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ealth Minister Marisol Touraine, who was heading for Rennes on Friday, pledged to "get to the bottom... of this tragic accident".

The study was a Phase I clinical trial, in which healthy volunteers take the medication to evaluate the safety of its use, the ministry said.

Phase I tests for safety. A small number of people, sometimes healthy, and sometimes with a medical condition, are given a tiny dose of the drug under careful supervision, not to test if the drug works, but in order to check for any side effects Phase II sees the drug given to people who have a medical condition to see if it does indeed help them Phase III trials are only for medicines or devices that have already passed the first two stages, and involve them being compared to existing treatments or a placebo. The trials often last a year or more, involving several thousand patients

Clinical trials are the key to getting that data - and without volunteers to take part in the trials, there would be no new treatments for serious diseases such as cancer, multiple sclerosis and arthritis.

Since we’re nowhere close to that point — in particular, testing is still far behind what’s needed — we’re months away from a safe end of the lockdown. This is causing severe hardship for workers, businesses, hospitals and — last but not least — state and local governments, which unlike the federal government must balance their budgets.

Yet at the moment further relief legislation is stalled. And let’s be clear: Republicans are responsible for the impasse.

But the special loan program for small businesses has already been exhausted. State and city governments are reporting drastic losses in revenue and soaring expenses. And the Postal Service is on the edge of bankruptcy.

So we need another large relief package, targeted at these gaps. Where would the money come from? Just borrow it. Right now, the economy is awash in excess savings with nowhere to go. The interest rate on inflation-protected federal bonds is minus 0.56 percent; in effect, investors are willing to pay our government to make use of their money

What policy can and should do is mitigate that hardship. And the last relief package did, in fact, do a lot of the right things. But it didn’t do enough of them.

It’s true that Senate Republicans are trying to push through an extra $250 billion in small-business lending — and Democrats are willing to go along. But the Democrats also insist that the package include substantial aid for hospitals and for state and local governments. And Mitch McConnell, the Senate majority leader, is refusing to include this aid.

Everyone, and I mean everyone, knows what is really happening: McConnell is trying to get more money for businesses while continuing to shortchange state and local governments. After all, “starve the beast” — forcing governments to cut services by depriving them of resources — has been Republican strategy for decades

At a basic level, then, anti-government ideologues are preventing us from responding adequately to the worst economic disaster since the Great Depression.

Their obstructionism will cause vast suffering, as crucial public services are curtailed. It will also compound the economic damage.

In the near future, we’ll see millions of unnecessary job losses as impoverished families cut back spending, as local governments lay off teachers and firefighters, as the post office, if it survives at all, becomes a shadow of its former self.

And many of these job losses will probably persist even after the pandemic subsides.

If there’s a silver lining to all this, it is that the people sabotaging our response to Covid-19 economics may also be sabotaging their own political future. Trump is, after all, counting on rapid economic recovery to erase public memories of his disastrous handling of the pandemic itself. Yet he and his allies in the Senate are making such a recovery much less likely.

Navalny rose to fame for his investigations that exposed corruption, and for political mobilization against Putin's regime. He recently reprised that role, releasing a bombshell video that accuses Putin of using a slush fund to build a palace on the Black Sea. That report has now been viewed nearly 100 million times on YouTube.

Navalny says his fraud conviction was retribution for his activism. Election officials have also cited the mark on his record as justification to reject his attempt to run against Putin for the presidency.

With Navalny now ordered to remain in jail, a court will weigh imposing a prison sentence on Feb. 2 stemming from the earlier case, according to state-run media.

When Navalny was in Germany, he spent weeks in a medically induced coma as doctors sought to help his body recover from a variant of Novichok, a lethal Soviet-era nerve agent.

"There has been a lot of speculation lately that the convict Navalny was unable to show up at the inspectorate as he was in a coma," said Yelena Korobkova, a department head at the FSIN. "However, he had systematically violated the terms of his probationary period even before his hospitalization," she said, accusing Navalny of missing other dates in the first half of 2020.

Give me a real crisis with enough urgency to invest the parties with ownership, set up a credible process, find a mediator with will and skill, add a little luck, and poof, you too can have a chance at an agreement. Less is more here. Toward that end, here are a half dozen rules of the road on when and how negotiations actually work.

Own up: Former World Bank and Harvard President Larry Summers was right. In the history of the world nobody ever washed a rental car. People really care only about what they own. And without those in conflict actually investing themselves in the need for an agreement, there won’t be one.

Another Fisher principle was to develop objective criteria so that when there was disagreement, there would be some reasonable baseline to resolve them

Nobody Gets 100%: The Rolling Stones got this one right: You get what you need, not always what you want. To do a deal that lasts requires a balance of interests where both leaders can convince themselves they got enough on the substance—and persuade their publics too. A third party mediator can often help to make the sale by being creative in packaging. But the substance has to be real.

A Credible Process: The so-called peace process—now in a coma—has gotten a bad name. And it’s easy to see why. But if you want to reach an agreement, you’ll need a process that’s credible all the same. Negotiations on complex issues involving identity, religion, security take time. Expectations need to be managed. And there must be a sense that the process—however difficult—is heading toward mutually agreeable goals.

The 3rd Party: It would be nice to fantasize that the Arabs and Israelis could do this peace thing without the help of a third party, but history says no. Sure, the two sides often start the process. But the gaps are too wide, the mistrust too deep, and the need for assurances—economic, technical and security assistance—too great to go it alone.

put down those academic books. Get yourself to the nearest video store and rent West Side Story and the Godfather. That’s what real world negotiations look like.

The last American to be freed before the most recent three was Otto Warmbier, who had been detained in North Korea for 17 months, and died a week after returning home. North Korea said he had been in a coma for a year after contracting botulism, but his family say he was subjected to "awful torturous mistreatment".

The captured individuals were intended to help train North Korean spies in Japanese language and customs.

If they didn’t have the coronavirus before coming to our hospital, they probably do now. So much for gatherings of 10 people or fewer.

Meanwhile, my colleagues tend to patients in the critical-care bay with dipping oxygen levels, patients who can barely speak and may need breathing tubes.

Earlier in the month, we were told that positive-pressure oxygen masks, such as CPAP machines, were risky, as they would aerosolize the virus, increasing health-care workers’ risk of infection

But in recent days, running dangerously low on ventilators, we have attempted using CPAP machines to stave off the need for medically induced comas.

Nevertheless, we need to perform an alarming number of of intubations. Our ventilators are almost all in use, and the ICUs are at capacity.

On Wednesday, I greeted a patient I had discharged only one week prior. When I saw his name pop up on the board, my heart sank. He is just shy of 50, with hardly any past medical history, and he had seemed fine. Now he was gasping for air. His chest X-ray was no relief—COVID-19 for sure. I needed to admit him to the hospital, and set him up with oxygen, heart monitoring, and a bed.

My colleagues and I discuss this pandemic with a sardonic sense of helplessness. Some of us are getting sick. Our reality alters by the moment. Every day, we change our triage system. Each day could be the day that the masks run out. There is much we think but are too afraid to say to one another.

I do not want to see you in my hospital. I do not want you to go to any hospital in the United States. I do not want you to leave your home, except for essential food and supplies. I do not want you to get tested for the coronavirus, unless you need to be admitted to a hospital.

If you have mild symptoms, assume that you have the coronavirus. Stay home, wash your hands, call your doctor. Don’t come to the emergency department just because of a fever or cough. Receiving a test won’t change our recommendation that you remain in self-isolation. We don’t want you to expose yourself to those who definitely do have the virus.

Social distancing, while still crucial, came too late in New York to prevent a crisis. Maybe, just maybe, extreme measures can prevent this from happening in other cities around the country.

the hospital received one piece of good news yesterday. A coronavirus patient was successfully taken off a ventilator after two weeks, a first for our Medical ICU and a victory for the staff and, of course, the patient.

If the United States is forced to defend itself or its allies, “we will have no choice but to totally destroy North Korea,” President Trump told the gathering.

Mr. Trump emphasized that it was against the interest of the entire world for North Korea — which he called a “band of criminals” — to obtain missiles and nuclear weapons.

“Rocket man is on a suicide mission for himself,” he said of Mr. Kim.

Mr. Trump accused Mr. Kim of overseeing a regime that has starved its people, brutalized an imprisoned American college student who was returned home in a coma, and assassinated Mr. Kim’s older brother, a potential rival, with poison chemicals.

“If this is not twisted enough, now North Korea’s reckless pursuit of missiles and nuclear weapons threatens the entire world,” Mr. Trump said.

While he thanked Russia and China for supporting recent United Nations sanctions on North Korea, Mr. Trump also took an indirect swipe at them for continuing to do business with Mr. Kim.

“It is an outrage that some nations would not only trade with such a regime, but would arm, supply and financially support a country that imperils the world,” Mr. Trump said.

“As president, I will always put America first, just like you as the leaders of your countries will always — and should always — put your countries first,” he said.

To forcibly wrest power from Trump, Vice President Mike Pence would have to be on board, according to the text of the amendment

Pence would also need either a majority of Trump's Cabinet officials to agree the President is unfit for office and temporarily seize power from him.

Pence and the Cabinet would then have four days to dispute him, Congress would then vote -- it requires a two-thirds supermajority, usually 67 senators and 290 House members to permanently remove him.

House Speaker Nancy Pelosi, during the last Congress, introduced a bill to create a congressional body for this purpose, but it was not signed into law.

The 25th Amendment was enacted in the wake of the assassination of John F. Kennedy, whose predecessor Dwight Eisenhower suffered major heart attacks. It was meant to create a clear line of succession and prepare for urgent contingencies.

The portion of the 25th Amendment that allows the vice president and Cabinet to remove the president had in mind a leader who was in a coma or suffered a stroke

The storming of the Capitol by rioters at the request of the President may end up being the first such contingency in the nation's history.

"Our country's being held hostage right now by Donald Trump," he said. "Mitch McConnell and Speaker Pelosi cannot even meet in the Capitol today ... so I think we now have to go into our constitutional kit bag and find what we can do to control Donald Trump and certainly the 25th Amendment is there."

"I remember the first time (Kasparov) was in jail, he didn't eat a thing because he was afraid that they'd poison him. And we all laughed at him! We thought he was paranoid. He is the only person I know who took any security measures."

Navalny's brilliant sting operation won't lead to an arrest and may only increase the chances he'll be targeted again with a less subtle method

Putin, who worked as a KGB officer before his political ascendance, once said himself that "there's no such thing as former KGB man." While he has always prioritized the security services during his two decades in power, the decay within Russia's intelligence agency is obvious as the country stagnates under dictatorship

But you don't have to be a master assassin when you can keep trying with impunity, even after being caught red-handed.

I don't fly with the state-owned airline Aeroflot, and I don't travel to countries where Putin might be able to put pressure on local authorities to do him a favor. But no one is untouchable in a world where criminals go unpunished.

The Kremlin has doubled down on its lies and denials, spreading a flood of contradictory stories by officials and in the state-run media. Putin himself was dismissive as usual, refusing to even mention Navalny by name when asked about the case. He denied the poisoning, saying, "If (FSB agents) wanted to, they would've probably finished it."

Even in the face of one of the worst cyberattacks in US history, Trump has refused to call out Russia as the culprit, even when his own secretary of state said, "We can say pretty clearly that it was the Russians that engaged in this activity."

Putin's henchmen are sloppy because they can afford to be. Just like their boss, they don't fear any repercussions

Meanwhile, the Trump administration is sending a clear message to all despots as it considers granting legal immunity for Saudi crown prince Mohammed bin Salman, who ordered the gruesome killing of journalist Jamal Khashoggi, according to the CIA

Yet, there is always talk about the need for more international engagement with these despots and thugs, not less. The dubious theory that globalization and closer economic ties will inevitably liberalize dictatorships has been refuted many times over. We see this with China's Xi Jinping, who has become more authoritarian and aggressive since the US welcomed China into the World Trade Organization. Instead, engagement -- or appeasement by another name -- reinforces their sense of impunity

Russia and some of Putin's oligarchs have already been under piecemeal sanctions since the 2014 invasion of Ukraine and annexation of Crimea. But these sanctions are merely a slap on the wrist, and it's clear they do not go far or high enough.