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Opinion | Why Are There So Few Courageous Senators? - The New York Times - 0 views

  • This doesn’t just mean old politicians — today’s average senator is, after all, over 60. It means senators with the stature to stand alone
  • As a septuagenarian who entered the Senate after serving as his party’s presidential nominee, Mr. Romney contrasts sharply with up-and-comers like Josh Hawley and Ted Cruz, who seem to view the institution as little more than a steppingstone to the White House. But historically, senators like Mr. Romney who have reached a stage of life where popularity matters less and legacy matters more have often proved better able to defy public pressure.
  • Not every Republican senator nearing retirement exhibited Mr. Romney or Mr. McCain’s bravery. Lamar Alexander of Tennessee, an octogenarian former presidential candidate himself, voted not only against impeaching Mr. Trump last January, but against even subpoenaing witnesses.
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  • Courage cannot be explained by a single variable. Politicians whose communities have suffered disproportionately from government tyranny may show disproportionate bravery in opposing it. Mr. Romney, like the Arizona Republican Jeff Flake — whose opposition to Mr. Trump likely ended his senatorial career — belongs to the Church of Jesus Christ of Latter-day Saints, which was once persecuted on American soil. In the fevered days after Sept. 11, the only member of Congress to oppose authorizing the “war on terror” was a Black woman, Barbara Lee.
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Middle Ages - Definition, Timeline & Facts - HISTORY - 0 views

  • People use the phrase “Middle Ages” to describe Europe between the fall of Rome in 476 CE and the beginning of the Renaissance in the 14th century.
  • The phrase “Middle Ages” tells us more about the Renaissance that followed it than it does about the era itself.
  • European thinkers, writers and artists began to look back and celebrate the art and culture of ancient Greece and Rome.
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  • the Catholic Church became the most powerful institution of the medieval period.
  • After the prophet Muhammad’s death in 632 CE, Muslim armies conquered large parts of the Middle East, uniting them under the rule of a single caliph
  • Under the caliphs, great cities such as Cairo, Baghdad and Damascus fostered a vibrant intellectual and cultural life
  • Crusaders, who wore red crosses on their coats to advertise their status, believed that their service would guarantee the remission of their sins and ensure that they could spend all eternity in Heaven.
  • No one “won” the Crusades; in fact, many thousands of people from both sides lost their lives.
  • Romanesque cathedrals are solid and substantial: They have rounded masonry arches and barrel vaults supporting the roof, thick stone walls and few windows.
  • Gothic structures, such as the Abbey Church of Saint-Denis in France and the rebuilt Canterbury Cathedral in England, have huge stained-glass windows, pointed vaults and arches (a technology developed in the Islamic world), and spires and flying buttresses. In contrast to heavy Romanesque buildings, Gothic architecture seems to be almost weightless.
  • illuminated manuscripts: handmade sacred and secular books with colored illustrations, gold and silver lettering and other adornments.
  • Between 1347 and 1350, a mysterious disease known as the " Black Death " (the bubonic plague) killed some 20 million people in Europe—30 percent of the continent’s population.
  • Symptoms of the Black Death included fever, chills, vomiting, diarrhea, terrible aches and pains – and then death. Victims could go to bed feeling healthy and be dead by morning.
  • The plague killed cows, pigs, goats, chickens and even sheep, leading to a wool shortage in Europe.
  • Today, scientists know the plague was caused by a bacillus called Yersina pestis, which travels through the air and can also be contracted through the bite of an infected flea or rat, both of which were common in the Middle Ages, especially on ships. 
  • In a feudal society, the king granted large pieces of land called fiefs to noblemen and bishops. Landless peasants known as serfs did most of the work on the fiefs: They planted and harvested crops and gave most of the produce to the landowner. In exchange for their labor, they were allowed to live on the land.
  • By 1300, there were some 15 cities in Europe with a population of more than 50,000.
  • The Renaissance was a time of great intellectual and economic change, but it was not a complete “rebirth”: It had its roots in the world of the Middle Ages.
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The Not-So-Soft Bigotry of COVID Indifference - The Bulwark - 0 views

  • As the coronavirus pandemic continues to cut a wide swath through American communities, many have started to ignore it or, worse, rationalize the country’s mounting losses as a “sad but unavoidable” fact of life. The “sadness” appears to be of a very limited type. A recent poll found nearly 60 percent of Republicans view the deaths we’ve experienced as “acceptable.
  • There may be a relatively simple explanation for this complacency: the pandemic has disproportionately affected populations that are mostly out of sight and mind for the majority of Americans
  • COVID-19, for much of America, is something that happens to other people and many of the others are very old, very poor, people of color, or some combination of all these characteristics.
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  • Our real concern, the logic goes, should be for younger people who have their whole lives ahead of them and are sacrificing their economic futures to lockdowns. This collapse of the inter-generational compact has been far more effective at killing them off than any death panel dreamed up in Sarah Palin’s fevered imagination.
  • Similarly, ethnic and racial minorities including African Americans, Latinos/Hispanics, and Native Americans have all been disproportionately affected by COVID-19
  • Farm and food processing workers—dominated by Latino and other immigrant workers—are another population that has disproportionately been affected by COVID-19.
  • That social reciprocity has broken down to this degree ought to be an embarrassment and shame to us all.
  • Heavily agricultural regions like California’s Central Valleyand Washington State’s Yakima Valley have seen huge COVID spikes. In response, the U.S. Department of Labor has so far levied just $29,000 in fines against two companies, Smithfield and JBS, who have combined sales of $65 billion per year.
  • Adding to the misery of COVID-vulnerable populations is an unfortunate, and very human, tendency to find reasons to blame disadvantaged groups for their illness.
  • Reviewing the data and history pandemic discrimination, it’s hard to escape the conclusion that the majority of America has concluded that these groups—the poor, the minority, the imprisoned, and the elderly—are the “acceptable” losses.
  • Were the situation reversed and the white, middle aged, and middle/upper classes the primary victims of the pandemic—one of the features of the 1918 influenza—COVID-19 would be a true national emergency and there would be far less complaining about disrupted schools, work, and social life brought about by social distancing requirements and economic shutdowns
  • Last are the millions of Americans behind bars. Per statistics from the Marshall Project, there have been more than 121,000 COVID-19 cases reported among prisoners and more than a thousand deaths.
  • The message seems to be that Americans have abandoned e pluribus unum (out of many, one) for “everyone—or at least every group—for themselves.”
  • Pro-lifers have for decades protested American indifference to the deaths of millions of unborn children (another invisible and voiceless minority), and they have been right to do so. Where are these champions of human life when other weak and vulnerable populations are dying at the rate of a thousand a week or more?
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Addressing climate change post-coronavirus | McKinsey - 0 views

  • Addressing climate change in a post-pandemic world
  • the coronavirus outbreak seems to indicate that the world at large is equally ill prepared to prevent or confront either.
  • By contrast, financial shocks—whether bank runs, bubble bursts, market crashes, sovereign defaults, or currency devaluations—are largely driven by human sentiment, most often a fear of lost value or liquidity.
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  • Physical shocks, however, can only be remedied by understanding and addressing the underlying physical causes. Our recent collective experience, whether in the public or the private sector, has been more often shaped by financial shocks, not physical ones. The current pandemic provides us perhaps with a foretaste of what a full-fledged climate crisis could entail
  • Pandemics and climate risk also share many of the same attributes. Both are systemic, in that their direct manifestations and their knock-on effects propagate fast across an interconnected world.
  • They are both nonstationary, in that past probabilities and distributions of occurrences are rapidly shifting and proving to be inadequate or insufficient for future projections.
  • Both are nonlinear, in that their socioeconomic impact grows disproportionally and even catastrophically once certain thresholds are breached
  • They are both risk multipliers, in that they highlight and exacerbate hitherto untested vulnerabilities inherent in the financial and healthcare systems and the real economy
  • Both are regressive, in that they affect disproportionally the most vulnerable populations and subpopulations of the world.
  • Finally, neither can be considered as a “black swan,” insofar as experts have consistently warned against both over the years
  • They also require a present action for a future reward that has in the past appeared too uncertain and too small given the implicit “discount rate.” This is what former Bank of England Governor Mark Carney has called the “tragedy of the horizon.”
  • addressing pandemics and climate risk requires the same fundamental shift, from optimizing largely for the shorter-term performance of systems to ensuring equally their longer-term resiliency
  • The coronavirus pandemic and the responses that are being implemented (to the tune of several trillion dollars of government stimulus as of this writing) illustrate how expensive the failure to build resiliency can ultimately prove
  • In climate change as in pandemics, the costs of a global crisis are bound to vastly exceed those of its prevention.
  • both reflect “tragedy of the commons” problems, in that individual actions can run counter to the collective good and deplete a precious, common resource.
  • Neither pandemics nor climate hazards can be confronted without true global coordination and cooperation
  • there are also some notable differences between pandemics and climate hazards.
  • A global public-health crisis presents imminent, discrete, and directly discernable dangers, which we have been conditioned to respond to for our survival.
  • The risks from climate change, by contrast, are gradual, cumulative, and often distributed dangers that manifest themselves in degrees and over time.
  • What lessons can be learned from the current pandemic for climate change? What implications—positive or negative—could our pandemic responses hold for climate action?
  • the timescales of both the occurrence and the resolution of pandemics and climate hazards are different.
  • What this means is that a global climate crisis, if and when ushered in, could prove far lengthier and far more disruptive than what we currently see with the coronavirus (if that can be imagined).
  • Finally, pandemics are a case of contagion risk, while climate hazards present a case of accumulation risk.
  • Contagion can produce perfectly correlated events on a global scale (even as we now witness), which can tax the entire system at once; accumulation gives rise to an increased likelihood of severe, contemporaneous but not directly correlated events that can reinforce one another.
  • Climate change—a potent risk multiplier—can actually contribute to pandemics
  • For example, rising temperatures can create favorable conditions for the spread of certain infectious, mosquito-borne diseases, such as malaria and dengue fever, while disappearing habitats may force various animal species to migrate, increasing the chances of spillover pathogens between them.
  • Third, investors may delay their capital allocation to new lower-carbon solutions due to decreased wealth.
  • Factors that could support and accelerate climate action
  • For starters, certain temporary adjustments, such as teleworking and greater reliance on digital channels, may endure long after the lockdowns have ended, reducing transportation demand and emissions
  • Second, supply chains may be repatriated, reducing some Scope 3 emissions (those in a company’s value chain but not associated with its direct emissions or the generation of energy it purchases)
  • Third, markets may better price in risks (and, in particular, climate risk) as the result of a greater appreciation for physical and systemic dislocations.
  • There may, additionally, be an increased public appreciation for scientific expertise in addressing systemic issues.
  • there may also be a greater appetite for the preventive and coordinating role of governments in tackling such risks
  • Moreover, lower interest rates may accelerate the deployment of new sustainable infrastructure
  • lastly, the need for global cooperation may become more visible and be embraced more universally.
  • Factors that may hamper and delay climate action
  • Simultaneously, though, very low prices for high-carbon emitters could increase their use and further delay energy transition
  • A second crosscurrent is that governments and citizens may struggle to integrate climate priorities with pressing economic needs in a recovery
  • he environmental impact of some of the measures taken to counter the coronavirus pandemic have been seen by some as a full-scale illustration of what drastic action can produce in a short amount of time.
  • Finally, national rivalries may be exacerbated if a zero-sum-game mentality prevails in the wake of the crisis.
  • For governments, we believe four sets of actions will be important
  • First, build the capability to model climate risk and to assess the economics of climate change.
  • Second, devote a portion of the vast resources deployed for economic recovery to climate-change resiliency and mitigation
  • Third, seize the opportunity to reconsider existing subsidy regimes that accelerate climate change
  • Fourth, reinforce national and international alignment and collaboration on sustainability, for inward-looking, piecemeal responses are by nature incapable of solving systemic and global problems.
  • For companies, we see two priorities. First, seize the moment to decarbonize, in particular by prioritizing the retirement of economically marginal, carbon-intensive assets
  • Second, take a systematic and through-the-cycle approach to building resilience.
  • For all—individuals, companies, governments, and civil society—we see two additional priorities. First, use this moment to raise awareness of the impact of a climate crisis, which could ultimately create disruptions of great magnitude and duration.
  • That includes awareness of the fact that physical shocks can have massive nonlinear impacts on financial and economic systems and thus prove extremely costly.
  • Second, build upon the mindset and behavioral shifts that are likely to persist after the crisis (such as working from home) to reduce the demands we place on our environment—or, more precisely, to shift them toward more sustainable sources.
  • Moving toward a lower-carbon economy presents a daunting challenge, and, if we choose to ignore the issue for a year or two, the math becomes even more daunting.
  • it is also critical that we begin now to integrate the thinking and planning required to build a much greater economic and environmental resiliency as part of the recovery ahead.
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A Timeline of Trump's Symptoms and Treatments - The New York Times - 1 views

  • A timeline of events about the president’s illness is drawn from his tweets, news conferences, statements from the White House and reporting from The New York Times.
  • A timeline of events about the president’s illness is drawn from his tweets, news conferences, statements from the White House and reporting from The New York Times.
  • Mr. Trump and his team traveled to Minnesota for a rally that lasted about 45 minutes — about half the length of his typical campaign speeches.
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  • On the return trip, Mr. Trump slept as some of his advisers spoke about the condition of Ms. Hicks, who was isolated in the back of the plane.
  • News that Ms. Hicks tested positive for the virus came as Mr. Trump left the White House by helicopter around 1 p.m. for a fund-raiser at his golf club in Bedminster, N.J.
  • On a call with Iowa voters and in an interview with Sean Hannity on Fox News, Mr. Trump sounded raspy.Later that night, Mr. Trump and the first lady, Melania Trump, tested positive for the coronavirus, officials said.The president had a mild cough, nasal congestion and fatigue.
  • Close to 1 a.m., Mr. Trump said on Twitter that he and the first lady had tested positive for the coronavirus.
  • Later in the morning, Mr. Trump had a high fever and his oxygen saturation levels dipped below 94 percent, Dr. Sean Conley, the White House physician, said.
  • After about a minute on two liters of supplemental oxygen, Mr. Trump’s saturation levels were back over 95 percent, Dr. Conley said. The president stayed on the supplemental oxygen for about an hour at the White House.
  • Mr. Trump received an 8-gram dose of an experimental polyclonal antibody cocktail. He also took zinc, vitamin D, famotidine, melatonin and aspirin.
  • The president also was given his first dose of remdesivir, an antiviral drug that has an emergency approval from the Food and Drug Administration as a Covid-19 therapy.
  • Mr. Trump has mild heart disease, similar to many men in their 70s. He also takes a statin drug to treat high cholesterol and aspirin to prevent heart attacks. His health summary, released in June, showed that he crossed the line into obesity at 244 pounds.
  • Mr. Trump was given a second dose of remdesivir and did not exhibit any known side effects, doctors said.
  • Doctors wanted him to eat, drink and be out of bed as much as possible.
  • Doctors were tracking any damage to his lungs for signs of pneumonia.“There’s some expected findings, but nothing of any major clinical concern,” Dr. Conley said.
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Trump: New details on Capitol insurrection are devastating indictment - CNNPolitics - 0 views

  • Impeachment prosecutors took senators on a wrenching journey inside the horror of the US Capitol insurrection, making a devastating case that Donald Trump had plotted, incited and celebrated a vile crime against the United States.
  • Surveillance footage depicted then-Vice President Mike Pence being hustled away with rioters calling for him to be hanged only yards away. A police officer screamed in pain, trapped between a door and an invading crowd. In a horrific scene, Trump supporter Ashli Babbitt tried to climb through a window smashed by rioters before falling back, shot dead by a Capitol Police officer.
  • The stunningly powerful presentation painted the most complete narrative yet of the assault on the Congress as it met to certify Joe Biden's election win on January 6.Read MoreTheir explicit and unsettling case made clear that the terror inside the corridors of power was even more frightening than it had first appeared. It's now apparent that only good luck, and the bravery of police, prevented senior members of Congress injured or killed.
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  • The managers built a methodical case, juxtaposing Trump's inflammatory behavior over months with the frightful looting and violence inside the Capitol to make a cause-and-effect argument of the ex-President's culpability.They showed how Trump had set out to undermine the election in the minds of his supporters weeks before votes were cast and demonstrated how his lies about fraud had acted like a fuse on the primed fury of his supporters after he lost.
  • Of course, impeachment is a political process, not a judicial one, so even the most compelling evidence will have little impact if jurors -- the 100 senators -- have already made up their minds. And most GOP members of the chamber want to avoid falling afoul of Trump's personality cult, after spending four years abetting his abuses of power in the most unchained presidency in history.
  • "Donald Trump sent them here on this mission," said Virgin Islands Del. Stacey Plaskett, one of the impeachment managers
  • "President Trump put a target on their backs and his mob broke into the Capitol to hunt them down," Plaskett said.One of her colleagues, Rep. Joe Neguse of Colorado, handled the evidence on how Trump had rebuffed calls, even from Republicans, to intervene in his role as President to protect another branch of government under assault.
  • And the House prosecutors laid out timelines that showed how the President had done nothing to stop the insurrection of a mob he referred to as "special people."
  • One video showed Sen. Mitt Romney, a Utah Republican, being saved from running into the mob by Capitol Police Office Eugene Goodman, who has previously been hailed as a hero for directing rioters away from the Senate chamber.
  • As the only Republican senator to vote to convict Trump in his first impeachment trial, Romney would have been in mortal danger had he encountered the Trump mob. Another video showed now-Senate Majority Leader Chuck Schumer, a New York Democrat, hurriedly reversing course with his security detail and running from the crowd.
  • Sen. Lisa Murkowski of Alaska, one of the Republicans seen as a possible vote to convict Trump, remarked on how the evidence brought home the "total awareness of that, the enormity of this, this threat, not just to us as people, as lawmakers, but the threat to the institution and what Congress represents. It's disturbing. Greatly disturbing."
  • Sen. Bill Cassidy of Louisiana was rebuked by his own state party for voting on Tuesday to allow the trial to proceed on constitutional grounds.
  • And Sen. Roy Blunt, who unlike Cassidy faces reelection in 2024, appeared to be among those searching for a way to justify a vote to spare Trump -- the first-ever twice-impeached President
  • "Well, you know, you have a summer where people all over the country are doing similar kinds of things. I don't know what the other side will show from Seattle and Portland and other places, but you're going to see similar kinds of tragedies there as well," Blunt said, drawing a comparison that stands up to serious scrutiny only in the fevered swamps of conservative media.
  • "Because hypocrisy is pretty large for these people, standing up to, you know, rioters when they came to my house, Susan Collins' house, I think this is a very hypocritical presentation by the House," Graham said.
  • Many Republican senators are adopting the questionable argument that it is not constitutional to try a president who was impeached while he was in office, once he has reverted to being a private citizen after his term ends.
  • "The question before all of you in this trial: Is this America?" the Maryland Democrat asked the senators seated in a chamber that was a crime scene on January 6."Can our country and our democracy ever be the same if we don't hold accountable the person responsible for inciting the violent attack against our country?"
  • But so far, senators have heard only one side of the story and fair legal process requires the ex-President to have a robust defense.
  • But their widely criticized and confusing opening statements on Tuesday, which infuriated the former President, did not suggest they have the evidentiary case or presentational skills of the House managers.
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Opinion | America Looks Hopelessly Broke. It Isn't. - The New York Times - 0 views

  • The Price of Peace,” Zachary Carter’s incisive biography of the British economist John Maynard Keynes, which illustrates the awesome power of economic theory to alter the fates of nations and the lives of millions of people.
  • “The Deficit Myth,” in which the economist Stephanie Kelton convincingly overturns the conventional wisdom that federal budget deficits are somehow bad for the nation.
  • Together, they suggest a compelling political, moral and economic case for the federal government to begin to do, again, what it once saw as its duty — to make big, bold and even expensive investments to improve the lives of Americans, and perhaps of people around the world.
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  • whenever anyone is brave enough to suggest that the government itself should provide useful services to Americans — whether big-ticket items like health care, child care and college education, or smaller things like an upgraded electric grid or a national broadband service — the first reaction from many on the right and the left is one of defeat and resignation. “How will you pay for it?” they ask. And, often, the whole conversation stops right there, because with a $26.5 trillion national debt, America looks hopelessly broke.
  • t is not. Kelton argues that our government’s inability to provide for citizens isn’t due to a lack for money; instead, our leaders lack political will.
  • Modern Monetary Theory, or M.M.T. The theory argues that because the government is in charge of its own currency, it cannot “run out” of money the way a household or a business can, and it therefore does not need to raise taxes to fund government spending.
  • Instead of being constrained by deficits, Kelton and other M.M.T.ers argue, policymakers should care about “real” measures of economic activity: unemployment and inflation.
  • Whatever the deficit, if unemployment is rife, it’s an indication that aggregate demand is low; to boost demand, the government can freely spend, spend, spend — and should stop spending only when there is a danger that it will lead to a rise in prices — that is, inflation
  • In practice, Kelton and other M.M.T.ers propose a federal jobs guarantee, in which the government would hire anyone who needs a job for a set wage. The policy, she argues, would promote full employment while keeping inflation stable.
  • in the 40 years since Ronald Reagan won the White House, both the left and the right have been unnecessarily obsessed with deficits, to the detriment of the well-being of citizens.
  • The cruelest example of this mind-set occurred after the Great Recession in 2008. At the time, many experts suggested that an adequate response to the downturn would require the government to spend a trillion dollars or more to boost demand. Instead, Obama and his aides, worried about sticker shock, lowballed their stimulus, and millions of people remained unemployed.
  • Keynesianism “is not so much a school of economic thought as a spirit of radical optimism, unjustified by most of human history and extremely difficult to conjure up precisely when it is most needed: during the depths of a depression or amid the fevers of war.”
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Moderna coronavirus vaccine: Early results from trial show participants developed antib... - 0 views

  • Study subjects who received Moderna's Covid-19 vaccine had positive early results, according to the biotech company, which partnered with the National Institutes of Health to develop the vaccine. If future studies go well, the company's vaccine could be available to the public as early as January, Dr. Tal Zaks, Moderna's chief medical officer, told CNN.
  • These early data come from the Phase 1 clinical trial, which typically studies a small number of people and focuses on whether a vaccine is safe and elicits an immune response.
  • Moderna has vaccinated dozens of study participants and measured antibodies in eight of them. All eight developed neutralizing antibodies to the virus at levels reaching or exceeding the levels seen in people who've naturally recovered from Covid-19, according to the company.
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  • While the vaccine had promising results in the lab, it's not known if it will protect people in the real world. The US Food and Drug Administration has cleared the company to begin Phase 2 trials, which typically involve several hundred of people, and Moderna plans to start large-scale clinical trials, known as Phase 3 trials, in July, which typically involve tens of thousands of people.
  • "We've demonstrated that these antibodies, this immune response, can actually block the virus," Zaks said. "I think this is a very important first step in our journey towards having a vaccine."
  • "It shows that not only did the antibody bind to the virus, but it prevented the virus from infecting the cells," said Dr. Paul Offit, a member of the NIH panel that's setting a framework for vaccine studies in the US.
  • In the Moderna study, three participants developed fever and other flu-like symptoms when they received the vaccine at a dose of 250 micrograms. Moderna anticipates the Phase 3 study on dosage will be between 25 and 100 micrograms.
  • So far, the Moderna study subjects who were vaccinated even at 25 and 100 micrograms achieved antibody levels similar to or even higher than people who naturally became infected with coronavirus.
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Thousands disregarded health guidance over the weekend despite rising coronavirus cases... - 0 views

  • Packing beaches, pool parties and outdoor gatherings all over the US, many Americans used the holiday weekend to mark the unofficial beginning of summer -- ditching the face masks and social distancing urged by health officials.
  • The holiday weekend push for a return to normal life comes as health officials continue to warn that the US has not contained the virus. So far, more than 1.6 million Americans have been infected and at least 98,223 have died, according to data from Johns Hopkins University.
  • But in 18 states -- including Georgia, Arkansas, California and Alabama -- the number of new cases is rising.
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  • The second wave of the pandemic would likely not hit before the fall, but a second peak in this first wave could be much sooner, officials said.
  • "A hallmark of coronaviruses is its ability to amplify in certain settings, its ability to cause transmission -- or super spreading events. And we are seeing in a number of situations in these closed settings. When the virus has an opportunity, it can transmit readily," Van Kerkhove said.
  • "This reckless behavior endangers countless people and risks setting us back substantially from the progress we have made in slowing the spread of COVID-19," County Executive Dr. Sam Page said in a statement.
  • In southern California, officials shut down the Eaton Canyon Natural Areas and Trails for part of Sunday and all of Monday after "overwhelming crowds," CNN affiliate KCBS reported.
  • "The large number of visitors to Eaton Canyon this weekend have made it evident that many people are not practicing key requirements and recommendations set forth by Public Health ... such as wearing face coverings, physical distancing and avoiding crowded areas," the department said, according to the affiliate.
  • Meanwhile, officials in at least 26 states are also investigating hundreds of cases of multisystem inflammatory syndrome in children, a condition doctors believe is linked to coronavirus.
  • Symptoms do not look like the classic symptoms of coronavirus and may mostly include stomach pain and vomiting, along with fever and perhaps a rash, the experts told other doctors during a meeting last week organized by the CDC.
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Tainted Cutter polio vaccine killed and paralyzed children in 1955 - The Washington Post - 0 views

  • On Aug. 30, 1954, Bernice E. Eddy, a veteran scientist at the National Institutes of Health in Bethesda, Md., was checking a batch of a new polio vaccine for safety.Created by Jonas Salk, the vaccine was hailed as the miracle drug that would conquer the dreaded illness that killed and paralyzed children. Eddy’s job was to examine samples submitted by the companies planning to make it.As she checked a sample from Cutter Laboratories in Berkeley, Calif., she noticed that the vaccine designed to protect against the disease had instead given polio to a test monkey. Rather than containing killed virus to create immunity, the sample from Cutter contained live, infectious virus.
  • As scientists and politicians desperately search for medicines to slow the deadly coronavirus, and as President Trump touts a malaria drug as a remedy, a look back to the 1955 polio vaccine tragedy shows how hazardous such a search can be, especially under intense public pressure.
  • Despite Eddy’s warnings, an estimated 120,000 children that year were injected with the Cutter vaccine
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  • Roughly 40,000 got “abortive” polio, with fever, sore throat, headache, vomiting and muscle pain. Fifty-one were paralyzed, and five died,
  • It was “one of the worst biological disasters in American history: a man-made polio epidemic,” Offit wrote.
  • “People weren’t sure how you got it,” he said in an interview last week. “Therefore, they were scared of everything. They didn’t want to buy a piece of fruit at the grocery store. It’s the same now. … Everybody’s walking around with gloves on, with masks on, scared to shake anybody’s hand.”
  • The worst polio outbreak in U.S. history struck in 1952, the year after Offit was born. It infected 57,000 people, paralyzed 21,000 and killed 3,145. The next year there were 35,000 infections, and 38,000 the year after that.
  • Many survivors had to wear painful metal braces on their paralyzed legs or had to be placed in so-called iron lungs, which helped them breathe
  • In 1951, Jonas Salk of the University of Pittsburgh’s medical school received a grant from the National Foundation for Infantile Paralysis to find a vaccine. During intense months of research, he took live polio virus and killed it with formaldehyde until it was not infectious but still provided virus-fighting antibodies.
  • On April 26, 1954, Randy Kerr, a 6-year-old second-grader from Falls Church, Va., stood in the cafeteria of the Franklin Sherman Elementary School in McLean and became the first to be vaccinated in a massive field study.Salk’s vaccine was given to 420,000 children. A placebo was given to 200,000. And 1.2 million were given nothing.
  • She had started at NIH in 1937, had headed testing of vaccines for influenza, and in 1954 was asked to help test the Salk polio vaccine. The pressure was intense. “For weeks she and her staff worked around-the-clock, seven days a week,” O’Hern wrote.“This was a product that had never been made before, and they were going to use it right away,” Eddy had said.She began testing Cutter’s samples in August 1954 and continued through November, according to a later report in the Congressional Record. She found that three of the six samples paralyzed test monkeys.“What do you think is wrong with these monkeys?” she asked a colleague, Offit recounted.“They were given polio,” the colleague replied.“No,” Eddy said. “They were given the … vaccine.”
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Think a 'mild' case of Covid-19 doesn't sound so bad? Think again | Adrienne Matei | Op... - 0 views

  • Doctors now know that Covid-19 not only affects the lungs and blood, but kidneys, liver and brain – the last potentially resulting in chronic fatigue and depression, among other symptoms. Although the virus is not yet old enough for long-term effects on those organs to be well understood, they may manifest regardless of whether a patient ever required hospitalization, hindering their recovery process.
  • For a Dutch report published earlier this month (an excerpt is translated here) researchers surveyed 1,622 Covid-19 patients with an average age of 53, who reported a number of enduring symptoms, including intense fatigue (88%) persistent shortness of breath (75%) and chest pressure (45%). Ninety-one per cent of the patients weren’t hospitalized, suggesting they suffered these side-effects despite their cases of Covid-19 qualifying as “mild”
  • After being diagnosed with Covid-19, 26-year-old Fiona Lowenstein experienced a long, difficult and nonlinear recovery first-hand. Lowenstein became sick on 17 March, and was briefly hospitalized for fever, cough and shortness of breath. Doctors advised she return to the hospital if those symptoms worsened – but something else happened instead. “I experienced this whole slew of new symptoms: sinus pain, sore throat, really severe gastrointestinal issues,” she told me. “I was having diarrhea every time I ate. I lost a lot of weight, which made me weak, a lot of fatigue, headaches, loss of sense of smell …”
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  • By the time she felt mostly better, it was mid-May, although some of her symptoms still routinely re-emerge, she says.
  • “To me, and I think most people, the definition of ‘mild’, passed down from the WHO and other authorities, meant any case that didn’t require hospitalization at all, that anyone who wasn’t hospitalized was just going to have a small cold and could take care of it at home,”
  • “From my point of view, this has been a really harmful narrative and absolutely has misinformed the public. It both prohibits people from taking relevant information into account when deciding their personal risk levels, and it prevents the long-haulers from getting the help they need.”
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Hard Times in the Red Dot - The American Interest - 0 views

  • Deaths per million in Singapore equal about 4; the comparable U.S. figure, as of June 15, is 356.
  • traits with cultural roots planted deep from experience that run through all of East Asia to one degree or another. Unlike most Americans, East Asians retain some imagination for tragedy, and that inculcates a capacity for stoicism that can be summoned when needed.
  • Stoicism here wears off faster now, along with any vestigial passion for politics, in rough proportion to the burgeoning in recent decades of affluence and a culture of conspicuous consumption
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  • it wears off faster among the young and energetic than among the older, more world-weary but also more patient
  • Middle-class Singaporean families often refer to themselves nowadays as the “sandwich generation,” by which they mean that between needing to care for elderly parents and spending heavily on tuition or tutoring and uniforms for school-age children, they have little left to spend on themselves
  • There are more than 10,000 cases, and numbers are rising fast. More than 800 cases were registered in just five and a half days this past week, more than the previous all-time record for a full week.
  • The Singaporean system lacks an open-ended entitlement akin to the U.S. Social Security system. It uses a market-based system with much to commend it, but it isn’t perfect. The system is designed to rely in part on multigenerational families taking care of the elderly, so as is the case everywhere, when a family doesn’t cohere well for one reason or another, its elderly members often suffer most.
  • with the coming of Singapore’s second monsoon season, the island is suffering the worst bout of dengue fever infections in more than a decade.
  • No country in the world has benefited more than Singapore from U.S. postwar grand strategy, except perhaps China. Which is an interesting observation, often made here, in its own right.
  • He proceeded to explain that the U.S. effort in Vietnam had already bought the new nations of Southeast Asia shelter from communist onslaught for three to four precious years.
  • LKY’s son, current Prime Minister Lee Hsien Loong, repeated the same conclusion in a recent Foreign Affairs essay. He added that ever since the Vietnam War era, regardless of the end of the Cold War and dramatic changes in China, the U.S. role in East Asia has been both benign—he did not say error-free—and stabilizing.
  • More than that, U.S. support for an expanding free-trade accented global economic order has enabled Singapore to surf the crest of burgeoning economic growth in Asia, becoming the most successful transshipment platform in history. It has enabled Singapore to benefit from several major technological developments—containerization is a good example—that have revolutionized international trade in manufactures
  • Few realize that military power can do more than either compel or deter. Most of the time most military power in the hands of a status quo actor like the United States neither compels nor deters; it “merely” reassures, except that over time there is nothing mere about it
  • The most important of these reasons—and, I’ve learned, the hardest one for foreigners to understand—is that the Protestant/Enlightenment DNA baked indelibly into the American personality requires a belief in the nation’s exceptionalist virtue to justify an activist role abroad
  • Singapore has ridden the great whale of Asian advancement in a sea of American-guaranteed tranquility.
  • Singapore’s approach to dealing with China has been one of strategic hedging. There is no getting around the need to cooperate economically and functionally with China, for Chinese influence permeates the entire region. Do a simple thought experiment: Even if Singaporeans determined to avoid China, how could they avoid the emanations of Chinese relations with and influence on Malaysia, Indonesia, the Philippines, Vietnam, Thailand, Japan, and Korea? Impossible.
  • Singapore’s close relationship with the United States needs to be seen as similarly enmeshed with the greater web of U.S. relationships in littoral Asia, as well as with India and the Middle East. It is misleading, therefore, to define the issue as one of Singapore’s confidence, or lack thereof, that the United States will come to Singapore’s aid and defense en extremis.
  • The utility of the U.S. role vis-à-vis China is mainly one of regional balancing that indirectly benefits Singaporean security.
  • Singapore’s hedging strategy, which reflects a similar disposition throughout Southeast Asia with variations here and there, only works within certain ranges of enabling reality. It doesn’t work if American power or will wanes too much, and it doesn’t work if the broader Sino-American regional balance collapses into glaring enmity and major-power conflict.
  • Over the past dozen years the worry has been too much American waning, less of capability than of strategic attention, competence, and will. Now, over the past year or two, the worry has shifted to anxiety over potential system collapse into conflict and even outright war.
  • It’s no fun being a sentient ping pong ball between two behemoths with stinging paddles, so they join together in ASEAN hoping that this will deflect such incentives. It won’t, but people do what they can when they cannot do what they like.
  • the flat-out truth: The United States is in the process of doing something no other great power in modern history has ever done. It is knowingly and voluntarily abdicating its global role and responsibilities
  • It is troubled within, so is internally directed for reasons good and otherwise. Thus distracted from the rest of the world in a Hamlet-like act sure to last at least a decade, it is unlikely ever to return in full to the disinterested, active, and constructive role it pioneered for itself after World War II.
  • The recessional began already at the end of the George W. Bush Administration, set roots during the eight years of the Obama presidency, and became a bitter, relentless, tactless, and barely shy of mad obsession during the Trump presidency.
  • the strategy itself is unlikely to be revivified for several reasons.
  • One Lee Kuan Yew vignette sums up the matter. In the autumn of 1968, at a dinner in his honor at Harvard, the Prime Minister had to sit through a litany of complaints from leading scholars about President Johnson’s disastrously escalatory war policies in Vietnam. When they were through, no doubt expecting sympathy from an Asian leader, LKY, never one to bite his tongue, turned on his hosts and announced: “You make me sick.”
  • When, for justifiable reasons or not, the nation loses its moral self-respect, it cannot lift its chin to look confidently upon the world, or bring itself to ask the world to look upon America as a worthy model, let alone a leader.
  • That fact that most Americans today also increasingly see expansive international engagement as too expensive, too dangerous, too complex to understand, and unhelpful either to the “main street” American economy or to rock-bottom American security, is relevant too
  • the disappearance of a single “evil” adversary in Soviet communism, the advent of near-permanent economic anxiety punctuated by the 2008-9 Great Recession—whatever numbers the stock market puts up—and the sclerotic polarization of American politics have left most Americans with little bandwidth for foreign policy narratives.
  • Few listen to any member of our tenured political class with the gumption to argue that U.S. internationalism remains in the national interest. In any event, few try, and even fewer manage to make any sense when they do.
  • In that context, pleas from thoughtful observers that we must find a mean between trying to do too much and doing too little are likely to be wasted. No thoughtful, moderate approach to any public policy question can get an actionable hearing these days.
  • what has happened to “the America I knew and so admired” that its people could elect a man like Donald Trump President? How could a great country deteriorate so quickly from apparent competence, lucidity of mind, and cautious self-confidence into utterly debilitating spasms of apparent self-destruction?
  • The political culture as a whole has become a centrism incinerator, an immoderation generator, a shuddering dynamo of shallow intellectual impetuosity of every description.
  • in the wake of the George Floyd unrest one side thinks a slogan—“law and order”—that is mighty close to a dogwhistle for “shoot people of color” can make it all better, while the other side advocates defunding or abolishing the police, for all the good that would do struggling inner-city underclass neighborhoods.
  • To any normal person these are brazenly unserious propositions, yet they suck up nearly all the oxygen the U.S. media has the inclination to report about. The optic once it reaches Singapore, 9,650 miles away, is one of raving derangement.
  • Drop any policy proposal into any of the great lava flows of contemporary American irrationality and any sane center it may possess will boil away into nothingness in a matter of seconds
  • It’s hard for many to let go of hoary assurances about American benignity, constancy, and sound judgment
  • It is a little like trying to peel a beloved but thoroughly battered toy out of the hands of a four-year old. They want to hold onto it, even though at some level they know it’s time to loosen their grip.
  • Since then the mendacious narcissism of Donald Trump, the eager acquiescence to it of nearly the entire Republican Party, and its deadly metathesis in the COVID-19 and George Floyd contexts, have changed their questions. They no longer ask how this man could have become President. Now they ask where is the bottom of this sputtering cacophonous mess? They ask what will happen before and then on and after November 3
  • Singapore’s good fortune in recent decades is by no means entirely an accident of its ambient geostrategic surroundings, but it owes much to those surroundings. While Singaporeans were honing the arts of good government, saving and investing in the country, educating and inventing value-added jobs for themselves, all the while keeping intercommunal relations inclined toward greater tolerance and harmony, the world was cooperating mightily with their ambitions. At the business end of that world was the United States
  • The U.S. grand strategy of providing security goods to the global commons sheltered Singapore’s efforts in more ways than one over the years
  • In 1965, when Singapore was thrust into independence from the Malaysian union, a more fraught environment could barely have been imagined. Indonesia was going crazy in the year of living dangerously, and the konfrontasi spilled over violently onto Singapore’s streets, layering on the raw feelings of race riots here in 1964. Communist Chinese infiltration of every trade union movement in the region was a fact of life, not to exclude shards of Singapore’s, and the Cultural Revolution was at full froth in China. So when U.S. Marines hit the beach at Da Nang in February 1965 the independence-generation leadership here counted it as a blessing.
  • this is exactly the problem now: Those massively benign trends are at risk of inanition, if not reversal.
  • While China is no longer either Marxist or crazy, as it was during Mao’s Cultural Revolution, it is still Leninist, as its recent summary arrogation of Hong Kong’s negotiated special status shows. It has meanwhile grown mighty economically, advanced technologically at surprising speed, and has taken to investing grandly in its military capabilities. Its diplomacy has become more assertive, some would even say arrogant, as its Wolf Warrior nationalism has grown
  • The downward economic inflection of the pandemic has exacerbated pre-existing economic strains
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A Deadly Coronavirus Was Inevitable. Why Was No One Ready? - WSJ - 0 views

  • When Disease X actually arrived, as Covid-19, governments, businesses, public-health officials and citizens soon found themselves in a state of chaos, battling an invisible enemy with few resources and little understanding—despite years of work that outlined almost exactly what the virus would look like and how to mitigate its impact.
  • Governments had ignored clear warnings and underfunded pandemic preparedness. They mostly reacted to outbreaks, instead of viewing new infectious diseases as major threats to national security. And they never developed a strong international system for managing epidemics, even though researchers said the nature of travel and trade would spread infection across borders.
  • Underlying it all was a failure that stretches back decades. Most everyone knew such an outcome was possible. And yet no one was prepared.
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  • Last year, a Chinese scientist he worked with published a specific forecast: “It is highly likely that future SARS- or MERS-like coronavirus outbreaks will originate from bats, and there is an increased probability that this will occur in China.”
  • Humans today are exposed to more deadly new pathogens than ever. They typically come from animals, as global travel, trade and economic development, such as meat production and deforestation, push people, livestock and wildlife closer together
  • Scientists knew infectious disease outbreaks were becoming more common, with 2010 having more than six times the outbreaks of pathogens from animal origins than in 1980, according to data in a study by Brown University researchers.
  • Yet plenty was left undone, in areas including funding, early-warning systems, the role of the WHO and coordination with China. A big chunk of U.S. funding went toward protecting Americans against a bioterror attack. Government funding for pandemics has come largely in emergency, one-time packages to stop an ongoing outbreak.
  • She said a better solution would be to fund public health more like national defense, with much more guaranteed money, year in, year out.
  • “Will there be another human influenza pandemic?” Dr. Webster asked in a paper presented at an NIH meeting in 1995. “The certainty is that there will be.”
  • Experts including Dr. Webster were particularly concerned about the potential for spillover in southern China, where large, densely populated cities were expanding rapidly into forests and agricultural lands, bringing people into closer contact with animals. Two of the three influenza pandemics of the 20th century are thought to have originated in China.
  • Dr. Webster and others warned it could re-emerge or mutate into something more contagious. With U.S. funding, he set up an animal influenza surveillance center in Hong Kong. The WHO, which hadn’t planned for pandemics before, started compiling protocols for a large-scale outbreak, including contingency plans for vaccines.
  • At a dinner back in the U.S., he remembers one guest saying, “Oh, you really needed to have someone in the U.S. to be impacted to really galvanize the government.”
  • That “drove home the reality in my own mind of globalization,” said Dr. Fukuda. SARS showed that viruses can crisscross the globe by plane in hours, making a local epidemic much more dangerous.
  • The WHO’s director-general, Gro Harlem Brundtland, publicly criticized China. The government under new leaders reversed course. It implemented draconian quarantines and sanitized cities, including a reported 80 million people enlisted to clean streets in Guangdong.
  • By May 2003, the number of new SARS cases was dwindling. It infected around 8,000 people world-wide, killing nearly 10%.
  • After SARS, China expanded epidemiologist training and increased budgets for new laboratories. It started working more closely in public health with the U.S., the world’s leader. The U.S. CDC opened an office in Beijing to share expertise and make sure coverups never happened again. U.S. CDC officials visiting a new China CDC campus planted a friendship tree.
  • In Washington in 2005, a powerful player started driving U.S. efforts to become more prepared. President George W. Bush had read author John M. Barry’s “The Great Influenza,” a history of the 1918 flu pandemic
  • Mr. Bush leaned toward the group of 10 or so officials and said, “I want to see a plan,” according to Dr. Venkayya. “He had been asking questions and not getting answers,” recalled Dr. Venkayya, now president of Takeda Pharmaceutical Co. ’s global vaccine business unit. “He wanted people to see this as a national threat.”
  • Mr. Bush launched the strategy in November, and Congress approved $6.1 billion in one-time funding.
  • The CDC began exercises enacting pandemic scenarios and expanded research. The government created the Biomedical Advanced Research and Development Authority to fund companies to develop diagnostics, drugs and vaccines.
  • A team of researchers also dug into archives of the 1918 pandemic to develop guidelines for mitigating the spread when vaccines aren’t available. The tactics included social distancing, canceling large public gatherings and closing schools—steps adopted this year when Covid-19 struck, though at the time they didn’t include wide-scale lockdowns.
  • A year after the plan was released, a progress report called for more real-time disease surveillance and preparations for a medical surge to care for large numbers of patients, and stressed strong, coordinated federal planning.
  • A European vaccine makers’ association said its members had spent around $4 billion on pandemic vaccine research and manufacturing adjustments by 2008.
  • The $6.1 billion Congress appropriated for Mr. Bush’s pandemic plan was spent mostly to make and stockpile medicines and flu vaccines and to train public-health department staff. The money wasn’t renewed. “The reality is that for any leader it’s really hard to maintain a focus on low-probability high-consequence events, particularly in the health arena,” Dr. Venkayya said.
  • In the U.S., President Barack Obama’s administration put Mr. Bush’s new plan into action for the first time. By mid-June, swine flu, as it was dubbed, had jumped to 74 countries. The WHO officially labeled it a pandemic, despite some evidence suggesting the sickness was pretty mild in most people.
  • That put in motion a host of measures, including some “sleeping” contracts with pharmaceutical companies to begin vaccine manufacturing—contracts that countries like the United Kingdom had negotiated ahead of time so they wouldn’t have to scramble during an outbreak.
  • In August, a panel of scientific advisers to Mr. Obama published a scenario in which as many as 120 million Americans, 40% of the population, could be infected that year, and up to 90,000 people could die.
  • H1N1 turned out to be much milder. Although it eventually infected more than 60 million Americans, it killed less than 13,000. In Europe, fewer than 5,000 deaths were reported.
  • The WHO came under fire for labeling the outbreak a pandemic too soon. European lawmakers, health professionals and others suggested the organization may have been pressured by the pharmaceutical industry.
  • France ordered 94 million doses, but had logged only 1,334 serious cases and 312 deaths as of April 2010. It managed to cancel 50 million doses and sell some to other countries, but it was still stuck with a €365 million tab, or about $520 million at the time, and 25 million extra doses.
  • The WHO had raised scares for SARS, mad-cow disease, bird flu and now swine flu, and it had been wrong each time, said Paul Flynn, a member of the Council of Europe’s Parliamentary Assembly and a British lawmaker, at a 2010 health committee hearing in Strasbourg.
  • Ultimately, an investigation by the council’s committee accused the WHO and public-health officials of jumping the gun, wasting money, provoking “unjustified fear” among Europeans and creating risks through vaccines and medications that might not have been sufficiently tested.
  • “I thought you might have uttered a word of regret or an apology,” Mr. Flynn told Dr. Fukuda, who as a representative of the WHO had been called to testify.
  • Back in Washington, scientist Dennis Carroll, at the U.S. Agency for International Development, was also convinced that flu wasn’t the only major pandemic threat. In early 2008, Dr. Carroll was intrigued by Dr. Daszak’s newly published research that said viruses from wildlife were a growing threat, and would emerge most frequently where development was bringing people closer to animals.
  • If most of these viruses spilled over to humans in just a few places, including southern China, USAID could more easily fund an early warning system.
  • “You didn’t have to look everywhere,” he said he realized. “You could target certain places.” He launched a new USAID effort focused on emerging pandemic threats. One program called Predict had funding of about $20 million a year to identify pathogens in wildlife that have the potential to infect people.
  • Drs. Daszak, Shi and Wang, supported by funds from Predict, the NIH and China, shifted their focus to Yunnan, a relatively wild and mountainous province that borders Myanmar, Laos and Vietnam.
  • One key discovery: a coronavirus resembling SARS that lab tests showed could infect human cells. It was the first proof that SARS-like coronaviruses circulating in southern China could hop from bats to people. The scientists warned of their findings in a study published in the journal Nature in 2013.
  • Evidence grew that showed people in the area were being exposed to coronaviruses. One survey turned up hundreds of villagers who said they recently showed symptoms such as trouble breathing and a fever, suggesting a possible viral infection.
  • Over the next several years, governments in the U.S. and elsewhere found themselves constantly on the defensive from global viral outbreaks. Time and again, preparedness plans proved insufficient. One, which started sickening people in Saudi Arabia and nearby
  • On a weekend morning in January 2013, more than a dozen senior Obama administration officials met in a basement family room in the suburban home of a senior National Security Council official. They were brainstorming how to help other countries upgrade their epidemic response capabilities, fueled by bagels and coffee. Emerging disease threats were growing, yet more than 80% of the world’s countries hadn’t met a 2012 International Health Regulations deadline to be able to detect and respond to epidemics.
  • The session led to the Global Health Security Agenda, launched by the U.S., the WHO and about 30 partners in early 2014, to help nations improve their capabilities within five years.
  • Money was tight. The U.S. was recovering from the 2008-09 financial crisis, and federal funding to help U.S. states and cities prepare and train for health emergencies was declining. Public-health departments had cut thousands of jobs, and outdated data systems weren’t replaced.
  • “It was a Hail Mary pass,” said Tom Frieden, who was director of the CDC from 2009 to 2017 and a force behind the creation of the GHSA. “We didn’t have any money.”
  • At the WHO, Dr. Fukuda was in charge of health security. When the Ebola outbreak was found in March 2014, he and his colleagues were already stretched, after budget cuts and amid other crises.
  • The United Nations created a special Ebola response mission that assumed the role normally played by the WHO. Mr. Obama sent the U.S. military to Liberia, underscoring the inability of international organizations to fully handle the problem.
  • It took the WHO until August to raise an international alarm about Ebola. By then, the epidemic was raging. It would become the largest Ebola epidemic in history, with at least 28,600 people infected, and more than 11,300 dead in 10 countries. The largest outbreak before that, in Uganda, had involved 425 cases.
  • Congress passed a $5.4 billion package in supplemental funds over five years, with about $1 billion going to the GHSA. The flood of money, along with aggressive contact tracing and other steps, helped bring the epidemic to a halt, though it took until mid-2016.
  • Global health experts and authorities called for changes at the WHO to strengthen epidemic response, and it created an emergencies program. The National Security Council warned that globalization and population growth “will lead to more pandemics,” and called for the U.S. to do more.
  • r. Carroll of USAID, who had visited West Africa during the crisis, and saw some health workers wrap themselves in garbage bags for protection, started conceiving of a Global Virome Project, to detect and sequence all the unknown viral species in mammals and avian populations on the planet.
  • Billionaire Bill Gates warned in a TED talk that an infectious disease pandemic posed a greater threat to the world than nuclear war, and urged world leaders to invest more in preparing for one. The Bill & Melinda Gates Foundation helped form a new initiative to finance vaccines for emerging infections, the Coalition for Epidemic Preparedness Innovations.
  • Congress established a permanent Infectious Diseases Rapid Response Fund for the CDC in fiscal 2019, with $50 million for that year and $85 million in fiscal 2020.
  • In May 2018, John Bolton, then President Trump’s national security adviser, dismantled an NSC unit that had focused on global health security and biodefense, with staff going to other units. The senior director of the unit left.
  • It pushed emerging disease threats down one level in the NSC hierarchy, making pandemics compete for attention with issues such as North Korea, said Beth Cameron, a previous senior director of the unit. She is now vice president for global biological policy and programs at the Nuclear Threat Initiative.
  • Deteriorating relations with China reduced Washington’s activities there just as researchers were becoming more certain of the threat from coronaviruses.
  • Dr. Carroll had earlier been ordered to suspend his emerging pandemic threats program in China.
  • Dr. Carroll pitched to USAID his Global Virome Project. USAID wasn’t interested, he said. He left USAID last year. A meeting that Dr. Carroll planned for last August with the Chinese CDC and Chinese Academy of Sciences to form a Chinese National Virome Project was postponed due to a bureaucratic hang-up. Plans to meet are now on hold, due to Covid-19.
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Can you catch coronavirus twice? What we know about Covid-19 so far | World news | The ... - 0 views

  • But we do have some clues. “We know from ‘normal’ coronavirus studies done in the past you can infect people after about a year following an initial infection,” said Dr Ben Killingley, consultant in acute medicine and infectious diseases at University College London hospital.
  • “I have yet to see a definitive case of reinfection reported in the scientific literature [to date]. To truly prove reinfection, and discriminate from prolonged viral shedding related to the first infection, would require sequencing of both the first and second viruses and demonstration that the two viruses are genetically different,” he said, adding it will also be important to look at symptoms and how long reinfection lasts.
  • What happened in South Korea, where patients tested positive after having recovered from Covid-19?
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  • That’s because the PCR (or “have-you-got-it”) test is based on detecting genetic material from the virus – on its own it does not reveal whether that virus is active, and infectious, or not.
  • Experts say it is unlikely. “I know some have discussed ‘reactivation’ of virus, but this seems unhelpful and unsupported to me,” said Altmann. “It’s a term that’s borrowed from other viruses, especially the herpes virus family, that can hide in the body in a latent state to reactivate years later. [There is] no evidence of that at all for coronaviruses.”
  • “[We are] at the beginning of describing what may be a complex picture of chronic disease that may ensue from the initial infection – coming and going in relapsing waves, sometimes almost like a kind of chronic fatigue syndrome,” he said. “[These cases] may reflect examples of virus not fully cleared, or alternatively, some kind of damaging post-hoc disturbance to immune or inflammatory function,” he said.
  • “In some persons they begin to feel well again and signs and symptoms including fever decrease, but some then go on to develop respiratory distress and must be provided oxygen in hospital,” said David Heymann, professor of infectious disease epidemiology at the London School of Hygiene and Tropical Medicine. “It appears to be a delayed immune response that is more serious in some persons and that reacts to remaining virus in various organs.”
  • How long are people with Covid-19 infectious for? A recent study of 60 coronavirus patients in China showed 10 patients tested positive for Covid-19 after discharge from hospital. However, once again, experts say this could be down to the test picking up genetic material from inactive virus, with other studies, including work in South Korea, suggesting those who test positive with Covid-19 after recovering from the disease are not infectious.
  • “It’s not uncommon to find virus in the nose or throat for up to four weeks after initial infection, but tests to establish whether this is live infectious virus – as opposed to just genetic material detection – are not normally positive for much longer than a week,” said Killingley, adding: “I haven’t come across relapse cases whereby the initial infection acquired weeks ago reignites itself into an infectious case.”
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Is Holocaust Denial Conservative Now? - The Bulwark - 0 views

  • his leadership is sabotaging conservatism.
  • Trump retweeted an “America First” post featuring disgraced columnist Michelle Malkin complaining about conservatives being silenced on social media. Trump has retweeted unsavory characters before, but in this case, he added an endorsement: “The radical left is in total command & control of Facebook, Instagram, Twitter and Google. The administration is working to remedy this illegal situation. Stay tuned, and send names & events. Thank you Michelle!”
  • In the name of standing up for aggrieved conservatives, Trump soils the brand
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  • The “radical left” is not in control of those outlets, and even if it were, they are private entities, and therefore perfectly free to make their own judgements about content
  • Another detail: Trump has 19.7 million followers on Instagram, 26.7 million on Facebook, and 80 million on Twitter. Perhaps what keeps him so popular is his audience’s inexhaustible appetite for whining.
  • The woman Trump thanked is a columnist and social media entrepreneur who was a respected member of the conservative commentariat
  • In the past two years though, she has been pretty well shunned by respectable conservative outlets, or what passes for such nowadays.
  • Her most grotesque relationship though, and the one that got her booted from the Young America’s Foundation, was with a group calling themselves “groypers,” led by a 21-year-old YouTube host named Nick Fuentes. To get a sense of just how loathsome this figure is, have a look at this video in which he wonders, grinning, about whether 6 million “cookies” could really be baked in ovens and how the “math doesn’t add up.”
  • The occasion for the deplatforming was Malkin’s swan dive into the right-wing fever swamps.
  • Fuentes, you will not be shocked to learn, is one of the “very fine people” who marched with neo-Nazis at the 2017 Unite the Right rally in Charlottesville. Remember Pepe the Frog? He’s their mascot. He described the mass murder in an El Paso Walmart as an “act of desperation.” Turning Point USA is too tame for his tastes, and his group has lately been heckling speakers like Ben Shapiro, Dan Crenshaw, and even Donald Trump, Jr
  • In other words, if anything is beyond the pale for a civilized country, the “groypers” are it.
  • Yet Michelle Malkin has declared herself the “mother of groypers” and called them “good kids.” When she was rebuked by mainstream conservatives, she declared her allegiances proudly
  • In fact, Trump probably did not know much about those he praised, either Malkin or, by extension, Fuentes. But he has a duty to know. Yes, he’s an indolent ignoramus, but guess what, the taxpayers are paying for a huge staff.
  • He doesn’t use them because he doesn’t care. His moral reasoning is primitive. If you are pro-Trump, no matter what else you are (a murderous dictator, a racist troll), you’re fine in his book
  • He has no objective moral standards. Everything is about him. On a scale of moral reasoning, he is subzero
  • But the world of conservative opinion shapers does still attempt, however weakly, to maintain some guard rails. With every passing day of Donald Trump’s leadership, those standards crumble a bit more.
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Pfizer's Vaccine Offers Strong Protection After First Dose - The New York Times - 0 views

  • The coronavirus vaccine made by Pfizer and BioNTech provides strong protection against Covid-19 within about 10 days of the first dose, according to documents published on Tuesday by the Food and Drug Administration before a meeting of its vaccine advisory group.
  • Last month, Pfizer and BioNTech announced that their two-dose vaccine had an efficacy rate of 95 percent after two doses administered three weeks apart. The new analyses show that the protection starts kicking in far earlier.
  • What’s more, the vaccine worked well regardless of a volunteer’s race, weight or age. While the trial did not find any serious adverse events caused by the vaccine, many participants did experience aches, fevers and other side effects.
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  • Pfizer and BioNTech began a large-scale clinical trial in July, recruiting 44,000 people in the United States, Brazil and Argentina. Half of the volunteers got the vaccine, and half got the placebo.
  • Many experts have expressed concern that the coronavirus vaccines might protect some people better than others. But the results in the briefing materials indicate no such problem.
  • Even if the vaccine is authorized by the F.D.A., the trial will continue. In the briefing documents, the companies said that they would encourage people to stay in the trial as long as possible, not knowing whether they got the vaccine or the placebo, so that the researchers could continue to collect information about whether the vaccine was safe and effective.
  • The F.D.A. concluded that there were no “meaningful imbalances” in serious health complications, known as adverse events, between the two groups. The agency noted that four people in the vaccinated group experienced a form of facial paralysis called Bell’s palsy, with no cases in the placebo group. The difference between the two groups wasn’t meaningful, and the rate in the vaccinated group was not significantly higher than in the general population.
  • The new Pfizer analysis revealed that many volunteers who received the vaccine felt ill in the hours after the second dose, suggesting that many people might have to request a day off work or be prepared to rest until the symptoms subside. Among those between ages 16 and 55, more than half developed fatigue, and more than half also reported headaches. Just over one-third felt chills, and 37 percent felt muscle pain. About half of those over age 55 felt fatigued, one-third developed a headache and about one-quarter felt chills, while 29 percent experienced muscle pain.
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Trump Isn't 'Out of the Woods,' but We're in the Dark - The New York Times - 0 views

  • There must be someone who knows exactly what’s happening with President Trump’s health.But it’s certainly not the American people.
  • the White House has spent days releasing conflicting and incomplete information about the true nature of his battle with Covid-19.
  • Dr. Sean P. Conley, said that Mr. Trump’s health had improved and that he would be returning to the White House after spending three nights at Walter Reed National Military Medical Center. But he also said Mr. Trump “may not entirely be out of the woods yet.”
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  • his plummeting blood oxygenation, high fever and treatment with medication reserved for patients with severe Covid-19. Yet Mr. Trump and his team have insisted on projecting a rosy image of a president nearly undisturbed by his illness.
  • Mr. Trump told his Twitter followers today not to fear Covid-19 and “don’t let it dominate your life,”
  • Often the deceptions and exaggerations spread by Mr. Trump and his allies have been about the president’s image and self-regard: the size of his rallies, for example, or his net worth or charitable foundation.
  • His health is a far more serious matter, one that puts national security at risk.
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Trump Leaves Hospital, Minimizing Virus and Urging Americans 'Not to Let It Dominate Yo... - 0 views

  • Not to Let It Dominate Your Life
  • persuade Americans to take the pandemic seriously.
  • Mr. Trump has undermined public health experts trying to
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  • As your leader, I had to do that. I knew there’s danger to it, but I had to do it. I stood out front. I led.
  • he president’s dismissal of a virus that in recent weeks has been killing another 700 people each day in the United States set off alarm bells among health specialists who worried that it would send the wrong message to the public.
  • Doctors said the president had gone 72 hours without a fever and had normal blood oxygen readings after two earlier bouts of falling levels that led to him being given supplemental oxygen.
  • without immediately putting his mask back on even though staff members were nearby and he could still be contagious, according to medical studies of the virus timeline. At that point, he filmed the video, which was quickly uploaded to Twitter. A separate video, set to triumphal music, showed Marine One’s return and his saluting pose, and was posted online within an hour of his landing.The president looked stronger than he did on Friday when he was first taken to the hospital, but he did appear to breathe heavily once reaching the top of the White House stairs. He has been taking steroids that are known to produce a feeling of energy, even exhilaration, while suppressing pain or discomfort.After largely laying off Twitter, his favorite form of communication, for three days, Mr. Trump woke up Monday morning and began blasting out a string of messages in all capital letters in machine gun fashion shortly after 6 a.m., amplifying campaign messages like “LAW & ORDER. VOTE!” and “SAVE OUR SECOND AMENDMENT. VOTE!” By afternoon, he added, “Don’t be afraid of Covid. Don’t let it dominate your life.”
  • The three joined a growing list of people around the president who have tested positive, including Melania Trump, the first lady; Hope Hicks, a senior adviser;
  • ested negative on
  • His doctor said that Mr. Pence was not quarantining because he had not been close enough to any infected individuals for long enough to qualify as “a close contact.”
  • he is 74, male and overweight
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Severity of Trump's illness unclear as coronavirus rips through White House | Reuters - 0 views

  • Trump’s announcement of his diagnosis landed like a bombshell on Friday, some 48 hours after his first presidential debate with Democratic challenger Joe Biden, highlighting the uncertainty that has marked a highly unusual campaign during a deadly pandemic.
  • a steroid, dexmethasone, that is normally used only in the most severe cases
  • Trump was running a high fever on Friday and had been given supplemental oxygen after his blood oxygen levels dropped
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  • which has painted a rosy picture of his condition
  • Trump will need to continue treatment
  • Kayleigh McEnany said she had tested positive for the virus after “testing negative consistently” every day since Thursday.
  • held a briefing for reporters on Thursday in which she did not wear a face mask.
  • A Reuters/Ipsos poll released on Sunday showed Trump trailing Biden nationally by 10 percentage points. About 65% of Americans said Trump would not have been infected had he taken the virus more seriously.
  • But the growing number of COVID-19 cases in the White House as well as Congress - three Republican senators have tested positive for the virus in the last week - threatens to place Trump’s response to the pandemic under a finer microscope.
  • Trump is also under fire for a statement that he met with soldiers and first responders at the hospital in Bethesda - moves that potentially exposed even more people to the virus, as well as the drive-by on Sunday and a fundraising trip he made to New Jersey last week.
  • Major U.S. stock markets were trading higher on Monday amid hints of Trump’s potential release and signs of progress with a new fiscal stimulus bill in Congress. Wall Street’s main indexes slumped on Friday after Trump’s COVID-19 announcement.
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President Trump Received Regeneron Experimental Antibody Treatment - The New York Times - 0 views

  • single dose of an antibody cocktail made by the biotech company Regeneron
  • egeneron, in addition to several other drugs, including zinc, vitamin D and the generic version of the heartburn treatment Pepcid,
  • tested positive for the coronavirus. The president has a low-grade fever, nasal congestion and a cough, according to two people close to Mr. Trump
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  • “he completed the infusion without incident
  • All we can say is that they asked to be able to use it, and we were happy to oblige,”
  • are decided on a case-by-case basis and he is not the first patient to be granted permission to use the treatment this way.
  • unproven or scientifically questionable treatments for the virus, and himself took the malaria drug hydroxychloroquine in the hopes that it could prevent infection.
  • Neither drug has gone through the rigorous F.D.A. approval process to determine that it is safe and effective, although dexamethasone is widely available for other uses, and remdesivir has received emergency authorization.
  • which allows patients and their doctors to directly request an experimental treatment from a company,
  • without first seeking approval from the F.D.A., which typically approves the vast majority of such requests. The Right to Try law is rarely used, however, with most doctors and hospitals preferring to use the existing process of seeking company and then agency approval.Some ethics experts said it was not surprising that Mr. Trump was given an experimental drug, given that it has passed safety trials.
  • Antibody treatments have shown promise against other viruses, including Ebola.
  • 275 volunteers who were treated after being diagnosed with Covid-19.
  • $500 million from the federal government to develop and manufacture its product before the clinical trials have concluded.
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