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Javier E

Why College Graduates Are Irrationally Optimistic - NYTimes.com - 0 views

  • Because of the power of optimism, enhancing graduates’ faith in the American dream by presenting them with rare examples as proof may be just what the doctor ordered. Their hopes may not be fully realized, but they will be more successful, healthier and happier if they hold on to positively biased expectations.
  • Whether you are 9 or 90, male or female, of African or European descent, you are likely to have an optimism bias. In fact, 80 percent of the world does. (Many believe optimism is unique to Americans; studies show the rest of the world is just as optimistic.)
  • In fact, the people who accurately predict the likelihood of coming events tend to be mildly depressed.
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  • with the development of non-invasive brain imaging techniques, we have gathered evidence that suggests our brains are hard-wired to be unrealistically optimistic. When we learn what the future may hold, our neurons efficiently encode unexpectedly good information, but fail to incorporate information that is unexpectedly bad.
  • Underestimating risk makes us less likely to practice safe sex, save for retirement, buy insurance or undergo medical screenings.
  • Take the financial crisis of 2008. Each investor, homeowner, banker or economic regulator expected slightly better profits than were realistically warranted. On its own, each bias would not have created huge losses. Yet when combined in one market they produced a giant financial bubble that did just that.
  • The optimal solution then? Believe you will live a long healthy life, but go for frequent medical screenings. Aspire to write the next “Harry Potter” series, but have a safety net in place too.
qkirkpatrick

BBC Sport - NFL stars to donate brains for medical research - 0 views

  • Two American Football stars say they will donate their brains for medical research after their deaths.
  • Many former players in the sport suffer degenerative brain disease
  • "There are a lot of issues that stem from brain injuries and it's not just professional athletes. This affects everybody,"
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  • About 4,500 former players are suing the National Football League (NFL) over head injuries suffered during their careers. They are close to a settlement worth about $1bn (£655m).
  • Rice estimates he suffered between 15 and 20 concussions playing American Football from the age of eight.
  • "I had my fair share of fun in the NFL," he said. "Unfortunately, I wasn't educated enough on what concussions can lead to. The brain studies by the doctors will be huge to help, maybe prevent."
carolinewren

Journalists debunk vaccine science denial - 0 views

  • extra difficulties imposed irrationally by antiscience.
  • Large outbreaks in the U.S. of the highly infectious disease have become more common in the past two years, even though measles hasn’t been indigenous since 2000, according to the Centers for Disease Control and Prevention.
  • difficult because concerns about a possible link between vaccines and autism—now debunked by science—have expanded to more general, and equally groundless, worries about the effects of multiple shots on a child’s immune system, vaccine experts and doctors say.
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  • It summarized and condemned the scientific and medical fraud that the British researcher Andrew Wakefield perpetrated. Years earlier, he had falsely linked the measles, mumps, and rubella (MMR) vaccine to autism. The editorial lamented that “the damage to public health continues, fuelled by unbalanced media reporting and an ineffective response from government, researchers, journals, and the medical profession.”
  • Reporters also seek to ensure that viewers, listeners, or readers understand that measles can afflict a victim more powerfully than does a mere passing ailment.
  • Measles doesn’t spread in most U.S. communities because people are protected by “herd immunity,” meaning that 92% to 94% of the population is vaccinated or immune. That level of protection makes it hard for one case of measles to spread even from one unvaccinated person to another without direct contact.
  • a study that “found that only 51 percent of Americans were confident that vaccines are safe and effective, which is similar to the proportion who believe that houses can be haunted by ghosts.”
  • In some parts of California, resistance to vaccinations including the MMR shot is stronger than ever, despite cases of measles hitting five US states.
  • “Vaccines are a great idea, but they are poisoning us, adding things that kick in later in life so they can sell us more drugs.”
  • Health professionals say those claims are unfounded or vastly overstated.
  • “the anti-vaccination movement is fueled by an over-privileged group of rich people grouped together who swear they won’t put any chemicals in their kids (food or vaccines or whatever else), either because it’s trendy to be all-natural or they don’t understand or accept the science of vaccinations. Their science denying has been propelled further by celebrities
  • the outbreak “should worry and enrage the public.” It indicted the anti-vaxxers’ “ignorant and self-absorbed rejection of science” and declared, “Getting vaccinated is good for the health of the inoculated person and also part of one’s public responsibility to help protect the health of others.”
  • “It’s wrong,” the editors emphasized, “to allow public health to be threatened while everyone else waits for these science-denying parents to open their eyes.”
  • “It’s because these people are highly educated and they get on the Internet and read things and think they can figure things out better than their physician.”
  • linked vaccination opposition to the “political left, which has long been suspicious of the lobbying power of the pharmaceutical industry and its influence on government regulators, and also the fringe political right, which has at different times seen vaccination, fluoridisation and other public-health initiatives as attempts by big government to impose tyrannical limits on personal freedom.”
  • Attempts to increase concerns about communicable diseases or correct false claims about vaccines may be especially likely to be counterproductive.
  • “attempting balance by giving vaccine skeptics and pro-vaccine advocates equal weight in news stories leads people to believe the evidence for and against vaccination is equally strong.”
  • A recent edition of the Washington Post carried a letter defending anti-vaxxers as “people who generally are pro-science and highly educated, who have high incomes and who have studied this issue carefully before coming to the conclusion that the risk to their children is greater than the slim possibility of contracting a childhood disease that [in many cases leaves] little or no residual consequences.”
  • anecdotal evidence suggests that some journalists, rather than omitting anti-vaxxers’ views, prefer to expose them and then oppose them.
  • “unwarranted fear . . . an assault on one of the greatest public-health inventions in world history.”
Javier E

The Narrative Frays for Theranos and Elizabeth Holmes - The New York Times - 1 views

  • Few people, let alone those just 31 years old, have amassed the accolades and riches bestowed on Elizabeth Holmes, founder and chief executive of the blood-testing start-up Theranos.
  • This year President Obama named her a United States ambassador for global entrepreneurship. She gave the commencement address at Pepperdine University. She was the youngest person ever to be awarded the Horatio Alger Award in recognition of “remarkable achievements accomplished through honesty, hard work, self-reliance and perseverance over adversity.” She is on the Board of Fellows of Harvard Medical School.
  • Time named her one of the 100 Most Influential People in the World this year. She was the subject of lengthy profiles in The New Yorker and Fortune. Over the last week, she appeared on the cover of T: The New York Times Style Magazine, and Glamour anointed her one of its eight Women of the Year. She has been on “Charlie Rose,” as well as on stage at the Clinton Global Initiative, the World Economic Forum at Davos and the Aspen Ideas Festival, among numerous other conferences.
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  • Theranos, which she started after dropping out of Stanford at age 19, has raised more than $400 million in venture capital and has been valued at $9 billion, which makes Ms. Holmes’s 50 percent stake worth $4.5 billion. Forbes put her on the cover of its Forbes 400 issue, ranking her No. 121 on the list of wealthiest Americans.
  • Thanks to an investigative article in The Wall Street Journal this month by John Carreyrou, one of the company’s central claims, and the one most exciting to many investors and doctors, is being called into question. Theranos has acknowledged it was only running a limited number of tests on a microsample of blood using its finger-prick technology. Since then, it said it had stopped using its proprietary methods on all but one relatively simple test for herpes.
  • “The constant was that nobody had any idea how this works or even if it works,” Mr. Loria told me this week. “People in medicine couldn’t understand why the media and technology worlds were so in thrall to her.
  • that so many eminent authorities — from Henry Kissinger, who had served on the company’s board; to prominent investors like the Oracle founder Larry Ellison; to the Cleveland Clinic — appear to have embraced Theranos with minimal scrutiny is a testament to the ageless power of a great story.
  • Ms. Holmes seems to have perfectly executed the current Silicon Valley playbook: Drop out of a prestigious college to pursue an entrepreneurial vision; adopt an iconic uniform; embrace an extreme diet; and champion a humanitarian mission, preferably one that can be summed up in one catchy phrase.
  • She stays relentlessly on message, as a review of her numerous conference and TV appearances make clear, while at the same time saying little of scientific substance.
  • The natural human tendency to fit complex facts into a simple, compelling narrative has grown stronger in the digital age of 24/7 news and social media,
  • “We’re deluged with information even as pressure has grown to make snap decisions,”
  • “People see a TED talk. They hear this amazing story of a 30-something-year-old woman with a wonder procedure. They see the Cleveland Clinic is on board. A switch goes off and they make an instant decision that everything is fine. You see this over and over: Really smart and wealthy people start to believe completely implausible things with 100 percent certainty.”
  • Ms. Holmes’s story also fits into a broader narrative underway in medicine, in which new health care entrepreneurs are upending ossified hospital practices with the goal of delivering more effective and patient-oriented care.
  • as a medical technology company, Theranos has bumped up against something else: the scientific method, which puts a premium on verification over narrative.
  • “You have to subject yourself to peer review. You can’t just go in a stealthy mode and then announce one day that you’ve got technology that’s going to disrupt the world.”
  • Professor Yeo said that he and his colleagues wanted to see data and testing in independent labs. “We have a small army of people ready and willing to test Theranos’s products if they’d ask us,” he said. “And that can be done without revealing any trade secrets.”
  • “Every other company in this field has gone through peer review,” said Mr. Cherny of Evercore. “Why hold back so much of the platform if your goal is the greater good of humanity?”
clairemann

Is It Bad To Get Too Much Sleep? | HuffPost Life - 0 views

  • For years, we’ve been told how detrimental a lack of sleep can be for our mental and physical health.
  • But is it bad to get too much sleep — and if so, how much is too much?
  • “It’s important to remember that not everyone’s ‘too much sleep’ is the same,” sleep psychologist Jade Wu, a researcher at the Duke University School of Medicine, told HuffPost. “And sleep needs change over the lifetime. For example, a teenager or young adult may very well need nine or more hours per night, whereas a retiree likely doesn’t.”
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  • Oversleeping — typically defined as more than nine or 10 hours in research studies — is associated with certain health risks, including stroke, obesity, depression, diabetes, heart disease and dementia. However, it’s not clear if oversleeping causes these conditions or if it’s just an indicator that something else is wrong.
  • “In other words, we don’t know if it’s the long sleep that’s causing problems over time, or if some underlying health problem is causing someone to sleep longer,”
  • “If someone seems to be an unusually long sleeper, it’s possible that they are simply wired to need more sleep,” Wu said. (That said, it can’t hurt to mention it to your doctor if you have some concerns.)
  • “A number of factors, such as medical conditions, medication side effects, and undiagnosed sleep disorders, can lead to poor sleep quality and non-restful sleep,” she added.
  • if sleep quantity isn’t the issue, then sleep quality probably is. Conditions like sleep apnea can disrupt sleep and leave you feeling fatigued even after spending ample time in bed.
  • “Poor quality sleep means that an individual does not get to the deeper stages of sleep or REM sleep, which restore the brain and body and makes you feel refreshed and rejuvenated the next day,”
  • “Get lots of sunlight, get physically active — or at least decrease long stretches of sitting — and go out of your way to plan some fun and social activities,” Wu said. “Make efforts to prioritize physical and mental health. You may find yourself waking up with more energy after making these changes.”
anonymous

What Comorbidities Qualify for Covid Vaccine? That Depends. - The New York Times - 0 views

  • So, What’s Your ‘Fauxmorbidity’?
  • People are racing to get vaccinated — even those who don’t yet technically qualify. And that’s good news.
  • After Covid-19 vaccines from Pfizer and Moderna were approved for use in late 2020, anecdotes proliferated about rich people finding ways to jump the distribution priority line.
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  • “I heard a lot from friends in Miami about people flying in, because they were giving it to everybody,”
  • , it began to seem like anyone could get a vaccine if they were willing to hunt one down or stretch the truth about their medical history.
  • “the equivalent of knocking over an old lady for a taxi and feeling good about yourself,” as she put it in an interview.
  • “It’s broadcasting status, that you got the vaccine ahead of others,”
  • “We should all consider taking up the Garbo challenge and stay off social media for a spell instead of broadcasting every waking second of the day, including your vax shot.”
  • Those people seemed just fine when they were splashing in bikinis in Turks and Caicos at Christmas,
  • “What’s funny is that many of them just post their vaccination selfies to green circle Close Friends.”
  • “On some level, they know it’s tone-deaf for a wide audience but have their group where they feel safe,”
  • Occasionally, those posting on Instagram have said that they were trying to say to others that the vaccine is safe and effective
  • “I mean, come on. You’re not Joe Biden. You’re not the queen,”
  • Three psychiatrists interviewed for this article said their patients all seemed to understand that attention deficit disorder and mild anxiety do not meet the state definition of an “intellectual” or “developmental” disorder sufficient to place them in the Centers for Disease Control and Prevention’s
  • “I have patients who brought stacks of medical info when they went to get vaccinated. No one ever asks to see it.”
  • “I’ve never had so many people happy to be told they’re obese,”
  • “At this point, the goal is to get as many people vaccinated as possible,”
  • He sees no issue with giving a note to a patient who had a melanoma five years back. Cancer is cancer. Elevated blood pressure is fine too, even if it’s sometimes less a reason than an excuse.
  • “Young people are the super-spreaders!
  • Some young people get around the fauxmorbidity issue by volunteering at a vaccine site.
  • . “It was basically treated as a given when I got there,”
  • “I get that people are eager to shame those who are gaming the system,” she said, “but let’s shame the people who set up that system.”
katedriscoll

Confirmation Bias - an overview | ScienceDirect Topics - 0 views

  • Confirmation bias is a ubiquitous phenomenon, the effects of which have been traced as far back as Pythagoras’ studies of harmonic relationships in the 6th century B.C. (Nickerson, 1998), and is referenced in the writings of William Shakespeare and Francis Bacon (Risinger, Saks, Thompson, & Rosenthal, 2002). It is also a problematic phenomenon, having been implicated in “a significant fraction of the disputes, altercations, and misunderstandings that occur among individuals, groups, and nations” throughout human history, including the witch trials of Western Europe and New England, and the perpetuation of inaccurate medical diagnoses, ineffective medical treatments, and erroneous scientific theories (Nickerson, 1998, p. 175).
  • For over a century, psychologists have observed that people naturally favor information that is consistent with their beliefs or desires, and ignore or discount evidence to the contrary. In an article titled “The Mind’s Eye,” Jastrow (1899) was among the first to explain how the mind plays an active role in information processing, such that two individuals with different mindsets might interpret the same information in entirely different ways (see also Boring, 1930). Since then, a wealth of empirical research has demonstrated that confirmation bias affects how we perceive visual stimuli (e.g., Bruner & Potter, 1964; Leeper, 1935), how we gather and evaluate evidence (e.g., Lord, Ross, & Lepper, 1979; Wason, 1960), and how we judge—and behave toward—other people (e.g., Asch, 1946; Rosenthal & Jacobson, 1966; Snyder & Swann, 1978).
caelengrubb

Believing in Overcoming Cognitive Biases | Journal of Ethics | American Medical Associa... - 0 views

  • Cognitive biases contribute significantly to diagnostic and treatment errors
  • A 2016 review of their roles in decision making lists 4 domains of concern for physicians: gathering and interpreting evidence, taking action, and evaluating decisions
  • Confirmation bias is the selective gathering and interpretation of evidence consistent with current beliefs and the neglect of evidence that contradicts them.
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  • It can occur when a physician refuses to consider alternative diagnoses once an initial diagnosis has been established, despite contradicting data, such as lab results. This bias leads physicians to see what they want to see
  • Anchoring bias is closely related to confirmation bias and comes into play when interpreting evidence. It refers to physicians’ practices of prioritizing information and data that support their initial impressions, even when first impressions are wrong
  • When physicians move from deliberation to action, they are sometimes swayed by emotional reactions rather than rational deliberation about risks and benefits. This is called the affect heuristic, and, while heuristics can often serve as efficient approaches to problem solving, they can sometimes lead to bias
  • Further down the treatment pathway, outcomes bias can come into play. This bias refers to the practice of believing that good or bad results are always attributable to prior decisions, even when there is no valid reason to do so
  • The dual-process theory, a cognitive model of reasoning, can be particularly relevant in matters of clinical decision making
  • This theory is based on the argument that we use 2 different cognitive systems, intuitive and analytical, when reasoning. The former is quick and uses information that is readily available; the latter is slower and more deliberate.
  • Consideration should be given to the difficulty physicians face in employing analytical thinking exclusively. Beyond constraints of time, information, and resources, many physicians are also likely to be sleep deprived, work in an environment full of distractions, and be required to respond quickly while managing heavy cognitive loads
  • Simply increasing physicians’ familiarity with the many types of cognitive biases—and how to avoid them—may be one of the best strategies to decrease bias-related errors
  • The same review suggests that cognitive forcing strategies may also have some success in improving diagnostic outcomes
  • Afterwards, the resident physicians were debriefed on both case-specific details and on cognitive forcing strategies, interviewed, and asked to complete a written survey. The results suggested that resident physicians further along in their training (ie, postgraduate year three) gained more awareness of cognitive strategies than resident physicians in earlier years of training, suggesting that this tool could be more useful after a certain level of training has been completed
  • A 2013 study examined the effect of a 3-part, 1-year curriculum on recognition and knowledge of cognitive biases and debiasing strategies in second-year residents
  • Cognitive biases in clinical practice have a significant impact on care, often in negative ways. They sometimes manifest as physicians seeing what they want to see rather than what is actually there. Or they come into play when physicians make snap decisions and then prioritize evidence that supports their conclusions, as opposed to drawing conclusions from evidence
  • Fortunately, cognitive psychology provides insight into how to prevent biases. Guided reflection and cognitive forcing strategies deflect bias through close examination of our own thinking processes.
  • During medical education and consistently thereafter, we must provide physicians with a full appreciation of the cost of biases and the potential benefits of combatting them.
lucieperloff

Opinion | Why the Latest Republican Assault on L.G.B.T.Q. Rights Is Different - The New... - 0 views

  • Last month, Gov. Bill Lee of Tennessee signed into law a discriminatory bill to prevent transgender people from using restrooms aligning with their gender identity at any business or place of public accommodation.
  • hese new laws are the latest in a series of unprecedented legislative assaults aimed at trans people that have swept state houses t
  • are not simply living in a state of emergency; we are living in many states of imminent danger
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  • Anti-equality extremists are clearly targeting transgender people again to score political points by demonizing marginalized communities and mischaracterizing movements like Black Lives Matter.
  • We need to take action now to prove the anti-trans arguments are wrong and unjust, and to draw maximum attention to what Republican leaders in these states are trying to do.
  • there simply is not a sudden population explosion of trans people, nor any sort of demand for special or new rights. This is about fairness and equal treatment.
  • t has significant health and safety consequences, especially for trans youth.
  • This includes laws like those in Arkansas, where legislators have banned critical, gender-affirming medical care for transgender children,
  • Active resistance is needed from administrators within the education system who are tasked with enforcing discriminatory trans sports bans, which isolate and prevent trans students from playing sports on teams consistent with their gender identity.
  • which requires businesses with “formal or informal” policies of allowing transgender people to use the appropriate restroom to post offensive and humiliating signage
  • So far in 2021, we are on track to exceed the number of trans and gender-nonconforming people murdered in 2020
  • extremist legislators continue advancing measures at a breakneck pace
  • Sometimes we have to make uncomfortable decisions because we are pushed to the fringes.
cvanderloo

3 medical innovations fueled by COVID-19 that will outlast the pandemic - 0 views

  • When COVID-19 struck, mRNA vaccines in particular were ready to be put to a real-world test. The 94% efficacy of the mRNA vaccines surpassed health officials’ highest expectations.
  • DNA and mRNA vaccines offer huge advantages over traditional types of vaccines, since they use only genetic code from a pathogen – rather than the entire virus or bacteria.
  • Gene-based vaccines also produce precise and effective immune responses. They stimulate not only antibodies that block an infection, but also a strong T cell response that can clear an infection if one occurs.
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  • These devices can measure a person’s temperature, heart rate, level of activity and other biometrics. With this information, researchers have been able to track and detect COVID-19 infections even before people notice they have any symptoms.
  • Wearables can detect symptoms of COVID-19 or other illnesses before symptoms are noticeable. While they have proved to be capable of detecting sickness early, the symptoms wearables detect are not unique to COVID-19.
  • So a logical way to look for new drugs to treat a specific disease is to study individual genes and proteins that are directly affected by that disease.
  • But this idea of mapping the protein interactions of diseases to look for novel drug targets doesn’t apply just to the coronavirus. We have now used this approach on other pathogens as well as other diseases including cancer, neurodegenerative and psychiatric disorders.
margogramiak

Brain tissue yields clues to causes of PTSD -- ScienceDaily - 0 views

  • diagnosed with post-traumatic stress disorder (PTSD)
  • diagnosed with post-traumatic stress disorder (PTSD)
    • margogramiak
       
      We have talked about PTSD in class, and how certain triggers associate with memories and feelings.
  • why women are more susceptible to it
    • margogramiak
       
      I didn't realize women were more susceptible.
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  • prefrontal cortex
    • margogramiak
       
      This is another thing we have talked and read about.
  • Major differences in gene activity particularly affected two cell types in PTSD patients -- interneurons, which inhibit neural activity, and microglia, immune system cells in the central nervous system, the researchers report Dec. 21 in the journal Nature Neuroscience.
    • margogramiak
       
      I had no idea there was any sort of genetic links with PTSD. That's very interesting, and I'm assuming important info to know from a medical standpoint.
  • as many as 35% exhibit PTSD symptoms.
    • margogramiak
       
      Not that I know a lot about PTSD, but this makes sense to me.
  • About 8% of the general population has been diagnosed with PTSD.
    • margogramiak
       
      That's a lot of people.
  • These differences might help explain why women are more than twice as likely to develop PTSD and other anxiety disorders than men and why they are likely to experience more severe symptoms, the findings suggest.
    • margogramiak
       
      That's super interesting. Again, I had no idea how disproportionately women were affected.
  • "This is a new beginning for the PTSD field,
    • margogramiak
       
      Awesome! Maybe that means closer to a cure.
  • "We need new treatments for PTSD, and studies like this will provide the scientific foundation for a new generation of medication development efforts."
    • margogramiak
       
      That's fantastic.
ilanaprincilus06

Bringing genetics into trans identity is a terrifying path | Fury | Opinion | The Guardian - 0 views

  • This study was looking at the relationship between these genes and the possibility that they are a factor in what causes gender dysphoria.
  • By examining a link between genetics and gender dysphoria, this study is investigating a potential biological cause for the existence of transgender people.
  • “This is nothing new. These arguments have happened before with research into the ‘gay gene’ in the late 1980s and early 90s.”
    • ilanaprincilus06
       
      Have we found evidence of a "straight gene"? It is sad that the presumed assumption of everyone being born straight is still an ongoing argument.
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  • “In their study, they found that some of these gene variants were significantly more associated with being trans women, and not just being male. That doesn’t establish causality, and it is just an association. And in fact, its a weak association,”
  • genetic markers are not assumed to be the only factor in what shapes something like gender.
  • When publishing material that supports the idea that there is a biological element to gender identity, scientists, policy makers and the general public are less inclined to listen to trans activists.
  • Trans activists seek to educate people on their fundamental human right to experiment with dress, movement, identity and presentation.
  • “The way that science, technology and science is progressing can be incredibly dangerous in regards to things like eugenics.”
  • Until 2013, trans people in Sweden were required to undergo sterilization before they could access gender-affirming treatment.
  • Given the rising accessibility of gene testing, this sort of research can easily be weaponised as justification for sterilisation, persecution or the abortion of fetuses with these genes.
  • It also further troubles the tenuous relationship that the scientific and medical community have with the trans community.
  • Fostering the notion of a genetic factor to gender dysphoria threatens to further complicate trans people’s access to appropriate care.
  • it takes away their right to self determination and the right to bodily autonomy in regards to gender expression and creativity.”
  • raises questions about the repeated and unchecked power discrepancies between science, medicine and the trans and gender diverse community.
katedriscoll

Phantom limb pain: A literature review - 0 views

  • . The purpose of this review article is to summarize recent researches focusing on phantom limb in order to discuss its definition, mechanisms, and treatments.
  • The incidence of phantom limb pain has varied from 2% in earlier records to higher rates today. Initially, patients were less likely to mention pain symptoms than today which is a potential explanation for the discrepancy in incidence rates. However, Sherman et al.4 discuss that only 17% phantom limb complaints were initiated treated by physicians. Consequently, it is important to determine what constitutes phantom pain in order to provide efficacious care. Phantom pain is pain sensation to a limb, organ or other tissue after amputation and/or nerve injury.5 In podiatry, the predominant cause of phantom limb pain is after limb amputation due to diseased state presenting with an unsalvageable limb. Postoperative pain sensations from stump neuroma pain, prosthesis, fibrosis, and residual local tissue inflammation can be similar to phantom limb pain (PLP). Patients with PLP complain of various sensations including burning, stinging, aching, and piercing pain with changing warmth and cold sensation to the amputated area which waxes and wanes.6 Onset of symptoms may be elicited by environmental, emotional, or physical changes.
  • The human body encompasses various neurologic mechanisms allowing reception, transport, recognition, and response to numerous stimuli. Pain, temperature, crude touch, and pressure sensory information are carried to the central nervous system via the anterolateral system, with pain & temperature information transfer via lateral spinothalamic tracts to the parietal lobe. In detail, pain sensation from the lower extremity is transported from a peripheral receptor to a first degree pseudounipolar neurons in the dorsal root ganglion and decussate and ascend to the third-degree neurons within the thalamus.7 This sensory information will finally arrive at the primary sensory cortex in the postcentral gyrus of the parietal lobe which houses the sensory homunculus.8 It is unsurprising that with an amputation that such an intricate highway of information transport to and from the periphery may have the potential for problematic neurologic developments.
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  • How does pain sensation, a protection mechanism for the human body, become chronic and unrelenting after limb loss? This is a question researchers still ask today with no concise conclusion. Phantom limb pain occurs more frequently in patients who also experience longer periods of stump pain and is more likely to subside as the stump pain subsides.9 Researchers have also found dorsal root ganglion cells change after a nerve is completely cut. The dorsal root ganglion cells become more active and sensitive to chemical and mechanical changes with potential for plasticity development at the dorsal horn and other areas.10 At the molecular level, increasing glutamate and NMDA (N-methyl d-aspartate) concentrations correlate to increased sensitivity which contributes to allodynia and hyperalgesia.11 Flor et al.12 further described the significance of maladaptive plasticity and the development of memory for pain and phantom limb pain. They correlated it to the loss of GABAergic inhibition and the development of glutamate induced long-term potentiation changes and structural changes like myelination and axonal sprouting.
  • Phantom limb pain in some patients may gradually disappear over the course of a few months to one year if not treated, but some patients suffer from phantom limb pain for decades. Treatments include pharmacotherapy, adjuvant therapy, and surgical intervention. There are a variety of medications to choose from, which includes tricyclic antidepressants, opioids, and NSAIDs, etc. Among these medications, Tricyclic antidepressant is one of the most common treatments. Studies have shown that Amitriptyline (a tricyclic antidepressant) has a good effect on relieving neuropathic pain.25
  • Phantom limb pain is very common in amputees. As a worldwide issue, it has been studied by a lot of researchers. Although phantom limb sensation has already been described and proposed by French military surgeon Ambroise Pare 500 years ago, there is still no detailed explanation of its mechanisms. Therefore, more research will be needed on the different types of mechanisms of phantom limb pain. Once researchers and physicians are able to identify the mechanism of phantom limb pain, mechanism-based treatment will be rapidly developed. As a result, more patients will be benefit from it in the long run.
  •  
    One of the articles we read mentioned phantom limbs. This article goes more indepth on what a phantom limb is, why it happens and some cures.
anonymous

It's Science: Eat Dinner Together - The Family Dinner Project - The Family Dinner Project - 0 views

  • It turns out that sitting down for a nightly meal is great for the brain, the body and the spirit
  • And that nightly dinner doesn’t have to be a gourmet meal that took three hours to cook, nor does it need to be made with organic arugula and heirloom parsnips.
  • For starters, researchers found that for young children, dinnertime conversation boosts vocabulary even more than being read aloud t
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  • Other researchers reported a consistent association between family dinner frequency and teen academic performance. Adolescents who ate family meals 5 to 7 times a week were twice as likely to get A’s in school as those who ate dinner with their families fewer than two times a week.
  • Children who eat regular family dinners also consume more fruits, vegetables, vitamins and micronutrients, as well as fewer fried foods and soft drinks.
  • And the nutritional benefits keep paying dividends even after kids grow up: young adults who ate regular family meals as teens are less likely to be obese and more likely to eat healthily once they live on their own.
  • Some research has even found a connection between regular family dinners and the reduction of symptoms in medical disorders, such as asthma.
  • The benefit might be due to two possible byproducts of a shared family meal: lower anxiety and the chance to check in about a child’s medication compliance.
  • The dinner atmosphere is also important. Parents need to be warm and engaged, rather than controlling and restrictive, to encourage healthy eating in their children.
  • In a very recent study, kids who had been victims of cyberbullying bounced back more readily if they had regular family dinners.
  • Family dinners have been found to be a more powerful deterrent against high-risk teen behaviors than church attendance or good grades.
  • In a New Zealand study, a higher frequency of family meals was strongly associated with positive moods in adolescents. Similarly, other researchers have shown that teens who dine regularly with their families also have a more positive view of the future, compared to their peers who don’t eat with parents.
  • dinner is the most reliable way for families to connect and find out what’s going on with each other
  • American teens were asked when they were most likely to talk with their parents: dinner was their top answer
  • Kids who eat dinner with their parents experience less stress and have a better relationship with them
  • Of course, the real power of dinners lies in their interpersonal quality. If family members sit in stony silence, if parents yell at each other, or scold their kids, family dinner won’t confer positive benefits.
  • But, dinner may be the one time of the day when a parent and child can share a positive experience – a well-cooked meal, a joke, or a story – and these small moments can gain momentum to create stronger connections away from the table.
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    Suggestion and effects of having family dinner!
tongoscar

A Model of Ambiguity and Vagueness in Clinical Practice Guideline Recommendations - 0 views

  • Ambiguity and vagueness in clinical practice guidelines reduce the likelihood of clinician adherence. They lead to inconsistent interpretation and, in turn, to inappropriate practice variation and medical errors.
  • mbiguity and vagueness have been the subject of considerable attention in linguistics and philosophy
  • both vagueness and ambiguity and the term “disambiguation” has been used to describe the resolution of both vagueness and ambiguity.
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  • Ambiguity exists when a term can reasonably be interpreted in more than one way, for example, the word “bank” can refer to a financial institution or a riverside. Vagueness occurs when the boundaries of a word’s meaning are not well defined, as in the word “tall”5. Vagueness also exists when a word or phrase reduces the level of information contained in a statement, as in stating that an action “may be appropriate”; this phrase reduces the clarity about whether or not the action should be performed.
  • The importance of context on the interpretation of vague terms was shown by Mapes who conducted a study in which physicians were asked to assign a numerical value to the phrase “side effects with [this drug] are rare” in two different contexts: beta adrenergic blocking agents and antihistaminic drugs11.
  • Creating a controlled vocabulary of vague terms has the potential to reduce variable interpretation. Researchers have found hundreds of vague terms used in the medical literature, and reducing these to a manageable set of terms is a viable solution.
  • Researchers have noticed that a rank order of vague terms relative to one other was maintained across studies, despite wide variability in the interpretation of specific terms in the individual studies. This finding indicates it might be possible to create an ordinal scale of ranked vague terms from which authors could select when deliberately using vague terms.
sanderk

7 Surprising Ways Cell Phones Affect Your Health - ABC News - 0 views

  • In a study published in the journal Annals of Clinical Microbiology, researchers at Ondokuz Mayis University in Samsun, Turkey screened the mobile phones of 200 health care workers in hospitals for germs that are known to be dangerous to human health.
  • The solution to this problem may be decidedly low tech -- disinfectant spray and a paper towel.
  • Specifically, researchers at Carnegie Mellon University studied the brain waves of drivers using cell phones -- and they found that even just listening to a conversation reduced the amount of brain activity devoted to driving by 37 percent
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  • "The science tells [us] when [we're] on the phone while driving, it is a high-risk activity -- very, very risky,"
  • Even hands-free phones appear to contribute to unsafe driving
  • These sorts of injuries, known as repetitive strain injuries or a repetitive motion disorders, are sometimes minor. But they can also lead to serious medical problems.
  • Our reliance on our cell phones may actually be "training" some of us to believe it is vibrating when it is not. In the case of cell phones, people are rewarded when they pick up their calls and read their incoming text messages, which causes them to pick up their cell phones more and more frequently.
  • The sores and blisters that some experience from too much texting and typing have earned monikers such as "BlackBerry thumb." And while the sore thumbs may seem like a new phenomenon, medical experts say there is a rational explanation for this modern-day nuisance.
  • What they found was that when children were on the cell phones, their attention to traffic -- the number of times a participant looked right or left -- went down 20 percent. The risk of getting hit by a car, or the number of close calls, went up 43 percent
  • According to statistics from the U.S. Centers for Disease Control and Prevention (http://www.cdc.gov/healthyyouth/noise/index.htm), about 12.5 percent of children and adolescents 6 and 19 years old and 17 percent of adults between 20 and 69 years of age have suffered permanent damage to their hearing from excessive exposure to noise. In total, this accounts for more than 30 million people.
  • Sounds louder than 85 decibels can damage hearing. Normal conversation is about 60 decibels, and stereo headphones out of our MP3-enabled devices often reach 100 decibels.
katherineharron

How to be a human lie detector of fake news - CNN - 0 views

  • Fake news existed long before the internet. In an essay on political lying in the early 18th century, the writer Jonathan Swift noted that "Falsehood flies and the truth comes limping after it." You have to hire a train to pull the truth, explained English pastor Charles Spurgeon in the 19th century, while a lie is "light as a feather ... a breath will carry it."
  • MIT researchers recently studied more than 10 years' worth of data on the most shared stories on Facebook. Their study covered conspiracy theories about the Boston bombings, misleading reports on natural disasters, unfounded business rumors and incorrect scientific claims. There is an inundation of false medical advice online, for example, that encourages people to avoid life-saving treatments such as vaccines and promotes unproven therapies. (Gwyneth Paltrow's Goop is just one example.)
  • The psychological research does, however, offer us a silver lining to this storm cloud, with various experiments demonstrating that people can learn to be better lie detectors with a little training in critical thinking.
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  • If you would like to improve your own lie detection, a good first step is to learn the common logical fallacies -- red herrings, appeals to ignorance, straw men and "ad populum" appeals to the bandwagon -- that purveyors of misinformation may use to create the illusion of truth.
  • These efforts are often called "inoculations," since they use a real-life example in one domain to teach people about the strategies used to spread lies and therefore equipping people to spot them more easily. Educating people about the tobacco industry's attempts to question the medical consensus on smoking, for example, led people to be more skeptical of articles denying climate change, according to one study.
  • Another project aimed to inoculate students at North Carolina State University in Raleigh, involved a course on misinformation throughout history. The class was taught about everything from the myth that aliens somehow built the Egyptian pyramids to the theories that NASA's moon landings were faked. Along the way, the students had to identify the erroneous logic that helped create the arguments, and the motivations that may lead some people to spread those ideas.
  • You could also try basic strategies such as cross-checking different outlets and finding the original source of a claim. You might also look at independent fact-checking websites used in the MIT study such as Snopes, PolitiFact and TruthOrFiction.com.
  • The psychological literature offers us one good strategy against bias, called the "consider the opposite" method. This involves asking yourself whether you would have been so credulous of a claim if its opinions had differed from your own. And if not, what kind of additional scrutiny might you have applied? This should help you to identify the weaknesses in your own thinking.
  • Falsehoods may fly, but with this lie detection kit, you can better ensure your actions and beliefs remain grounded in the truth.
johnsonel7

We're Being Bombarded by Ads for Drugs | Psychology Today Canada - 0 views

  • "Next time you see a TV commercial for a prescription drug, remind yourself that you know nothing about medical treatment and that everybody who made the commercial has a financial interest in your future behavior." —Eric Horowitz, Psychology Today, How Pharmaceutical Ads Distort Healthcare Markets
  • "According to Kantar Media, a firm that tracks multimedia advertising, 771,368 such ads were shown in 2016, the last full year for which data is (sic) available, an increase of almost 65 percent over 2012."
  • What catches my ears is the way in which drug presentations are made, often beginning with a personal story about someone suffering from a specific disease and how a particular drug helped them along. All well and good, until we learn that the players are usually fake patients called "actor portrayals" and fake doctors, often referred to as "actor portrayals" or "doctor dramatizations." After learning what a drug might be good for, the ads consist of rapid staccato-like talk about possible side-effects and lists in tiny text that are virtually impossible to read.
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  • The cost of the drugs also isn't given, although there has been a push that commercials offer this vital information. Furthermore, we're not offered quantitative information about risks or side-effects.
  • When you think about it, it’s actually the perfect cycle for the pharmaceutical companies whereby an increase in sales of one medication directly increases the demand of the other with the only losers being us, the consumers."
Javier E

New cancer treatment destroys tumours in terminally ill, finds trial | Cancer | The Gua... - 0 views

  • In a landmark trial, a cocktail of immunotherapy medications harnessed patients’ immune systems to kill their own cancer cells and prompted “a positive trend in survival”, according to researchers at the Institute of Cancer Research (ICR), London, and the Royal Marsden NHS foundation trust.
  • Scientists found the combination of nivolumab and ipilimumab medications led to a reduction in the size of tumours in terminally-ill head and neck patients. In some, their cancer vanished altogether, with doctors stunned to find no detectable sign of disease.
  • the immunotherapy treatment also triggered far fewer side-effects compared with the often gruelling nature of “extreme” chemotherapy,
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  • The results from the phase 3 trial, involving almost 1,000 dying head and neck cancer patients, were early and not statistically significant but were still “clinically meaningful”, the ICR said, with some patients living months or years longer and suffering fewer side effects.
  • When the research nurses called to tell me that, after two months, the tumour in my throat had completely disappeared, it was an amazing moment,” said Ambrose. “While there was still disease in my lungs at that point, the effect was staggering.”
Javier E

How Depression and Anxiety Affect Your Physical Health - The New York Times - 1 views

  • It’s no surprise that when a person gets a diagnosis of heart disease, cancer or some other life-limiting or life-threatening physical ailment, they become anxious or depressed.
  • But the reverse can also be true: Undue anxiety or depression can foster the development of a serious physical disease, and even impede the ability to withstand or recover from one.
  • The human organism does not recognize the medical profession’s artificial separation of mental and physical ills. Rather, mind and body form a two-way street.
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  • What happens inside a person’s head can have damaging effects throughout the body, as well as the other way around. An untreated mental illness can significantly increase the risk of becoming physically ill, and physical disorders may result in behaviors that make mental conditions worse.
  • In studies that tracked how patients with breast cancer fared, for example, Dr. David Spiegel and his colleagues at Stanford University School of Medicine showed decades ago that women whose depression was easing lived longer than those whose depression was getting worse. His research and other studies have clearly shown that “the brain is intimately connected to the body and the body to the brain,”
  • “The body tends to react to mental stress as if it was a physical stress.”
  • Anxiety disorders affect nearly 20 percent of American adults. That means millions are beset by an overabundance of the fight-or-flight response that primes the body for action.
  • “We often talk about depression as a complication of chronic illness,” Dr. Frownfelter wrote in Medpage Today in July. “But what we don’t talk about enough is how depression can lead to chronic disease. Patients with depression may not have the motivation to exercise regularly or cook healthy meals. Many also have trouble getting adequate sleep.”
  • These protective actions stem from the neurotransmitters epinephrine and norepinephrine, which stimulate the sympathetic nervous system and put the body on high alert. But when they are invoked too often and indiscriminately, the chronic overstimulation can result in all manner of physical ills, including digestive symptoms like indigestion, cramps, diarrhea or constipation, and an increased risk of heart attack or stroke.
  • While it’s normal to feel depressed from time to time, more than 6 percent of adults have such persistent feelings of depression that it disrupts personal relationships, interferes with work and play, and impairs their ability to cope with the challenges of daily life
  • “Depression diminishes a person’s capacity to analyze and respond rationally to stress,” Dr. Spiegel said. “They end up on a vicious cycle with limited capacity to get out of a negative mental state.”
  • Although persistent anxiety and depression are highly treatable with medications, cognitive behavioral therapy and talk therapy, without treatment these conditions tend to get worse.
  • When you’re stressed, the brain responds by prompting the release of cortisol, nature’s built-in alarm system. It evolved to help animals facing physical threats by increasing respiration, raising the heart rate and redirecting blood flow from abdominal organs to muscles that assist in confronting or escaping danger.
  • Improving sleep is especially helpful, Dr. Spiegel said, because “it enhances a person’s ability to regulate the stress response system and not get stuck in a mental rut.”
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