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Javier E

Scientists Found a Surprising Way to Make Fungus Happy - The New York Times - 0 views

  • around Day 3 of the experiment, the fungi treated with sound went into overdrive. T. harzianum spores became bright green in color, and the white noise dishes were soon a mossy viridian. By Day 5, the researchers were able to calculate that exposing the fungi to sound had made them grow seven times as fast and produce more than four times as many spores.
  • It’s not clear why the sound had these effects. Dr. Robinson speculates that the sound waves may be striking receptors in the fungal cells that are sensitive to pressure. These receptors could then lead to a cascade of signals that switch on growth genes. The researchers plan to look closer at what genes are switched on and off in the presence of sound to help understand the effects.
  • Why would microbes evolve to grow better in the presence of sound? Perhaps silence indicates a hostile environment, one where no other organism has been able to grow. It might also be that certain kinds of sound fend some microbes off but give off a come-hither vibe to others. The researchers will be experimenting with other sounds and with communities of several microorganisms in future work, so they can better understand the connection between sounds and microbes’ response.
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  • “It might be you can create a certain soundscape that has an invigorating, growth-promoting effect,” he said — music to a forest’s ears.
Javier E

A Common Sense Democrat manifesto - by Matthew Yglesias - 0 views

  • when you lose an election, a leadership void opens up. And that void will be filled — with people and institutions and, hopefully, with ideas — and I would like the ideas that fill the current void to be good.
  • I believe the answer is that the Democratic Party should embrace commonsense moral values and move away from academic fads and deliberate tent-shrinking, while redoubling their commitment to ideas that have been pillars of Democratic campaigns for decades.
  • Being a Democrat should mean caring more than Republicans about the lives of poor people, about equal rights and non-discrimination, about restraining big business in matters related to pollution and fraudulent practices, and about protecting social insurance for the elderly and disabled.
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  • because they are important progressive ideas, I think that anyone who identifies as a leftist or a progressive should vote for Democrats.
  • that doesn’t mean that Democrats’ agenda should be driven by those on the far left. A big-tent Democratic coalition needs leftists. But left-wing candidates are rarely winning tough elections, and too often, they’re not improving governance of the solidly blue places where they’re elected.
  • Democrats have allowed those on the far left to exert much too much influence over their policy agenda in recent years. Most elected Democrats are not, themselves, actually that far left, and when faced with acute electoral peril, they swiftly ditch ideas like defund the police or openness to unlimited asylum claims. But what they haven’t generally done is publicly disavow the kind of simplistic disparate impact analysis that leads to conclusions like policing is bad.
  • Similarly, the Democrats are not a degrowth party. When good GDP numbers come in, Joe Biden and his team celebrate them — they believe in taking credit for strong growth. But even without being a degrowth party, Democrats are heavily influenced by the views of major environmentalist organizations that do have a degrowth ideology at their core.
  • Critics on the right charge that Democrats are in the grips of radical ideology, but the truth is more boring: Many elected officials are just not particularly rigorous thinkers (think of how much backbench Republicans have shifted on various policies since Trump took over). Most only really understand a few issues and do a lot of going along to get along.
  • Which is why Democrats need to build a strong, explicit commonsense faction with institutions and leaders and think tanks and media. A faction that wins primaries and provides a staffing pipeline, that generates new policy ideas.
  • Winning elections is important, because if you don’t win, you can’t govern.
  • It doesn’t make sense to say Democrats have to do X to win — there are lots of ways to win, and dumb luck is very important in politics — but this is how I think Democrats should try to win.
  • these are the principles I’d like to see the Democratic party embrace:
  • Economic self-interest for the working class includes both robust economic growth and a robust social safety net.
  • The government should prioritize maintaining functional public systems and spaces over tolerating anti-social behavior.
  • Climate change — and pollution more broadly — is a reality to manage, not a hard limit to obey.
  • We should, in fact, judge people by the content of their character rather than by the color of their skin, rejecting discrimination and racial profiling without embracing views that elevate anyone’s identity groups over their individuality.
  • Race is a social construct, but biological sex is not. Policy must acknowledge that reality and uphold people’s basic freedom to live as they choose.
  • Academic and nonprofit work does not occupy a unique position of virtue relative to private business or any other jobs.
  • Politeness is a virtue, but obsessive language policing alienates most people and degrades the quality of thinking.
  • Public services and institutions like schools deserve adequate funding, and they must prioritize the interests of their users, not their workforce or abstract ideological projects.
  • All people have equal moral worth, but democratic self-government requires the American government to prioritize the interests of American citizens.
  • A big part of my intellectual project here at Slow Boring is making the case that there are, in fact, deep complementarities between the common sense reform project in the blue zones and the common sense electoral viability project in the red zones
  • When you lose fair and square — an experience familiar to Republicans from 2008, 2012, and, even if they don’t like to admit it, 2020 — you are truly beaten, and it feels bad.
  • I worry about all kinds of things, and I cannot assure anyone that things will be okay.
  • What I can do is reassure everyone that in retrospect, the mid-aughts were the most exciting and generative time in Democratic Party politics that I can remember.
  • Peril focused the mind, and leaders became more serious about tradeoffs and less indulgent of frivolity. Smart people grew bolder and less risk-averse. New institutions were created, and (some) old ones were re-invigorated.
  • New modes of communication came to the fore. New policy ideas came into play. We saved Social Security, we retook Congress, and the most brilliant political talent of our time “jumped the line,” beat the party establishment, and entered the White House.
  • A Harris administration would have continued the kind of straddle that has paralyzed Democrats since Bernie Sanders’ failed insurgency in 2016 — cycle after cycle after cycle of establishment Democrats giving enough ground to their leftist critics to stay in charge but not enough to satisfy those critics. In the process, many mainstream Democrats have completely lost their identity, going far enough left that moderate voters find them unrecognizable, while leftists still deride them as the same tired establishment.
  • This is a time for new blood and new leadership and a new round of frank argumentation. Do we want a sectarian party whose only chance of gaining power is for Trump to do something truly catastrophic?
Javier E

The Cumulative Toll of Democrats' Delusions - The Atlantic - 0 views

  • Surprised? No, I was not surprised,” Torres, who represents a poor and working-class district in the Bronx, told me. “Much of my side in politics, and much of the media, was in a state of self-deception. We confused analysis with wishful thinking.”
  • too many in Torres’s party assumed that they were heralds of virtue and endangered democratic values
  • There’s no need to assume—as some commentators have after Donald Trump’s sweeping victory Tuesday—that the United States has a uniquely fallen electorate; across the globe, voters have tossed out governments on the left and right over the disruptions of the past five years. “A majority of Americans disapprove of Biden’s performance and felt they were worse off,” Torres said; Vice President Kamala Harris, the Democratic nominee, “was not responsible for the inflation, but objectively, that was a near-insurmountable disadvantage.”
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  • Torres pointed as well to the cumulative toll taken by progressives who for at least a decade have loudly championed cultural causes and chanted slogans that turned off rank-and-file Democrats across many demographics
  • “Donald Trump had no greater friend than the far left,” Torres told me, “which alienated historic numbers of Latinos, Blacks, Asians, and Jews with absurdities like ‘Defund the police’ or ‘From the river to the sea’ or ‘Latinx.’”
  • Torres emphasized that in his view, Harris ran a vigorous and effective campaign, given the circumstances. He did not discern many missteps. Although she sometimes tossed up clouds of vagueness when asked about past positions, she was disciplined and avoided mouthing the buzzwords of the cultural left during her 2024 campaign
  • But she could not sidestep her previous concessions to liberal cultural fevers, as she discovered when the Trump campaign bludgeoned her with endless commercials highlighting her decision, during her bid for the 2020 Democratic presidential nomination, to champion state-funded gender-transition surgery for prisoners.
  • In recent election cycles, Democrats have invested much hope that “people of color”—the widely varied and disparate peoples long imagined to be a monolith—would embrace an expansive list of progressive causes and rearrange American politics.
  • Politics, alas, is more complex than simply arranging virtuous ethnic and racial voting bloc
  • Four years ago, even as Biden triumphed, a majority of Asian and Latino voters in California rejected a ballot proposition that would have restored affirmative action in education and hiring.
  • A week before the election, Marcel Roman, a Harvard government professor, explained on X that he and a Georgetown colleague had discovered that Latino voters deeply dislike being labeled Latinx, a gender-neutral term now widespread in academia. This term also came into use by Democratic politicians eager to establish their bona fides with progressive activists. Alas, voters liked it not so much.
  • This problem seems easily remedied: Refer to voters by the term they prefer—Latino, say, or Hispanic. Roman drew a different conclusion, calling for “political education meant to root out queerphobia in Latino communities.”
  • Democrats might do well to listen carefully and respectfully to the tens of millions of Americans whom they claim to want to represent. This need not entail a turn away from populist economics so much as remaining clear-eyed about self-righteous rhetoric and millennialist demands.
  • He noted in our conversation that he is strongly in favor of immigration, and his majority-Latino district has many hardworking undocumented residents who need his aid.
  • But he recognizes that the national electorate, not least many Latino and Black voters, now seeks to at least partially close the door and tighten restrictions. He accepts that reality. “You have to recognize that in a democracy, public opinion matters,” he said. “We cannot just assume that we can reshape the world in a utopian way.”
Javier E

Biden and Environmental Groups Try to Protect Climate Policies from Trump - The New Yor... - 0 views

  • Mr. Trump has said he wants to erase virtually all of Mr. Biden’s climate policies, which include rules intended to slash carbon emissions from power plants, automobiles and oil wells. He intends to make it easier to drill on public lands and in waters where Mr. Biden put up roadblocks. And he has called for repeal of Mr. Biden’s signature climate law, the Inflation Reduction Act.
  • The 2022 law provides at least $390 billion over 10 years in tax breaks, grants and subsidies for wind and solar power, electric vehicle battery production and other clean energy projects. Roughly 80 percent of the money spent in the first two years has flowed to Republican congressional districts, making a repeal politically challenging even if Republicans win complete control of Congress.
  • “Canceling electric vehicle plants in Georgia and battery factories in South Carolina is a losing strategy,” Mr. Markey said, adding, “The problem for Trump is the green revolution is blue and red.”
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  • The U.S. Treasury has issued guidance for 21 of the 24 tax provisions in the climate law. By the end of this year, it will finalize the last rules detailing who can claim tax credits for hydrogen production and tax credits for any facility that generates energy without producing greenhouse gases, whether that’s wind, solar, nuclear, hydropower or another source.
  • A handful of environmental regulations will be finalized, Mr. Podesta said. This week, the Interior Department issued two of them: a congressionally mandated plan for leases in the Arctic National Wildlife Refuge that the Biden administration is restricting to the smallest parcels permitted by law; and a blueprint for protecting the greater sage grouse by limiting drilling, mining and livestock grazing across nearly 65 million acres of its habitat in 10 Western states. The E.P.A. is also expected to issue restrictions on pollution from gas-fired power plants.
  • Mr. Jealous of the Sierra Club said the environmental movement needed to do a better job of telling Americans how clean energy was creating jobs.
  • “We are the movement that is literally leading this country and rebuilding the manufacturing sector,” he said. “Trump can’t change the reality that an overwhelming majority of Americans want more clean energy, not more fossil fuels. Through investments in the Inflation Reduction Act, we are creating millions of new clean energy jobs. Clean energy is already cheaper in most cases than dirty fossil fuels, and wind and solar now generate more power in the U.S. than coal.”
Javier E

This Rout Is an Opportunity for Democrats--Shenk - 0 views

  • What do Democrats stand for? Over the last eight years, the answer has been simple: whatever Donald Trump is against. They have been the party of the so-called Resistance, defending institutions against a dangerous and fundamentally undemocratic movement
  • It has defined what it means to be a Democrat. And it failed spectacularly this week, helping clear a path for Mr. Trump to return to the White House with a clean victory in the popular vote
  • The first step for Democrats is reckoning with how they got here.
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  • In 2011, with Mr. Trump making headlines as the leading spokesman for birtherism, Barack Obama’s team seized the opportunity to cast him as the face of the entire Republican opposition. Years later, David Plouffe, an Obama campaign manager turned presidential adviser, explained the strategy. “Let’s really lean into Trump here,” Mr. Plouffe remembered thinking. “That’ll be good for us.”
  • the anti-MAGA coalition had rallied time and again, conveniently relieving Democrats of the burden that comes with deciding what to believe other than not being Mr. Trump.
  • But there was a price to be paid. No matter how progressive the rhetoric, Resistance politics inevitably feels conservative. It’s reactionary in a literal sense: The other side decides the terms of debate, and it usually ends with finding yet another norm under assault, a new outrage to be tutted over or another institution that needs protecting.
  • her biggest challenges were downstream from the failure to build a Democratic identity beyond #Resistance. Commitment to stitching together an anti-MAGA coalition made it impossible to lay out the priorities that would have guided a Harris administration
  • There was no way to tie her policies together into a unifying vision that set her apart from Mr. Biden, no account of what Democrats learned presiding over a country that most Americans feel is on the wrong track.
  • This fundamental problem explains the strange incoherence of Ms. Harris’s strategy. Judge the campaign by how it was described in the press, and you’d think the chief targets were Never Trump Republicans
  • Check out the ads that ran in swing states, though, and you’d hear a populist message that wouldn’t have sounded out of place coming from Bernie Sanders,
  • she struggled to harness material frustrations, even though testing from her chief super PAC, Future Forward, repeatedly demonstrated that it was her strongest argument with swing voters
  • the broad-based character of the shift toward Republicans is the classic tell of an electorate frustrated with an incumbent party. For now, the election looks like a rejection of Mr. Biden, not a realignment for Mr. Trump.
  • the pendulum that swung against Democrats on Tuesday will bring them back into power eventually. If history is any guide, that day will probably arrive sooner than feels possible right now.
  • Still, progressives worried that fascism is on the march would benefit from taking a closer look at how these movements gain power.
  • Reflecting on Hitler’s rise in her native Germany, Hannah Arendt pointed out that by the final days of the Weimar Republic, politics had split into two irreconcilable factions: “those who wanted the status quo at any price” versus “those who wanted change at any price.” One thing both groups had in common, she added, was “the tacit assumption that the electorate would go to the polls because it was frightened.”
  • He was impeached, indicted and convicted, and then he won more votes in a fair fight with what could well be the most racially diverse Republican coalition in decades. Trumpism doesn’t have a generational lock on American politics, but it has broad and deep support, with the potential to grow in the years to come.
  • It’s going to take a sprawling, messy and sometimes brutal debate inside the Democratic coalition — a debate that ends with a party that can plausibly present itself as a champion of ordinary people trying to make a better life in a broken system.
  • The Resistance has run into a dead end
  • it does mean giving up on the hope that laws, norms or one last impeachment will deliver us from Trumpism
Javier E

A happiness expert's frank advice for Joe Biden - The Atlantic - 0 views

  • the ancient Hindu teaching on the stages of life, or ashramas, and the advice I received from a guru in southern India named Nochur Venkataraman. He taught me that many successful people get stuck in a stage called Grihastha—which is where you enjoy professional success and adulation—rather than progressing to Vanaprastha, which is where one should become more of a teacher (“crystallized intelligence”).
  • But there’s one more stage nearer the end called Sannyasa, which is to be fully enlightened and not working in the worldly domain. That transition is also sticky for many people—politicians, CEOs, sports figures, perhaps even the president—who struggle to stop doing what made them famous and admired. But that is the essence of truly retiring, and retiring well.
  • Matt: The United States seems to have the persistent problem of a geriatric ruling class. What’s your analysis of why that appears in our political elite?
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  • Arthur: Part of it is because we have a rigid system of power, and so we’re ridiculously institutionalized in the way that people can rise and prosper
  • Americans speak a good line about meritocracy, but we don’t have a meritocracy. When it comes to our politics, we have a gerontocracy that is based on seniority, loyalty, and tenure. We have leaders with tons of wisdom, but they don’t have the vigor and the focus and the energy to be putting in the grinding work of national and international governance.
  • Matt: Happiness is your principal subject, and your work usually frames it in terms of advice to the individual: How can you be happy? How can I be happy? But in this political moment, there’s also a dimension of this that’s about collective happiness, the public good—a general happiness that is at stake in Biden’s decision. How do you balance that?
  • Arthur: You know the famous Zen Buddhist koan: What is the sound of one hand clapping? One interpretation of that koan is that the sound of one hand clapping is an illusion. And one version of that illusion is that your personal happiness is somehow meaningful. In fact, the clapping becomes a reality only when there’s a second hand.
  • In other words, your happiness is real only when somebody else is happy as well. So if you’re a public figure, then the good of the public is required to get the second hand clapping. Otherwise you’ll be living in illusion.
  • a philosopher at the University of Cambridge named Stephen Cave who wrote a really important book called Immortality. In it, he talks about how one of the ways to become immortal is to build a legacy, and the way to think about that is the internal struggle of Achilles. Obviously, the Greek hero is a mythological character, but his story presents an emblematic dilemma: The best way to achieve immortality is to secure your legacy through a heroic end; the worst way to get immortality—and the most efficacious way to destroy your legacy—is to just hang around. Do you see the irony? People who hang around because of their legacy are diminishing their legacy.
  • Arthur: So there’s personal advice and there’s political advice. The personal advice is that for all successful people, there comes a time to decide between being special and being happy. Being special—staying on top—is hard, tiring work. But it is an addiction, which is why people keep at it way beyond what seems reasonable, at great harm to themselves and others. Get sober; choose happiness.
  • The political advice is based on a lesson from history, that the mark of great leadership is what happens after leaders leave the scene. Did they teach the next generation and set up those who came after for success? And then did they step aside with grace and humility? Be able to answer yes to both of those questions.
Javier E

Paris Wanted a Green Olympics. Team USA Wants Air Conditioning. - WSJ - 0 views

  • That’s not to say organizers are letting athletes slow-broil for three weeks. The Village here, located just north of Paris, was built with a cooling system that runs cold water through the floors, which officials say can reduce the ambient temperature by 10 to 20 degrees Fahrenheit and achieve a target range of 73 to 79 Fahrenheit. The effort is part of the hosts’ larger plan to make Paris the greenest Olympics in modern history, which includes measures such as reducing the number of vehicles by 40% from previous Games, building fewer new venues, and cutting the Games’ carbon footprint by half compared with the average of London 2012 and Rio 2016. 
  • But for those athletes who remain unconvinced and worry about their performance being derailed by sleeping in sweatbox apartments, Paris 2024 has made air conditioning units available for hire. And there are no gold medals for guessing which delegation leads the way. 
  • The 592-strong Team USA delegation isn’t risking the slightest discomfort. Every single U.S. room and some common areas have been equipped with portable A/C units, according to a spokesman for the U.S. Olympic & Paralympic Committee. The Americans will all be able to take on any Paris heat wave by hanging out in meat-locker conditions, even though temperatures over the next 10 days aren’t expected to top 90.
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  • Out of the 7,000 rooms in the Village, 2,500 have been supplied mobile air conditioning units at the teams’ requests, a Paris 2024 spokesman said
  • Keeping cool at all times is that much more important given the erratic schedules that some of the athletes here are facing, said Carroll, the Australian Olympic committee executive. Since many athletes’ events are at night, they’ll need to sleep during the hottest part of the day. So the decision to pay for air conditioners was a no-brainer.
  • But not everyone is all-in on A/C. Germany’s Olympic sports federation will have one of the larger contingents in the village with around 350 athletes. That includes 6-foot-7½-inch decathlon medal favorite Leo Neugebauer, who recently won the NCAA title competing for the Texas Longhorns in Austin, where air conditioning isn’t merely a suggestion—it’s a way of life.
  • When Germany asked its individual sport federations if they wanted to order air conditioning units for the athletes’ village, demand for frigid air was lukewarm, according to Olympic committee spokesman Michael Schirp.
  • “A total of 11 AC have been ordered. Eleven,” he wrote, adding an emoji of a face wearing sunglasses.
Javier E

Ilya Sutskever, OpenAI Co-Founder Who Helped Oust Sam Altman, Starts His Own Company - ... - 0 views

  • The new start-up is called Safe Superintelligence. It aims to produce superintelligence — a machine that is more intelligent than humans — in a safe way, according to the company spokeswoman Lulu Cheng Meservey.
  • Last year, Dr. Sutskever helped create what was called a Superalignment team inside OpenAI that aimed to ensure that future A.I. technologies would not do harm. Like others in the field, he had grown increasingly concerned that A.I. could become dangerous and perhaps even destroy humanity.
  • Jan Leike, who ran the Superalignment team alongside Dr. Sutskever, has also resigned from OpenAI. He has since been hired by OpenAI’s competitor Anthropic, another company founded by former OpenAI researchers.
Javier E

Opinion | In Indiana, the MAGA Revolution Eats Its Own - The New York Times - 0 views

  • According to the Public Religion Research Institute’s 2023 American Values Atlas, 55 percent of Trump supporters are Christian nationalists, as measured by their agreement with statements like “Being Christian is an important part of being truly American” and “God has called Christians to exercise dominion over all areas of American society.”
  • The Christian right increasingly sees American politics as zero-sum, meaning it is either going to triumph or face subjugation. As Justice Samuel Alito of the Supreme Court was recorded saying, “One side or the other is going to win.”
Javier E

Opinion | The Pandemic Probably Started in a Lab. These 5 Key Points Explain Why. - The... - 0 views

  • a growing volume of evidence — gleaned from public records released under the Freedom of Information Act, digital sleuthing through online databases, scientific papers analyzing the virus and its spread, and leaks from within the U.S. government — suggests that the pandemic most likely occurred because a virus escaped from a research lab in Wuhan, China.
  • If so, it would be the most costly accident in the history of science.
  • The SARS-like virus that caused the pandemic emerged in Wuhan, the city where the world’s foremost research lab for SARS-like viruses is located.
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  • Dr. Shi’s group was fascinated by how coronaviruses jump from species to species. To find viruses, they took samples from bats and other animals, as well as from sick people living near animals carrying these viruses or associated with the wildlife trade. Much of this work was conducted in partnership with the EcoHealth Alliance, a U.S.-based scientific organization that, since 2002, has been awarded over $80 million in federal funding to research the risks of emerging infectious diseases.
  • Their research showed that the viruses most similar to SARS‑CoV‑2, the virus that caused the pandemic, circulate in bats that live roughly 1,000 miles away from Wuhan. Scientists from Dr. Shi’s team traveled repeatedly to Yunnan province to collect these viruses and had expanded their search to Southeast Asia. Bats in other parts of China have not been found to carry viruses that are as closely related to SARS-CoV-2.
  • When the Covid-19 outbreak was detected, Dr. Shi initially wondered if the novel coronavirus had come from her laboratory, saying she had never expected such an outbreak to occur in Wuhan.
  • The SARS‑CoV‑2 virus is exceptionally contagious and can jump from species to species like wildfire. Yet it left no known trace of infection at its source or anywhere along what would have been a thousand-mile journey before emerging in Wuhan.
  • The year before the outbreak, the Wuhan institute, working with U.S. partners, had proposed creating viruses with SARS‑CoV‑2’s defining feature
  • The laboratory pursued risky research that resulted in viruses becoming more infectious: Coronaviruses were grown from samples from infected animals and genetically reconstructed and recombined to create new viruses unknown in nature. These new viruses were passed through cells from bats, pigs, primates and humans and were used to infect civets and humanized mice (mice modified with human genes). In essence, this process forced these viruses to adapt to new host species, and the viruses with mutations that allowed them to thrive emerged as victors.
  • Worse still, as the pandemic raged, their American collaborators failed to publicly reveal the existence of the Defuse proposal. The president of EcoHealth, Peter Daszak, recently admitted to Congress that he doesn’t know about virus samples collected by the Wuhan institute after 2015 and never asked the lab’s scientists if they had started the work described in Defuse.
  • By 2019, Dr. Shi’s group had published a database describing more than 22,000 collected wildlife samples. But external access was shut off in the fall of 2019, and the database was not shared with American collaborators even after the pandemic started, when such a rich virus collection would have been most useful in tracking the origin of SARS‑CoV‑2. It remains unclear whether the Wuhan institute possessed a precursor of the pandemic virus.
  • In 2021, The Intercept published a leaked 2018 grant proposal for a research project named Defuse, which had been written as a collaboration between EcoHealth, the Wuhan institute and Ralph Baric at the University of North Carolina, who had been on the cutting edge of coronavirus research for years. The proposal described plans to create viruses strikingly similar to SARS‑CoV‑2.
  • Coronaviruses bear their name because their surface is studded with protein spikes, like a spiky crown, which they use to enter animal cells. The Defuse project proposed to search for and create SARS-like viruses carrying spikes with a unique feature: a furin cleavage site — the same feature that enhances SARS‑CoV‑2’s infectiousness in humans, making it capable of causing a pandemic. Defuse was never funded by the United States.
  • owever, in his testimony on Monday, Dr. Fauci explained that the Wuhan institute would not need to rely on U.S. funding to pursue research independently.
  • While it’s possible that the furin cleavage site could have evolved naturally (as seen in some distantly related coronaviruses), out of the hundreds of SARS-like viruses cataloged by scientists, SARS‑CoV‑2 is the only one known to possess a furin cleavage site in its spike. And the genetic data suggest that the virus had only recently gained the furin cleavage site before it started the pandemic.
  • Ultimately, a never-before-seen SARS-like virus with a newly introduced furin cleavage site, matching the description in the Wuhan institute’s Defuse proposal, caused an outbreak in Wuhan less than two years after the proposal was drafted.
  • When the Wuhan scientists published their seminal paper about Covid-19 as the pandemic roared to life in 2020, they did not mention the virus’s furin cleavage site — a feature they should have been on the lookout for, according to their own grant proposal, and a feature quickly recognized by other scientists.
  • At the Wuhan Institute of Virology, a team of scientists had been hunting for SARS-like viruses for over a decade, led by Shi Zhengl
  • In May, citing failures in EcoHealth’s monitoring of risky experiments conducted at the Wuhan lab, the Biden administration suspended all federal funding for the organization and Dr. Daszak, and initiated proceedings to bar them from receiving future grants. In his testimony on Monday, Dr. Fauci said that he supported the decision to suspend and bar EcoHealth.
  • Separately, Dr. Baric described the competitive dynamic between his research group and the institute when he told Congress that the Wuhan scientists would probably not have shared their most interesting newly discovered viruses with him. Documents and email correspondence between the institute and Dr. Baric are still being withheld from the public while their release is fiercely contested in litigation.
  • In the end, American partners very likely knew of only a fraction of the research done in Wuhan. According to U.S. intelligence sources, some of the institute’s virus research was classified or conducted with or on behalf of the Chinese military.
  • In the congressional hearing on Monday, Dr. Fauci repeatedly acknowledged the lack of visibility into experiments conducted at the Wuhan institute, saying, “None of us can know everything that’s going on in China, or in Wuhan, or what have you. And that’s the reason why — I say today, and I’ve said at the T.I.,” referring to his transcribed interview with the subcommittee, “I keep an open mind as to what the origin is.”
  • The Wuhan lab pursued this type of work under low biosafety conditions that could not have contained an airborne virus as infectious as SARS‑CoV‑2.
  • Labs working with live viruses generally operate at one of four biosafety levels (known in ascending order of stringency as BSL-1, 2, 3 and 4) that describe the work practices that are considered sufficiently safe depending on the characteristics of each pathogen. The Wuhan institute’s scientists worked with SARS-like viruses under inappropriately low biosafety conditions.
  • ​​Biosafety levels are not internationally standardized, and some countries use more permissive protocols than others.
  • In one experiment, Dr. Shi’s group genetically engineered an unexpectedly deadly SARS-like virus (not closely related to SARS‑CoV‑2) that exhibited a 10,000-fold increase in the quantity of virus in the lungs and brains of humanized mice. Wuhan institute scientists handled these live viruses at low biosafety levels, including BSL-2.
  • Even the much more stringent containment at BSL-3 cannot fully prevent SARS‑CoV‑2 from escaping. Two years into the pandemic, the virus infected a scientist in a BSL-3 laboratory in Taiwan, which was, at the time, a zero-Covid country. The scientist had been vaccinated and was tested only after losing the sense of smell. By then, more than 100 close contacts had been exposed. Human error is a source of exposure even at the highest biosafety levels, and the risks are much greater for scientists working with infectious pathogens at low biosafety.
  • An early draft of the Defuse proposal stated that the Wuhan lab would do their virus work at BSL-2 to make it “highly cost-effective.” Dr. Baric added a note to the draft highlighting the importance of using BSL-3 to contain SARS-like viruses that could infect human cells, writing that “U.S. researchers will likely freak out.”
  • Years later, after SARS‑CoV‑2 had killed millions, Dr. Baric wrote to Dr. Daszak: “I have no doubt that they followed state determined rules and did the work under BSL-2. Yes China has the right to set their own policy. You believe this was appropriate containment if you want but don’t expect me to believe it. Moreover, don’t insult my intelligence by trying to feed me this load of BS.”
  • SARS‑CoV‑2 is a stealthy virus that transmits effectively through the air, causes a range of symptoms similar to those of other common respiratory diseases and can be spread by infected people before symptoms even appear. If the virus had escaped from a BSL-2 laboratory in 2019, the leak most likely would have gone undetected until too late.
  • One alarming detail — leaked to The Wall Street Journal and confirmed by current and former U.S. government officials — is that scientists on Dr. Shi’s team fell ill with Covid-like symptoms in the fall of 2019. One of the scientists had been named in the Defuse proposal as the person in charge of virus discovery work. The scientists denied having been sick.
  • The hypothesis that Covid-19 came from an animal at the Huanan Seafood Market in Wuhan is not supported by strong evidence.
  • In December 2019, Chinese investigators assumed the outbreak had started at a centrally located market frequented by thousands of visitors daily. This bias in their search for early cases meant that cases unlinked to or located far away from the market would very likely have been missed
  • To make things worse, the Chinese authorities blocked the reporting of early cases not linked to the market and, claiming biosafety precautions, ordered the destruction of patient samples on January 3, 2020, making it nearly impossible to see the complete picture of the earliest Covid-19 cases. Information about dozens of early cases from November and December 2019 remains inaccessible.
  • A pair of papers published in Science in 2022 made the best case for SARS‑CoV‑2 having emerged naturally from human-animal contact at the Wuhan market by focusing on a map of the early cases and asserting that the virus had jumped from animals into humans twice at the market in 2019
  • More recently, the two papers have been countered by other virologists and scientists who convincingly demonstrate that the available market evidence does not distinguish between a human superspreader event and a natural spillover at the market.
  • Furthermore, the existing genetic and early case data show that all known Covid-19 cases probably stem from a single introduction of SARS‑CoV‑2 into people, and the outbreak at the Wuhan market probably happened after the virus had already been circulating in humans.
  • Not a single infected animal has ever been confirmed at the market or in its supply chain. Without good evidence that the pandemic started at the Huanan Seafood Market, the fact that the virus emerged in Wuhan points squarely at its unique SARS-like virus laboratory.
  • With today’s technology, scientists can detect how respiratory viruses — including SARS, MERS and the flu — circulate in animals while making repeated attempts to jump across species. Thankfully, these variants usually fail to transmit well after crossing over to a new species and tend to die off after a small number of infections
  • investigators have not reported finding any animals infected with SARS‑CoV‑2 that had not been infected by humans. Yet, infected animal sources and other connective pieces of evidence were found for the earlier SARS and MERS outbreaks as quickly as within a few days, despite the less advanced viral forensic technologies of two decades ago.
  • Even though Wuhan is the home base of virus hunters with world-leading expertise in tracking novel SARS-like viruses, investigators have either failed to collect or report key evidence that would be expected if Covid-19 emerged from the wildlife trade. For example, investigators have not determined that the earliest known cases had exposure to intermediate host animals before falling ill.
  • No antibody evidence shows that animal traders in Wuhan are regularly exposed to SARS-like viruses, as would be expected in such situations.
  • In previous outbreaks of coronaviruses, scientists were able to demonstrate natural origin by collecting multiple pieces of evidence linking infected humans to infected animals
  • In contrast, virologists and other scientists agree that SARS‑CoV‑2 required little to no adaptation to spread rapidly in humans and other animals. The virus appears to have succeeded in causing a pandemic upon its only detected jump into humans.
  • it was a SARS-like coronavirus with a unique furin cleavage site that emerged in Wuhan, less than two years after scientists, sometimes working under inadequate biosafety conditions, proposed collecting and creating viruses of that same design.
  • a laboratory accident is the most parsimonious explanation of how the pandemic began.
  • Given what we now know, investigators should follow their strongest leads and subpoena all exchanges between the Wuhan scientists and their international partners, including unpublished research proposals, manuscripts, data and commercial orders. In particular, exchanges from 2018 and 2019 — the critical two years before the emergence of Covid-19 — are very likely to be illuminating (and require no cooperation from the Chinese government to acquire), yet they remain beyond the public’s view more than four years after the pandemic began.
  • it is undeniable that U.S. federal funding helped to build an unprecedented collection of SARS-like viruses at the Wuhan institute, as well as contributing to research that enhanced them.
  • Advocates and funders of the institute’s research, including Dr. Fauci, should cooperate with the investigation to help identify and close the loopholes that allowed such dangerous work to occur. The world must not continue to bear the intolerable risks of research with the potential to cause pandemics.
  • A successful investigation of the pandemic’s root cause would have the power to break a decades-long scientific impasse on pathogen research safety, determining how governments will spend billions of dollars to prevent future pandemics. A credible investigation would also deter future acts of negligence and deceit by demonstrating that it is indeed possible to be held accountable for causing a viral pandemic
  • Last but not least, people of all nations need to see their leaders — and especially, their scientists — heading the charge to find out what caused this world-shaking event. Restoring public trust in science and government leadership requires it.
Javier E

The Bottomless College Parent Trap - WSJ - 0 views

  • Payments to thousands of former and current athletes will approach $2.8 billion, minus the trial lawyers’ cut of the class-action suits. This follows the NCAA’s decision to let college athletes benefit financially from their names, images and likenesses
  • Most legal analysis of the settlement concludes that the days of the “amateur” college athlete are over. In the future, the men and women on Division I teams and others likely will be regarded as professionals who will be paid to play by universities through revenue-sharing agreements up to $20 million a year per school.
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