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The new study provides “unassailable” evidence that the central nervous system can control the peripheral immune system, Tracey says. “It’s an incredibly important contribution to the fields of neuroscience and immunology.”

Just as researchers have traced sensory and motor processing to specific brain regions, Tracey suspects that a similar neurological “map” of immunologic information also exists. This new study, he says, is the first direct evidence of that map. “It’s going to be really exciting to see what comes next,” he adds.

a new book, The Experience Machine: How Our Minds Predict and Shape Reality, which is remarkable for how it connects the high-level concepts to everyday examples of how our brains make predictions, how that process can lead us astray, and what we can do about it.

being driven to stay within your own viability envelope is crucial to the kind of intelligence that we know about—the kind of intelligence that we are

If you ask what is a predictive brain for, the answer has to be: staying alive. Predictive brains are a way of staying within your viability envelope as an embodied biological organism: getting food when you need it, getting water when you need it.

in predictive processing, perception is structured around prediction. Perception is about the brain having a guess at what’s most likely to be out there and then using sensory information to refine the guess.

artificial curiosity. Predictive-processing systems automatically have that. They’re set up so that they predict the conditions of their own survival, and they’re always trying to get rid of prediction errors. But if they’ve solved all their practical problems and they’ve got nothing else to do, then they’ll just explore. Getting rid of any error is going to be a good thing for them. If you’re a creature like that, you’re going to be a really good learning system. You’re going to love to inhabit the environments that you can learn most from, where the problems are not too simple, not too hard, but just right.

It’s an effect that you also see in Marieke Jepma et al.’s work on pain. They showed that if you predict intense pain, the signal that you get will be interpreted as more painful than it would otherwise be, and vice versa. Then they asked why you don’t correct your misimpression. If it’s my expectation that is making it feel more painful, why don’t I get prediction errors that correct it?

The reason is that there are no errors. You’re expecting a certain level of pain, and your prediction helps bring that level about; there is nothing for you to correct. In fact, you’ve got confirmation of your own prediction. So it can be a vicious circle

Do you think this self-fulfilling loop in psychosis and pain perception helps to account for misinformation in our society’s and people’s susceptibility to certain narratives?Absolutely. We all have these vulnerabilities and self-fulfilling cycles. We look at the places that tend to support the models that we already have, because that’s often how we judge whether the information is good or not

Given that we know we’re vulnerable to self-fulfilling information loops, how can we make sure we don’t get locked into a belief?Unfortunately, it’s really difficult. The most potent intervention is to remind ourselves that we sample the world in ways that are guided by the models that we’ve currently got. The structures of science are there to push back against our natural tendency to cherry-pick.

What the research has found is that the brains of trans people are unique: neither female nor male, exactly, but something distinct.

But what does that mean, a male brain, or a female brain, or even a transgender one?

It’s a fraught topic, because brains are a collection of characteristics, rather than a binary classification of either/or

yet scientists continue to study the brain in hopes of understanding whether a sense of the gendered self can, at least in part, be the result of neurology

Well, not entirely. Because not every person with a Y chromosome is male, and not every person with a double X is female. The world is full of people with other combinations: XXY (or Klinefelter Syndrome), XXX (or Trisomy X), XXXY, and so on. There’s even something called Androgen Insensitivity Syndrome, a condition that keeps the brains of people with a Y from absorbing the information in that chromosome. Most of these people develop as female, and may not even know about their condition until puberty — or even later.

t there’s a problem with using neurology as an argument for trans acceptance — it suggests that, on some level, there is something wrong with transgender people, that we are who we are as a result of a sickness or a biological hiccup.

trying to open people’s hearts by saying “Check out my brain!” can do more harm than good, because this line of argument delegitimizes the experiences of many trans folks. It suggests that there’s only one way to be trans — to feel trapped in the wrong body, to go through transition, and to wind up, when all is said and done, on the opposite-gender pole. It suggests that the quest trans people go on can only be considered successful if it ends with fitting into the very society that rejected us in the first place.

All the science tells us, in the end, is that a biological male — or female — is not any one thing, but a collection of possibilities.

No one who embarks upon a life as a trans person in this country is doing so out of caprice, or a whim, or a delusion. We are living these wondrous and perilous lives for one reason only — because our hearts demand it.

what we need now is not new legislation to make things harder. What we need now is understanding, not cruelty. What we need now is not hatred, but love.

the important thing is not that they feel like a woman, or a man, or something else. What matters most is the plaintive desire, to be free to feel the way I feel.

People believe that memory should be effortless, but their expectations for how much they should remember are totally out of whack with how much they’re capable of remembering.1

What is the most common misconception about memory?

Another misconception is that memory is supposed to be an archive of the past. We expect that we should be able to replay the past like a movie in our heads.

we don’t replay the past as it happened; we do it through a lens of interpretation and imagination.

How much are we capable of remembering, from both an episodic2 2 Episodic memory is the term for the memory of life experiences. and a semantic3 3 Semantic memory is the term for the memory of facts and knowledge about the world. standpoint?

I would argue that we’re all everyday-memory experts, because we have this exceptional semantic memory, which is the scaffold for episodic memory.

If what we’re remembering, or the emotional tenor of what we’re remembering, is dictated by how we’re thinking in a present moment, what can we really say about the truth of a memory?

But if memories are malleable, what are the implications for how we understand our “true” selves?

your question gets to a major purpose of memory, which is to give us an illusion of stability in a world that is always changing. Because if we look for memories, we’ll reshape them into our beliefs of what’s happening right now. We’ll be biased in terms of how we sample the past. We have these illusions of stability, but we are always changing

And depending on what memories we draw upon, those life narratives can change.

we have this illusion that much of the world is cause and effect. But the reason, in my opinion, that we have that illusion is that our brain is constantly trying to find the patterns

One thing that makes the human brain so sophisticated is that we have a longer timeline in which we can integrate information than many other species. That gives us the ability to say: “Hey, I’m walking up and giving money to the cashier at the cafe. The barista is going to hand me a cup of coffee in about a minute or two.”

There is this illusion that we know exactly what’s going to happen, but the fact is we don’t. Memory can overdo it: Somebody lied to us once, so they are a liar; somebody shoplifted once, they are a thief.

If people have a vivid memory of something that sticks out, that will overshadow all their knowledge about the way things work. So there’s kind of an illus

I know it sounds squirmy to say, “Well, I can’t answer the question of how much we remember,” but I don’t want readers to walk away thinking memory is all made up.

I think of memory more like a painting than a photograph. There’s often photorealistic aspects of a painting, but there’s also interpretation. As a painter evolves, they could revisit the same subject over and over and paint differently based on who they are now. We’re capable of remembering things in extraordinary detail, but we infuse meaning into what we remember. We’re designed to extract meaning from the past, and that meaning should have truth in it. But it also has knowledge and imagination and, sometimes, wisdom.

memory, often, is educated guesses by the brain about what’s important. So what’s important? Things that are scary, things that get your desire going, things that are surprising. Maybe you were attracted to this person, and your eyes dilated, your pulse went up. Maybe you were working on something in this high state of excitement, and your dopamine was up.

It could be any of those things, but they’re all important in some way, because if you’re a brain, you want to take what’s surprising, you want to take what’s motivationally important for survival, what’s new.

On the more intentional side, are there things that we might be able to do in the moment to make events last in our memories? In some sense, it’s about being mindful. If we want to form a new memory, focus on aspects of the experience you want to take with you.

If you’re with your kid, you’re at a park, focus on the parts of it that are great, not the parts that are kind of annoying. Then you want to focus on the sights, the sounds, the smells, because those will give you rich detail later on

Another part of it, too, is that we kill ourselves by inducing distractions in our world. We have alerts on our phones. We check email habitually.

When we go on trips, I take candid shots. These are the things that bring you back to moments. If you capture the feelings and the sights and the sounds that bring you to the moment, as opposed to the facts of what happened, that is a huge part of getting the best of memory.

this goes back to the question of whether the factual truth of a memory matters to how we interpret it. I think it matters to have some truth, but then again, many of the truths we cling to depend on our own perspective.

There’s a great experiment on this. These researchers had people read this story about a house.8 8 The study was “Recall of Previously Unrecallable Information Following a Shift in Perspective,” by Richard C. Anderson and James W. Pichert. One group of subjects is told, I want you to read this story from the perspective of a prospective home buyer. When they remember it, they remember all the features of the house that are described in the thing. Another group is told, I want you to remember this from the perspective of a burglar. Those people tend to remember the valuables in the house and things that you would want to take. But what was interesting was then they switched the groups around. All of a sudden, people could pull up a number of details that they didn’t pull up before. It was always there, but they just didn’t approach it from that mind-set. So we do have a lot of information that we can get if we change our perspective, and this ability to change our perspective is exceptionally important for being accurate. It’s exceptionally important for being able to grow and modify our beliefs