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Studies with a popular laboratory model, the nematode Caenorhabditis elegans, have revealed a possible therapeutic avenue for a rare but deadly condition in which children are born without the ability to make molybdenum cofactor (Moco) on their own

Moco is essential for life

This suggests that such protein-Moco complexes could be used as a treatment for Moco deficiency in people.

C. elegans

The researchers found that the worms could take in Moco as a range of purified Moco-protein complexes. These included complexes with proteins from bacteria, bread mold, green algae and cow's milk. Ingesting these complexes saved the Moco-deficient worms.

"We do not want to overstate our findings, especially as they relate to patients, but we are extremely excited about the therapeutic and fundamental implications of this work."

I learned something more useful: the existence of non-fiction literature that can teach you anything.

something felt odd. Whenever a conversation revolved around a serious non-fiction book I read, such as ‘Sapiens’ or ‘Thinking Fast and Slow,’ I could never remember much. Turns out, I hadn’t absorbed as much information as I’d believed. Since I couldn’t remember much, I felt as though reading wasn’t an investment in knowledge but mere entertainment.

When I opened up about my struggles, many others confessed they also can’t remember most of what they read, as if forgetting is a character flaw. But it isn’t.

It’s the way we work with books that’s flawed.

there’s a better way to read. Most people rely on techniques like highlighting, rereading, or, worst of all, completely passive reading, which are highly ineffective.

Since I started applying evidence-based learning strategies to reading non-fiction books, many things have changed. I can explain complex ideas during dinner conversations. I can recall interesting concepts and link them in my writing or podcasts. As a result, people come to me for all kinds of advice.

What’s the Architecture of Human Learning and Memory?

Human brains don’t work like recording devices. We don’t absorb information and knowledge by reading sentences.

we store new information in terms of its meaning to our existing memory

we give new information meaning by actively participating in the learning process — we interpret, connect, interrelate, or elaborate

To remember new information, we not only need to know it but also to know how it relates to what we already know.

Learning is dependent on memory processes because previously-stored knowledge functions as a framework in which newly learned information can be linked.”

Human memory works in three stages: acquisition, retention, and retrieval. In the acquisition phase, we link new information to existing knowledge; in the retention phase, we store it, and in the retrieval phase, we get information out of our memory.

Retrieval, the third stage, is cue dependent. This means the more mental links you’re generating during stage one, the acquisition phase, the easier you can access and use your knowledge.

we need to understand that the three phases interrelate

creating durable and flexible access to to-be-learned information is partly a matter of achieving a meaningful encoding of that information and partly a matter of exercising the retrieval process.”

Next, we’ll look at the learning strategies that work best for our brains (elaboration, retrieval, spaced repetition, interleaving, self-testing) and see how we can apply those insights to reading non-fiction books.

The strategies that follow are rooted in research from professors of Psychological & Brain Science around Henry Roediger and Mark McDaniel. Both scientists spent ten years bridging the gap between cognitive psychology and education fields. Harvard University Press published their findings in the book ‘Make It Stick.

#1 Elaboration

“Elaboration is the process of giving new material meaning by expressing it in your own words and connecting it with what you already know.”

Why elaboration works: Elaborative rehearsal encodes information into your long-term memory more effectively. The more details and the stronger you connect new knowledge to what you already know, the better because you’ll be generating more cues. And the more cues they have, the easier you can retrieve your knowledge.

How I apply elaboration: Whenever I read an interesting section, I pause and ask myself about the real-life connection and potential application. The process is invisible, and my inner monologues sound like: “This idea reminds me of…, This insight conflicts with…, I don’t really understand how…, ” etc.

For example, when I learned about A/B testing in ‘The Lean Startup,’ I thought about applying this method to my startup. I added a note on the site stating we should try it in user testing next Wednesday. Thereby the book had an immediate application benefit to my life, and I will always remember how the methodology works.

How you can apply elaboration: Elaborate while you read by asking yourself meta-learning questions like “How does this relate to my life? In which situation will I make use of this knowledge? How does it relate to other insights I have on the topic?”

While pausing and asking yourself these questions, you’re generating important memory cues. If you take some notes, don’t transcribe the author’s words but try to summarize, synthesize, and analyze.

#2 Retrieval

With retrieval, you try to recall something you’ve learned in the past from your memory. While retrieval practice can take many forms — take a test, write an essay, do a multiple-choice test, practice with flashcards

the authors of ‘Make It Stick’ state: “While any kind of retrieval practice generally benefits learning, the implication seems to be that where more cognitive effort is required for retrieval, greater retention results.”

Whatever you settle for, be careful not to copy/paste the words from the author. If you don’t do the brain work yourself, you’ll skip the learning benefits of retrieval

Retrieval strengthens your memory and interrupts forgetting and, as other researchers replicate, as a learning event, the act of retrieving information is considerably more potent than is an additional study opportunity, particularly in terms of facilitating long-term recall.

How I apply retrieval: I retrieve a book’s content from my memory by writing a book summary for every book I want to remember. I ask myself questions like: “How would you summarize the book in three sentences? Which concepts do you want to keep in mind or apply? How does the book relate to what you already know?”

I then publish my summaries on Goodreads or write an article about my favorite insights

How you can apply retrieval: You can come up with your own questions or use mine. If you don’t want to publish your summaries in public, you can write a summary into your journal, start a book club, create a private blog, or initiate a WhatsApp group for sharing book summaries.

a few days after we learn something, forgetting sets in

#3 Spaced Repetition

With spaced repetition, you repeat the same piece of information across increasing intervals.

The harder it feels to recall the information, the stronger the learning effect. “Spaced practice, which allows some forgetting to occur between sessions, strengthens both the learning and the cues and routes for fast retrieval,”

Why it works: It might sound counterintuitive, but forgetting is essential for learning. Spacing out practice might feel less productive than rereading a text because you’ll realize what you forgot. Your brain has to work harder to retrieve your knowledge, which is a good indicator of effective learning.

How I apply spaced repetition: After some weeks, I revisit a book and look at the summary questions (see #2). I try to come up with my answer before I look up my actual summary. I can often only remember a fraction of what I wrote and have to look at the rest.

“Knowledge trapped in books neatly stacked is meaningless and powerless until applied for the betterment of life.”

How you can apply spaced repetition: You can revisit your book summary medium of choice and test yourself on what you remember. What were your action points from the book? Have you applied them? If not, what hindered you?

By testing yourself in varying intervals on your book summaries, you’ll strengthen both learning and cues for fast retrieval.

Why interleaving works: Alternate working on different problems feels more difficult as it, again, facilitates forgetting.

How I apply interleaving: I read different books at the same time.

1) Highlight everything you want to remember

#5 Self-Testing

While reading often falsely tricks us into perceived mastery, testing shows us whether we truly mastered the subject at hand. Self-testing helps you identify knowledge gaps and brings weak areas to the light

“It’s better to solve a problem than to memorize a solution.”

Why it works: Self-testing helps you overcome the illusion of knowledge. “One of the best habits a learner can instill in herself is regular self-quizzing to recalibrate her understanding of what she does and does not know.”

How I apply self-testing: I explain the key lessons from non-fiction books I want to remember to others. Thereby, I test whether I really got the concept. Often, I didn’t

instead of feeling frustrated, cognitive science made me realize that identifying knowledge gaps are a desirable and necessary effect for long-term remembering.

How you can apply self-testing: Teaching your lessons learned from a non-fiction book is a great way to test yourself. Before you explain a topic to somebody, you have to combine several mental tasks: filter relevant information, organize this information, and articulate it using your own vocabulary.

Now that I discovered how to use my Kindle as a learning device, I wouldn’t trade it for a paper book anymore. Here are the four steps it takes to enrich your e-reading experience

How you can apply interleaving: Your brain can handle reading different books simultaneously, and it’s effective to do so. You can start a new book before you finish the one you’re reading. Starting again into a topic you partly forgot feels difficult first, but as you know by now, that’s the effect you want to achieve.

it won’t surprise you that researchers proved highlighting to be ineffective. It’s passive and doesn’t create memory cues.

2) Cut down your highlights in your browser

After you finished reading the book, you want to reduce your highlights to the essential part. Visit your Kindle Notes page to find a list of all your highlights. Using your desktop browser is faster and more convenient than editing your highlights on your e-reading device.

Now, browse through your highlights, delete what you no longer need, and add notes to the ones you really like. By adding notes to the highlights, you’ll connect the new information to your existing knowledge

3) Use software to practice spaced repetitionThis part is the main reason for e-books beating printed books. While you can do all of the above with a little extra time on your physical books, there’s no way to systemize your repetition praxis.

Readwise is the best software to combine spaced repetition with your e-books. It’s an online service that connects to your Kindle account and imports all your Kindle highlights. Then, it creates flashcards of your highlights and allows you to export your highlights to your favorite note-taking app.

Common Learning Myths DebunkedWhile reading and studying evidence-based learning techniques I also came across some things I wrongly believed to be true.

#2 Effective learning should feel easyWe think learning works best when it feels productive. That’s why we continue to use ineffective techniques like rereading or highlighting. But learning works best when it feels hard, or as the authors of ‘Make It Stick’ write: “Learning that’s easy is like writing in sand, here today and gone tomorrow.”

In Conclusion

I developed and adjusted these strategies over two years, and they’re still a work in progress.

Try all of them but don’t force yourself through anything that doesn’t feel right for you. I encourage you to do your own research, add further techniques, and skip what doesn’t serve you

“In the case of good books, the point is not to see how many of them you can get through, but rather how many can get through to you.”— Mortimer J. Adler

the real purpose of the experiment: to determine how well they could remember where the foods were located in the room.

Of the 512 people in the experiment, half did the test by tasting, half by smelling the food. After leaving the room, they smelled or tasted the foods again in random order and were asked to locate them on a map of the room they had just traversed.

they were 27 percent more likely to correctly place the high-calorie foods than the low-calorie foods they tasted, and 28 percent more likely to correctly locate the high-calorie foods they smelled.

“Our results seem to suggest that human minds are adapted to finding energy rich food in an efficient way,”

“This may have implications for how we navigate our modern food environment.”

Instead, however, while there was indeed detectable neural activity for the so-called attended memory item (AMI)—the one that the subjects knew they would need right away—there was none at all for the unattended memory items (UMI), which the subjects might also need, but not until later.

All the same, when subjects were asked about a UMI, a peak appeared for it just as it did for an AMI. In both cases, working memory worked just fine, but in one case it did so without the benefit of any visible storage system.

unattended memories are maintained in what the researchers called “a privileged state” only as long as they had to be.

Whatever the explanation, the work has implications for understanding not just memory but other cognitive functions like perception, attention and goal maintenance.

if noninvasive brain stimulation techniques can be used to reactivate and potentially strengthen latent memories”—in other words, recovering information that had been forever lost.

The IBL hopes to overcome these flaws. Scientists on the project will work on exactly the same problems in precisely the same way. Animal experiments, for example, will use one strain of mouse, and all will be trained, tested and scored in the same way. It is an obvious strategy, but not a common one in science: in any lab, there is a constant urge to tweak experiments to make them better. “Ultimately, the reason it’s worth addressing is in the proverb: ‘alone we go fast, together we go far’,” said Churchland.

Decision-making is a field in itself, so IBL researchers will focus on simple, so-called perceptual decisions: those that involve responding to sights or sounds, for example. In one standard test, scientists will record how neurons fire in mice as they watch faint dots appear on a screen and spin a Lego wheel to indicate if the dots are on the left or the right. The mice make mistakes when the dots are faint, and it is these marginal calls that are most interesting to scientists.

one that has conservative groups wrestling for control over how climate science will be taught to American students. The science classroom, after all, remains the dominant venue in which those students first encounter the topic, and it greatly informs how students eventually square-up to the veracity of climate change — either as something they believe to be happening and worth responding to politically, or as a phenomenon of nature, underserving of public funds and political action.

The outcome matters: Whoever wins over the minds of this upcoming cohort of American voters will, to a large extent, shape the nation’s policies on climate change for decades to come.

“Teachers are facing pressure to not only eliminate or de-emphasize climate change science, but also to introduce non-scientific ideas in science classrooms,” the statement said.

For advocates of inserting climate change skepticism into the classroom, the notion of “teaching both sides of the debate” is a familiar refrain, and it’s one used to mask the more fundamental motive: Fostering doubt in students that the scientific community conclusively agrees climate change is occurring.

For those science teachers who remain in the classroom, a comprehensive understanding of climate science itself is not a given. One recent report found that less than half of K-12 science teachers received formal climate science training during their own college education — a comprehension void that helps explain why political ideology has been shown to be the most consistent indicator of how a teacher presents climate science to their own students.

Trying to continue with lessons on climate science despite this intensifying atmosphere of hostility has forced some teachers to become savvier — or more secretive — about how they present the information to their students. In Texas, Nina Corley is careful to keep explicit mentions of climate change out of her lessons, for fear that her skeptical administrators might try to censor the science. “The administrators in a school can have total control, because they’re your boss, you have to remember that. It’s going to be how you word it,” she said. “I’m not going to say my lesson plan is on climate change today, I’ll just talk about how we’re investigating the effects of carbon dioxide.”

Recalling one student who was hostile to her lessons on climate change, Erin Stutzman realized the more personal ramifications catalyzed by the student changing his mind. “He was tightly engrossed in the skepticism, that belief was engrained in him. And his initial resistance wasn’t to the science, really, it was that someone was challenging his parents and his friend’s parents,”

The researchers then conditioned the participants to be afraid of certain images by showing them pictures of ordinary-looking rooms lit with lamps of various hues, some of which were paired with a mild shock to the finger. Through the shocks, they were taught to fear the rooms that were lit by certain colors.

The subjects with more REM sleep also had less activity in those areas of the brain. That suggests that the more well-rested subjects may not have been hard-wiring those fears into their brains quite as strongly.

PTSD is already known to be associated with sleep disturbances, and past studies have shown that sleep-deprived people have more activity in their amygdalae upon being shown upsetting pictures.

“REM is very unique because it’s the only time that area of the brain is completely silent,” said Shira Lupkin, one of the study’s authors and a researcher with the Center for Molecular and Behavioral Neuroscience at Rutgers University.

Because of that, people who get plenty of REM sleep might be less reactive to emotional stimuli.

If the study is replicated, there could be real-world implications for stopping trauma—before it starts.

To do this they have been focusing on the sensory pathways linked to these deep structures. She and her group discovered that adults with dyslexia have weaker pathway connections between a visual subcortical structure (the left visual thalamus) with an area of the cortex called V5/MT, which is critical for the perception of visual motion. In the auditory mode, there was a similar finding. The team discovered weaker connections between the left auditory thalamus and a cortex structure linked to auditory motion, which is important for speech perception. These connections could therefore be important for reading and for predicting reading skill, according to Dr von Kriegstein.

So how might this translate into helping people with dyslexia? This is basic science, says Prof. von Kriegstein, so first it’s crucial to understand the mechanisms behind communications disorders before developing therapy training tools, although she is optimistic these could lie within reach.

The way the brain encodes information and in turn directs perception of that sensory experience is a highly variable process.

The sensory overload or distorted and heightened perceptions described by schizophrenia patients, for instance, could relate to these deficits. Sensory dysfunction has also been linked to delusions and hallucinations as well as difficulties with attention and reading the emotions or tone of others – all of which can affect social interaction.

According to Dr Fellin, decreased connectivity between nerve cells (neurons) appears to play an important role in the progression of schizophrenia. So far, Dr Fellin and his group have identified which specific neurons influence sensory responses in mouse studies, but not yet in animal models of schizophrenia, with similar investigations in glial cells  - the supporting cells of the nervous system.

When we feel so fundamentally disenfranchised, it’s comforting to concoct a fictional universe that systemically denies you the right cards. It gives you something to fight against and makes you self-deterministic. It provides an “us and them” narrative that allows you to conceive of yourself as a little David raging against a rather haughty, intellectual establishment Goliath. This is what worries me about journalists writing columns or tweets sneering at the supposed stupidity of the pseudoscientists and con spiracy theorists – it only serves to enforce this “us and them” worldview.

We ink-stained wretches admired Obama’s thoughtful ways around a subject, his meandering along pathways of implication and possibility, culminating in a formulation that, often as not, would be punctuated with an ellipsis rather than a period. One could often see his mind working as he spoke.

When Obama speaks, he obviously chooses each word with great care. He understands his responsibility to the nation and the world by expressing himself so carefully that nothing is left to interpretation.

Obama’s natural elegance, contrasted to Trump’s bombastic bleats, provided a reawakening to our better angels and the higher truths that have been diminished or forgotten these past four years.

we’ve learned that governance isn’t only about policies; it’s also about the persona embodied by the president of the United States.

Obama’s early losses, of his father through abandonment and his mother from premature death, are what propelled him to the summit. I spotted both engines in him long ago because I share them.

I was relieved -- we wouldn't have to make what felt like an impossible decision -- but then I kept reading. My father had noted that he did not want to be supported by a ventilator or hooked up to a feeding tube for any length of time. He had been connected to both for nearly two weeks.

There was grief on her face, but also curiosity. What had finally gotten to her younger son, the one who so rarely showed emotion during his father's hospitalization?

I called the hospital and approved the DNR. They told me his status was still dire. I called my dad's closest friends and started preparing them for the worst.

My father's lungs showed no signs of progress. The double pneumonia they diagnosed days before was worsening. His kidneys were failing. Dialysis was required but would put a strain on his blood pressure, which was already dangerously low. There was a special form of dialysis designed for delicate situations like this -- continuous veno-venous hemofiltration -- but it wasn't available at Lawrence

The morning after I searched for my father's health directive and drafted his obituary, I woke up and tried to turn on my laptop. It wouldn't start. When it eventually booted up, it asked if I wanted to restore an unsaved document. No, I thought, let's see what happens today.

It was the same doctor as yesterday, the one who asked about the DNR. "Look, your dad is on a ventilator. That's a form of life support. He's experiencing kidney failure and requires dialysis. His situation is still very acute. He was in good health before the Covid, but his kidney, heart, and lungs are 69 years old. It's tough for them to recover. But the numbers from today are undeniably better than yesterday. There's been an improvement at almost every level. Your dad is a tough guy."

One of my close friends, a nurse practitioner, would help me understand all the terminology and its implications. He was treating Covid patients at an ICU upstate. At the end of our calls I'd ask him how he was doing. "We ran out of gowns," he told me one day. "My ICU is out of ventilators -- we're diverting people to Albany," he said another time.

"There's a difference between good intentions and good outcomes," I explained to her. She would wave me away and pick up. Inevitably the call would bring her tears. I stewed on the porch. My brother, uncle and I would spend hours trying to ease her mind and pacify her anxiety. Any inquiry or outreach was like sticking a finger in the open wound of her anguish.

"He's only improving," I told her, "because of the life-saving care you guys have given him. The whole city is in awe of you. They should have a parade for you down the Canyon of Heroes."

The nurses and doctors who took care of my father -- first for four days at NewYork-Presbyterian Lawrence Hospital, then for nearly a month at NewYork-Presbyterian/Columbia -- were always empathetic, straightforward and willing to trust me with complicated details.

About a week after writing -- then refusing to recover -- my father's obituary, his condition was continuing to improve.

I called my friend, the nurse practitioner, and gave him the latest update. He seemed upset. "You OK, dude?" "A nurse from my hospital died," he explained.

I wrote about my dad's volunteer work -- at the Special Olympics, at an organization he founded that helps police families with special needs, and at just about any Italian-American group that needed a lawyer. He was so proud of his Italian-American heritage. He loathed the mafioso caricatures and stereotypes found on TV -- he wrote countless op-eds attacking those -- but he revered the old-school virtues he associated with his Italian-American upbringing: loyalty, humility, hard work, dedication to family.

"Yesterday was a stumble, but we're getting back on course," I emailed the group. "We always knew this recovery wasn't going to be a straight line. It's important to remain resilient and optimistic even when there are temporary setbacks."

"Oh Lou, I've been waiting for your call. I have such good news. They are planning to extubate him tomorrow. They are going to take your father off the ventilator!" She was practically screaming with excitement. I was speechless.

I had been withholding certain information from my family and friends during this whole ordeal. My dad had developed a blood clot two weeks into his hospitalization. Clots are extremely dangerous, of course, but it was small and in a relatively manageable location.

I called my brother and told him about the plan to get my father off the ventilator. Since there were a number of contingencies, we debated telling my mother. She was living and dying with every update.

My father's breathing was labored on the morning they were planning to extubate. They delayed the procedure a day. That next morning, April 16, a doctor called. I was in the shower and rushed out to answer my cell. He said they were doing the extubation within the hour. What do we want to do if the extubation fails?

"It went as well as we could have hoped for," the doctor said. "His vitals are stable and he's breathing well. He's resting now." She explained that my father was disoriented and it probably wasn't a great idea to speak with him that day. Whatever, I thought, I'll speak with him when he gets home. He had been on a ventilator for 28 days.

I called the doctor later in the day. She told me my dad seemed distressed. He was trying to speak, but his vocal cords were too swollen. "It's so frustrating," she told me. "I don't know what he wants to tell me."

"Each facility has their own Covid rules," she explained. "I'll send you over a list." On the list was the nursing home where my grandfather had died several years before. My father had visited him every day.

I called the step-down unit where he had been the past three days. They transferred me to his nurse. "He's doing better, love. We took him off the pressor and his blood pressure is in a good range. His heart rate is good. He's breathing fine. The doctors decided he didn't need to go back to the ICU. He's ok."

"I've repeatedly said that recovery isn't a straight line. ... Yesterday we managed the roller coaster ride as a family. My brother, uncle and I were with my mother the entire day. We never lost hope or confidence in my dad's medical care and ultimate recovery. If there's a light at the end of the tunnel, it's a blinking one. Right now, it shines again."

I drove back to my mom's house. I scanned the block for my brother's car. He had not arrived. I parked. I have to wait for him and then tell my mother, brother and uncle all at once, right? Should I call my wife first? Should I call my dad's best friend?

I called my wife. I called my dad's best friend. I called the guys he grew up with. I called his former colleagues. I began every conversation the same way, "This is that call." I listened to each of them yell and cry and ask if I was serious. Then I said I had to make another call.

I wrote about my father's career. How he got his law degree at night school and became a prosecutor at the city, state, and federal level. How he convicted mobsters, drug dealers, and those who abused power.

Covid-19 was new and largely unstudied. Maybe one of these seemingly odd treatments would work.

He was a Covid patient for 31 days. It was a painful experience, but ultimately unimportant. It doesn't matter how a man dies. It matters how he lives.

"Kansas is one of only five states that has all-but abolished the defense -- a step that the majority upheld today. But the most important implication of the decision may be in opening the door to additional states that want to follow suit," he said.

Kagan stressed that Kansas law allows a defendant to "present psychiatric and other evidence of mental illness" through testimony to prove that "he had no intent to kill" to defend himself against a criminal charge."The defendant can use that evidence to show that his illness left him without cognitive capacity to form the requisite intent," she said. And, she said, Kansas permits a defendant to offer whatever mental health evidence he "deems relevant at sentencing."