The site simplebits.com provides a tip on how to make background links, objects, artwork, etc. easily clickable. If I had the time, I would use this effect on my portfolio page, designing each article and zen site feature to afford some sort of action.
Here is a great site that offers CSS templates and layouts, and best of all, they are free! As you scroll down the left side of the screen, you will see many clickable options to copy.