective roofs may cause unwanted glare, for example, and may modestly increase heating costs in winter. But answers to these issues are exactly the ones we’re working hard to find.
  • In our opinion, all of these arguments and studies suggest that selective use of white and other reflective roofs makes sense as part of an integrated strategy
  • n an urban environment you also have thermal mass to take into account, I don`t have the mathematics to put here, however a simple analogy would be if you painted a piece of concrete black and put it in the sun and had another identical piece painted white, the black piece would still be radiating heat longer after the sun has gone down.
  • Most urban environment are made of high thermal mass products, Concrete, Bitumen Steel, these all will heat up more if they are darker colors and radiate back into the local environment after dark. Where as if they radiated heat back into the air instead of absorbing it all day, there might be a better chance of a cool down before the sun comes up the next day.
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Painting Bill Clinton's "white roofs" into reality | The Great Debate - 0 views

  • Painting black tar roofs with a white, solar-reflective coating is a low cost, quick and tangible way to reduce the risk of power grid ‘brown-outs’, save millions of dollars in energy costs, and curb climate change. The statistics are as simple as they are staggering: A roof covered with solar-reflective white paint reflects up to 90% of sunlight as opposed to the 20% reflected by a traditional black roof. On a 90°F day, a black roof can be up to 180°F. That heat has a major impact on interior building temperature, potentially heating your room to between 115 – 125°F. A white roof stays a cool 100°F. Plus the inside of the building stays cooler than the air outdoors, around 80°F in this example, reducing cooling costs.
  • White roofs also reduce the “urban heat island” effect in which temperatures rise in dense urban areas because of the proliferation of heat-radiating, black tar surfaces. For example, the Urban Heat Island effect causes New York City to be about 5 degrees warmer than surrounding suburbs and accounts for 5 to 10 percent of summer electricity use.
  • Volunteers saw that all it takes is a paint roller, some solar-reflective white coating and a little hard work to start curbing climate change.
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The Prognosis for Medical Innovation - NYTimes.com - 0 views

  • innovations like the da Vinci robot, which costs more than a million dollars and yet has never been shown by a randomized trial to improve the outcomes of prostate surgery.
  • this is a pseudo-innovation — a technology that increases costs without improving patients’ health.
  • by providing incentives for hospitals to reduce infections, errors and readmissions, giving doctors more information on the comparative effectiveness of medical interventions and emphasizing preventive care over expensive services, the act will stimulate a panoply of true medical innovations
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  • we need to stop glorifying every new technology as an innovation. “New” matters only when it’s proved better than what we had before, when it prolongs survival, reduces side effects or improves quality of life — or maintains the current standard of care at a lower cost.
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Romney's Big Fat Wet Kiss to Keynesian Economics -- Daily Intel - 0 views

  • Romney openly repudiated the central argument his party has been making against President Obama for the last three years: that he spent too much money and therefore deepened the economic crisis.
  • in his Halperin interview, Romney frankly admits that reducing the budget deficit in the midst of an economic crisis would be a horrible idea:
  • Romney: Well because, if you take a trillion dollars for instance, out of the first year of the federal budget, that would shrink GDP over 5%. That is by definition throwing us into recession or depression.  So I’m not going to do that, of course.
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  • Of course! Romney says this as if it’s completely obvious that reducing the deficit in the short term would throw the economy back into recession, even though he and his party have been arguing the opposite case with hysterical fervor.
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Does Facebook's IPO Prove That Zuckerberg Isn't Up to the Job? - The Daily Beast - 0 views

  • The IPO disaster simply creates an incentive to pry even deeper into the lives of users, “the one thing people hate most,” Wadhwa says. Facebook can track people even when they’re not on the site, watching where they go and what they do. That information, sliced and analyzed the right way, could be of great value to advertisers.
  • Placing ads next to Google search results works well because people using Google are already searching for products. Advertising on Facebook is less effective because people go to the site to talk to their friends, not look for products.
  • nobody would be complaining if Facebook stock had gone up instead of down, a feat the company could have accomplished so easily, just by selling fewer shares at a lower price. But Facebook didn’t want to leave money on the table. Zuckerberg and his bankers let hubris, self-delusion, and ego get the better of them.
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This Is How We Ride - NYTimes.com - 0 views

  • More than 200 cities around the world have bike-share programs. We’re not the first, but ours will be one of the largest systems. The program will start with 420 stations spread through the lower half of Manhattan, Long Island City and much of western Brooklyn; eventually more than 10,000 bikes will be available. It will cost just under $10 for a day’s rental. The charge includes unlimited rides during a 24-hour period, as long as each ride is under 30 minutes
  • Bogotá bike use has increased by a factor of five. Significantly, the increased biking has affected the city’s economy, as Bogotá recently extended a network of bicycle paths through lower-income neighborhoods around the city’s periphery, making it easier and more affordable for those who don’t live in affluent areas to get to work. Bike paths = jobs.
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The Facebook Illusion - Douthat-NYTimes.com - 0 views

  • Mark Zuckerberg’s social networking site has always struck me as one of the most noxious, dependent for its success on the darker aspects of online life: the zeal for constant self-fashioning and self-promotion, the pursuit of virtual forms of “community” and “friendship” that bear only a passing resemblance to the genuine article, and the relentless diminution of the private sphere in the quest for advertising dollars.
  • the problem is not that Facebook doesn’t make money. It’s that it doesn’t make that much money, and doesn’t have an obvious way to make that much more of it, because (like so many online concerns) it hasn’t figured out how to effectively monetize its million upon millions of users.
  • This “huge reach, limited profitability” problem is characteristic of the digital economy as a whole
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  • the Internet is a wonder when it comes to generating “cheap fun.” But because “so many of its products are free,” and because so much of a typical Web company’s work is “performed more or less automatically by the software and the servers,” the online world is rather less impressive when it comes to generating job growth.
  • the more purely digital a company’s product, the fewer jobs it tends to create and the fewer dollars it can earn per user
  • From the lowbrow to the highbrow, LOLcats to Wikipedia, vast amounts of Internet content are created by people with no expectation of remuneration. The “new economy,” in this sense, isn’t always even a commercial economy at all. Instead, as Slate’s Matthew Yglesias has suggested, it’s a kind of hobbyist’s paradise, one that’s subsidized by surpluses from the old economy it was supposed to gradually replace.
  • Despite nearly two decades of dot-com enthusiasm, the information sector is still quite small relative to other sectors of the economy; it currently has one of the nation’s higher unemployment rates; and it’s one of the few sectors where unemployment has actually risen over the last year.
  • None of this makes the Internet any less revolutionary. But it’s created a cultural revolution more than an economic one.
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