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Hitler was on a steady stream of barbiturate tranquilizers, morphine, nasal and eye drops containing cocaine and other drugs — along with bulls’ semen to boost his testosterone — thanks to his Berlin-based personal physician, Theodor Morell, according to the report

He was characterized as “a quack and a fraud and a snake oil salesman”

Hitler was shown to have signs of Parkinson's disease by the end of World War II in 1945, and the dizzying array of drugs likely contributed to his serious health issues.

The treatment helped 13.4% of patients with their addiction, compared with 2.5% of the placebo group.

This medication therapy provides another tool for doctors to try with patients.

"As we understand the complexity of the human brain, it becomes very much of a magical thinking that one pill will solve the problem of addiction,"

The treatment regimen in the trial combined two medications that have been studied separately for treating methamphetamine addiction with limited success.

This clinical trial was successful enough that the National Institute on Drug Addiction's Volkow says she expects to move forward toward securing FDA approval.

lack of medical treatments for those addicted to meth has complicated efforts to curb demand for the drug.

The human cost has been catastrophic. Researchers say overdose deaths linked to meth increased fourfold over the last decade.

Even users who don't overdose often experience damage to the heart and other tissues, and can see their lives spiral out of control.

"For heroin users, there's methadone, there's suboxone. I just wonder why we haven't researched [treatments for] this drug yet,"

"It's about evidence-based care, it's about empathy and it's about survivability,"

Now we have a body of research that makes the connection between stress and addiction definitive. More surprising, it shows that we can change the path to addiction by changing our environment.

Neuroscientists have found that food and recreational drugs have a common target in the “reward circuit” of the brain, and that the brains of humans and other animals who are stressed undergo biological changes that can make them more susceptible to addiction.

In a 2010 study, Diana Martinez and colleagues at Columbia scanned the brains of a group of healthy controls and found that lower social status and a lower degree of perceived social support — both presumed to be proxies for stress — were correlated with fewer dopamine receptors, called D2s, in the brain’s reward circuit

The reward circuit evolved to help us survive by driving us to locate food or sex in our environment

Today, the more D2 receptors you have, the higher your natural level of stimulation and pleasure — and the less likely you are to seek out recreational drugs or comfort food to compensate

people addicted to cocaine, heroin, alcohol and methamphetamines experience a significant reduction in their D2 receptor levels that persists long after drug use has stopped. These people are far less sensitive to rewards, are less motivated and may find the world dull, once again making them prone to seek a chemical means to enhance their everyday life.

Drug exposure also contributes to a loss of self-control. Dr. Volkow found that low D2 was linked with lower activity in the prefrontal cortex, which would impair one’s ability to think critically and exercise restraint

Food, like drugs, stimulates the brain’s reward circuit. Chronic exposure to high-fat and sugary foods is similarly linked with lower D2 levels, and people with lower D2 levels are also more likely to crave such foods. It’s a vicious cycle in which more exposure begets more craving.

At this point you may be wondering: What controls the reward circuit in the first place? Some of it is genetic. We know that certain gene variations elevate the risk of addiction to various drugs. But studies of monkeys suggest that our environment can trump genetics and rewire the brain.

simply by changing the environment, you can increase or decrease the likelihood of an animal becoming a drug addict.

The same appears true for humans. Even people who are not hard-wired for addiction can be made dependent on drugs if they are stressed

Is it any wonder, then, that the economically frightening situation that so many Americans experience could make them into addicts? You will literally have a different brain depending on your ZIP code, social circumstances and stress level.

In 1990, no state in our country had an adult obesity rate above 15 percent; by 2015, 44 states had obesity rates of 25 percent or higher. What changed?

What happened is that cheap, calorie-dense foods that are highly rewarding to your brain are now ubiquitous.

Nothing in our evolution has prepared us for the double whammy of caloric modern food and potent recreational drugs. Their power to activate our reward circuit, rewire our brain and nudge us in the direction of compulsive consumption is unprecedented.

The processed food industry has transformed our food into a quasi-drug, while the drug industry has synthesized ever more powerful drugs that have been diverted for recreational use.

Fortunately, our brains are remarkably plastic and sensitive to experience. Although it’s far easier said than done, just limiting exposure to high-calorie foods and recreational drugs would naturally reset our brains to find pleasure in healthier foods and life without drugs.

comparing even the best TV shows with Dickens, or Henry James, also suggests how much the novel can achieve that TV doesn’t even attempt.

Television gives us something that looks like a small world, made by a group of people who are themselves a small world. The novel gives us sounds pinned down by hieroglyphs, refracted flickerings inside an individual.

Spectacle and melodrama remain at the heart of TV, as they do with all arts that must reach a large audience in order to be economically viable. But it is voice, tone, the sense of the author’s mind at work, that are the essence of literature, and they exist in language, not in images.

At this point in our technological evolution, to read a novel is to engage in probably the second-largest single act of pleasure-based data transfer that can take place between two human beings, exceeded only by sex. Novels are characterized by their intimacy, which is extreme, by their scale, which is vast, and by their form, which is linguistic and synesthetic. The novel is a kinky beast.

Televised evil, for instance, almost always takes melodramatic form: Our anti-heroes are mobsters, meth dealers or terrorists. But this has nothing to do with the way we encounter evil in real life, which is why a character like Gilbert Osmond, in “The Portrait of a Lady,” is more chilling in his bullying egotism than Tony Soprano

television and the novel travel in opposite directions.

the cost-benefit analysis of “breaking bad” when the alternative is imminently “dying alone” is rigged in favor of the very short term, i.e. zero-sum evil. If Walt had had to weigh a long, unpredictable lifetime of unending fear and constant danger for his family and himself, he would have stopped cooking meth.

was he happy? Yes, but in a way that never really reflects any inner peace. He is happy in a way that all millionaires and tyrants are happy.

Breaking Bad should be taught alongside Machiavelli – as a riveting companion piece.

It should be taught because it really does convey the egoist appeal of evil, of acting ruthlessly in the world

The benefits only work if your life is nasty, brutish and short. The costs are seen in the exhausted, broken eyes of Skyler, the betrayal of an only painfully faithful son, the murder of a brother-in-law, the grisly massacre of dozens, the endless nervous need to be on the alert, to run and hide and lie and lie and lie again, until life itself becomes merely a means to achieve temporary security.

Machiavelli differs from later realists like Hobbes—and more contemporary “neorealists” like the late Kenneth Waltz—in recognizing that human agency matters as much as the structural fact of international anarchy in determining both foreign policy behavior and ultimate outcomes in world politics.

a leader’s choices can have a pivotal impact on politics, both domestic and international.

Though fortune be capricious and history contingent, the able leader may shape his fate and that of his state through the exercise of virtu. This is not to be mistaken for “virtue”, as defined by Christian moral teaching (implying integrity, charity, humility, and the like). Rather, it denotes the human qualities prized in classical antiquity, including knowledge, courage, cunning, pride, and strength.

The important thing to remember amid all this, and the thing that has changed the game when it comes to the free speech/content moderation conversation, is that Elon Musk himself loves conspiracy theorie

The media isn’t just unduly critical—a perennial sore spot for Musk—but “all news is to some degree propaganda,” meaning he won’t label actual state-affiliated propaganda outlets on his platform to distinguish their stories from those of the New York Times.

In his mind, they’re engaged in the same activity, so he strikes the faux-populist note that the people can decide for themselves what is true, regardless of objectively very different track records from different sources.

Musk’s “just asking questions” maneuver is a classic Trump tactic that enables him to advertise conspiracy theories while maintaining a sort of deniability.

At what point should we infer that he’s taking the concerns of someone like Loomer seriously not despite but because of her unhinged beliefs?

Musk’s skepticism seems largely to extend to criticism of the far-right, while his credulity for right-wing sources is boundless.

This is part of the argument for content moderation that limits the dispersal of bullshit: People simply don’t have the time, energy, or inclination to seek out the boring truth when stimulated by some online outrage.

Refuting bullshit requires some technological literacy, perhaps some policy knowledge, but most of all it requires time and a willingness to challenge your own prior beliefs, two things that are in precious short supply online.

Brandolini’s Law holds that the amount of energy needed to refute bullshit is an order of magnitude bigger than that needed to produce it.

Here we can return to the example of Loomer’s tweet. People did fact-check her, but it hardly matters: Following Musk’s reply, she ended up receiving over 5 million views, an exponentially larger online readership than is normal for her. In the attention economy, this counts as a major win. “Thank you so much for posting about this, @elonmusk!” she gushed in response to his reply. “I truly appreciate it.”

the problem isn’t limited to elevating Loomer. Musk had his own stock of misinformation to add to the pile. After interacting with her account, Musk followed up last Tuesday by tweeting out last week a 2021 Federalist article claiming that Facebook founder Mark Zuckerberg had “bought” the 2020 election, an allegation previously raised by Trump and others, and which Musk had also brought up during his recent interview with Tucker Carlson.

If Zuckerberg wanted to use his vast fortune to tip the election, it would have been vastly more efficient to create a super PAC with targeted get-out-the-vote operations and advertising. Notwithstanding legitimate criticisms one can make about Facebook’s effect on democracy, and whatever Zuckerberg’s motivations, you have to squint hard to see this as something other than a positive act addressing a real problem.

It’s worth mentioning that the refutations I’ve just sketched of the conspiratorial claims made by Loomer and Musk come out to around 1,200 words. The tweets they wrote, read by millions, consisted of fewer than a hundred words in total. That’s Brandolini’s Law in action—an illustration of why Musk’s cynical free-speech-over-all approach amounts to a policy in favor of disinformation and against democracy.

Moderation is a subject where Zuckerberg’s actions provide a valuable point of contrast with Musk. Through Facebook’s independent oversight board, which has the power to overturn the company’s own moderation decisions, Zuckerberg has at least made an effort to have credible outside actors inform how Facebook deals with moderation issues

Meanwhile, we are still waiting on the content moderation council that Elon Musk promised last October:

The problem is about to get bigger than unhinged conspiracy theorists occasionally receiving a profile-elevating reply from Musk. Twitter is the venue that Tucker Carlson, whom advertisers fled and Fox News fired after it agreed to pay $787 million to settle a lawsuit over its election lies, has chosen to make his comeback. Carlson and Musk are natural allies: They share an obsessive anti-wokeness, a conspiratorial mindset, and an unaccountable sense of grievance peculiar to rich, famous, and powerful men who have taken it upon themselves to rail against the “elites,” however idiosyncratically construed

f the rumors are true that Trump is planning to return to Twitter after an exclusivity agreement with Truth Social expires in June, Musk’s social platform might be on the verge of becoming a gigantic rec room for the populist right.

These days, Twitter increasingly feels like a neighborhood where the amiable guy-next-door is gone and you suspect his replacement has a meth lab in the basement.

even if Twitter’s increasingly broken information environment doesn’t sway the results, it is profoundly damaging to our democracy that so many people have lost faith in our electoral system. The sort of claims that Musk is toying with in his feed these days do not help. It is one thing for the owner of a major source of information to be indifferent to the content that gets posted to that platform. It is vastly worse for an owner to actively fan the flames of disinformation and doubt.