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“People began to fixate on individual liberties without understanding that one of the most fundamental civil liberties in the US is the right to health – the right to stay alive.”

Demographic data suggests that younger people, between the ages of 18 and 50, are fueling the current wave of infections, accounting for nearly 60% of cases statewide. “Maybe they feel invincible, so they go out to bars, they gather in big groups,” Riley said. “But then they can spread the virus to their grandmas and grandpas, their parents, their buddies with asthma or diabetes, who are more vulnerable.”

Among the hardest-hit regions are rural counties in the south and the Central Valley, where farmworkers have been toilin

The vast majority – more than 90% – of farmworkers in California are Latinx, working in precariously crowded environments. More than 60% of workers involved in food preparation are Latinx as well

Latinx, Black and other minority groups are disproportionately infected with and dying of Covid-19, according to a tracking tool designed by UCLA, and early metrics suggest that the state’s reopening has exacerbated disparities. Devastating outbreaks in California’s prisons and homeless shelters have further fueled inequities.

the state rushed its reopening plan. Initially, officials had set two weeks of declining as a benchmark for advancing through each phase of reopening. “We wanted to not only flatten the curve but see a downturn,” he said. “Then we began seeing the anti-lockdown protests, basically egged on with a wink and a nod from Donald Trump, and the governor faced increasing pressure to move faster.”

the governor’s recent orders pausing the California’s reopening, and his statewide mandate requiring residents to wear masks, are laudable, he said. “Still, we’re only successful if people follow the order – and right now, they’re not doing it.”

the fact that airplanes help spread disease across geographies does not mean that you are necessarily at risk during flight.

Airplanes also use the same air filter — a HEPA filter — recommended by the CDC for isolation rooms with recirculated air. Such filters capture 99.97 percent of airborne particles.

Consider one study that examined a passenger with tuberculosis on an airplane. It found that the median risk of infection to the other 169 passengers on the airplane was between 1 in 10,000 to 1 in a million.

Wearing a mask, as some airlines now require, reduced the incidence of infection another 10-fold.

The required aircraft systems do a really good job of controlling airborne bacteria and viruses.

To get technical, airplanes deliver 10 to 12 air changes per hour. In a hospital isolation room, the minimum target is six air changes per hour for existing facilities and 12 air changes per hour for new.

If planes made you sick, we would expect to see millions of people sick every year attributable to flights. We haven’t seen it because it’s just not happening.

What’s more, airplanes are essentially designed to isolate airflow. Even if someone coughs on your flight without a mask, it is likely those virus particles will travel one or two rows,

To guard against transmission via large droplets and contaminated surfaces, we do need to take some additional steps. Wearing a mask on planes should be mandated, and wiping down tables and arm rests with a disinfectant provides an additional layer of defense.

you are more at risk of getting sick when traveling, but it’s not the airplane that’s making you sick.

Every time you fly, you may also take a cab, bus or subway; stand in long lines in the airport; eat unhealthy foods; sit for extended durations; spend time in spaces with hundreds or thousands of other travelers; stay at a hotel or friend’s home; arrive in a different climate and change time zones, disrupting your sleep. All of these factors are known to affect your immune system.

In 2013, I was one of the lead authors of a report for the Transportation Research Board of the National Academies on infectious disease mitigation in airports and airplanes. Let me distill some of the recommendations from that report

For starters, airports should mandate mask wearing; increase ventilation rates; make bathrooms touchless; consider deploying upper-room germicidal UV fixtures in areas with high-occupant density; institute temperature screening; deploy hand-sanitizer stations; and, once passengers arrive at their gates, require that they stay in their designated area except for bathroom usage.

Airlines should ensure gate-based ventilation is operating during boarding and disembarkation; carefully choreograph the loading of airplanes; mandate mask use; and provide meals and bottled water during boarding and discontinue in-flight meal and drink service.

Individuals have an important role to play, too. First, stay home and do not travel if sick. Comply with rules for mask wearing; wash hands before and after each step at the airport; keep the personal overhead ventilation on and pointed down; and maintain physical distancing to the extent possible.

On February 13, 1819, Rep. James Tallmadge of New York added a rider to the Missouri Statehood bill that came to consume Congress for almost a year and would ultimately shape the legal history of slavery and constitutional history of the state for the next 45 years. Missouri, Tallmadge suggested, should be admitted to the union only if it outlawed slavery.

In 1820 the threat to the union was allayed, or at least delayed, with the Missouri Compromise, one of the most notorious compromises in the history of the United States: Slavery would be allowed in Missouri. In exchange for Missouri’s admission as a slave state, Maine was admitted as a free state.

n addition to sanctioning slavery, the Missouri Constitution of 1820 directed the legislature of the new state “to prevent free negroes and mulattoes from coming to and settling in this State, under any pretext whatsoever.”

The provision reflected the particular sort of white supremacy that was characteristic of much of the growing population of the state of Missouri and the city of St. Louis. It was consonant with the politics of the American Colonization Society, which had emerged on the East Coast in 1817, and which sought the ethnic cleansing of the North through the removal of free black people to Africa.

Many of these white men were migrants from Virginia, where representation in the state legislature had, like representation in the U.S. Congress, been apportioned on the basis of population rather than suffrage — the three-fifths compromise, most notorious of them all, which provided an enduring political subsidy to slaveholders, who were able to increase their political representation in proportion (3/5) to the number of human beings they owned.

In Missouri things would be different and only “free white male inhabitants” would be counted: The state, under its 1820 Constitution, would be ruled by and for white men rather than slaveholders.

In order for Missouri to be admitted to the union, the state constitution had to be sent back to Washington and approved by the United States Congress. At stake was the question of negro exclusion. Article IV, Section 2 of the United States Constitution provides that “The Citizens of each State shall be entitled to all Privileges and Immunities of Citizens in the several States.” Termed the principle of “interstate comity,” in practice this clause means (and was in 1820 taken to mean) that individual states are not allowed to discriminate against the citizens of other states.

The Missouri Constitution of 1820’s deliberate exclusion of the free black citizens of other states declared that when it came to free people of color, the state of Missouri was a territory apart.

Under the constitution of 1820, free black people in Missouri were denizens, not citizens. Much like Indians, they fell under the law of the state without the ability to invoke its provided protections. Under an 1835 law, free black children were legally required to be apprenticed to white families. An 1843 revision to the state code restricted the immigration of all free blacks unless they could demonstrate they were citizens of another state — a near impossibility for most, because states did not issue proof-of-citizenship documents.

Rethinking the history of the coming of the Civil War from the West, from the standpoint of imperial expansion, demands we reconsider the racist legacy of the victory of the United States of America over the Confederate States. It helps explain just how deeply ingrained anti-blackness is in American life then, and now.

Think about that: Stop testing. Then we’ll have no knowledge. Then we’ll have no numbers. Then we’ll have no virus. Why didn’t I think of that?

this impugning of scientific methods, this embrace of conspiracy theories, this undermining of truth and data by our president and vice president — this is not happening in other countries. This is not happening in Germany, France, China, South Korea, Denmark, Canada, Israel or Japan. This is a form of American “exceptionalism” that we never imagined possible.

“A prime difference between the Enlightenment and the Dark Ages is respect for knowledge, respect for science. The whole idea of progress requires objectively looking at problems, finding and testing solutions, and then spreading and using the best of them. That’s how we grow, that’s how we learn, that’s how we prosper.”

As for respecting nature, that has two meanings. The first is to respect the power of nature

She doesn’t negotiate. You cannot seduce her or sue her. She does whatever chemistry, biology and physics dictate. Full stop. Which means in a pandemic that she will just keep infecting people — relentlessly, mercilessly, silently and exponentially — until she runs out of people to infect or a vaccine or exposure makes enough of us immune. She also doesn’t keep score. She’ll make you sick and then blow down your house with a tornado.

Respect for nature also means understanding that we live on a hard rock called planet Earth with a thin cover of oceans and topsoil, enveloped by a thin layer of atmosphere. Abuse that soil, junk up those oceans with plastics, distort that atmospheric blanket and we will likely (further) destroy the perfect Garden of Eden that has been the basis of all human civilization.

remember, as bad as this pandemic is, it’s just training wheels for the big, irreversible atmospheric pandemic: climate change.

Respect each other? That’s not so easy in the midst of our other pandemic — a pandemic of incivility.

We have a level of inequality that is so endemic that your ZIP code is now a better predictor of life expectancy than your genetic code.

Respecting each other means ensuring each other’s equal access to the American dream — and right now, Black, Hispanic and white Americans are climbing very different housing, education and health care ladders, which simply has to be fixed.

We have so many important issues to discuss among ourselves right now, but for that discussion to be productive we can’t just go from justifiable outrage straight to firings, public shamings or disbanding police departments — without pausing for respectful dialogue and moral distinctions.

The other is getting people out of Facebook and into each other’s faces again — not to shout or denounce, but to listen

It’s even more important what you say when you listen. Listening is a sign of respect. And it is amazing what people will let you say to them if they first think that you respect them. That’s our job.

Respect science, respect nature, respect each other. Biden 2020.

“Respect science, respect nature, respect each other.”

Biden should highlight his commitment to all three values in every speech and interview he gives. They draw such a clear, simple and easy to remember contrast with Trump.

The claim plaintiffs bring alleges something horrific: that locaters in Mali sold them as children to an Ivorian farm where overseers forced them to work,” Mr. Katyal said

The plaintiffs sued under the Alien Tort Statute, a cryptic 1789 law that allows federal district courts to hear “any civil action by an alien for a tort only, committed in violation of the law of nations or a treaty of the United States.”

They sued Nestlé USA and Cargill, saying the firms had aided and profited from the practice of forced child labor.

“Even where the claims touch and concern the territory of the United States,” he wrote, “they must do so with sufficient force to displace the presumption against extraterritorial application.”

The court said foreign corporations may not be sued under the 1789 law, but it left open the question of the status of domestic corporations.

In Tuesday’s case, Nestlé USA v. Doe, No. 19-416, the companies sought to expand both sorts of limitations. They said the 1789 law did not allow suits even when some of the defendants’ conduct was said to have taken place in the United States, and they urged the court to bar suits under the law against all corporations, whether foreign or domestic.

Those questions suggested that the court could rule for the companies without making a broad statement about corporate immunity

Mr. Katyal said there were ways to hold such a corporation accountable. But he said the 1789 law was not one of them

hey will have enough to vaccinate no more than 22.5 million Americans by January.

Based on its recent discussions, the C.D.C. committee will almost certainly recommend that the nation’s 21 million health care workers be eligible before anyone else, along with three million mostly elderly people living in nursing homes and other long-term care facilities.

Federal officials have said they plan to ship the first 6.4 million doses within 24 hours after the F.D.A. authorizes a vaccine, and the number each state receives will be based on a formula that considers its adult population.

Some participants in both Pfizer’s and Moderna’s trials have said they experienced symptoms including fever, muscle aches, bad headaches and fatigue after receiving the shots, but the side effects generally did not last more than a day.

By September, Pfizer’s trial had 44,000 participants; no serious safety concerns have been reported.

Probably. Although people who have contracted the virus do have immunity, it is too soon to know how long it lasts. So for now, it makes sense for them to get the shot. The question is when.

It’s sad that voters feel like they only have a choice between democratic socialism and white supremacy.

Ms. Witzke’s ascent in Joseph R. Biden Jr.’s home state may be the nadir of the Delaware Republican Party’s rapid swerve from patrician moderation to the far-right fringe

Republicans running statewide are facing a choice: Appeal to the vocal extreme or find some way to assemble a more centrist coalition that could actually elect them.

That was an easy case to make not long ago in tiny Delaware, population 974,000, where “the Delaware way” was a model of centrist political accommodation.

The F.B.I. has warned that QAnon poses a potential domestic terrorism threat.

“People are so tired of George Bush-era politics. Nationalist populism is the future,” Ms. Witzke said. “America First is the future. And that is what I am.”

The Republican Party has to be open-minded about the people who live in this country and get back on some sort of track that makes sense to the average voter,

You can’t just have ideological beliefs that don’t appeal to a majority of people in a state — or the country.

Ms. Witzke’s message to moderates, she said: “It’s me or Antifa.”

On Wednesday, a day after Mr. Trump’s Proud Boys remarks during the first presidential debate, Ms. Witzke took to Twitter to create more headaches for her party. “The Proud Boys showed up to one of my rallies to provide free security for me when #BLM and ANTIFA were protesting my candidacy,” she wrote, neglecting to mention that the Proud Boys outnumbered the McDole family protesters at the event.

“We are sick and tired of pandering and people electing government officials who will cave to the mob,”

Gathered with her in the parking lot of the Republican Party headquarters here was a self-appointed security guard with a gun on his hip, a political adviser whose losing clients include candidates accused of racism and anti-Semitism, and a smattering of Proud Boys, the far-right brawlers whom President Trump told to “stand back and stand by.”

It's not clear that investigators ever had concrete evidence of a relevant bank transfer from the Egyptian bank. But multiple sources said there was sufficient information to justify the subpoena and keep the criminal campaign finance investigation open after the Mueller probe ended.

Justice Department confirmed that when the special counsel's office shut down in 2019, Mueller transferred an ongoing foreign campaign contribution investigation to prosecutors in Washington. Some of CNN's sources have confirmed that the case, which Mueller cryptically called a "foreign campaign contribution" probe, was in fact the Egypt investigation.

The probe was confirmed this week by a Justice Department senior official who responded to CNN's queries: "The case was first looked at by the Special Counsel investigators who failed to bring a case, and then it was looked at by the US attorney's office, and career prosecutors in the national security section, who also were unable to bring a case. Based upon the recommendations of both the FBI and those career prosecutors, Michael Sherwin, the acting US attorney, formally closed the case in July."

there could have been money from an Egyptian bank that ended up backing Trump's last-minute injection of $10 million into his 2016 campaign, according to two of the sources.

Yet neither the special counsel's office, nor prosecutors who carried on the case after Mueller, got a complete picture of the President's financial entanglements. Prosecutors in Washington even proposed subpoenaing financial records tied to Trump, before top officials finally concluded this summer they had reached a dead end, the sources said.

Mueller's primary task was to investigate Russian government attempts to interfere in the 2016 election, which had consumed the political and investigative conversations in the early days of Trump's presidency. But Mueller's mandate also allowed him to take on related criminal investigations, which in this case included another probe of potential foreign influence connected to the campaign.

Zainab Ahmad, a former international terrorism prosecutor, and Brandon Van Grack, a national security and counterintelligence specialist, co-led it, according to sources. Public records also show they focused on cases separate from other trial attorneys in the special counsel's office and had senior titles equivalent to other Mueller team leaders.

Mueller's team tried to understand both the $10 million contribution Trump gave to his campaign 11 days before the 2016 election and the Trump campaign's ties to Egyptian President Abdel Fattah el-Sisi, according to sources and redacted interview records released from the Mueller investigation.

One official familiar with the work said some investigators believed the Egypt inquiry presented a more direct avenue for Mueller's team to examine Trump's finances, in part because it did not have an obvious tie to Russia.

Needing a final push before Election Day as the polls tightened in 2016, the Trump campaign was running low on cash. Trump's top campaign officials scrambled to convince Trump to inject money, according to memos of witness interviews from the investigation and contemporaneous news reports. Trump lagged well behind a pledge he made to spend $100 million of his own money on his campaign. Less than two weeks before Election Day, Trump wrote his campaign a $10 million check, publicly calling it a loan. Campaign finance records showed it as his single largest political contribution, by far, and not one the campaign would reimburse him for.

Mueller's office pressed witnesses to explain how the Trump-Sisi meeting in late 2016 came about. Ahmad, whose aims on the investigation were cloaked in secrecy, was repeatedly present in interviews touching on both Trump's $10 million contribution to his campaign and the campaign's ties to Egypt.

In a session months later, Bannon was asked about Trump's $10 million contribution to his campaign, according to another recent release of Mueller's interview memos.

Mueller asked the President, "Did any person or entity inform you during the campaign that any foreign government or foreign leader, other than Russia or Vladimir Putin, had provided, wished to provide, or offered to provide tangible support to your campaign?" Trump wrote back in his written answers that he had "no recollection of being told during the campaign" of support from a foreign government.

Soon enough, the bank was arguing it shouldn't have to give Mueller records because it was interchangeable with the foreign government that owned it. The US courts disagreed repeatedly, saying the company couldn't be immune from the Mueller team subpoena.  

When the federal appeals court in Washington, DC, heard arguments in the case in December 2018, security cleared journalists from an entire floor of the federal courthouse, allowing attorneys involved in the case to enter and exit the building and the courtroom without being seen.

The case even landed before the Supreme Court in early 2019. The high court ultimately declined the company's bid to block Mueller's subpoena in March 2019.  Even then, however, the standoff between US prosecutors and the Egyptian bank ended in a stalemate. 

In the end, it was the bank's word against the investigators. The court proceedings ended with prosecutors getting nothing more than what the bank was willing to turn over, and the bank was excused from hundreds of thousands of dollars in fines that had accrued for defying the subpoena. It appeared to be a dead end -- and not justification enough for Mueller to keep his office open to finish this case alone.

In late March 2019, shortly after Mueller's investigation concluded, Howell, overseeing final court proceedings in the Egyptian bank's subpoena case,  asked a prosecutor point-blank if the investigation was over. "No, it's continuing. I can say it's continuing robustly," David Goodhand of the DC US attorney's office told the court.

Liu told prosecutors she didn't believe they had met the standard needed to seek the records. The investigation stagnated, but Liu didn't close the case. She declined to comment for this story.

It's unclear how much activity occurred after Liu rejected the subpoena request. Prosecutors who disagreed with her decision believed it was now impossible to resolve questions about Trump's 2016 campaign contribution. Liu told people in her office that if the investigation had produced enough evidence, Mueller would have made the decision to take additional steps, according to sources.

On paper, Mueller described the investigation with only three vague words: "Foreign campaign contribution."

“You don’t grant immunity to individuals unless you are getting something from them — and we wouldn’t be here.”

Six months earlier, Matthew G. Whitaker, the acting attorney general who ran the department from November 2018 until Mr. Barr arrived in February 2019, rejected a request from Mr. Berman for permission to file criminal charges against the bank, two lawyers involved in the investigation said. Mr. Whitaker blocked the move shortly after Mr. Erdogan repeatedly pressed Mr. Trump in a series of conversations in November and December 2018 to resolve the Halkbank matter.

Mr. Erdogan had a big political stake in the outcome, because the case had become a major embarrassment for him in Turkey.

And Mr. Trump’s sympathetic response to Mr. Erdogan was especially jarring because it involved accusations that the bank had undercut Mr. Trump’s policy of economically isolating Iran, a centerpiece of his Middle East plan.

Former White House officials said they came to fear that the president was open to swaying the criminal justice system to advance a transactional and ill-defined agenda of his own.

the administration’s bitterness over Mr. Berman’s unwillingness to go along with Mr. Barr’s proposal would linger, and ultimately contribute to Mr. Berman’s dismissal.

It predated Mr. Trump’s election but came to encompass a broad cast of players, including Rudolph W. Giuliani, the former New York mayor; Michael T. Flynn, Mr. Trump’s first national security adviser; and Brian D. Ballard, a lobbyist and fund-raiser for the president.

he investigation of Halkbank, Mr. Erdogan claimed, was a “big conspiracy” instigated by his rival Fethullah Gulen, a charismatic Muslim cleric. Mr. Gulen left Turkey in the late 1990s and moved to Pennsylvania, where, in Mr. Erdogan’s telling, he plotted an unsuccessful coup attempt just a month earlier, according to a summary of the conversation provided to The Times by the Biden aide.

“Top leadership in Turkey felt that Trump would be a tough-minded businessman, but a businessman they could work with,” Robert Amsterdam, a lobbyist for Turkey, recalled.

Mr. Erdogan also wanted the Obama administration to remove the judge overseeing Mr. Zarrab’s case in Manhattan, the Biden aide said. And he wanted Mr. Zarrab released and allowed to return to Turkey.

“If the president were to take this into his own hands, what would happen would be he would be impeached for violating the separation of powers,” Mr. Biden said

Mr. Erdogan asked Mr. Biden to remove Preet Bharara, then the U.S. attorney for the Southern District of New York. That office was in the early stages of an investigation into Halkbank and had already indicted a Turkish-Iranian gold trader, Reza Zarrab, for helping to orchestrate the sanctions-evasion scheme.

ust how idiosyncratic became more apparent last October, when Mr. Erdogan sent troops into Syria. Mr. Trump, who had initially given Mr. Erdogan the green light to do so, then faced an intense bipartisan backlash, leading him within days to take a tougher line with Turkey, threatening economic reprisals.

But the investigation by the federal prosecutors in Manhattan ground ahead. By early 2018, it had led to the indictments of nine defendants, including Turkey’s former economy minister and three Halkbank officials, on charges such as bank fraud and money laundering related to the sanctions-evasion scheme.

ut Mr. Mnuchin raised concerns about how large a fine might be imposed on Halkbank. The French banking giant Société Générale agreed that same year to pay U.S. authorities more than $2 billion to resolve charges that it had violated U.S. sanctions against Cuba and bribed officials in Libya, among other accusations

A fine on that scale would threaten the future of Halkbank, lobbyists and lawyers for the bank argued, as did top Turkish officials in conversations with members of the Trump administration

Mr. Erdogan made clear that he was frustrated with the continued pestering by Southern District prosecutors concerning Halkbank, and he wanted Mr. Trump to intervene to help wrap up the investigation, Mr. Bolton said in the interview

Mr. Trump also told Mr. Erdogan that he wanted to replace the prosecutors in Mr. Berman’s office in Manhattan, whom Mr. Trump considered to be holdovers from the Obama era.

Mr. Rosenstein was convinced that the evidence was compelling, perhaps even more so than in other sanctions-evasion cases in which the United States had charged banks, lawyers familiar with the investigation said. The memo from the prosecutors also noted that the actions Halkbank was accused of taking were helping to support Iran’s economy, which was antithetical to Mr. Trump’s foreign policy goal of tightening economic pressure on the country.

Mr. Rosenstein urged Mr. Berman to come to Washington to present the Southern District’s argument to Mr. Whitaker. The goal was not to file charges immediately against the bank. Instead, the plan was to give the Southern District more leverage to squeeze Halkbank to accept a deferred prosecution agreement that included an admission of wrongdoing.

Discussions between Halkbank and the Southern District continued, according to lawyers involved in the case. But the bank maintained its refusal to admit to wrongdoing and insisted on a deal that would end investigations and drop existing charges.

At times, the prosecutors were left with the impression that bank officials felt they had all the leverage because of the relationship between Mr. Trump and Mr. Erdogan.

The suggestion that the Justice Department would offer Turkish officials protection from criminal charges, even without their agreement to assist in the investigation, was unacceptable and unethical, Mr. Berman argued, according to lawyers close to the investigation.

Mr. Barr sought to persuade Mr. Berman that the so-called global settlement would enforce U.S. sanctions law and avert a rift with an ally in a volatile part of the world.

“That is the biggest prize that Erdogan could ever receive,” Mr. Erdemir said. “Erdogan was not trying to save the bank. He was trying to save his ministers and save himself.”

The National Security Council asked the Education Department about a network of charter schools, partly funded with federal money, that were said to be linked to Mr. Gulen, the Erdogan rival who was living in Pennsylvania. The agency was then asked if the money could be blocked, one official involved in the conversations said. But Education Department officials resisted, saying they did not have the legal authority to stop the funding.

On Oct. 15, the Justice Department gave the prosecutors in Manhattan approval to file charges against Halkbank, a direct slap at Mr. Erdogan.The prosecutors rushed to present evidence before a grand jury and secured a six-count indictment that same day charging Halkbank with money laundering, bank fraud and conspiracy to violate the Iran sanctions. So far, no additional individuals have been charged.

On Tuesday, Microsoft, Amazon’s closest competitor in cloud computing, also reported its most profitable quarter, growing 30 percent from a year earlier.

Amazon reported record sales, and an almost 200 percent rise in profits, as the pandemic accelerated the transition to online shopping. Despite a boycott of its advertising over the summer, Facebook had another blockbuster quarter.

Twitter’s stock dropped about 14 percent in after-hours trading on Thursday

Sales were $96.1 billion, up 37 percent from a year earlier, and profits rose to $6.3 billion.

Amazon said sales could reach $121 billion in the fourth quarter because of the confluence of Prime Day, the holiday shopping season and the turn to online spending.

Apple’s services segment, which includes revenues from the App Store and offerings like Apple Music, increased 16 percent to $14.5 billion. Sales rose 46 percent for iPads, 29 percent for Mac computers and 21 percent for wearables.

acism leads to social vulnerability, she said, with people holding low wage jobs that place them at higher risk of infection and living in crowded neighborhoods and households.

situations that tend to apply more often to people of color — are getting sick and dying from Covid-19 at a much higher rate than the rest of the population.

If the C.D.C. committee follows the National Academy’s framework, 10 percent of the total amount of vaccine available would be reserved for people in hard-hit communities.

The first phase offers a vaccine to health care workers, a large group that constitutes at least 15 million people and includes low-wage workers, such as nursing assistants and housekeepers in nursing homes.

60 million essential workers who are not in health care

When the first two phases of vaccines are distributed, 1.7 million more doses would be offered to mostly worse-off Black and Hispanic communities using the vulnerability index preferred by the National Academies than with the deprivation index, he and other colleagues reported in another paper.

The allocation proposal, “is built on the assumption that people who for generations have been underserved and disadvantaged should get a leg up if we can afford it,” said Dr. Matthew Wynia, an ethicist and infectious disease physician at the University of Colorado. But, he said, leaders in some states may refuse.

Vaccinations could begin in the second half of December, Fauci said.

Vaccinations are expected to begin with high-risk groups and to be available for the rest of the population next spring

15,000 study participants were given a placebo, which is a shot of saline that has no effect. Over several months, 90 of them developed Covid-19, with 11 developing severe forms of the disease.

The vaccines deliver messenger RNA, or mRNA, which is a genetic recipe for making the spikes that sit atop the coronavirus

A small percentage of those who received it experienced symptoms such as body aches and headaches.

Fauci says he expects the first Covid-19 vaccinations to begin "towards the latter part of December, rather than the early part of December."

Another 15,000 participants were given the vaccine, and only five of them developed Covid-19. None of the five became severely ill.

Pfizer's and Moderna's vaccines have similar results because they use the same technique to activate the body's immune system.

Initially, there won't be enough vaccine for everyone.

No vaccine currently on the market uses mRNA.

"There has always been skepticism about mRNA -- it's brand new and would it work?" Fauci said. "What we saw in the trials is there was no real safety concern, and the efficacy is quite impressive. We saw nearly identical results [with Pfizer and Moderna] and it almost really validates the mRNA platform."

Both vaccines are given in two doses several weeks apart.

While the two vaccines appear to have very similar safety and efficacy profiles, Moderna's vaccine has a significant practical advantage over Pfizer's.

Pfizer's vaccine has to be kept at minus 75 degrees Celsius. No other vaccine in the US needs to be kept that cold, and doctors' offices and pharmacies do not have freezers that go that low.

Moderna's vaccine can be kept at minus 20 degrees Celsius. Other vaccines, such as the one against chickenpox, need to be kept at that temperature.

Another advantage of Moderna's vaccine is that it can be kept for 30 days in the refrigerator, the company announced Monday. Pfizer's vaccine can last only five days in the refrigerator

Both companies said they expected to apply within weeks to the F.D.A. for emergency authorization to begin vaccinating the public. In addition to the evidence for effectiveness, the companies must also submit two months of safety data on at least half of the participants.

An additional concern is that both vaccines must be stored and transported at low temperatures — minus 4 degrees Fahrenheit for Moderna, and minus 94 Fahrenheit for Pfizer — which could complicate their distribution, particularly to low-income areas in hot climates.

Researchers say the positive results from Pfizer and Moderna bode well for other vaccines, because all of the candidates being tested aim at the same target — the so-called spike protein on the coronavirus that it uses to invade human cells.

The drugmaker Moderna announced on Monday that its coronavirus vaccine was 94.5 percent effective, joining Pfizer as a front-runner in the global race to contain a raging pandemic that has killed 1.2 million people worldwide.

the Trump administration’s program to accelerate development of vaccines and treatments for Covid-19, said that if any early vaccine candidates received permission for emergency use, immunization could begin sometime in December.

Both companies plan to apply within weeks to the Food and Drug Administration for emergency authorization to begin vaccinating the public

But a vaccine that would be widely available to the public is still months away, while the need for one is becoming increasingly urgent

Covid-19 is killing more than 1,100 Americans a day, and the last million cases occurred in just six days.

This vaccine presents the opportunity of using doctors’ offices, clinics and pharmacies as vaccination sites,” he said, adding that he would not be surprised, should both vaccines become available, if vaccination sites requested Moderna’s.

Moderna said it would have 20 million doses ready by the end of 2020

Moderna is the second company to report preliminary results from a large trial testing a vaccine. But there are still months to go before it will be widely available to the public.

The company announced on Oct. 22 that it had completed enrollment of its 30,000-person study, and that 25,650 participants had already received two shots.

Moderna has received a commitment of $955 million from the U.S. government’s Biomedical Advanced Research and Development Authority for research and development of its vaccine, and the United States has committed up to $1.525 billion to buy 100 million doses.

A new composite forecast from the US Centers for Disease Control and Prevention projects a total of 332,000 to 362,000 Covid-19 deaths by January 2.

Covid-19 hospitalizations also reached a new record high of 106,688 on Wednesday, according to the COVID Tracking Project.

more than 221,000 new infections were reported in just one da

"We are in a totally unprecedented health crisis in this country,"

Health care workers are exhausted. Hospitals are totally full."

"Unfortunately, with the volume of new cases that we are seeing and the implications it has on hospital utilization, during a period of widespread, community transmission, activities such as eating, drinking and smoking in close proximity to others, should not continue."

If the FDA grants emergency use authorization in the coming days, the first Americans outside of clinical trials could start getting inoculated this month.

in the coming months it's crucial that Americans stay vigilant and follow safety guidelines, like wearing face masks, social distancing and hunkering down in their social bubbles.

But the country will likely not see any meaningful impact until well into 2021 -- and that's if enough people get vaccinated, said Dr. Anthony Fauci, director of the National Institute for Allergy and Infectious Diseases.

"Let's say we get 75%, 80% of the population vaccinated. I believe if we do it efficiently enough over the second quarter of 2021, by the time we get to the end of the summer ... we may actually have enough herd immunity protecting our society that as we get to the end of 2021, we could approach very much, some degree of normality that is close to where we were before,"

"We want to make sure that the vaccines are actually administered, and we're afraid that won't happen," Paul Ostrowski, who is leading supply, production and distribution for Operation Warp Speed, told "Good Morning America" Wednesday.

"Baltimore City has not had to implement such severe restrictions since the very earliest days of the pandemic and the implementation of the stay-at-home order," the city's health department tweeted.

The daily death toll from Covid-19 reached a record high of 3,124 Wednesday, according to Johns Hopkins University.

Indiana's Republican Gov. Eric Holcomb ordered hospitals to postpone or reschedule non-emergency procedures done in an inpatient hospital setting from December 16 through January 3 to preserve hospital capacity.

In Alabama, Republican Gov. Kay Ivey announced Wednesday she's extending the state's Safer at Home order, which includes a statewide mask mandate for another six weeks.

About 53% of respondents said they would get the vaccine promptly -- up from 51% before Thanksgiving and 38% in early October.

The first emergency use authorization for a vaccine is expected soon, and about 20 million people could likely get vaccinated in the next few weeks, Secretary of Health and Human Services Alex Azar said Wednesday.

In the UK, "thousands" of people were already vaccinated Tuesday, the first day of the Pfizer/BioNTech vaccine rollout there, according to the National Health Service (NHS).

The FDA will not "cut any corners" when deciding whether to authorize the vaccine, Azar said, saying he was sure what happened in the UK would be "something the FDA looks at."

"For now, we need to double down on the steps that can keep us all safe."

President-elect Joe Biden's team has magnified the giant hurdles that loom for government officials as they try to ensure the smooth delivery of millions of vaccine doses within the 50 states and cities with different ideas about the best way to administer them.

Trump told guests that with the help of "certain very important people -- if they have wisdom and if they have courage -- we're going to win this election." The crowd chanted "four more years."

the crucial question is whether Trump and his administration are equipping the incoming Biden administration with the knowledge and tools they need to carry out an unprecedented vaccination operation as Trump's White House grudgingly passes the baton.

Trump is pursuing a new round in his quixotic bid to overturn the November election by attempting to intervene in a lawsuit filed with the Supreme Court.

There were signs Wednesday, however, that cooperation is slowly beginning to take shape behind the scenes. Health and Human Services Secretary Alex Azar said that he has met with Biden's team -- a rare acknowledgment of the former vice president's victory from a top Trump official -- and he insisted that he wants "to make sure they get everything that they need."

"Twenty million people should get vaccinated in just the next several weeks, and then we'll just keep rolling out vaccines through January, February, March as they come off the production lines," Azar said, trying to offer a note of reassurance about continuity during an interview on CNN's New Day.

The vaccine distribution challenges surrounding a once-in-a-lifetime pandemic would normally be at the top of the agenda for any commander-in-chief. But unsurprisingly, Trump is refusing to acknowledge the potential problems as he spreads disinformation to his supporters, and his administration -- at his behest -- continues to target Biden's son Hunter, who revealed Wednesday that his taxes are under federal investigation.

"Unless a court makes some other decision, the Electoral College is the defining outcome of the presidential race," Moran said. Asked what would be next if Trump doesn't concede, Moran said: "There is a transition that just occurs -- occurs under our laws under the Constitution."

Kansas Sen. Jerry Moran, a Republican, said "it is unhealthy for the well-being of the country" to continue debating the outcome of the election "once the presidential race has been determined."

The attorney representing Trump, John Eastman, is known for recently pushing a racist conspiracy theory -- that Trump himself later amplified -- claiming Vice President-elect Kamala Harris might not be eligible for the role because her parents were immigrants.

With hopes riding on the vaccine authorization discussion Thursday, the country continued to grapple with an alarming rise in cases around the country as medical professionals began to see the post-Thanksgiving spike materialize and some regions reverted to shutdowns to try to preserve hospital capacity.

"This is by far, the worst surge to date," Colfax said. "The reality is unfortunately proving to be as harsh as we expected. ... The vaccine will not save us from this current surge -- there is simply not enough time."

"The more terrible truth is that over 8,000 people, ... who were beloved members of their family, are not coming back. And their deaths are an incalculable loss to their friends and their family, as well as our community."

Though Trump has said that the vaccination program will "quickly and dramatically reduce deaths," a new White House task force report warns that the vaccine "will not substantially reduce viral spread, hospitalizations, or fatalities until the 100 million Americans with comorbidities can be fully immunized, which will take until the late spring."

The FDA is expected to conduct its authorization review between December 11 and the 14, with first shipment of the vaccine going out by December 15. Needles, syringes and other materials to deliver the vaccines are already on their way to states.

Gen. Gustave Perna, said that 2.9 million doses of vaccine will go out in the first shipment from Pfizer once the FDA grants emergency use authorization.

Initially the federal government expected to receive 6.4 million doses from Pfizer as the first shipment. But because the vaccine is administered in two doses, the math is more complicated. About 500,000 doses will be set aside as a reserve supply, and the remaining number was divided in half to set aside what is needed for the second dose of the Pfizer vaccine, which brought down the total in the first shipment to 2.9 million doses.

"We just want to make sure that Americans understand exactly the science that went into this, understand the gold standard of the FDA and the approval process. We want to make sure that the vaccines are actually administered, and we're afraid that that won't happen," Ostrowski said.

He said more than one million Israelis are descended from those who originally lived in Morocco.

The United Nations and much of the rest of the world refused to affirm Morocco’s claim over the area, and the United States had supported a 1991 cease-fire between the kingdom and the Western Sahara’s pro-independence Polisario Front.

After a border incident last month, the Polisario declared war on Morocco, shattering a three-decade cease-fire and threatening a full-blown military conflict in the disputed desert territory in northwest Africa.

The deal is likely to be highly popular in Israel,

By contrast, Sudan has stopped short of declaring full and normalized relations with Israel and recently threatened to withdraw from the agreement if Congress does not give it immunity from terrorism lawsuits that families of victims of the Sept. 11, 2001, attacks want to bring against the country for harboring Osama bin Laden years before the attacks.

The treatments — a monoclonal antibody developed by Eli Lilly and a cocktail of two monoclonal antibodies developed by Regeneron — won emergency use authorization, or an E.U.A., from the Food and Drug Administration last month for outpatients with “mild to moderate” disease

“One of the challenges is the E.U.A. criteria really are so broad, it could be half of the people with Covid could qualify, but there is clearly not enough,”

Even some top officials at the F.D.A. — both career employees and political appointees — have privately expressed concern in recent months that people with connections to the White House appeared to be getting access to the antibody treatments,

In fact, the antibody treatments are so scarce that officials in Utah have developed a ranking system to determine who is most likely to benefit from the drugs, while Colorado is using a lottery system.

The infusions must be administered in outpatient settings, but infusion centers, which also care for immune-suppressed cancer patients, are loath to treat people who have an infectious disease.

Dr. Wynia in Colorado expressed concern that the therapies might not be distributed equitably across racial and ethnic lines, with hard-hit minority communities not getting their fair share.

Both Mr. Trump and Mr. Christie, a longtime friend of his and former New Jersey governor, got the antibodies before they were approved by the F.D.A. Dr. Caplan, the medical ethicist, said he had no problem with Mr. Trump, 74, getting the therapy — he is, after all, the president, “a special person unto him- or herself.”

“Exactly the same, his doctor sent me here; he talked me into it,” Mr. Giuliani said of Mr. Trump’s physician, adding, “The minute I took the cocktail yesterday, I felt 100 percent better. It works very quickly, wow.”

Once state and local health agencies determine which hospitals or medical facilities should get the drugs, they are shipped out by a third-party distributor. Then it is up to health care providers to figure out what to do with them.

“The notion that we are going to be able to treat a significant percentage of the people who qualify for the drug with the drug — it’s not going to happen,”

While testing has been comparatively limited, the continent appears to have bucked the doomsday predictions of global health experts. The telltale signs of severe outbreaks seen elsewhere — crowded hospitals and a spike in deaths — have emerged in only a handful of African countries. Surveys done by the World Health Organization have found negligible excess mortality rates in most African countries, reducing suspicion that many covid-19 deaths are going uncounted.

even as more research emerges, public health experts caution that the explanation for why Africa’s caseload has remained low will be complicated.

“It is highly unlikely that there is a single, definitive answer as to why this is the case,” said Ngoy Nsenga, a Congolese epidemiologist and the WHO’s program manager for emergency response in Africa. “Youthful populations, warmer climates, less time indoors, less traveling, less obesity and diabetes, immunities derived from other diseases — even other coronaviruses — are all playing a part, we think. But what distinguishes Africa from other places like Brazil that might share those factors, but were still hard-hit, are our human interventions.”

Those interventions have exacted immense economic damage, however, and with many African governments not seeing uncontrolled growth in cases, they have been rolled back in many places.

Health officials, however, caution that the threat is far from over — even if hospitals aren’t filling up.

“During the holiday season, there will be a tendency for large movement from capital cities to villages, remote areas, for people to connect with families. That might drive the pandemic,”

Ndongo Dia, head of the respiratory virus diagnostic laboratory at the Pasteur Institute in Senegal’s capital, Dakar, isn’t sure why Senegal dodged the worst of the pandemic.

The nation has garnered widespread praise for its quick response, which included sealing its border, rolling out four-hour tests while Americans waited days for results, and imposing a curfew until infections slowed.

Beyond that, Dia said, “our luck is the composition of our population. The number of severe cases is going to be much lower compared to the northern countries, where there are more elderly people.”

Death rates have been higher in South Africa, Algeria, Egypt and Tunisia, where a larger percentage of the population is over the age of 65. Those four countries make up two-thirds of all coronavirus deaths in Africa.

Preliminary analyses done by the WHO indicate that Africans may be twice as likely to experience covid-19 without any illness, and that more than 80 percent of cases on the continent have been asymptomatic — a far higher percentage than elsewhere in the world.

“It is not different strains — that I can refute. We have a network of laboratories all over the continent and the world,” he said. “We have sequenced from many places, we haven’t seen dramatically different strains here.”

Staff on the frontlines say they are increasingly battling burnout after months of devastation and with a dark winter ahead. “I’ve seen younger people come in through the door, and be admitted right away to the ICU,”

It was frustrating that the public no longer seemed to be taking Covid protocols seriously, Santini said. “Every day we go to work, we’re putting our lives and our family’s lives on the line.”

“Even lower-risk activities now carry substantial risk because there is more virus out there than ever before. Simply put and bluntly put, we can’t get away with things that we’ve been able to get away with so far.”

Some restaurants have invested thousands in outdoor dining infrastructure they hoped would last them through the pandemic, only to see those facilities ordered to close.

the organization’s research has shown that 43% of restaurant owners are unsure whether their business will survive the next six months. “People who started out frustrated – today they are feeling just outright desperate.”

the latest Covid surge continues to shine a harsh light on inequality. California has seen record levels of unemployment and countless businesses have been shuttered for good, yet some sectors – notably the tech industry – have continued to rake in revenue.

post-pandemic, California could see a so-called “K-shaped recovery”, where the incomes of the highest earners continue to rise just as quickly as they plummet for those who are struggling.

Latinos in LA county, many of whom are working essential jobs, are also contracting the virus at more than double the rate of white residents. The toll in working-class neighborhoods has been especially devastating for undocumented people, who have been unable to access aid.

“We have the confluence of factors where people are facing financial instability, and feel like they have no choice but to work even if they get sick,” she said. “And particularly in California, we have a large population of undocumented people who have been demonized by the federal government and are especially vulnerable.”