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peterconnelly

Opinion: No more union-busting. It's time for companies to give their workers what they... - 0 views

  • This year, workers at Amazon, Starbucks and other major corporations are winning a wave of union elections, often in the face of long odds and employer resistance. These wins are showing it's possible for determined groups of workers to break through powerful employers' use of union-busting tactics, ranging from alleged retaliatory firings to alleged surveillance and forced attendance at anti-union "captive audience meetings." But workers should not have to confront so many obstacles to exercising a guaranteed legal right to unionize and bargain for improvements in their work lives and livelihoods.
  • For decades, wage suppression, growing income inequality and persistent racial and gender wage gaps have characterized the US labor market.
  • But now, as workers are pointing the way to better workplaces and a more equitable economy, employers and policymakers need to pay attention. Policymakers must better protect workers' union rights, and employers must start respecting workers' right to participate in union elections without interference or coercion.
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  • Unions are among the most effective mechanisms available for addressing massive economic inequalities. Congress should adopt labor law reforms to better protect workers' right to organize, starting with the widely popular Protecting the Right to Organize (PRO) Act. Among other things, the PRO Act would create the first serious monetary penalties for employers that retaliate against workers for unionizing.
  • Congress must also adequately fund the National Labor Relations Board (NLRB) so the agency can enforce labor law.
  • Many US workers say they want a union, but far too few have one. Right now, workers who've won recent union elections are inviting employers to meet them as equals and start bargaining union contracts.
  • Labor unions are highly correlated with safer conditions because they give workers a voice in setting workplace policies and the ability to engage management in addressing concerns without fear of retaliation.
  • The Black-led, multiracial committees that have led organizing drives at Amazon warehouses and the young women baristas leading breakthrough organizing victories at Starbucks are changing the public face of the labor movement in powerful and promising ways.
  • Two-thirds of union workers are women and/or workers of color.
  • In any company, the transparency and consistency of a union contract that sets wage rates, scheduled raises and procedures for promotions helps guard against forms of discriminatory bias that otherwise disadvantage women and workers of color.
  • Unionizing workers will continue to need extraordinary solidarity, persistence and public support in order to succeed. This is a moment of opportunity for all of us. Anyone ready to start reversing the worst economic inequalities the US has seen in almost a century can choose now to join and support workers who are organizing unions.
Javier E

Book Review: 'The Maniac,' by Benjamín Labatut - The New York Times - 0 views

  • it quickly becomes clear that what “The Maniac” is really trying to get a lock on is our current age of digital-informational mastery and subjection
  • When von Neumann proclaims that, thanks to his computational advances, “all processes that are stable we shall predict” and “all processes that are unstable we shall control,” we’re being prompted to reflect on today’s ubiquitous predictive-slash-determinative algorithms.
  • When he publishes a paper about the feasibility of a self-reproducing machine — “you need to have a mechanism, not only of copying a being, but of copying the instructions that specify that being” — few contemporary readers will fail to home straight in on the fraught subject of A.I.
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  • Haunting von Neumann’s thought experiment is the specter of a construct that, in its very internal perfection, lacks the element that would account for itself as a construct. “If someone succeeded in creating a formal system of axioms that was free of all internal paradoxes and contradictions,” another of von Neumann’s interlocutors, the logician Kurt Gödel, explains, “it would always be incomplete, because it would contain truths and statements that — while being undeniably true — could never be proven within the laws of that system.”
  • its deeper (and, for me, more compelling) theme: the relation between reason and madness.
  • Almost all the scientists populating the book are mad, their desire “to understand, to grasp the core of things” invariably wedded to “an uncontrollable mania”; even their scrupulously observed reason, their mode of logic elevated to religion, is framed as a form of madness. Von Neumann’s response to the detonation of the Trinity bomb, the world’s first nuclear explosion, is “so utterly rational that it bordered on the psychopathic,” his second wife, Klara Dan, muses
  • fanaticism, in the 1930s, “was the norm … even among us mathematicians.”
  • Pondering Gödel’s own descent into mania, the physicist Eugene Wigner claims that “paranoia is logic run amok.” If you’ve convinced yourself that there’s a reason for everything, “it’s a small step to begin to see hidden machinations and agents operating to manipulate the most common, everyday occurrences.”
  • the game theory-derived system of mutually assured destruction he devises in its wake is “perfectly rational insanity,” according to its co-founder Oskar Morgenstern.
  • Labatut has Morgenstern end his MAD deliberations by pointing out that humans are not perfect poker players. They are irrational, a fact that, while instigating “the ungovernable chaos that we see all around us,” is also the “mercy” that saves us, “a strange angel that protects us from the mad dreams of reason.”
  • But does von Neumann really deserve the title “Father of Computers,” granted him here by his first wife, Mariette Kovesi? Doesn’t Ada Lovelace have a prior claim as their mother? Feynman’s description of the Trinity bomb as “a little Frankenstein monster” should remind us that it was Mary Shelley, not von Neumann and his coterie, who first grasped the monumental stakes of modeling the total code of life, its own instructions for self-replication, and that it was Rosalind Franklin — working alongside, not under, Maurice Wilkins — who first carried out this modeling.
  • he at least grants his women broader, more incisive wisdom. Ehrenfest’s lover Nelly Posthumus Meyjes delivers a persuasive lecture on the Pythagorean myth of the irrational, suggesting that while scientists would never accept the fact that “nature cannot be cognized as a whole,” artists, by contrast, “had already fully embraced it.”
Javier E

Why Didn't the Government Stop the Crypto Scam? - 0 views

  • By 1935, the New Dealers had set up a new agency, the Securities and Exchange Commission, and cleaned out the FTC. Yet there was still immense concern that Roosevelt had not been able to tame Wall Street. The Supreme Court didn’t really ratify the SEC as a constitutional body until 1938, and nearly struck it down in 1935 when a conservative Supreme Court made it harder for the SEC to investigate cases.
  • It took a few years, but New Dealers finally implemented a workable set of securities rules, with the courts agreeing on basic definitions of what was a security. By the 1950s, SEC investigators could raise an eyebrow and change market behavior, and the amount of cheating in finance had dropped dramatically.
  • Institutional change, in other words, takes time.
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  • It’s a lesson to remember as we watch the crypto space melt down, with ex-billionaire Sam Bankman-Fried
  • It’s not like perfidy in crypto was some hidden secret. At the top of the market, back in December 2021, I wrote a piece very explicitly saying that crypto was a set of Ponzi schemes. It went viral, and I got a huge amount of hate mail from crypto types
  • one of the more bizarre aspects of the crypto meltdown is the deep anger not just at those who perpetrated it, but at those who were trying to stop the scam from going on. For instance, here’s crypto exchange Coinbase CEO Brian Armstrong, who just a year ago was fighting regulators vehemently, blaming the cops for allowing gambling in the casino he helps run.
  • FTX.com was an offshore exchange not regulated by the SEC. The problem is that the SEC failed to create regulatory clarity here in the US, so many American investors (and 95% of trading activity) went offshore. Punishing US companies for this makes no sense.
  • many crypto ‘enthusiasts’ watching Gensler discuss regulation with his predecessor “called for their incarceration or worse.”
  • Cryptocurrencies are securities, and should fit under securities law, which would have imposed rules that would foster a de facto ban of the entire space. But since regulators had not actually treated them as securities for the last ten years, a whole new gray area of fake law had emerged
  • Almost as soon as he took office, Gensler sought to fix this situation, and treat them as securities. He began investigating important players
  • But the legal wrangling to just get the courts to treat crypto as a set of speculative instruments regulated under securities law made the law moot
  • In May of 2022, a year after Gensler began trying to do something about Terra/Luna, Kwon’s scheme blew up. In a comically-too-late-to-matter gesture, an appeals court then said that the SEC had the right to compel information from Kwon’s now-bankrupt scheme. It is absolute lunacy that well-settled law, like the ability for the SEC to investigate those in the securities business, is now being re-litigated.
  • Securities and Exchange Commission Chair Gary Gensler, who took office in April of 2021 with a deep background in Wall Street, regulatory policy, and crypto, which he had taught at MIT years before joining the SEC. Gensler came in with the goal of implementing the rule of law in the crypto space, which he knew was full of scams and based on unproven technology. Yesterday, on CNBC, he was again confronted with Andrew Ross Sorkin essentially asking, “Why were you going after minor players when this Ponzi scheme was so flagrant?”
  • it wasn’t just the courts who were an impediment. Gensler wasn’t the only cop on the beat. Other regulators, like those at the Commodities Futures Trading Commission, the Federal Reserve, or the Office of Comptroller of the Currency, not only refused to take action, but actively defended their regulatory turf against an attempt from the SEC to stop the scams.
  • Behind this was the fist of political power. Everyone saw the incentives the Senate laid down when every single Republican, plus a smattering of Democrats, defeated the nomination of crypto-skeptic Saule Omarova in becoming the powerful bank regulator at the Comptroller of the Currency
  • Instead of strong figures like Omarova, we had a weakling acting Comptroller Michael Hsu at the OCC, put there by the excessively cautious Treasury Secretary Janet Yellen. Hsu refused to stop bank interactions with crypto or fintech because, as he told Congress in 2021, “These trends cannot be stopped.”
  • It’s not just these regulators; everyone wanted a piece of the bureaucratic pie. In March of 2022, before it all unraveled, the Biden administration issued an executive order on crypto. In it, Biden said that virtually every single government agency would have a hand in the space.
  • That’s… insane. If everyone’s in charge, no one is.
  • And behind all of these fights was the money and political prestige of some most powerful people in Silicon Valley, who were funding a large political fight to write the rules for crypto, with everyone from former Treasury Secretary Larry Summers to former SEC Chair Mary Jo White on the payroll.
  • (Even now, even after it was all revealed as a Ponzi scheme, Congress is still trying to write rules favorable to the industry. It’s like, guys, stop it. There’s no more bribe money!)
  • Moreover, the institution Gensler took over was deeply weakened. Since the Reagan administration, wave after wave of political leader at the SEC has gutted the place and dumbed down the enforcers. Courts have tied up the commission in knots, and Congress has defanged it
  • Under Trump crypto exploded, because his SEC chair Jay Clayton had no real policy on crypto (and then immediately went into the industry after leaving.) The SEC was so dormant that when Gensler came into office, some senior lawyers actually revolted over his attempt to make them do work.
  • In other words, the regulators were tied up in the courts, they were against an immensely powerful set of venture capitalists who have poured money into Congress and D.C., they had feeble legal levers, and they had to deal with ‘crypto enthusiasts' who thought they should be jailed or harmed for trying to impose basic rules around market manipulation.
  • The bottom line is, Gensler is just one regulator, up against a lot of massed power, money, and bad institutional habits. And we as a society simply made the choice through our elected leaders to have little meaningful law enforcement in financial markets, which first became blindingly obvious in 2008 during the financial crisis, and then became comical ten years later when a sector whose only real use cases were money laundering
  • , Ponzi scheming or buying drugs on the internet, managed to rack up enough political power to bring Tony Blair and Bill Clinton to a conference held in a tax haven billed as ‘the future.’
Javier E

Book review - The Dawn of Everything: A New History of Humanity | The Inquisitive Biolo... - 0 views

  • Every few years, it seems, there is a new bestselling Big History book. And not infrequently, they have rather grandiose titles.
  • , I hope to convince you why I think this book will stand the test of time better.
  • First, rather than one author’s pet theory, The Dawn of Everything is the brainchild of two outspoken writers: anthropologist David Graeber (a figurehead in the Occupy Wall Street movement and author of e.g. Bullshit Jobs) and archaeologist David Wengrow (author of e.g. What Makes Civilization?). I expect a large part of their decade-long collaboration consisted of shooting holes in each other’s arguments
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  • Colonisation exposed us to new ideas that shocked and confused us. Graeber & Wengrow focus on the French coming into contact with Native Americans in Canada, and in particular on Wendat Confederacy philosopher–statesman Kandiaronk as an example of European traders, missionaries, and intellectuals debating with, and being criticized by indigenous people. Historians have downplayed how much these encounters shaped Enlightenment ideas.
  • this thought-provoking book is armed to the teeth with fascinating ideas and interpretations that go against mainstream thinking
  • ather than yet another history book telling you how humanity got here, they take their respective disciplines to task for dealing in myths.
  • Its legacy, shaped via several iterations, is the modern textbook narrative: hunter-gathering was replaced by pastoralism and then farming; the agricultural revolution resulted in larger populations producing material surpluses; these allowed for specialist occupations but also needed bureaucracies to share and administer them to everyone; and this top-down control led to today’s nation states. Ta-daa!
  • this simplistic tale of progress ignores and downplays that there was nothing linear or inevitable about where we have ended up.
  • ake agriculture. Rather than humans enthusiastically entering into what Harari in Sapiens called a Faustian bargain with crops, there were many pathways and responses
  • Experiments show that plant domestication could have been achieved in as little as 20–30 years, so the fact that cereal domestication here took some 3,000 years questions the notion of an agricultural “revolution”. Lastly, this book includes many examples of areas where agriculture was purposefully rejected. Designating such times and places as “pre-agricultural” is misleading, write the authors, they were anti-agricultural.
  • The idea that agriculture led to large states similarly needs revision
  • correlation is not causation, and some 15–20 additional centres of domestication have since been identified that followed different paths. Some cities have previously remained hidden in the sediments of ancient river deltas until revealed by modern remote-sensing technology.
  • “extensive agriculture may thus have been an outcome, not a cause, of urbanization”
  • And cities did not automatically imply social stratification. The Dawn of Everything fascinates with its numerous examples of large settlements without ruling classes, such as Ukrainian mega-sites, the Harappan civilization, or Mexican city-states.
  • These instead relied on collective decision-making through assemblies or councils, which questions some of the assumptions of evolutionary psychology about scale: that larger human groups require complex (i.e. hierarchical) systems to organize them.
  • e what is staring them in the face
  • humans have always been very capable of consciously experimenting with different social arrangements. And—this is rarely acknowledged—they did so on a seasonal basis, spending e.g. part of the year settled in large communal groups under a leader, and another part as small, independently roving bands.
  • Throughout, Graeber & Wengrow convincingly argue that the only thing we can say about our ancestors is that “there is no single pattern. The only consistent phenomenon is the very fact of alteration […] If human beings, through most of our history, have moved back and forth fluidly between different social arrangements […] maybe the real question should be ‘how did we get stuck?
  • Next to criticism, the authors put out some interesting ideas of their own, of which I want to quickly highlight two.
  • The first is that some of the observed variations in social arrangements resulted from schismogenesis. Anthropologist Gregory Bateson coined this term in the 1930s to describe how people define themselves against or in opposition to others, adopting behaviours and attitudes that are different.
  • The second idea is that states can be described in terms of three elementary forms of domination: control of violence, control of information, and individual charisma, which express themselves as sovereignty, administration, and competitive politics.
  • Our current states combine these three, and thus we have state-endorsed violence in the form of law enforcement and armies, bureaucracy, and the popularity contests we call elections in some countries, and monarchs, oligarchs, or tyrants in other countries. But looking at history, there is no reason why this should be and the authors provide examples of societies that showed only one or two such forms of control
  • Asking which past society most resembles today’s is the wrong question to ask. It risks slipping into an exercise in retrofitting, “which makes us scour the ancient world for embryonic versions of our modern nation states”
  • I have left unmentioned several other topics: the overlooked role of women, the legacy of Rousseau’s and Hobbes’s ideas, the origins of inequality and the flawed assumptions hiding behind that question
  • There are so many historical details and delights hiding between these covers that I was thoroughly enthralle
  • If you have any interest in big history, archaeology, or anthropology, this book is indispensable. I am confident that the questions and critiques raised here will remain relevant for a long time to come.
  • I was particularly impressed by the in-depth critique by worbsintowords on his YouTube channel What is Politics? of (so far) five videos
Javier E

Avoidance, not anxiety, may be sabotaging your life - The Washington Post - 0 views

  • Anxiety, for many people, is like an unwelcome houseguest — a lingering presence that causes tension, clouds the mind with endless “what ifs” and shows up as various physical sensations.
  • About 12 percent of U.S. adults regularly felt worry, nervousness or anxiety, according to a National Health Interview Survey conducted between October and December 2022.
  • Anxiety, though, is not the puppeteer pulling the strings in many of our lives. There is a more subtle and insidious marionette, and it’s called psychological avoidance. When we avoid certain situations and decisions, it can lead to heightened anxiety and more problems.
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  • Psychological avoidance is akin to an ostrich burying its head in the sand, choosing ignorance over confrontation, all while a storm brews in the background.
  • depression and anxiety disorders cost the global economy $1 trillion each year in lost productivity.
  • avoidance, a strategy that not only fails to solve problems but fuels them.
  • Psychological avoidance isn’t about the actions we take or don’t take, but the intentions behind them. If our actions aim to squash discomfort hastily, then we’re probably 2favoiding
  • the three ways people tend to practice psychological avoidance.
  • Reacting
  • It’s when we reply hastily to an email that upsets us or raise our voices without considering the consequences.
  • Reacting is any response that seeks to eliminate the source of discomfort
  • Retreating
  • Retreating is the act of moving away or pulling back from anxiety-inducing situations
  • For example, my client with the fear of public speaking took a different job to avoid it. Others may reach for a glass of wine to numb out o
  • Remaining
  • Remaining is sticking to the status quo to avoid the discomfort of change.
  • Psychological avoidance is a powerful enemy, but there are three science-based skills to fight it.
  • Shifting involves checking in with your thoughts, especially when anxiety comes knocking. In those moments, we often have black-and-white, distorted thoughts, just like my client, who was worried about being in a romantic relationship, telling himself, “I will never be in a good relationship.”
  • Shifting is taking off dark, monochrome glasses and seeing the world in color again. Challenge your thoughts, clean out your lenses, by asking yourself, “Would I say this to my best friend in this scenario?
  • Approaching
  • taking a step that feels manageable.
  • The opposite of avoiding is approaching
  • Ask yourself: What is one small step I can take toward my fears and anxiety to overcome my avoidance.
  • Aligning
  • Aligning is living a values-driven life, where our daily actions are aligned with what matters the most to us: our values.
  • This is the opposite of what most of us do while anxious. In moments of intense anxiety, we tend to let our emotions, not our values, dictate our actions. To live a values-driven life, we need to first identify our values, whether that is health, family, work or something else. Then we need to dedicate time and effort to our values.
Javier E

Why it's as hard to escape an echo chamber as it is to flee a cult | Aeon Essays - 0 views

  • there are two very different phenomena at play here, each of which subvert the flow of information in very distinct ways. Let’s call them echo chambers and epistemic bubbles. Both are social structures that systematically exclude sources of information. Both exaggerate their members’ confidence in their beliefs.
  • they work in entirely different ways, and they require very different modes of intervention
  • An epistemic bubble is when you don’t hear people from the other side. An echo chamber is what happens when you don’t trust people from the other side.
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  • start with epistemic bubbles
  • That omission might be purposeful
  • But that omission can also be entirely inadvertent. Even if we’re not actively trying to avoid disagreement, our Facebook friends tend to share our views and interests
  • An ‘echo chamber’ is a social structure from which other relevant voices have been actively discredited. Where an epistemic bubble merely omits contrary views, an echo chamber brings its members to actively distrust outsiders.
  • an echo chamber is something like a cult. A cult isolates its members by actively alienating them from any outside sources. Those outside are actively labelled as malignant and untrustworthy.
  • In epistemic bubbles, other voices are not heard; in echo chambers, other voices are actively undermined.
  • The way to break an echo chamber is not to wave “the facts” in the faces of its members. It is to attack the echo chamber at its root and repair that broken trust.
  • Looking to others for corroboration is a basic method for checking whether one has reasoned well or badly
  • They have been in the limelight lately, most famously in Eli Pariser’s The Filter Bubble (2011) and Cass Sunstein’s #Republic: Divided Democracy in the Age of Social Media (2017).
  • The general gist: we get much of our news from Facebook feeds and similar sorts of social media. Our Facebook feed consists mostly of our friends and colleagues, the majority of whom share our own political and cultural views
  • various algorithms behind the scenes, such as those inside Google search, invisibly personalise our searches, making it more likely that we’ll see only what we want to see. These processes all impose filters on information.
  • Such filters aren’t necessarily bad. The world is overstuffed with information, and one can’t sort through it all by oneself: filters need to be outsourced.
  • That’s why we all depend on extended social networks to deliver us knowledge
  • any such informational network needs the right sort of broadness and variety to work
  • Each individual person in my network might be superbly reliable about her particular informational patch but, as an aggregate structure, my network lacks what Sanford Goldberg in his book Relying on Others (2010) calls ‘coverage-reliability’. It doesn’t deliver to me a sufficiently broad and representative coverage of all the relevant information.
  • Epistemic bubbles also threaten us with a second danger: excessive self-confidence.
  • An ‘epistemic bubble’ is an informational network from which relevant voices have been excluded by omission
  • Suppose that I believe that the Paleo diet is the greatest diet of all time. I assemble a Facebook group called ‘Great Health Facts!’ and fill it only with people who already believe that Paleo is the best diet. The fact that everybody in that group agrees with me about Paleo shouldn’t increase my confidence level one bit. They’re not mere copies – they actually might have reached their conclusions independently – but their agreement can be entirely explained by my method of selection.
  • Luckily, though, epistemic bubbles are easily shattered. We can pop an epistemic bubble simply by exposing its members to the information and arguments that they’ve missed.
  • echo chambers are a far more pernicious and robust phenomenon.
  • amieson and Cappella’s book is the first empirical study into how echo chambers function
  • echo chambers work by systematically alienating their members from all outside epistemic sources.
  • Their research centres on Rush Limbaugh, a wildly successful conservative firebrand in the United States, along with Fox News and related media
  • His constant attacks on the ‘mainstream media’ are attempts to discredit all other sources of knowledge. He systematically undermines the integrity of anybody who expresses any kind of contrary view.
  • outsiders are not simply mistaken – they are malicious, manipulative and actively working to destroy Limbaugh and his followers. The resulting worldview is one of deeply opposed force, an all-or-nothing war between good and evil
  • The result is a rather striking parallel to the techniques of emotional isolation typically practised in cult indoctrination
  • cult indoctrination involves new cult members being brought to distrust all non-cult members. This provides a social buffer against any attempts to extract the indoctrinated person from the cult.
  • The echo chamber doesn’t need any bad connectivity to function. Limbaugh’s followers have full access to outside sources of information
  • As Elijah Millgram argues in The Great Endarkenment (2015), modern knowledge depends on trusting long chains of experts. And no single person is in the position to check up on the reliability of every member of that chain
  • Their worldview can survive exposure to those outside voices because their belief system has prepared them for such intellectual onslaught.
  • exposure to contrary views could actually reinforce their views. Limbaugh might offer his followers a conspiracy theory: anybody who criticises him is doing it at the behest of a secret cabal of evil elites, which has already seized control of the mainstream media.
  • Perversely, exposure to outsiders with contrary views can thus increase echo-chamber members’ confidence in their insider sources, and hence their attachment to their worldview.
  • ‘evidential pre-emption’. What’s happening is a kind of intellectual judo, in which the power and enthusiasm of contrary voices are turned against those contrary voices through a carefully rigged internal structure of belief.
  • One might be tempted to think that the solution is just more intellectual autonomy. Echo chambers arise because we trust others too much, so the solution is to start thinking for ourselves.
  • that kind of radical intellectual autonomy is a pipe dream. If the philosophical study of knowledge has taught us anything in the past half-century, it is that we are irredeemably dependent on each other in almost every domain of knowledge
  • Limbaugh’s followers regularly read – but do not accept – mainstream and liberal news sources. They are isolated, not by selective exposure, but by changes in who they accept as authorities, experts and trusted sources.
  • we depend on a vastly complicated social structure of trust. We must trust each other, but, as the philosopher Annette Baier says, that trust makes us vulnerable. Echo chambers operate as a kind of social parasite on that vulnerability, taking advantage of our epistemic condition and social dependency.
  • I am quite confident that there are plenty of echo chambers on the political Left. More importantly, nothing about echo chambers restricts them to the arena of politics
  • The world of anti-vaccination is clearly an echo chamber, and it is one that crosses political lines. I’ve also encountered echo chambers on topics as broad as diet (Paleo!), exercise technique (CrossFit!), breastfeeding, some academic intellectual traditions, and many, many more
  • Here’s a basic check: does a community’s belief system actively undermine the trustworthiness of any outsiders who don’t subscribe to its central dogmas? Then it’s probably an echo chamber.
  • much of the recent analysis has lumped epistemic bubbles together with echo chambers into a single, unified phenomenon. But it is absolutely crucial to distinguish between the two.
  • Epistemic bubbles are rather ramshackle; they go up easily, and they collapse easily
  • Echo chambers are far more pernicious and far more robust. They can start to seem almost like living things. Their belief systems provide structural integrity, resilience and active responses to outside attacks
  • the two phenomena can also exist independently. And of the events we’re most worried about, it’s the echo-chamber effects that are really causing most of the trouble.
  • new data does, in fact, seem to show that people on Facebook actually do see posts from the other side, or that people often visit websites with opposite political affiliation.
  • their basis for evaluation – their background beliefs about whom to trust – are radically different. They are not irrational, but systematically misinformed about where to place their trust.
  • Many people have claimed that we have entered an era of ‘post-truth’.
  • Not only do some political figures seem to speak with a blatant disregard for the facts, but their supporters seem utterly unswayed by evidence. It seems, to some, that truth no longer matters.
  • This is an explanation in terms of total irrationality. To accept it, you must believe that a great number of people have lost all interest in evidence or investigation, and have fallen away from the ways of reason.
  • echo chambers offers a less damning and far more modest explanation. The apparent ‘post-truth’ attitude can be explained as the result of the manipulations of trust wrought by echo chambers.
  • We don’t have to attribute a complete disinterest in facts, evidence or reason to explain the post-truth attitude. We simply have to attribute to certain communities a vastly divergent set of trusted authorities.
  • An echo chamber doesn’t destroy their members’ interest in the truth; it merely manipulates whom they trust and changes whom they accept as trustworthy sources and institutions.
  • in many ways, echo-chamber members are following reasonable and rational procedures of enquiry. They’re engaging in critical reasoning. They’re questioning, they’re evaluating sources for themselves, they’re assessing different pathways to information. They are critically examining those who claim expertise and trustworthiness, using what they already know about the world
  • none of this weighs against the existence of echo chambers. We should not dismiss the threat of echo chambers based only on evidence about connectivity and exposure.
  • Notice how different what’s going on here is from, say, Orwellian doublespeak, a deliberately ambiguous, euphemism-filled language designed to hide the intent of the speaker.
  • echo chambers don’t trade in vague, ambiguous pseudo-speech. We should expect that echo chambers would deliver crisp, clear, unambiguous claims about who is trustworthy and who is not
  • clearly articulated conspiracy theories, and crisply worded accusations of an outside world rife with untrustworthiness and corruption.
  • Once an echo chamber starts to grip a person, its mechanisms will reinforce themselves.
  • In an epistemically healthy life, the variety of our informational sources will put an upper limit to how much we’re willing to trust any single person. Everybody’s fallible; a healthy informational network tends to discover people’s mistakes and point them out. This puts an upper ceiling on how much you can trust even your most beloved leader
  • nside an echo chamber, that upper ceiling disappears.
  • Being caught in an echo chamber is not always the result of laziness or bad faith. Imagine, for instance, that somebody has been raised and educated entirely inside an echo chamber
  • when the child finally comes into contact with the larger world – say, as a teenager – the echo chamber’s worldview is firmly in place. That teenager will distrust all sources outside her echo chamber, and she will have gotten there by following normal procedures for trust and learning.
  • It certainly seems like our teenager is behaving reasonably. She could be going about her intellectual life in perfectly good faith. She might be intellectually voracious, seeking out new sources, investigating them, and evaluating them using what she already knows.
  • The worry is that she’s intellectually trapped. Her earnest attempts at intellectual investigation are led astray by her upbringing and the social structure in which she is embedded.
  • Echo chambers might function like addiction, under certain accounts. It might be irrational to become addicted, but all it takes is a momentary lapse – once you’re addicted, your internal landscape is sufficiently rearranged such that it’s rational to continue with your addiction
  • Similarly, all it takes to enter an echo chamber is a momentary lapse of intellectual vigilance. Once you’re in, the echo chamber’s belief systems function as a trap, making future acts of intellectual vigilance only reinforce the echo chamber’s worldview.
  • There is at least one possible escape route, however. Notice that the logic of the echo chamber depends on the order in which we encounter the evidence. An echo chamber can bring our teenager to discredit outside beliefs precisely because she encountered the echo chamber’s claims first. Imagine a counterpart to our teenager who was raised outside of the echo chamber and exposed to a wide range of beliefs. Our free-range counterpart would, when she encounters that same echo chamber, likely see its many flaws
  • Those caught in an echo chamber are giving far too much weight to the evidence they encounter first, just because it’s first. Rationally, they should reconsider their beliefs without that arbitrary preference. But how does one enforce such informational a-historicity?
  • The escape route is a modified version of René Descartes’s infamous method.
  • Meditations on First Philosophy (1641). He had come to realise that many of the beliefs he had acquired in his early life were false. But early beliefs lead to all sorts of other beliefs, and any early falsehoods he’d accepted had surely infected the rest of his belief system.
  • The only solution, thought Descartes, was to throw all his beliefs away and start over again from scratch.
  • He could start over, trusting nothing and no one except those things that he could be entirely certain of, and stamping out those sneaky falsehoods once and for all. Let’s call this the Cartesian epistemic reboot.
  • Notice how close Descartes’s problem is to our hapless teenager’s, and how useful the solution might be. Our teenager, like Descartes, has problematic beliefs acquired in early childhood. These beliefs have infected outwards, infesting that teenager’s whole belief system. Our teenager, too, needs to throw everything away, and start over again.
  • Let’s call the modernised version of Descartes’s methodology the social-epistemic reboot.
  • when she starts from scratch, we won’t demand that she trust only what she’s absolutely certain of, nor will we demand that she go it alone
  • For the social reboot, she can proceed, after throwing everything away, in an utterly mundane way – trusting her senses, trusting others. But she must begin afresh socially – she must reconsider all possible sources of information with a presumptively equanimous eye. She must take the posture of a cognitive newborn, open and equally trusting to all outside sources
  • we’re not asking people to change their basic methods for learning about the world. They are permitted to trust, and trust freely. But after the social reboot, that trust will not be narrowly confined and deeply conditioned by the particular people they happened to be raised by.
  • Such a profound deep-cleanse of one’s whole belief system seems to be what’s actually required to escape. Look at the many stories of people leaving cults and echo chambers
  • Take, for example, the story of Derek Black in Florida – raised by a neo-Nazi father, and groomed from childhood to be a neo-Nazi leader. Black left the movement by, basically, performing a social reboot. He completely abandoned everything he’d believed in, and spent years building a new belief system from scratch. He immersed himself broadly and open-mindedly in everything he’d missed – pop culture, Arabic literature, the mainstream media, rap – all with an overall attitude of generosity and trust.
  • It was the project of years and a major act of self-reconstruction, but those extraordinary lengths might just be what’s actually required to undo the effects of an echo-chambered upbringing.
  • we need to attack the root, the systems of discredit themselves, and restore trust in some outside voices.
  • Stories of actual escapes from echo chambers often turn on particular encounters – moments when the echo-chambered individual starts to trust somebody on the outside.
  • Black’s is case in point. By high school, he was already something of a star on neo-Nazi media, with his own radio talk-show. He went on to college, openly neo-Nazi, and was shunned by almost every other student in his community college. But then Matthew Stevenson, a Jewish fellow undergraduate, started inviting Black to Stevenson’s Shabbat dinners. In Black’s telling, Stevenson was unfailingly kind, open and generous, and slowly earned Black’s trust. This was the seed, says Black, that led to a massive intellectual upheaval – a slow-dawning realisation of the depths to which he had been misled
  • Similarly, accounts of people leaving echo-chambered homophobia rarely involve them encountering some institutionally reported fact. Rather, they tend to revolve around personal encounters – a child, a family member, a close friend coming out.
  • hese encounters matter because a personal connection comes with a substantial store of trust.
  • We don’t simply trust people as educated experts in a field – we rely on their goodwill. And this is why trust, rather than mere reliability, is the key concept
  • goodwill is a general feature of a person’s character. If I demonstrate goodwill in action, then you have some reason to think that I also have goodwill in matters of thought and knowledge.
  • f one can demonstrate goodwill to an echo-chambered member – as Stevenson did with Black – then perhaps one can start to pierce that echo chamber.
  • the path I’m describing is a winding, narrow and fragile one. There is no guarantee that such trust can be established, and no clear path to its being established systematically.
  • what we’ve found here isn’t an escape route at all. It depends on the intervention of another. This path is not even one an echo-chamber member can trigger on her own; it is only a whisper-thin hope for rescue from the outside.
Javier E

Cognitive Biases and the Human Brain - The Atlantic - 1 views

  • Present bias shows up not just in experiments, of course, but in the real world. Especially in the United States, people egregiously undersave for retirement—even when they make enough money to not spend their whole paycheck on expenses, and even when they work for a company that will kick in additional funds to retirement plans when they contribute.
  • hen people hear the word bias, many if not most will think of either racial prejudice or news organizations that slant their coverage to favor one political position over another. Present bias, by contrast, is an example of cognitive bias—the collection of faulty ways of thinking that is apparently hardwired into the human brain. The collection is large. Wikipedia’s “List of cognitive biases” contains 185 entries, from actor-observer bias (“the tendency for explanations of other individuals’ behaviors to overemphasize the influence of their personality and underemphasize the influence of their situation … and for explanations of one’s own behaviors to do the opposite”) to the Zeigarnik effect (“uncompleted or interrupted tasks are remembered better than completed ones”)
  • If I had to single out a particular bias as the most pervasive and damaging, it would probably be confirmation bias. That’s the effect that leads us to look for evidence confirming what we already think or suspect, to view facts and ideas we encounter as further confirmation, and to discount or ignore any piece of evidence that seems to support an alternate view
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  • Confirmation bias shows up most blatantly in our current political divide, where each side seems unable to allow that the other side is right about anything.
  • The whole idea of cognitive biases and faulty heuristics—the shortcuts and rules of thumb by which we make judgments and predictions—was more or less invented in the 1970s by Amos Tversky and Daniel Kahneman
  • versky died in 1996. Kahneman won the 2002 Nobel Prize in Economics for the work the two men did together, which he summarized in his 2011 best seller, Thinking, Fast and Slow. Another best seller, last year’s The Undoing Project, by Michael Lewis, tells the story of the sometimes contentious collaboration between Tversky and Kahneman
  • Another key figure in the field is the University of Chicago economist Richard Thaler. One of the biases he’s most linked with is the endowment effect, which leads us to place an irrationally high value on our possessions.
  • In an experiment conducted by Thaler, Kahneman, and Jack L. Knetsch, half the participants were given a mug and then asked how much they would sell it for. The average answer was $5.78. The rest of the group said they would spend, on average, $2.21 for the same mug. This flew in the face of classic economic theory, which says that at a given time and among a certain population, an item has a market value that does not depend on whether one owns it or not. Thaler won the 2017 Nobel Prize in Economics.
  • “The question that is most often asked about cognitive illusions is whether they can be overcome. The message … is not encouraging.”
  • that’s not so easy in the real world, when we’re dealing with people and situations rather than lines. “Unfortunately, this sensible procedure is least likely to be applied when it is needed most,” Kahneman writes. “We would all like to have a warning bell that rings loudly whenever we are about to make a serious error, but no such bell is available.”
  • At least with the optical illusion, our slow-thinking, analytic mind—what Kahneman calls System 2—will recognize a Müller-Lyer situation and convince itself not to trust the fast-twitch System 1’s perception
  • Kahneman and others draw an analogy based on an understanding of the Müller-Lyer illusion, two parallel lines with arrows at each end. One line’s arrows point in; the other line’s arrows point out. Because of the direction of the arrows, the latter line appears shorter than the former, but in fact the two lines are the same length.
  • Because biases appear to be so hardwired and inalterable, most of the attention paid to countering them hasn’t dealt with the problematic thoughts, judgments, or predictions themselves
  • Is it really impossible, however, to shed or significantly mitigate one’s biases? Some studies have tentatively answered that question in the affirmative.
  • what if the person undergoing the de-biasing strategies was highly motivated and self-selected? In other words, what if it was me?
  • Over an apple pastry and tea with milk, he told me, “Temperament has a lot to do with my position. You won’t find anyone more pessimistic than I am.”
  • I met with Kahneman
  • “I see the picture as unequal lines,” he said. “The goal is not to trust what I think I see. To understand that I shouldn’t believe my lying eyes.” That’s doable with the optical illusion, he said, but extremely difficult with real-world cognitive biases.
  • In this context, his pessimism relates, first, to the impossibility of effecting any changes to System 1—the quick-thinking part of our brain and the one that makes mistaken judgments tantamount to the Müller-Lyer line illusion
  • he most effective check against them, as Kahneman says, is from the outside: Others can perceive our errors more readily than we can.
  • “slow-thinking organizations,” as he puts it, can institute policies that include the monitoring of individual decisions and predictions. They can also require procedures such as checklists and “premortems,”
  • A premortem attempts to counter optimism bias by requiring team members to imagine that a project has gone very, very badly and write a sentence or two describing how that happened. Conducting this exercise, it turns out, helps people think ahead.
  • “My position is that none of these things have any effect on System 1,” Kahneman said. “You can’t improve intuition.
  • Perhaps, with very long-term training, lots of talk, and exposure to behavioral economics, what you can do is cue reasoning, so you can engage System 2 to follow rules. Unfortunately, the world doesn’t provide cues. And for most people, in the heat of argument the rules go out the window.
  • Kahneman describes an even earlier Nisbett article that showed subjects’ disinclination to believe statistical and other general evidence, basing their judgments instead on individual examples and vivid anecdotes. (This bias is known as base-rate neglect.)
  • over the years, Nisbett had come to emphasize in his research and thinking the possibility of training people to overcome or avoid a number of pitfalls, including base-rate neglect, fundamental attribution error, and the sunk-cost fallacy.
  • Nisbett’s second-favorite example is that economists, who have absorbed the lessons of the sunk-cost fallacy, routinely walk out of bad movies and leave bad restaurant meals uneaten.
  • When Nisbett asks the same question of students who have completed the statistics course, about 70 percent give the right answer. He believes this result shows, pace Kahneman, that the law of large numbers can be absorbed into System 2—and maybe into System 1 as well, even when there are minimal cues.
  • about half give the right answer: the law of large numbers, which holds that outlier results are much more frequent when the sample size (at bats, in this case) is small. Over the course of the season, as the number of at bats increases, regression to the mean is inevitabl
  • When Nisbett has to give an example of his approach, he usually brings up the baseball-phenom survey. This involved telephoning University of Michigan students on the pretense of conducting a poll about sports, and asking them why there are always several Major League batters with .450 batting averages early in a season, yet no player has ever finished a season with an average that high.
  • we’ve tested Michigan students over four years, and they show a huge increase in ability to solve problems. Graduate students in psychology also show a huge gain.”
  • , “I know from my own research on teaching people how to reason statistically that just a few examples in two or three domains are sufficient to improve people’s reasoning for an indefinitely large number of events.”
  • isbett suggested another factor: “You and Amos specialized in hard problems for which you were drawn to the wrong answer. I began to study easy problems, which you guys would never get wrong but untutored people routinely do … Then you can look at the effects of instruction on such easy problems, which turn out to be huge.”
  • Nisbett suggested that I take “Mindware: Critical Thinking for the Information Age,” an online Coursera course in which he goes over what he considers the most effective de-biasing skills and concepts. Then, to see how much I had learned, I would take a survey he gives to Michigan undergraduates. So I did.
  • he course consists of eight lessons by Nisbett—who comes across on-screen as the authoritative but approachable psych professor we all would like to have had—interspersed with some graphics and quizzes. I recommend it. He explains the availability heuristic this way: “People are surprised that suicides outnumber homicides, and drownings outnumber deaths by fire. People always think crime is increasing” even if it’s not.
  • When I finished the course, Nisbett sent me the survey he and colleagues administer to Michigan undergrads
  • It contains a few dozen problems meant to measure the subjects’ resistance to cognitive biases
  • I got it right. Indeed, when I emailed my completed test, Nisbett replied, “My guess is that very few if any UM seniors did as well as you. I’m sure at least some psych students, at least after 2 years in school, did as well. But note that you came fairly close to a perfect score.”
  • Nevertheless, I did not feel that reading Mindware and taking the Coursera course had necessarily rid me of my biases
  • For his part, Nisbett insisted that the results were meaningful. “If you’re doing better in a testing context,” he told me, “you’ll jolly well be doing better in the real world.”
  • The New York–based NeuroLeadership Institute offers organizations and individuals a variety of training sessions, webinars, and conferences that promise, among other things, to use brain science to teach participants to counter bias. This year’s two-day summit will be held in New York next month; for $2,845, you could learn, for example, “why are our brains so bad at thinking about the future, and how do we do it better?”
  • Philip E. Tetlock, a professor at the University of Pennsylvania’s Wharton School, and his wife and research partner, Barbara Mellers, have for years been studying what they call “superforecasters”: people who manage to sidestep cognitive biases and predict future events with far more accuracy than the pundits
  • One of the most important ingredients is what Tetlock calls “the outside view.” The inside view is a product of fundamental attribution error, base-rate neglect, and other biases that are constantly cajoling us into resting our judgments and predictions on good or vivid stories instead of on data and statistics
  • In 2006, seeking to prevent another mistake of that magnitude, the U.S. government created the Intelligence Advanced Research Projects Activity (iarpa), an agency designed to use cutting-edge research and technology to improve intelligence-gathering and analysis. In 2011, iarpa initiated a program, Sirius, to fund the development of “serious” video games that could combat or mitigate what were deemed to be the six most damaging biases: confirmation bias, fundamental attribution error, the bias blind spot (the feeling that one is less biased than the average person), the anchoring effect, the representativeness heuristic, and projection bias (the assumption that everybody else’s thinking is the same as one’s own).
  • most promising are a handful of video games. Their genesis was in the Iraq War
  • Together with collaborators who included staff from Creative Technologies, a company specializing in games and other simulations, and Leidos, a defense, intelligence, and health research company that does a lot of government work, Morewedge devised Missing. Some subjects played the game, which takes about three hours to complete, while others watched a video about cognitive bias. All were tested on bias-mitigation skills before the training, immediately afterward, and then finally after eight to 12 weeks had passed.
  • “The literature on training suggests books and classes are fine entertainment but largely ineffectual. But the game has very large effects. It surprised everyone.”
  • he said he saw the results as supporting the research and insights of Richard Nisbett. “Nisbett’s work was largely written off by the field, the assumption being that training can’t reduce bias,
  • even the positive results reminded me of something Daniel Kahneman had told me. “Pencil-and-paper doesn’t convince me,” he said. “A test can be given even a couple of years later. But the test cues the test-taker. It reminds him what it’s all about.”
  • Morewedge told me that some tentative real-world scenarios along the lines of Missing have shown “promising results,” but that it’s too soon to talk about them.
  • In the future, I will monitor my thoughts and reactions as best I can
Javier E

Crisis Negotiators Give Thanksgiving Tips - The New York Times - 1 views

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  • “Just shut up and listen,
  • “Repeating what the other person says, we call that paraphrasing. ‘So what you’re telling me is that the F.B.I. screwed you over by doing this and that,’ and then you repeat back to him what he said
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  • Also, emotional labeling: ‘You sound like you were hurt by that.’ ‘You sound like it must have been really annoying.’
  • “Say you’re sorry when you’re not sorry,” she said. “Let bygones be bygones.
  • instead of trying to bargain with the grandfather or acknowledge his presenting emotion by telling him he’s being impatient, you should address the underlying emotion
  • Little verbal encouragements: ‘Unh-huh,’ ‘Mm-hmm.’ A nod of the head to let them know you’re there.”
  • the unsolicited apology. “There’ve been times,” he said, “with people I was close with, when I didn’t think I was wrong, but I said, ‘You know, I realize I’ve been a jerk this entire time.’ Well over half the time, people are going to respond positively to that. They’re going to make a reciprocating sort of confession. Then you’re started on the right track.”
  • “You have to find creative ways to say, ‘I really appreciate your point of view, and it’s great to have an opportunity to hear how strongly you feel about that, but my own view is different.’ Try to find ways to acknowledge what they’re saying without agreeing or disagreeing with it.”
  • Tone is king here: subtle vocal inflections can impart either “I disagree, let’s move on,” or “I disagree, let’s turn this into ‘The Jerry Springer Show.’ 
  • maybe you just say: ‘I’m still searching. I’m not in the same place where you are about what you believe.’ ”
  • “Instead of lying, we call it minimizing. You try to get people to think that a situation isn’t so bad, you break it down for them so they see that it isn’t the end of the world, that maybe they don’t need to make such a big deal of it. We try to reframe things rather than flat-out lie.”
Javier E

George Orwell: The Prevention of Literature - The Atlantic - 0 views

  • the much more tenable and dangerous proposition that freedom is undesirable and that intellectual honesty is a form of antisocial selfishness
  • the controversy over freedom of speech and of the press is at bottom a controversy over the desirability, or otherwise, of telling lies.
  • What is really at issue is the right to report contemporary events truthfully, or as truthfully as is consistent with the ignorance, bias, and self-deception from which every observer necessarily suffers
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  • it is necessary to strip away the irrelevancies in which this controversy is usually wrapped up.
  • The enemies of intellectual liberty always try to present their case as a plea for discipline versus individualism.
  • The issue truth-versus-untruth is as far as possible kept in the background.
  • the writer who refuses to sell his opinions is always branded as a mere egoist, He is accused, that is, either of wanting to shut himself up in an ivory tower, or of making an exhibitionist display of his own personality, or of resisting the inevitable current, of history in an attempt to cling to unjustified privileges.
  • Each of them tacitly claims that “the truth” has already been revealed, and that the heretic, if he is not simply a fool, is secretly aware of “the truth” and merely resists it out of selfish motives.
  • Freedom of the intellect means the freedom to report what one has seen, heard, and fell, and not to be obliged to fabricate imaginary facts and feelings.
  • known facts are suppressed and distorted to such an extent as to make it doubtful whether a true history of our times can ever be written.
  • A totalitarian state is in effect a theocracy, and its ruling caste, in order to keep its position, has to be thought of as infallible. But since, in practice, no one is infallible, it is frequently necessary to rearrange past events in order to show that this or that mistake was not made, or that this or that imaginary triumph actually happened
  • Then, again, every major change in policy demands a corresponding change of doctrine and a revaluation of prominent historical figures. This kind of thing happens everywhere, but clearly it is likelier to lead to outright falsification in societies where only one opinion is permissible at any given moment.
  • The friends of totalitarianism in England usually tend to argue that since absolute truth is not attainable, a big lie is no worse than a little lie. It is pointed out that all historical records are biased and inaccurate, or, on the other hand, that modem physics has proved that what seems to us the real world is an illusion, so that to believe in the evidence of one’s senses is simply vulgar philistinism.
Javier E

Colonic electrical stimulation promotes colonic motility through regeneration of myente... - 0 views

  • Slow transit constipation (STC) is a common disease characterized by markedly delayed colonic transit time as a result of colonic motility dysfunction. It is well established that STC is mostly caused by disorders of relevant nerves, especially the enteric nervous system (ENS).
  • After 5 weeks of treatment, CES could enhance the colonic electromyogram (EMG) signal to promote colonic motility, thereby improving the colonic content emptying of STC beagles. HE staining and transmission electron microscopy confirmed that CES could regenerate ganglia and synaptic vesicles in the myenteric plexus.
  • Taken together, pulse train CES could induce the regeneration of myenteric plexus neurons, thereby promoting the colonic motility in STC beagles.
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  • onic constipation, a functional bowel disorder, affects approximately 14% of adults worldwide [1]. Slow transit constipation (STC) is the major cause of chronic constipation which is characterized by markedly prolonged colonic transit time as a result of the colonic motility function disorde
  • Usually, patients with STC suffer from a common sense of abdominal pain, nausea, depression and sickness, which seriously influence their social ability and health-related quality of life [4–6
  • Current clinical treatments include cathartics, prokinetics and aggressive surgery which can increase bowel movement frequency to a certain degree.
  • However, pharmacological interventions is prone to drug dependency and relapse after drug withdrawal [3]
  • Surgical treatments such as subtotal colectomy and total colectomy in STC patients may adversely affect the quality of life due to the risk of postoperative diarrhea or incontinence, and result in a heavy healthcare burden
  • The enteric nervous system (ENS), located in the intestinal wall, regulates various functions including contraction of intestine, homeostasis and blood flow [10]. As the ‘second brain’, the ENS contains large amounts of neurons working independently from the central nervous system [11]. Researches have identified that STCs are mostly caused by disorders of the relevant nerves, especially the ENS [12,13].
  • McCallum et al. [35] found that gastric electrical stimulation in combination with pharmacological treatment could also enhance emptying in patients with gastroparesis. Especially, gastric electrical stimulation has been approved as a clinical therapy method for gastroparesis and obesity in European and American countries [36].
  • we employed pulse train stimulation and implanted electrodes at the proximal colon in dogs.
  • After CES treatment, we observed the colonic transit time of the sham treatment group was longer than that of CES treatment and control groups, and electrical stimulation significantly enhanced the colonic electromyogram (EMG) signal.
  • histopathology and TEM analysis showed increased ganglia and synaptic vesicles existing in the colon myenteric plexus of the CES treatment group as compared with that of the sham CES group
  • Our results suggested that CES might reduce the degeneration of the myenteric plexus neurons, thereby contributing to the therapeutic effect on STC beagles.
  • the defecating frequency and the feces characteristics of STC beagles returned to normal after CES treatment. The result indicated that CES could improve the symptoms of STC.
  • The colonic EMG signal was strongly promoted by CES
  • Especially, the colonic EMG signal of the beagles with STC was remarkably enhanced by CES (Figure 3), indicating that CES could not only improve the colonic content emptying, but also enhance the EMG signal to promote colonic motility.
  • Colonic electrical stimulation (CES), a valuable alternative for the treatment of STC, was reported to improve the colon motility by adjusting the bioelectrical activity in animal models or patients with STC [17]. However, little report focuses on the underlying nervous mechanism to normalize the delayed colonic emptying and relieve symptoms. We hypothesized that CES may also repair the disorders of the relevant nerves and then improve the colonic motility.
  • The first study regarding the CES to modulate colonic motility was performed by Hughes et al. [37]. Since then, many researchers employed short-pulse CES in canine descending colon or pig cecum [20,21,38]. Researchers also applied long-pulse CES to stimulate the colon of human or animals [39]
  • Recently, studies showed that the prokinetic effect of pulse train CES is better than that of short-pulse CES or long-pulse CES [25]
  • Our study indicated that CES could enhance the colonic motility, and then accelerate the colonic content emptying. Thereafter, we investigated the underlying mechanism and presumed that CES might improve the STC symptom through the repairment of the ENS.
  • The neuropathy in ENS is considered to be responsible for various kinds of disordered motility including STC and the related pathophysiologic symptoms [40]. In agreement with this view, our study discovered the decreased number of ganglia in the myenteric plexus, as well as the destruction of the enteric nerve axon terminals and synaptic vesicles in the sham CES group beagles
  • The present study proves that CES with pulse trains has curative effects on the colonic motility and content emptying in STC beagles. The up-regulation of intestinal nerve related proteins such as SYP, PGP9.5, CAD and S-100B in the colonic myenteric plexus suggests that CES might reduce the degeneration of the myenteric plexus neurons, thereby producing the therapeutic effect on STC beagles. Further investigation for the underlying mechanism of nerve regeneration is necessary to better understand how CES promotes the recovery of delayed colonic motility induced by STC.
Javier E

Synthetic Thinking | Jerome Groopman | The New York Review of Books - 0 views

  • Did you hope to combine chemistry and political philosophy in some way in your medical career?
  • Chemistry requires synthetic thinking. You have to bring disparate pieces of knowledge together in order to look for a chemical structure. Political philosophy, to some degree, also involves disparate aspects of knowledge: economics, sociology, history, pure philosophy
  • I found that in medicine, you don’t have an answer when you start out. You’re looking for clues that are often distributed in different places: family history, as there might be a genetic predisposition; social history, because the person smoked or was exposed to a toxin; the physical examination, where you find that an organ might be disordered. Add to that the blood test, the CAT scan, all of it, but most importantly, the person, the psychology of the person you’re dealing with. It’s the same kind of synthetic process as political philosophy, but in a different dimension.
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  • Writing, especially the kind of writing that I do, brings together narrative, science, sometimes history, and an appreciation for the person who might be at the center of the narrative.
  • The greatest influence on me was Oliver Sacks, because he could capture people as people, and he always integrated serious science into his pieces.
  • The two subjects that were most prominent for him, as I once wrote for you, were identity and adaptation: Who is this person, despite their illness? How does that illness interface with their behavior and their decisions, how do people perceive them from the outside, and how do they try to find meaning and adapt to what looks like a disability, but sometimes—not always, but sometimes—gives them hidden strength?
  • I’ve gone from witnessing the depths of disability and death, like with AIDS: I saw some of the first people with AIDS in California, in 1982 or so. The average lifespan was six months. They were mostly young gay men, and it was devastating, the infections they got, the cancers they got. Now, with all the new drugs that have been developed, someone who gets HIV is projected to have a normal lifespan. From six months to fifty years: it’s miraculous
  • that’s part of what keeps you going: the belief that things can advance in a meaningful way.
  • Are there any major or interesting medical stories that the public doesn’t know enough about? 
  • The idea of genetic treatments. Often when people hear the words “genetics” or “DNA” or “RNA,” they shut down. The challenge is how to make it accessible.
  • There’s a wonderful line in the Talmud that says, “Whoever saves a single life saves the whole world.” There might be only a few hundred people in the whole country who have a particular genetic disorder. I
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