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"The experiments are elegant and seem to show that in the mouse sperm production can be achieved when only two genes from the Y-chromosomes are present.

"Whilst this is of limited use in understanding human fertility, this kind of work is important if we are to unravel to complexities of how genes control fertility."

What the research has found is that the brains of trans people are unique: neither female nor male, exactly, but something distinct.

But what does that mean, a male brain, or a female brain, or even a transgender one?

It’s a fraught topic, because brains are a collection of characteristics, rather than a binary classification of either/or

yet scientists continue to study the brain in hopes of understanding whether a sense of the gendered self can, at least in part, be the result of neurology

Well, not entirely. Because not every person with a Y chromosome is male, and not every person with a double X is female. The world is full of people with other combinations: XXY (or Klinefelter Syndrome), XXX (or Trisomy X), XXXY, and so on. There’s even something called Androgen Insensitivity Syndrome, a condition that keeps the brains of people with a Y from absorbing the information in that chromosome. Most of these people develop as female, and may not even know about their condition until puberty — or even later.

t there’s a problem with using neurology as an argument for trans acceptance — it suggests that, on some level, there is something wrong with transgender people, that we are who we are as a result of a sickness or a biological hiccup.

trying to open people’s hearts by saying “Check out my brain!” can do more harm than good, because this line of argument delegitimizes the experiences of many trans folks. It suggests that there’s only one way to be trans — to feel trapped in the wrong body, to go through transition, and to wind up, when all is said and done, on the opposite-gender pole. It suggests that the quest trans people go on can only be considered successful if it ends with fitting into the very society that rejected us in the first place.

All the science tells us, in the end, is that a biological male — or female — is not any one thing, but a collection of possibilities.

No one who embarks upon a life as a trans person in this country is doing so out of caprice, or a whim, or a delusion. We are living these wondrous and perilous lives for one reason only — because our hearts demand it.

what we need now is not new legislation to make things harder. What we need now is understanding, not cruelty. What we need now is not hatred, but love.

the important thing is not that they feel like a woman, or a man, or something else. What matters most is the plaintive desire, to be free to feel the way I feel.

His theory draws upon many of the most prominent views of how humans emerged. These range from our evolution of the ability to run long distances to our development of the earliest weapons, which involved the improvement of hand-eye coordination. Dramatic climate change in Africa over the course of a few tens of thousands of years also may have forced Australopithecus and Homo to adapt rapidly. And over roughly the same span, humans became cooperative hunters and serious meat eaters, vastly enriching our diet and favoring the development of more-robust brains. By themselves, Wilson says, none of these theories is satisfying. Taken together, though, all of these factors pushed our immediate prehuman ancestors toward what he called a huge pre-adaptive step: the formation of the earliest communities around fixed camps.

“Within groups, the selfish are more likely to succeed,” Wilson told me in a telephone conversation. “But in competition between groups, groups of altruists are more likely to succeed. In addition, it is clear that groups of humans proselytize other groups and accept them as allies, and that that tendency is much favored by group selection.” Taking in newcomers and forming alliances had become a fundamental human trait, he added, because “it is a good way to win.”

“The humans become consistent with all the others,” he said, and the evolutionary steps were likely similar—beginning with the formation of groups within a freely mixing population, followed by the accumulation of pre-adaptations that make eusociality more likely, such as the invention of campsites. Finally comes the rise to prevalence of eusocial alleles—one of two or more alternative forms of a gene that arise by mutation, and are found at the same place on a chromosome—which promote novel behaviors (like communal child care) or suppress old, asocial traits. Now it is up to geneticists, he adds, to “determine how many genes are involved in crossing the eusociality threshold, and to go find those genes.”

Wilson posits that two rival forces drive human behavior: group selection and what he calls “individual selection”—competition at the level of the individual to pass along one’s genes—with both operating simultaneously. “Group selection,” he said, “brings about virtue, and—this is an oversimplification, but—individual selection, which is competing with it, creates sin. That, in a nutshell, is an explanation of the human condition.

“When humans started having a camp—and we know that Homo erectus had campsites—then we know they were heading somewhere,” he told me. “They were a group progressively provisioned, sending out some individuals to hunt and some individuals to stay back and guard the valuable campsite. They were no longer just wandering through territory, emitting calls. They were on long-term campsites, maybe changing from time to time, but they had come together. They began to read intentions in each other’s behavior, what each other are doing. They started to learn social connections more solidly.”

If Wilson is right, the human impulse toward racism and tribalism could come to be seen as a reflection of our genetic nature as much as anything else—but so could the human capacity for altruism, and for coalition- and alliance-building. These latter possibilities may help explain Wilson’s abiding optimism—about the environment and many other matters. If these traits are indeed deeply written into our genetic codes, we might hope that we can find ways to emphasize and reinforce them, to build problem-solving coalitions that can endure, and to identify with progressively larger and more-inclusive groups over time.

We have dozens of new pronouns in colleges (for all those genders that have suddenly sprung into existence), and biological males competing in all-female high-school athletic teams (guess who wins at track).

Worse, we have constant admonitions against those who actually conform, as most human beings always have, to the general gender rule.

We have gone from rightly defending the minority to wrongly problematizing the majority. It should surprise no one that, at some point, the majority will find all of this, as Josh Barro recently explained, “annoying.”

I say this as someone happily in the minority — and who believes strongly in the right to subvert or adapt traditional gender roles.

But you can’t subvert something that you simultaneously argue doesn’t exist.

the core contradiction of ideological transgenderism. By severing the link between sex and gender completely, it abolishes the core natural framework without which the transgender experience makes no sense at all.

It’s also a subtle, if unintentional, attack on homosexuality. Most homosexuals are strongly attached to their own gender and attracted to traditional, natural expressions of it. That’s what makes us gay, for heaven’s sake. And that’s one reason the entire notion of a common “LGBT” identity is so misleading. How can a single identity comprise both the abolition of gender and at the same time its celebration?

Exceptions, in other words, need a rule to exist. Abolish gender’s roots in biology and sex — and you abolish gay people and transgender people as well.

I’m not in favor of boycotting Israel when we don’t boycott, say, Saudi Arabia. But seriously: making it illegal?

Transgender people exist and should be treated with absolutely the same human respect, decency, and civil equality as anyone else. But they don’t disprove traditional notions of gender as such — which have existed in all times, places, and cultures in human history and prehistory, and are rooted deeply in evolutionary biology and reproductive strategy.

Intersex people exist and, in my view, should not be genitally altered or “fixed” without their adult consent. But they do not somehow negate the overwhelming majority who have no such gender or sexual ambiguity.

the entire society does not need to be overhauled in order to make gay or trans experience central to it. Inclusion, yes. Revolution, no.

The added problem with this war on nature is the backlash it inevitably incurs. There’s a reason so many working-class men find it hard to vote for Democrats any more. And there’s a reason why a majority of white women last year voted for a man who boasted of sexual assault if the alternative was a triumph for contemporary left-feminism.

You can’t assault the core identity of most people’s lives and then expect them to vote for you. As a Trump supporter in Colorado just told a reporter from The New Yorker: “I’ve never been this emotionally invested in a political leader in my life. The more they hate him, the more I want him to succeed. Because what they hate about him is what they hate about me.”

One of the features you most associate with creeping authoritarianism is the criminalization of certain political positions. Is anything more anathema to a liberal democracy? If Trump were to suggest it, can you imagine the reaction?

And yet it’s apparently fine with a hefty plurality of the Senate and House. I’m referring to the remarkable bill introduced into the Congress earlier this year — with 237 sponsors and co-sponsors in the House and 43 in the Senate — which the ACLU and the Intercept have just brought to light. It’s a remarkably bipartisan effort, backed by Chuck Schumer and Ted Cruz, among many solid Trump-resisting Democrats and hard-line Republicans.

it would actually impose civil and criminal penalties on American citizens for backing or joining any international boycott of Israel because of its settlement activities. There are even penalties for simply inquiring about such a boycott. And they’re not messing around. The minimum civil penalty would be $250,000 and the maximum criminal penalty $1 million and 20 years in prison. Up to 20 years in prison for opposing the policies of a foreign government and doing something about it!

Yes, there’s a range of gender expression among those of the same sex. But it’s still tethered among most to the forces of chromosomes and hormones that make us irreducibly male and female. Nature can be interpreted; it can even be played with; but it cannot be abolished. After all, how can you be “queer” if there is no such thing as “normal”?

Every now and again, you just have to sit back and admire the extraordinary skills of the Greater Israel lobby. You’ve never heard of this bill, and I hadn’t either. But that is partly the point. AIPAC doesn’t want the attention — writers who notice this attempted assault on a free society will be tarred as anti-Semites (go ahead, it wouldn’t be the first time) and politicians who resist it will see their careers suddenly stalled.

pointing out this special interest’s distortion of democracy is not the equivalent of bigotry. It’s simply a defense of our democratic way of life.