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The researchers identified a common set of drastic changes that the United States would need to make over the next decade to stay on pace for zero emissions.

This year, energy companies will install 42 gigawatts of new wind turbines and solar panels, smashing records. But that annual pace would need to nearly double over the next decade

The capacity of the nation’s electric grid would have to expand roughly 60 percent by 2030 to handle vast amounts of wind and solar power

By 2030, at least 50 percent of new cars sold would need to be battery-powered, with that share rising thereafter.

Most homes today are heated by natural gas or oil. But in the next 10 years, nearly one-quarter would need to be warmed with efficient electric heat pumps, double today’s numbers.

Virtually all of the 200 remaining coal-burning power plants would have to shut down by 2030.

“The scale of what we have to build in a very short time frame surprised me,” said Christopher Greig, a senior scientist at Princeton’s Andlinger Center for Energy and the Environment.

To start, the United States could make enormous strides over the next decade by rapidly scaling up solutions already in use today, like wind, solar, electric cars and heat pumps. Doing so would require $2.5 trillion in additional investments by governments and industry by 2030.

Wind and solar power could be backed up by batteries, some existing nuclear reactors and a large fleet of natural-gas plants that run only occasionally or have been modified to burn clean hydrogen.

Devices that suck carbon dioxide from the atmosphere could help offset emissions.

But most of those technologies are still in early development. That would have to change quickly.

“We need to be building up our options now,” said Jesse Jenkins, an energy systems engineer at Princeton.

The studies found that, if done right, getting to net zero appears broadly affordable, largely because technologies like wind and solar have become so much cheaper than anyone expected over the past decade.

“It’s not a question of whether we have enough land, because we do,” said Eric Larson, a senior research engineer at Princeton. “But with that many new projects, you have to ask if they’ll run into local opposition.”

Then there are jobs to consider. Net zero would mean eliminating coal and drastically reducing oil and gas use, displacing hundreds of thousands of fossil-fuel workers.

On the flip side, millions of new green jobs would spring up for workers retrofitting homes or building wind farms, though those jobs might not be located in the same regions.

Politicians would need to figure out how to gain public acceptance for the sweeping changes unfolding, while protecting vulnerable Americans from harm.

What both studies do illustrate is that there’s little room for delay.

“It may seem like 2050 is a long way off,” said Dr. Jenkins. “But if you think about the timelines for policies, business decisions and capital investments, it’s really more like the day after tomorrow.”

Traditionally, a scientist submits her paper to a journal, which sends it to a (surprisingly small) group of peers for (several rounds of usually anonymous) comments; if the paper passes this (typically months-long) peer-review gantlet, it is published (often behind an expensive paywall). Languid and opaque, this system is ill-suited to a fast-moving outbreak. But biomedical scientists can now upload preliminary versions of their papers, or “preprints,” to freely accessible websites, allowing others to immediately dissect and build upon their results. This practice had been slowly gaining popularity before 2020, but proved so vital for sharing information about COVID‑19 that it will likely become a mainstay of modern biomedical research. Preprints accelerate science, and the pandemic accelerated the use of preprints. At the start of the year, one repository, medRxiv (pronounced “med archive”), held about 1,000 preprints. By the end of October, it had more than 12,000.

The U.S. is now catching up. In April, the NIH launched a partnership called ACTIV, in which academic and industry scientists prioritized the most promising drugs and coordinated trial plans across the country. Since August, several such trials have started.

Researchers have begun to uncover how SARS‑CoV‑2 compares with other coronaviruses in wild bats, the likely reservoir; how it infiltrates and co-opts our cells; how the immune system overreacts to it, creating the symptoms of COVID‑19. “We’re learning about this virus faster than we’ve ever learned about any virus in history,” Sabeti said.

Similar triumphs occurred last year—in other countries. In March, taking advantage of the United Kingdom’s nationalized health system, British researchers launched a nationwide study called Recovery, which has since enrolled more than 17,600 COVID‑19 patients across 176 institutions. Recovery offered conclusive answers about dexamethasone and hydroxychloroquine and is set to weigh in on several other treatments. No other study has done more to shape the treatment of COVID‑19.

SARS‑CoV‑2’s genome was decoded and shared by Chinese scientists just 10 days after the first cases were reported. By November, more than 197,000 SARS‑CoV‑2 genomes had been sequenced. About 90 years ago, no one had even seen an individual virus; today, scientists have reconstructed the shape of SARS‑CoV‑2 down to the position of individual atoms

Respiratory viruses, though extremely common, are often neglected. Respiratory syncytial virus, parainfluenza viruses, rhinoviruses, adenoviruses, bocaviruses, a quartet of other human coronaviruses—they mostly cause mild coldlike illnesses, but those can be severe. How often? Why? It’s hard to say, because, influenza aside, such viruses attract little funding or interest.

COVID‑19 has developed a terrifying mystique because it seems to behave in unusual ways. It causes mild symptoms in some but critical illness in others. It is a respiratory virus and yet seems to attack the heart, brain, kidneys, and other organs. It has reinfected a small number of people who had recently recovered. But many other viruses share similar abilities; they just don’t infect millions of people in a matter of months or grab the attention of the entire scientific community

Thanks to COVID‑19, more researchers are looking for these rarer sides of viral infections, and spotting them.

These factors pull researchers toward speed, short-termism, and hype at the expense of rigor—and the pandemic intensified that pull. With an anxious world crying out for information, any new paper could immediately draw international press coverage—and hundreds of citations.

“There’s a perception that they’re just colds and there’s nothing much to learn,” says Emily Martin of the University of Michigan, who has long struggled to get funding to study them. Such reasoning is shortsighted folly. Respiratory viruses are the pathogens most likely to cause pandemics, and those outbreaks could potentially be far worse than COVID‑19’s.

Their movements through the air have been poorly studied, too. “There’s this very entrenched idea,” says Linsey Marr at Virginia Tech, that viruses mostly spread through droplets (short-range globs of snot and spit) rather than aerosols (smaller, dustlike flecks that travel farther). That idea dates back to the 1930s, when scientists were upending outdated notions that disease was caused by “bad air,” or miasma. But the evidence that SARS‑CoV‑2 can spread through aerosols “is now overwhelming,”

Another pandemic is inevitable, but it will find a very different community of scientists than COVID‑19 did. They will immediately work to determine whether the pathogen—most likely another respiratory virus—moves through aerosols, and whether it spreads from infected people before causing symptoms. They might call for masks and better ventilation from the earliest moments, not after months of debate

They will anticipate the possibility of an imminent wave of long-haul symptoms, and hopefully discover ways of preventing them. They might set up research groups to prioritize the most promising drugs and coordinate large clinical trials. They might take vaccine platforms that worked best against COVID‑19, slot in the genetic material of the new pathogen, and have a vaccine ready within months

the single-minded focus on COVID‑19 will also leave a slew of negative legacies. Science is mostly a zero-sum game, and when one topic monopolizes attention and money, others lose out.

Long-term studies that monitored bird migrations or the changing climate will forever have holes in their data because field research had to be canceled.

negligence has left COVID‑19 long-haulers with few answers or options, and they initially endured the same dismissal as the larger ME community. But their sheer numbers have forced a degree of recognition. They started researching, cataloging their own symptoms. They gained audiences with the NIH and the World Health Organization. Patients who are themselves experts in infectious disease or public health published their stories in top journals. “Long COVID” is being taken seriously, and Brea hopes it might drag all post-infection illnesses into the spotlight. ME never experienced a pivot. COVID‑19 might inadvertently create one

Other epistemic trespassers spent their time reinventing the wheel. One new study, published in NEJM, used lasers to show that when people speak, they release aerosols. But as the authors themselves note, the same result—sans lasers—was published in 1946, Marr says. I asked her whether any papers from the 2020 batch had taught her something new. After an uncomfortably long pause, she mentioned just one.

The incentives to trespass are substantial. Academia is a pyramid scheme: Each biomedical professor trains an average of six doctoral students across her career, but only 16 percent of the students get tenure-track positions. Competition is ferocious, and success hinges on getting published

Conservationists who worked to protect monkeys and apes kept their distance for fear of passing COVID‑19 to already endangered species.

Among scientists, as in other fields, women do more child care, domestic work, and teaching than men, and are more often asked for emotional support by their students. These burdens increased as the pandemic took hold, leaving women scientists “less able to commit their time to learning about a new area of study, and less able to start a whole new research project,

published COVID‑19 papers had 19 percent fewer women as first authors compared with papers from the same journals in the previous year. Men led more than 80 percent of national COVID‑19 task forces in 87 countries. Male scientists were quoted four times as frequently as female scientists in American news stories about the pandemic.

American scientists of color also found it harder to pivot than their white peers, because of unique challenges that sapped their time and energy.

Science suffers from the so-called Matthew effect, whereby small successes snowball into ever greater advantages, irrespective of merit. Similarly, early hindrances linger. Young researchers who could not pivot because they were too busy caring or grieving for others might suffer lasting consequences from an unproductive year. COVID‑19 “has really put the clock back in terms of closing the gap for women and underrepresented minorities,”

In 1848, the Prussian government sent a young physician named Rudolf Virchow to investigate a typhus epidemic in Upper Silesia. Virchow didn’t know what caused the devastating disease, but he realized its spread was possible because of malnutrition, hazardous working conditions, crowded housing, poor sanitation, and the inattention of civil servants and aristocrats—problems that require social and political reforms. “Medicine is a social science,” Virchow said, “and politics is nothing but medicine in larger scale.”

entists discovered the microbes responsible for tuberculosis, plague, cholera, dysentery, and syphilis, most fixated on these newly identified nemeses. Societal factors were seen as overly political distractions for researchers who sought to “be as ‘objective’ as possible,” says Elaine Hernandez, a medical sociologist at Indiana University. In the U.S., medicine fractured.

New departments of sociology and cultural anthropology kept their eye on the societal side of health, while the nation’s first schools of public health focused instead on fights between germs and individuals. This rift widened as improvements in hygiene, living standards, nutrition, and sanitation lengthened life spans: The more social conditions improved, the more readily they could be ignored.

The ideological pivot away from social medicine began to reverse in the second half of the 20th century.

Politicians initially described COVID‑19 as a “great equalizer,” but when states began releasing demographic data, it was immediately clear that the disease was disproportionately infecting and killing people of color.

These disparities aren’t biological. They stem from decades of discrimination and segregation that left minority communities in poorer neighborhoods with low-paying jobs, more health problems, and less access to health care—the same kind of problems that Virchow identified more than 170 years ago.

In March, when the U.S. started shutting down, one of the biggest questions on the mind of Whitney Robinson of UNC at Chapel Hill was: Are our kids going to be out of school for two years? While biomedical scientists tend to focus on sickness and recovery, social epidemiologists like her “think about critical periods that can affect the trajectory of your life,” she told me. Disrupting a child’s schooling at the wrong time can affect their entire career, so scientists should have prioritized research to figure out whether and how schools could reopen safely. But most studies on the spread of COVID‑19 in schools were neither large in scope nor well-designed enough to be conclusive. No federal agency funded a large, nationwide study, even though the federal government had months to do so. The NIH received billions for COVID‑19 research, but the National Institute of Child Health and Human Development—one of its 27 constituent institutes and centers—got nothing.

The horrors that Rudolf Virchow saw in Upper Silesia radicalized him, pushing the future “father of modern pathology” to advocate for social reforms. The current pandemic has affected scientists in the same way

COVID‑19 could be the catalyst that fully reunifies the social and biological sides of medicine, bridging disciplines that have been separated for too long.

“To study COVID‑19 is not only to study the disease itself as a biological entity,” says Alondra Nelson, the president of the Social Science Research Council. “What looks like a single problem is actually all things, all at once. So what we’re actually studying is literally everything in society, at every scale, from supply chains to individual relationships.”

Serious adverse reactions were uncommon. There were three reports of a facial paralysis called Bell's palsy in the vaccine group and one in the placebo group. The FDA said there wasn't enough information to determine if the vaccine caused the cases.

Most everyone experienced pain at the injection site — 92%. Other common reactions included fatigue (69%), headache (63%) and muscle pain (60%).

The FDA analysis supports a case that the Moderna vaccine should be authorized for emergency use, a quicker approach than the standard for full licensure.

Authorization of Moderna's vaccine will be considered only for adults, so the meeting may go more smoothly.

“We said yes to science. We said yes to vaccines. We said yes to ending this pandemic. We said yes to people’s right to vote without fear of fake fraud and voter suppression

“As a health care worker, it was important to me to have a governor who follows science,” said Marc Martino, 26, who was dressed in blue scrubs as he dropped off his ballot in Irvine.

it was the politicization of the pandemic that propelled it onto the ballot as Californians became impatient with shutdowns of businesses and classrooms

We said yes to women’s fundamental constitutional right to decide for herself what she does with her body, her fate, her future. We said yes to diversity.”

Though polls showed that the recall was consistently opposed by some 60 percent of Californians, surveys over the summer suggested that likely voters were unenthusiastic about Mr. Newsom.

President Biden, Vice President Kamala Harris and Senators Elizabeth Warren of Massachusetts and Amy Klobuchar of Minnesota traveled to California to campaign for Mr. Newsom, while Senator Bernie Sanders of Vermont and former President Barack Obama appeared in his commercials

The governor charged that far-right extremists and supporters of former President Donald J. Trump were attempting a hostile takeover in a state where they could never hope to attain majority support in a regular election.

Democrats outnumber Republicans two to one in California, and pandemic voting rules encouraged high turnout, allowing ballots to be mailed to each of the state’s 22 million registered, active voters with prepaid postage. More than 40 percent of those Californians voted early.

Recall attempts are common in California, where direct democracy has long been part of the political culture.

Initially, Mr. Heatlie’s petition had difficulty gaining traction. But it gathered steam as the pandemic swept California and Mr. Newsom struggled to contain it

Californians who at first were supportive of the governor’s health orders wearied of shutdowns in businesses and classrooms, and public dissatisfaction boiled over in November when Mr. Newsom was spotted mask-free at the French Laundry, an exclusive wine country restaurant,

The recall campaign, the two men said, had expanded the small cadre that began the effort into a statewide coalition of 400,000 members who are already helping to push ballot proposals to fund school vouchers, forbid vaccine mandates in schools, and abolish public employee unions, which have been a longstanding Democratic force in California.

About one-quarter of the state’s registered voters are Republicans, and their numbers have been dwindling since the 1990s,

He took note of the voter fraud accusations that some in his party began to make well before the polls closed, echoing Mr. Trump, who claimed without evidence that Democrats had “rigged” the recall election.

Some Democratic observers were circumspect, warning that the disruption caused by the recall effort hinted at deeper problems.

And until the issues that created it get dealt with, people in power are in trouble. There’s a lot of anger and fear and frustration out there.

the governor moved aggressively to demonstrate that the state could both protect its economy and curb the virus. In recent months, he has rolled out vaccinations, cleaned up trash in neighborhoods neglected by pandemic-worn Californians, thrown motel rooms open to homeless Californians, announced stimulus checks and rent assistance for poor and middle-class Californians and stood repeatedly in front of a gold lamé curtain to host one of the nation’s largest vaccine lotteries.

Mr. Newsom and his team quickly cleared the field of potential Democratic alternatives.

Mr. Newsom painted the recall effort in national, partisan terms and rejected a defensive posture. His strategy galvanized major donors and his base.

Millions of voters chose not to answer the ballot’s second question, with Mr. Elder receiving about 44 percent of the vote from those who did. Kevin Paffrath, a Democrat, and Kevin Faulconer, a Republican and former mayor of San Diego, each had about 10 percent of the vote as of 10 p.m. Pacific time.

California has no limits on donations to committees for and against recalls, but the state caps contributions to candidates from individual donors.

Mr. Newsom capitalized on the rules, raising more than $50 million just in donations of more than $100,000 to oppose the recall.

D’Errico has developed a scenario to explain how number systems might have arisen through the very act of producing such artefacts. His hypothesis is one of only two published so far for the prehistoric origin of numbers.

It all started by accident, he suggests, as early hominins unintentionally left marks on bones while they were butchering animal carcasses. Later, the hominins made a cognitive leap when they realized that they could deliberately mark bones to produce abstract designs — such as those seen on an approximately 430,000-year-old shell found in Trinil, Indonesia6. At some point after that, another leap occurred: individual marks began to take on meaning, with some of them perhaps encoding numerical information

The Les Pradelles hyena bone is potentially the earliest known example of this type of mark-making, says D’Errico. He thinks that with further leaps, or what he dubs cultural exaptations, such notches eventually led to the invention of number signs such as 1, 2 and 37.

Overmann has developed her own hypothesis to explain how number systems might have emerged in prehistory — a task made easier by the fact that a wide variety of number systems are still in use around the world. For example, linguists Claire Bowern and Jason Zentz at Yale University in New Haven, Connecticut, reported in a 2012 survey that 139 Aboriginal Australian languages have an upper limit of ‘three’ or ‘four’ for specific numerals. Some of those languages use natural quantifiers such as ‘several’ and ‘many’ to indicate higher values

here is even one group, the Pirahã people of the Brazilian Amazon, that is sometimes claimed not to use numbers at all10.

In a 2013 study11, Overmann analysed anthropological data relating to 33 contemporary hunter-gatherer societies across the world. She discovered that those with simple number systems (an upper limit not much higher than ‘four’) often had few material possessions, such as weapons, tools or jewellery. Those with elaborate systems (an upper numeral limit much higher than ‘four’) always had a richer array of possessions.

In societies with complex number systems, there were clues to how those systems developed. Significantly, Overmann noted that it was common for these societies to use quinary (base 5), decimal or vigesimal (base 20) systems. This suggested to her that many number systems began with a finger-counting stage.

This finger-counting stage is important, according to Overmann. She is an advocate of material engagement theory (MET), a framework devised about a decade ago by cognitive archaeologist Lambros Malafouris at the University of Oxford, UK12. MET maintains that the mind extends beyond the brain and into objects, such as tools or even a person’s fingers. This extension allows ideas to be realized in physical form; so, in the case of counting, MET suggests that the mental conceptualization of numbers can include the fingers. That makes numbers more tangible and easier to add or subtract.

The societies that moved beyond finger-counting did so, argues Overmann, because they developed a clearer social need for numbers. Perhaps most obviously, a society with more material possessions has a greater need to count (and to count much higher than ‘four’) to keep track of objects.

An artefact such as a tally stick also becomes an extension of the mind, and the act of marking tally notches on the stick helps to anchor and stabilize numbers as someone counts.

some societies moved beyond tally sticks. This first happened in Mesopotamia around the time when cities emerged there, creating an even greater need for numbers to keep track of resources and people. Archaeological evidence suggests that by 5,500 years ago, some Mesopotamians had begun using small clay tokens as counting aids.

Overmann acknowledges that her hypothesis is silent on one issue: when in prehistory human societies began developing number systems. Linguistics might offer some help here. One line of evidence suggests that number words could have a history stretching back at least tens of thousands of years.

Evolutionary biologist Mark Pagel at the University of Reading, UK, and his colleagues have spent many years exploring the history of words in extant language families, with the aid of computational tools that they initially developed to study biological evolution. Essentially, words are treated as entities that either remain stable or are outcompeted and replaced as languages spread and diversif

Using this approach, Pagel and Andrew Meade at Reading showed that low-value number words (‘one’ to ‘five’) are among the most stable features of spoken languages14. Indeed, they change so infrequently across language families — such as the Indo-European family, which includes many modern European and southern Asian languages — that they seem to have been stable for anywhere between 10,000 and 100,000 years.

The district court agreed with the challengers that the law is unconstitutional, and it permanently blocked Kentucky from enforcing the law.

A divided 6th Circuit panel turned down Cameron’s request to join the case. It explained that Cameron’s plea had come “years into” the case, after both the district court’s ruling and the 6th Circuit’s opinion upholding that ruling. Granting a motion to intervene after the court of appeals has already issued its opinion, the court reasoned, would “provide potential intervenors every incentive to sit out litigation untill we issue a decision contrary to their preferences, whereupon they can spring into action.”

Cameron went to the Supreme Court in October 2020, asking the justices to weigh in on whether he should have been allowed to intervene and, if so, to send the case back to the lower courts for another look in light of their June 2020 decision in June Medical. In March 2021, the court agreed to take up only the procedural question.

In the Supreme Court, Cameron framed the case as a “dispute about a State’s sovereign ability to defend its laws.”

The attorney general’s office can’t enter the case now, the clinic wrote, because the office didn’t file a notice of appeal from the district court’s 2019 ruling. Allowing Cameron to intervene in the 6th Circuit in 2020, the clinic told the justices, “would create an impermissible end-run around Congress’s express statutory limits on appellate jurisdiction.”

there is no reason to disturb the denial of that motion by the court of appeals.

Arizona and 22 other states filed a “friend of the court” brief supporting Cameron in which they described the question presented by the case as one “of profound substantive importance to our democratic system of governance.” “States,” they wrote, “have a compelling and indisputable sovereign interest in defending the constitutionality of their laws when challenged in federal court.”

It can be hypocritical to call for a change in the law but to act in ways that would violate the changed law.

Nonetheless, it would not be hypocritical for Sheila herself to continue to drive on the left side of the road while Parliament considers her proposal. Indeed, it would be grossly irresponsible for her to start driving on the right side of the road before the law has changed.

The upshot is that it is sometimes but not always hypocritical to seek to change the law but continue to engage in behavior inconsistent with the change one seeks. Whether the charge of hypocrisy fairly applies in such circumstances depends on the nature of the law—to what extent it addresses freestanding evils versus solves collective action problems—as well as the grounds for seeking to change it.

Gerrymandering unfairly advantages the party in control of the state legislature, thereby undermining the right to vote and democratic principles. One might therefore think that someone who opposes political gerrymandering anywhere ought to oppose it everywhere. If so, New York legislators considering gerrymandering the state’s congressional districts to aid Democrats are indeed hypocrites.

Two years ago, in Rucho v. Common Cause, the Supreme Court held that federal courts could not adjudicate challenges to political gerrymandering.

Accordingly, even if one concludes that there is at least a soupçon of hypocrisy in the New York Democrats’ plan to gerrymander the state’s congressional districts, the only current alternative is worse. In this case, hypocrisy may be more than the tribute vice pays to virtue. It is itself a kind of virtue.

All or nothing, nothing or all.

it was not hard to discern what was happening: Reports of Trump supporters refusing to wear masks in big-box stores or indoor campaign events seemed to make liberals more inclined to wear masks even when outdoors with few people around; seeing mask wearing turned into a political statement, more partisan talisman than necessary tool, in turn made many conservatives less likely to mask up indoors when the circumstances justified it.

It might be tempting to chalk up the uniformity of Germans’ behavior to their penchant for rule-following

No, it seems to me that the likelier explanation for the less polarized approach to virus mitigation behavior is that Germany is, well, much less polarized. Politics are so consensus-driven here that for the past eight years Germany has had a governing coalition consisting of the two largest parties.

The difference between the share of Germans on the ideological right and left who thought there should have been fewer restrictions on public activity was 20 percentage points, a Pew survey found early this summer. In the United States, the difference between right and left on that question was a whopping 45 points, by far the largest gap of any country surveyed

The overall effect is of an environment set at a lower temperature, far closer to normalcy, where the public space is not forever on the verge of flaring into a divisive battleground of signaling, judgments and resistance.

Mr. Scholz invoked the unity and sense of purpose that Germany had demonstrated during the pandemic as his model for bringing the country together to confront other challenges, such as climate change. “We saw in this corona crisis that we can hold together, that solidarity is possible in this country,” he said.

“Whether the Delta variant is already at that plateau, or whether there’s going to be further increases before it gets to that plateau, I can’t say. But I do think that plateau exists.”

Antibodies, which can prevent the virus from entering our cells, are engineered to latch onto specific molecules on the surface of the virus, snapping into place like puzzle pieces. But genetic mutations in the virus can change the shape of those binding sites.

“If you change that shape, you can make it impossible for an antibody to do its job,”

But as more people acquire antibodies against the virus, mutations that allow the virus to slip past these antibodies will become even more advantageous.

The good news is that there are many different kinds of antibodies, and a variant with a few new mutations is unlikely to escape them all, experts said.

its sleeve to counteract the evolution of the virus,” Dr. Pepper said. “Knowing that there is this complex level of diversity in the immune system allows me to sleep better at night.”

“It’s a lot harder to evade T cell responses than antibody responses,”

And then there are B cells, which generate our army of antibodies. Even after we clear the infection, the body keeps churning out B cells for a while, deliberately introducing small genetic mutations. The result is an enormously diverse collection of B cells producing an array of antibodies, some of which might be a good match for the next variant that comes along.

Whether the virus will become more virulent — that is, whether it will cause more serious disease — is the hardest to predict,

Unlike transmissibility or immune evasion, virulence has no inherent evolutionary advantage.

Some scientists predict that the virus will ultimately be much like the flu, which can still cause serious illness and death, especially during seasonal surges.

“The virus has no interest in killing us,” Dr. Metcalf said. “Virulence only matters for the virus if it works for transmission.”

It is too early to say whether SARS-CoV-2 will change in virulence over the long-term. There could certainly be trade-offs between virulence and transmission; variants that make people too sick too quickly may not spread very far.

Then again, this virus spreads before people become severely ill. As long as that remains true, the virus could become more virulent without sacrificing transmissibility.

Moreover, the same thing that makes the virus more infectious — faster replication or tighter binding to our cells — could also make it more virulent.

Although many possible paths remain open to us, what is certain is that SARS-CoV-2 will not stop evolving — and that the arms race between the virus and us is just beginning.

We lost the first few rounds, by allowing the virus to spread unchecked, but we still have powerful weapons to bring to the fight. The most notable are highly effective vaccines, developed at record speed. “I think there is hope in the fact that the SARS-CoV-2 vaccines at this point are more effective than flu vaccines have probably ever been,”

“I have great faith that we can sort any detrimental evolutionary trajectories out by improving our current or next generation vaccines,”

be you have a re-infection, but it’s relatively mild, which also boosts your immunity,”

rising vaccination rates may already be suppressing new mutations.And the evolution rate could also slow down as the virus becomes better adapted to humans.

“There’s low-hanging fruit,” Dr. Lauring said. “So there are certain ways it can evolve and make big improvements, but after a while there aren’t areas to improve — it’s figured out all the easy ways to improve.”

Eventually, as viral evolution slows down and our immune systems catch up, we will reach an uneasy equilibrium with the virus, scientists predict. We will never extinguish it, but it will smolder rather than rage.

So far, studies suggest that our antibody, T cell and B cell responses are all working as expected when it comes to SARS-CoV-2. “This virus is mostly playing by immunological rules we understand,”

Others are more optimistic. “My guess is that one day this is going to be another cause of the common cold,”

There are four other coronaviruses that have become endemic in human populations. We are exposed to them early and often, and all four mostly cause run-of-the-mill colds.

much of the world remains unvaccinated, and this virus has already proved capable of surprising us. “We should be somewhat cautious and humble about trying to predict what it is capable of doing in the future,”

While we can’t guard against every eventuality, we can tip the odds in our favor by expanding viral surveillance, speeding up global vaccine distribution and tamping down transmission until more people can be vaccinated

The future, he said, “depends much, much more on what humans do than on what the virus does.”

From Reagan through Romney, the Republicans valorized entrepreneurs, C.E.O.s and Wall Street.

The Democratic Party became dominated by people in the creative class, who attended competitive colleges, moved to affluent metro areas, married each other and ladled advantages onto their kids so they could leap even farther ahead.

There was a bipartisan embrace of a culture of individualism, which opens up a lot of space for people with resources and social support but means loneliness and abandonment for people without. Four years of college became the definition of the good life, which left roughly two-thirds of the country out.

so came the crisis that Biden was elected to address — the poisonous combination of elite insularity and vicious populist resentment.

Read again Robert Kagan’s foreboding Washington Post essay on how close we are to a democratic disaster.

They are willing to torch our institutions because they are so resentful against the people who run them.

The Democratic spending bills are economic packages that serve moral and cultural purposes. They should be measured by their cultural impact, not merely by some wonky analysis.

In real, tangible ways, they would redistribute dignity back downward. They would support hundreds of thousands of jobs for home health care workers, child care workers, construction workers, metal workers, supply chain workers. They would ease the indignity millions of parents face having to raise their children in poverty.

Biden had it exactly right when he told a La Crosse, Wis., audience, “The jobs that are going to be created here — largely, it’s going to be those for blue-collar workers, the majority of whom will not have to have a college degree to have those jobs.”

we’re a nation enduring a national rupture, and the most violent parts of it may still be yet to come.

These packages say to the struggling parents and the warehouse workers: I see you. Your work has dignity. You are paving your way. You are at the center of our national vision.

This is how you fortify a compelling moral identity, which is what all of us need if we’re going to be able to look in the mirror with self-respect. This is the cultural transformation that good policy can sometimes achieve. Statecraft is soulcraft.

These measures would not solve our problems, obviously. In many large Western nations, there are vast tectonic forces concentrating wealth in the affluent metro areas and leaving vast swaths of the countryside behind. We don’t yet know how to do the sort of regional development that reverses this trend.

e can make it clear that we value people’s choices. For years, there was almost an officially approved life: Get a B.A., move to those places where capital and jobs are congregating, even if it means leaving your community, roots and extended family.

in parts of sub-Saharan Africa children contract malaria six times a year on average. Each year more than 260,000 African children die of it before their fifth birthdays.

Those who survive often suffer lifelong harm, including stunting, a form of impaired growth that affects the ability to learn.

the WHO says that the vaccine was found to be safe after more than 2.3m doses had been administered—clearing the air on three “safety signals” that had popped up in an earlier trial.

In 2018 a different whistleblower outed Facebook for its sketchy collaboration with Cambridge Analytica, a research organisation that allowed users’ data to be collected without their consent and used for political profiling by Donald Trump’s campaign. Facebook’s founder, Mark Zuckerberg, went to Washington, DC to apologise, and in 2019 America’s consumer-protection agency, the Federal Trade Commission, agreed to a $5bn settlement with Facebook. That is the largest fine ever levied against a tech firm.

Congress has repeatedly called in tech bosses for angry questioning and public shaming without taking direct action afterwards.

Senators, who cannot agree on such uncontroversial things as paying for the government’s expenses, united against a common enemy and promised Ms Haugen that they would hold Facebook to account.

Congress could update and strengthen the Children’s Online Privacy Protection Act (COPPA), which was passed in 1998 and bars the collection of data from children under the age of 13.

If Congress does follow through with legislation, it is likely to focus narrowly on protecting children online, as opposed to broader reforms, for which there is still no political consensus.

Social media’s harmful effects on children and teenagers is a concern that transcends partisanship and is easier to understand than sneaky data-gathering, viral misinformation and other social-networking sins.

Other legislative proposals take aim at manipulative marketing and design features that make social media so addictive for the young.

However, Ms Haugen’s most significant impact on big tech may be inspiring others to come forward and blow the whistle on their employers’ malfeasance.

“A case like this one opens the floodgates and will trigger hundreds more cases,” predicts Steve Kohn, a lawyer who has represented several high-profile whistleblowers.

One is the industry’s culture of flouting rules and a history of non-compliance. Another is a legal framework that makes whistleblowing less threatening and more attractive than it used to be.

The Dodd-Frank Act, which was enacted in 2010, gives greater protections to whistleblowers by preventing retaliation from employers and by offering rewards to successful cases of up to 10-30% of the money collected from sanctions against a firm.

If the threat of public shaming encourages corporate accountability, that is a good thing. But it could also make tech firms less inclusive and transparent, predicts Matt Perault, a former Facebook executive who is director of the Centre for Technology Policy at the University of North Carolina at Chapel Hill.

People may become less willing to share off-the-wall ideas if they worry about public leaks; companies may become less open with their staff; and executives could start including only a handful of trusted senior staff in meetings that might have otherwise been less restricted.

Facebook and other big tech firms, which have been criticised for violating people’s privacy online, can no longer count on any privacy either.

In interviews, former students described Mr. Maynard as anxious, troubled and, at times, inappropriate. One said he often taught his classes during the pandemic via Zoom from a darkened bedroom, revealing details about an ailing father, a lawsuit against his former landlord and his battles with his mental health.

Last year, his life appearing to unravel further, Mr. Maynard lived in his car, according to court documents. As he traversed Northern California, he sent messages to students that included rantings, as well as links to YouTube videos — meandering footage of trees and mountains — in which he ruminated on the state of the world. He also appeared fascinated by arson.

one frequently offered explanation is having a desire to serve in the military, but being excluded from doing so.

part of the Oath Keepers’ attraction to disabled veterans like himself is that it offers a way to serve beyond their time in the military, in the absence of other “boots on the ground fraternal organizations” that might provide outlets to carry out a drive to be “guardians and warriors.”

I often think about how many Americans sacrificed to make this country great. John Adams wrote that “it was the Duty of a good Citizen to sacrifice all to his Country.” Or, as the classic film Team America taught us: “Freedom isn’t free.”

Our country began with a willingness to make personal sacrifices for the collective good. It’s right there in the closing line of the Declaration of Independence: “We mutually pledge to each other our Lives, our Fortunes and our sacred Honor.”

Our country became great because every generation before us knew that liberty and duty go hand in hand. I am worried that many of my fellow Americans have now lost sight of that.

When I look at the response to this pandemic, I really worry about the future of our country. We have lost more than 600,000 Americans to COVID-19. Are we really this selfish and angry? Are we this partisan?

George Washington wrote, “Every post is honorable in which a man can serve his country.” When we wear a mask or get a vaccine, we are serving our country and our fellow citizens.

When people call this fascism, I can’t stand it. Just a few generations ago, this country stood up to real fascism. (And yes, I know that my father was on the wrong side of that conflict.) And we didn’t win just because of our love of freedom. We won because Americans came together and did their duty.

“Wearing a mask is nothing compared with what we were going through then,” one member of that generation, Bill Platts, recently told the Idaho Statesman. “It’s so comical nowadays to think that somebody won’t wear a mask when in those days they would do anything for the United States.”

We are fighting a war against what President Donald Trump correctly called an “invisible enemy.” Hospitals are once again filling up in some states. Deaths are rising.

Some people want to create an alternative America, where we have no responsibility to one another. That America has never existed.

They may tell you that what we are doing to fight the war against the coronavirus is unprecedented. They’re full of crap. They are lying to you because they make money from your anger.

As Americans, we have agreed to vaccinations to eradicate diseases since George Washington mandated the smallpox inoculation for his troops. “Upon the principle of self-defense, of paramount necessity, a community has the right to protect itself against an epidemic of disease which threatens the safety of its members,” the Supreme Court said in 1905, in a ruling supporting vaccine mandates.

We need to prove to ourselves and to the world that we can unite to defeat a common enemy, because, trust me, the coronavirus is not the biggest challenge we will face this century.What will you do for your country?

The problem was that, once the initial euphoria wore off, the public wasn’t much interested in it. Coverage in print media remained solid, but cable-news coverage of Afghanistan dropped off quickly, especially once

“America’s not at war” was a common refrain among the troops. “We’re at war. America’s at the mall.”

now those same Americans have the full withdrawal from Afghanistan they apparently want: Some 70 percent of the public supports a pullout.

Not that they care that intensely about it; as the foreign-policy scholar Stephen Biddle recently observed, the war is practically an afterthought in U.S. politics. “You would need an electron microscope to detect the effect of Afghanistan on any congressional race in the last decade,” Biddle said early this year. “It’s been invisible.”

What the public does care about, however, is using Afghanistan as raw material for cheap patriotism and partisan attacks (some right and some wrong, but few of them in good faith) on every president since 2001.

nor did they want to think about whether “draining the swamp” and modernizing and developing Afghanistan (which would mean a lot more than a few elections) was worth the cost and effort.

Maybe it would have been worth it. Or maybe such a project was impossible. We’ll never know for certain, because American political and military leaders only tried pieces of several strategies, never a coherent whole, mostly to keep the costs and casualties down and to keep the war off the front pages and away from a public that didn’t want to hear about it

Nor did Americans ever consider whether or when Afghanistan, as a source of terrorist threats to the U.S., had been effectively neutralized. Nothing is perfect, and risks are never zero. But there was no time at which we all decided that “close enough” was good enough, and that we’d rather come home than stay.

Biden’s policy, of course, is not that different from Trump’s, despite all the partisan howling about it from Republicans. As my colleague David Frum has put it: “For good or ill, the Biden policy on Afghanistan is the same as the Trump policy, only with less lying.”

But as comforting as it would be to blame Obama and Trump, we must look inward and admit that we told our elected leaders—of both parties—that they were facing a no-win political test. If they chose to leave, they would be cowards who abandoned Afghanistan. If they chose to stay, they were warmongers intent on pursuing “forever war.”

A serious people—the kind of people we once were—would have made serious choices, long before this current debacle was upon them. They would today be trying to learn something from nearly 2,500 dead service members and many more wounded

Biden was right, in the end, to bite the bullet and refuse to pass this conflict on to yet another president

His execution of this resolve, however, looks to be a tragic and shameful mess and will likely be a case study in policy schools for years to come. But there was no version of “Stop the forever war” that didn’t end with the fall of Kabul

before we move on, before we head back to the mall, before we resume posting memes, and before we return to bickering with each other about whether we should have to mask up at Starbuck’s, let us remember that this day came about for one reason, and one reason only.Because it is what we wanted.

If a less democratic world is needed to deal with the climate, who are the people who’d like to bring a less democratic world into being?

The aim is not to reach net zero faster – neither party has laid out workable plans to do so – but to endear climate-conscious voters to an ethno-nationalist cause.

It’s not just the right, however, that has considered a turn away from democracy for the planet’s sake.

As much as US and UK liberals have talked up the promise of spreading democracy throughout the world this century, though, many centrists – as the Progressive International’s David Adler wrote in 2018 – are pretty down on democracy itself. Analysing the World Values and the European Values surveys, Adler found that centrists in wealthy countries were less supportive of democracy than their counterparts on either the left or the far right. Less than half of centrists in the US thought elections were essential; only 25% saw civil rights as a critical feature of democracy.

Actually existing centrist politicians, meanwhile, such as Emmanuel Macron in France, haven’t shown any willingness to address the climate crisis at the speed or scale it demands.

Openly authoritarian governments hardly fare better. China has rolled out an impressive array of green technologies over the last decade with massive industrial policy. Yet still it continues to prioritise fossil-fuelled growth, with its 14th five-year plan pledging to reduce “emissions intensity” by just 18% through 2025, and the planned opening of 43 new coal-fuelled power stations

But India, like China, has missed the deadline to update its emissions reduction plan in advance of UN climate talks in Glasgow this November.

There is simply no class of enlightened technocrats in powerful governments waiting in the wings to save the day.

A proposal for curbing emissions from the developed world so that the billion individuals who live without electricity can enjoy its benefits would probably pass in a landslide in a world referendum,” the writer and filmmaker Astra Taylor has argued, “but it would likely fail if the vote were limited to people in the wealthiest countries.”

In the less upbeat SSP3, “resurgent nationalism” and “concerns about competitiveness and security” start to emerge as countries go their own way in trying to adapt to and (more rarely) mitigate rising temperatures.

A best-case scenario detailed in their report by IPCC scientists, Shared Socioeconomic Economic Pathway 1, involves “more inclusive development” and unprecedented collaboration among the world’s governments to manage the global commons

The best hope in the short term is for a popular front to browbeat the middling centrists who claim to “believe science” into actually acting on it, and beating back the illiberal right accordingly.

He sounded a similar alarm in his final lecture at Yale, in 2013. Liberal education, he said, was failing to provide students with a common set of values and the tools to make sense of the world.

“I find a kind of cultural void and ignorance of the past, a sense of rootlessness and aimlessness, as though not only the students but the whole world was born yesterday,”

The world that emerges from the pandemic will be shaped by an adversarial rivalry that is not just about each side’s relative power, but has become an existential competition as each side strives to demonstrate the superiority of its system of government.

Starting with the Winter Olympics in February and culminating with the 20th Communist Party congress later in the year, China will stage a series of tightly choreographed events designed to project the competence, clout and all-round superiority of party rule, and formalise Mr Xi’s position at its helm beyond the ten-year tenure that has hitherto been the norm.

As the year goes on, the near certainty that, health permitting, Mr Trump will be the Republican presidential candidate in 2024 means America’s political debate will be overshadowed by fears of the biggest constitutional crisis since the civil war.

If the theatre of politics makes Western democracy look dysfunctional relative to Chinese autocracy, 2022 may offer a different verdict on which system delivers the most competent economic management. From tech companies to post-pandemic reopening, China and America are taking starkly divergent approaches to similar challenges

America and the rest of the West will move into a living-with-covid mindset. The disease will not disappear, but become endemic. Booster jabs will become the norm, remaining travel restrictions will be relaxed and lockdowns will become a thing of the past

China, by contrast, will stick with a zero-covid policy throughout 2022. Having terrified its citizens about the disease and touted its toughness as a mark of superiority, China’s government cannot easily change course. The country will remain walled off from the rest of the world with long quarantines and sharply restricted travel.

In both of these cases, China’s draconian approach will eventually cause economic damage.

All this will complicate China’s already challenging macroeconomic environment. China-watchers have worried for years about the consequences of unwinding the country’s enormous property boom and the jaw-dropping levels of debt that accompanied it. The crisis at Evergrande, a huge developer, suggests that this tricky transition is at last under way. It will dominate 2022 as other property-related firms fail. Add to that structural challenges, from a shrinking workforce to a rapidly growing number of old-age dependents, and the economic pressures are considerable. Annual GDP growth could fall to 5%

With covid-19 behind it, its fiscal tightening mostly complete and (assuming some version of Mr Biden’s bill is passed) with a long-overdue effort to improve infrastructure under way, America’s economy could grow smartly, even as its politics frays. GDP growth of 4%, not far off China’s, is plausible.

in theory the two sides could make progress in plenty of areas, such as devising a sensible deal on trade and technology to replace the tariffs of the Trump era; agreeing on a common approach to cyber-security, nuclear non-proliferation or the militarisation of space; or finding ways to accelerate the clean-energy transition in the wake of the COP26 climate meeting in Glasgow.

The good news is that a military confrontation seems unlikely in 2022. The overriding need to preserve stability in the run-up to the party congress will discourage China from adventurism or excessive sabre-rattling, whether around Taiwan or in the South China Sea. The bad news is that the Thucydides Trap will not have gone away.