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Javier E

To Live Past 100, Mangia a Lot Less: Italian Expert's Ideas on Aging - The New York Times - 0 views

www.nytimes.com/...italy-aging-valter-longo.html

aging longevity italy research researcher diet genetics

shared by Javier E on 26 Mar 24 - No Cached
  • Valter Longo, a nutrition-obsessed Italian Ph.D. student, wrestled with a lifelong addiction to longevity.
  • “For studying aging, Italy is just incredible,
  • Italy has one of the world’s oldest populations, including multiple pockets of centenarians who tantalize researchers searching for the fountain of youth. “It’s nirvana.”
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  • Dr. Longo, who is also a professor of gerontology and director of the U.S.C. Longevity Institute in California, has long advocated longer and better living through eating Lite Italian, one of a global explosion of Road to Perpetual Wellville theories about how to stay young in a field that is itself still in its adolescence.
  • In addition to identifying genes that regulate aging, he has created a plant and nut-based diet with supplements and kale crackers that mimics fasting to, he argues, allow cells to shed harmful baggage and rejuvenate, without the down side of actually starving.
  • He has patented and sold his ProLon diet kits; published best-selling books (“The Longevity Diet”); and been called an influential “Fasting Evangelist” by Time magazine.
  • Last month, he published a new study based on clinical trials of hundreds of older people — including in the Calabria town from which his family hails — that he said suggests that periodic cycles of his own faux-fasting approach could reduce biological age and stave off illnesses associated with aging.
  • “It’s very similar to the original Mediterranean diet, not the present one,” she said, pointing at photographs on the wall of a bowl of ancient legumes similar to the chickpe
  • “Almost nobody in Italy eats the Mediterranean diet,”
  • He added that many Italian children, especially in the country’s south, are obese, bloated on what he calls the poisonous five Ps — pizza, pasta, protein, potatoes and pane (or bread).
  • in recent years, Silicon Valley billionaires who hope to be forever young have funded secretive labs. Wellness articles have conquered newspaper home pages and Fountains-of-Youth workout and diet ads featuring insanely fit middle-aged people teem on the social media feeds of not insanely fit middle-aged people.
  • he said Italy’s lack of investment in research was a disgrace.
  • even as concepts like longevity, intermittent fasting and biological age — you’re only as old as your cells feel! — have gained momentum, governments like Italy’s are fretting over a creakier future in which booming populations of old people drain resources from the dwindling young.
  • many scientists, nutritionists and longevity fanatics the world over continue to stare longingly toward Italy, seeking in its deep pockets of centenarians a secret ingredient to long life.
  • “Probably they kept breeding between cousins and relatives,” Dr. Longo offered, referring to the sometimes close relations in little Italian hill towns. “At some point, we suspect it sort of generated the super-longevity genome.”
  • The genetic drawbacks of incest, he hypothesized, slowly vanished because those mutations either killed their carriers before they could reproduce or because the town noticed a monstrous ailment — like early onset Alzheimer’s — in a particular family line and steered clear.
  • Dr. Longo wonders whether Italy’s centenarians had been protected from later disease by a starvation period and old-fashioned Mediterranean diet early in life, during rural Italy’s abject war-era poverty. Then a boost of proteins and fats and modern medicine after Italy’s postwar economic miracle protected them from frailty as they got older and kept them alive.
  • At age 16, he moved to Chicago to live with relatives and couldn’t help notice that his middle-aged aunts and uncles fed on the “Chicago diet” of sausages and sugary drinks suffered diabetes and cardiovascular disease that their relatives back in Calabria did not.
  • He eventually earned his Ph.D in biochemistry at U.C.L.A. and did his postdoctoral training in the neurobiology of aging at U.S.C. He overcame early skepticism about the field to publish in top journals and became a zealous evangelizer for the age-reversing effects of his diet. About 10 years ago, eager to be closer to his aging parents in Genoa, he took a second job at the IFOM oncology institute in Milan.
  • He found a fount of inspiration in the pescatarian-heavy diet around Genoa and all the legumes down in Calabria.
  • he also found the modern Italian diet — the cured meats, layers of lasagna and fried vegetables the world hungered for — horrendous and a source of disease.
  • His private foundation, also based in Milan, tailors diets for cancer patients, but also consults for Italian companies and schools, promoting a Mediterranean diet that is actually foreign to most Italians today.
  • “Italy’s got such incredible history and a wealth of information about aging,” he said. “But spends virtually nothing.”
  • He talked about how he and others had identified an important regulator of aging in yeast, and how he has investigated whether the same pathway was at work in all organisms.
  • Dr. Longo said he thinks of his mission as extending youth and health, not simply putting more years on the clock, a goal he said could lead to a “scary world,” in which only the rich could afford to live for centuries, potentially forcing caps on having children
  • A more likely short-term scenario, he said, was division between two populations. The first would live as we do now and reach about 80 or longer through medical advancements. But Italians would be saddled with long — and, given the drop in the birthrate, potentially lonely — years burdened by horrible diseases.
  • The other population would follow fasting diets and scientific breakthroughs and live to 100 and perhaps 110 in relative good health.
Javier E

In defense of science fiction - by Noah Smith - Noahpinion - 0 views

www.noahpinion.blog/...in-defense-of-science-fiction

science fiction dystopia effects billionaire

shared by Javier E on 31 Dec 23 - No Cached
  • I’m a big fan of science fiction (see my list of favorites from last week)! So when people start bashing the genre, I tend to leap to its defense
  • this time, the people doing the bashing are some serious heavyweights themselves — Charles Stross, the celebrated award-winning sci-fi author, and Tyler Austin Harper, a professor who studies science fiction for a living
  • The two critiques center around the same idea — that rich people have misused sci-fi, taking inspiration from dystopian stories and working to make those dystopias a reality.
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  • [Science fiction’s influence]…leaves us facing a future we were all warned about, courtesy of dystopian novels mistaken for instruction manuals…[T]he billionaires behind the steering wheel have mistaken cautionary tales and entertainments for a road map, and we’re trapped in the passenger seat.
  • t even then it would be hard to argue exogeneity, since censorship is a response to society’s values as well as a potential cause of them.
  • Stross is alleging that the billionaires are getting Gernsback and Campbell’s intentions exactly right. His problem is simply that Gernsback and Campbell were kind of right-wing, at least by modern standards, and he’s worried that their sci-fi acted as propaganda for right-wing ideas.
  • The question of whether literature has a political effect is an empirical one — and it’s a very difficult empirical one. It’s extremely hard to test the hypothesis that literature exerts a diffuse influence on the values and preconceptions of the citizenry
  • I think Stross really doesn’t come up with any credible examples of billionaires mistaking cautionary tales for road maps. Instead, most of his article focuses on a very different critique — the idea that sci-fi authors inculcate rich technologists with bad values and bad visions of what the future ought to look like:
  • I agree that the internet and cell phones have had an ambiguous overall impact on human welfare. If modern technology does have a Torment Nexus, it’s the mobile-social nexus that keeps us riveted to highly artificial, attenuated parasocial interactions for every waking hour of our day. But these technologies are still very young, and it remains to be seen whether the ways in which we use them will get better or worse over time.
  • There are very few technologies — if any — whose impact we can project into the far future at the moment of their inception. So unless you think our species should just refuse to create any new technology at all, you have to accept that each one is going to be a bit of a gamble.
  • As for weapons of war, those are clearly bad in terms of their direct effects on the people on the receiving end. But it’s possible that more powerful weapons — such as the atomic bomb — serve to deter more deaths than they cause
  • yes, AI is risky, but the need to manage and limit risk is a far cry from the litany of negative assumptions and extrapolations that often gets flung in the technology’s directio
  • I think the main problem with Harper’s argument is simply techno-pessimism. So far, technology’s effects on humanity have been mostly good, lifting us up from the muck of desperate poverty and enabling the creation of a healthier, more peaceful, more humane world. Any serious discussion of the effects of innovation on society must acknowledge that. We might have hit an inflection point where it all goes downhill from here, and future technologies become the Torment Nexuses that we’ve successfully avoided in the past. But it’s very premature to assume we’ve hit that point.
  • I understand that the 2020s are an exhausted age, in which we’re still reeling from the social ructions of the 2010s. I understand that in such a weary and fearful condition, it’s natural to want to slow the march of technological progress as a proxy for slowing the headlong rush of social progress
  • And I also understand how easy it is to get negatively polarized against billionaires, and any technologies that billionaires invent, and any literature that billionaires like to read.
  • But at a time when we’re creating vaccines against cancer and abundant clean energy and any number of other life-improving and productivity-boosting marvels, it’s a little strange to think that technology is ruining the world
  • The dystopian elements of modern life are mostly just prosaic, old things — political demagogues, sclerotic industries, social divisions, monopoly power, environmental damage, school bullies, crime, opiates, and so on
Javier E

Best of 2023: The Decadent Opulence of Modern Capitalism - 0 views

www.tracinskiletter.com/...-of-2023-the-decadent-opulence

opulence capitalism modern economics US income class middle-class

shared by Javier E on 31 Dec 23 - No Cached
  • while we tend to focus on stories about everything that has gone wrong, in the long run, the bigger news always ends up being the impact of growth and innovation. But because we’re so pre-occupied with everything else, it tends to sneak up on us.
  • In the left’s view, market crashes and recessions reveal the real essence of the capitalist system. In reality, they are just temporary glitches and setbacks in a larger story of persistent innovation and growth.
  • new figures showing the widening gap in wealth between the US and Europe. Jim Pethokoukis describes it as a Doom Loop of Decline and attributes it partly to the impact of heavy European regulation.
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  • The basic driver is this: “Europe has an aging population that values its free time and social benefits over work and productivity. (This reduces labor force participation, innovation potential, and the economic growth of the continent.)
  • The eurozone economy grew about 6% over the past 15 years, measured in dollars, compared with 82% for the US, according to International Monetary Fund data. That has left the average EU country poorer per head than every US state except Idaho and Mississippi
  • If the current trend continues, by 2035 the gap between economic output per capita in the US and EU will be as large as that between Japan and Ecuador today
  • even in Smith’s figures, there is no Northern European economy that outperforms the US.
  • The US economy has grown 82% in fifteen years! Barring anything more than a mild recession, that means that we can expect the US economy to more than double by the time we hit 20 years from 2008. Isn’t that wonderful?
  • It’s not just a case of doubling the overall size of the economy. The increase in wealth has been widely distributed.
  • Deciding what is “middle class” versus “lower middle class” versus “upper middle class” is difficult, and every analysis sets up different cutoffs between these categories. But Rose sets a reasonable level, describing “upper middle class” as an income between $100,000 and $350,000
  • I was struck by a calculation by George Washington University’s Stephen Rose that he describes at a center-left newsletter called The Liberal Patriot
  • Using this measure, there was real growth in every rung of the economic ladder over the period from 1979 to 2019, with each ascending step having slightly higher percentage gain….
  • In brief, economic growth from 1979 to 2019 led more of the population to move up to higher social classes. As Table 1 shows, the bottom two categories—poor and near-poor plus lower middle class—went from a combined 49 percent to 29 percent
  • The size of the [core middle class] also declined, down from 39 percent to 31 percent over these years
  • These declines manifest themselves in a massive—and massively under-covered—growth of the [upper middle class], spiking from 13 percent in 1979 to 37 percent in 2019.
  • America has always thought of itself as a middle-class country. But we are rapidly becoming an upper-middle-class country
  • This is now the largest category, and at the rate we’re going, it will soon be an outright majority.
  • upper-middle-class people can afford more welfare-state spending, and they also have more access to education and, frankly, the luxury of agonizing over something other than our pocketbooks. It has been a long time since most Americans were concerned about how to put a roof over our heads, so we have moved on from “kitchen table” issues to concerns about values and status and self-image.
  • in this context, the Old Left welfare-state programs look, not merely unnecessary, but callous and cruel
  • the incentives created by welfare programs discourage work for the poor. But in a growing and thriving upper-middle-class country, this looks like a way to create a permanent underclass who are kept in poverty so we can congratulate ourselves on our compassion and generosity
  • some of this may also explain the right’s belligerent opposition to immigration. If we are becoming an upper-middle-class country, perhaps we are taking on some of the attitudes of a gated community that wants to keep out the riff-raff.
Javier E

Jake Sullivan's Revolution - POLITICO - 0 views

www.politico.com/...n-globalization-biden-00141697

politics crisis history US economics policy biden strategy

shared by Javier E on 21 Feb 24 - No Cached
  • Sullivan first had to dismantle establishment orthodoxies within himself — the same orthodoxies he now sought to undo at Brookings: That globalization and free trade were an unalloyed good, growing economies and improving people’s lives in the process. What was good for the stock market, in effect, was great for everybody. Given enough time, swelling wallets would produce a steady middle class, one that demands its political and human rights from its government. Even the most repressive regimes, the thinking went, would eventually crumble under the weight of inflowing capital. Consistent pressure via greenbacks did the most good for the most people.
  • “Those were the heady days when the mainstream foreign policy consensus was that globalization was a force for good,” Sullivan recalled in a 2017 interview. There was, of course, reason to think this. Capitalism helped keep the Soviet Union at bay, China still wasn’t a major power and building the economies of enemies turned them into friends. Globalization, per its champions, had the benefit of making many people rich while making the world safer in general and U.S. foreign policy less costly.
  • “After the Second World War, the United States led a fragmented world to build a new international economic order. It lifted hundreds of millions of people out of poverty. It sustained thrilling technological revolutions. And it helped the United States and many other nations around the world achieve new levels of prosperity. But the last few decades revealed cracks in those foundations,”
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  • In other words, the Marshall Plan and the tech boom during the 1990s were products of their time and place. They wouldn’t necessarily have the desired effects in a modern context.
  • “A shifting global economy left many working Americans and their communities behind. A financial crisis shook the middle class. A pandemic exposed the fragility of our supply chains. A changing climate threatened lives and livelihoods. Russia’s invasion of Ukraine underscored the risks of overdependence.”
  • What was the solution? Instead of rampant globalization, Sullivan’s pitch was that a reenergized American economy made the country stronger. It was time to remake the Rust Belt into a Cobalt Corridor, to establish industries that led not only to blue-collar work but to azure-collared careers. If that was done right, a strengthened America could act more capably around the globe.
  • “This moment demands that we forge a new consensus. That’s why the United States, under President Biden, is pursuing a modern industrial and innovation strategy — both at home and with partners around the world,
  • Implicitly, Sullivan said the main assumptions undergirding America’s foreign and economic policy had been wrong for decades. China, and the Washington belief that liberalized markets would eventually lead to democracy within the halls of power in Beijing, was the most glaring example.
  • “By the time President Biden came into office, we had to contend with the reality that a large non-market economy had been integrated into the international economic order in a way that posed considerable challenges,” he said, citing China’s large-scale subsidization of multiple sectors that crushed America’s competitiveness across industries. Making matters worse, Sullivan continued, “economic integration didn’t stop China from expanding its military ambitions.” It also didn’t stop countries like Russia from invading their neighbors.
  • Standing in front of the esteemed audience, Sullivan was telling them he didn’t want to be caught flat-footed as the global economy reshaped around them. The U.S. government would be proactive, prepared and proud in search of an industrial strategy to undergird American power. Without saying the words, he was offering a plan to make America great again.
  • A self-proclaimed “A-Team” came together to move beyond the Trump era, but in some ways they embraced elements of it. Not the nativist demagoguery, but the need to return to fundamentals: a healthy middle class powered by a humming industrial base, a humility about what the U.S. military alone can accomplish, a solid cadre of allies, attention to the most existential threats and a refresh of the tenets that sustain American democracy.
  • “This strategy will take resolve — it will take a dedicated commitment to overcoming the barriers that have kept this country and our partners from building rapidly, efficiently, and fairly as we were able to do in the past,”
Javier E

Opinion | What Democrats Need to Do Now - The New York Times - 0 views

www.nytimes.com/...aga-trump-vance-democrats.html

Democratic party dynamism MAGA class struggle struggle class security 2024 platform culture politics policy

shared by Javier E on 19 Jul 24 - No Cached
  • Over the last eight years, think tankers, activists and politicians have developed MAGA into a worldview, a worldview that now transcends Donald Trump.
  • It has its roots in Andrew Jackson-style populism, but it is updated and more comprehensive. It is the worldview that represents one version of working-class interests and offers working-class voters respect.
  • J.D. Vance is the embodiment and one of the developers of this worldview — with his suspicion of corporate power, foreign entanglements, free trade, cultural elites and high rates of immigration.
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  • MAGA has replaced Reaganism as the chief operating system of the Republican Party.
  • If Democrats hope to win in the near future they have to take the MAGA worldview seriously, and respectfully make the case, especially to working-class voters, for something better.
  • In a volatile world, MAGA offers people security. It promises secure borders and secure neighborhoods. It offers protection from globalization, from the creative destruction of modern capitalism. It offers protection from an educated class that looks down on you and indoctrinates your children in school. It offers you protection from corporate predators.
  • the problem with MAGA — and here is where the Democratic opportunity lies — is that it emerges from a mode of consciousness that is very different from the traditional American consciousness.
  • Americans have a zeal for continual self-improvement, a “need tirelessly to tinker, improve everything and everybody, never leave anything alone.”
  • “the Spirit of America is best known in Europe by one of its qualities — energy.”
  • we saw ourselves, as the dynamic nation par excellence. We didn’t have a common past, but we dreamed of a common futur
  • Americans can’t be secure if the world is in flames. That’s why America has to be active abroad in places like Ukraine, keeping wolves like Vladimir Putin at bay.
  • Through most of our history, we were not known for our profundity or culture but for living at full throttle.
  • MAGA, on the other hand, emerges from a scarcity consciousness, a zero-sum mentality: If we let in tons of immigrants they will take all our jobs; if America gets browner, “they” will replace “us.”
  • MAGA is based on a series of victim stories: The elites are out to screw us. Our allies are freeloading off us. Secular America is oppressing Christian America.
  • MAGA looks less like an American brand of conservatism and more like a European brand of conservatism. It resembles all those generations of Russian chauvinists who argued that the Russian masses embody all that is good but they are threatened by aliens from the outside
  • MAGA looks like a kind of right-wing Marxism, which assumes that class struggle is the permanent defining feature of politics.
  • MAGA is a fortress mentality, but America has traditionally been defined by a pioneering mentality. MAGA offers a strong shell, but not much in the way of wings needed to soar.
  • If Democrats are to thrive, they need to tap into America’s dynamic cultural roots and show how they can be applied to the 21st century
  • My favorite definition of dynamism is adapted from the psychologist John Bowlby: All of life is a series of daring explorations from a secure base. If Democrats are to thrive, they need to offer people a vision both of the secure base and of the daring explorations.
  • The American consciousness has traditionally been an abundance consciousness.
  • Americans can’t be secure if the border is in chaos. Popular support for continued immigration depends on a sense that the government has things under control.
  • Americans can’t be secure if a single setback will send people to the depths of crushing poverty. That’s why the social insurance programs that Democrats largely built are so important.
  • offer people a vision of the daring explorations that await them. That’s where the pessimistic post-Reagan Republicans can’t compete
  • champion the abundance agenda that people like Derek Thompson and my colleague Ezra Klein have been writing about. We need to build things. Lots of new homes. Supersonic airplanes and high-speed trains.
  • If Republicans are going to double down on class war rhetoric — elites versus masses — Democrats need to get out of that business
  • They need to stand up to protectionism, not join the stampede.
  • Democrats need to throttle back the regulators who have been given such free rein that they’ve stifled innovation.
  • Democrats need to take on their teachers’ unions and commit to dynamism in the field of education.
  • tap back into the more traditional American aspiration: We are not sentenced to a permanent class-riven future but can create a fluid, mobile society.
  • The economist Michael Strain of the American Enterprise Institute has offered a telling psychic critique of MAGA economic thinking: “The economics of grievance is ineffective, counterproductive and corrosive, eroding the foundations of prosperity. Messages matter. Tell people that the system is rigged, and they will aspire to less
  • Champion personal responsibility, and they will lift their aspirations. Promoting an optimistic vision of economic life can increase risk tolerance, ambition, effort and dynamism.”
  • t aspiration is not like a brick that just sits there. Aspiration is more like a flame that can be fed or dampened
  • “The problem is desire. We need to *want* these things. The problem is inertia. We need to want these things more than we want to prevent these things.”
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