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Mr. Vance “extracted what he needed from Appalachia.” Before anything else, the senator’s first betrayal was of his own region, the first portion of his soul to be sold.

Shortly after “Hillbilly Elegy” was released, writers throughout Appalachia denounced the classism and elitism of the book, as well as the self-serving ambitions of its author.

Without too much hyperbole, it could be said that J.D. Vance — a possible heir to the MAGA movement who has embraced some of the most noxious elements of the alt-right and the national conservative movement — is an infernal creation of the powerful liberals who championed his writing and elevated his platform. It’s hard to imagine that without “Hillbilly Elegy,” which was adapted into a film by the Democratic Party donor Ron Howard in 2020, Mr. Vance would have become the junior senator of Ohio, much less a nominee for vice president

Since being elected to the Senate, in large part due to the financial support of the tech billionaire and right-wing activist Peter Thiel, Mr. Vance has become a zealous convert to the MAGA cause. That’s a stunning reversal for a figure who eight years ago was celebrated as an astute voice of Never Trumper Republicanism, a man of learning who could formulate a centrist conservatism to supplant the dark turn that had taken hold of the G.O.P.

As Mr. Vance noted in a Time magazine interview in 2016, Mr. Trump’s greatest failure as a political leader is that “he sees the worst in people, and he encourages the worst in people.” That’s turning out to be true of Mr. Vance, too.

Eight years ago, during the heated days of the 2016 Republican primary, Mr. Vance wrote that Mr. Trump’s policy proposals “range from immoral to absurd.” A few months later, he referred to Mr. Trump as “cultural heroin,” and called him “unfit for our nation’s highest office.” And memorably, in a text conversation with a former roommate, the future senator worried that Mr. Trump might be “America’s Hitler.”

Mr. Trump’s White House tenure, he said, had changed his mind, but it’s hard to take the senator entirely at his word.

At the outset of Christopher Marlowe’s late 16th-century play “The Tragical History of Dr. Faustus,” the scholar at the center of the tale abandons all the learning he has mastered. Law, philosophy, medicine — none of these have fulfilled his boundless ambition. Instead, he turns to magic, making the fateful decision to sell his soul to the demon Mephistopheles, for what he “most desires” — “a world of profit and delight, /Of power, of honor.”