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cvanderloo

3 medical innovations fueled by COVID-19 that will outlast the pandemic - 0 views

theconversation.com/ll-outlast-the-pandemic-156464

COVID innovations science health pandemic medicine knowledge research technology

shared by cvanderloo on 17 Mar 21 - No Cached
  • When COVID-19 struck, mRNA vaccines in particular were ready to be put to a real-world test. The 94% efficacy of the mRNA vaccines surpassed health officials’ highest expectations.
  • DNA and mRNA vaccines offer huge advantages over traditional types of vaccines, since they use only genetic code from a pathogen – rather than the entire virus or bacteria.
  • Gene-based vaccines also produce precise and effective immune responses. They stimulate not only antibodies that block an infection, but also a strong T cell response that can clear an infection if one occurs.
  • ...4 more annotations...
  • These devices can measure a person’s temperature, heart rate, level of activity and other biometrics. With this information, researchers have been able to track and detect COVID-19 infections even before people notice they have any symptoms.
  • Wearables can detect symptoms of COVID-19 or other illnesses before symptoms are noticeable. While they have proved to be capable of detecting sickness early, the symptoms wearables detect are not unique to COVID-19.
  • So a logical way to look for new drugs to treat a specific disease is to study individual genes and proteins that are directly affected by that disease.
  • But this idea of mapping the protein interactions of diseases to look for novel drug targets doesn’t apply just to the coronavirus. We have now used this approach on other pathogens as well as other diseases including cancer, neurodegenerative and psychiatric disorders.
anonymous

Was the US Capitol Riot a Coronavirus Superspreader Event? - The New York Times - 0 views

www.nytimes.com/...uper-spreader-coronavirus.html

shared by anonymous on 12 Jan 21 - No Cached
  • The riot on Wednesday may have started a coronavirus superspreader event, fueled by the mob that roamed through the halls of Congress and unmasked Republicans who jammed into cloistered secure rooms.
  • It could have been worse. Because of the pandemic, lawmakers were instructed to remain in their offices unless speaking during debate over the certification of votes
  • But the normal precautions — already haphazardly enforced — collapsed as pro-Trump supporters stormed the Capitol.
  • ...6 more annotations...
  • “It angers me when they refuse to adhere to the directions about keeping their masks on,” Ms. Watson Coleman, a lung cancer survivor who will turn 76 next month, said in an interview. “It comes off to me as arrogance and defiance. And you can be both, but not at the expense of someone else.”
  • On both sides of the Capitol, lawmakers, aides, police officers and reporters who had fled to secure locations have been warned that they might have been exposed to the coronavirus while hiding from the mob
  • The scene that unfolded on Wednesday in that one secure room — where an offer of masks from Representative Lisa Blunt Rochester, Democrat of Delaware, was rejected by a group of Republicans — is emblematic of the challenge that has dogged Capitol Hill’s disorderly response to the pandemic.
  • Republicans accused Democrats, who needed their narrow majority fully present in person to confirm Ms. Pelosi as speaker, of subverting their own rules on the first day of the Congress
  • permitting the construction of a small plexiglass enclosure with its own ventilation system in one of the galleries so that lawmakers in a protective quarantine could vote in person
  • Complicating matters further, lawmakers in both parties have delayed receiving a vaccination, despite being granted primary access, arguing that essential workers needed to receive it first.
ilanaprincilus06

New traumatic brain injury test is 'game-changing,' concussion experts say - ABC News - 0 views

abcnews.go.com/...story

brain medical community TBI

shared by ilanaprincilus06 on 13 Jan 21 - No Cached
  • In a world first, a newly authorized handheld device will allow doctors to detect traumatic brain injuries (TBIs) in under 15 minutes, potentially saving lives by dramatically shortening the time it takes to properly diagnose the issue.
  • Until now, health care providers have needed to rely on subjective measurements for TBIs, but we finally have a more objective tool to help evaluate patients.”
  • Unfortunately, many patients with mild TBI struggle to get an accurate and timely diagnosis, even as they grapple with ongoing symptoms. This ultimately results in delayed treatment.
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  • Abbott’s new blood test may serve as an objective tool to help doctors triage TBI patients, because it relies on molecular signatures in the blood rather than on murkier clues, such as patient interviews.
  • often use a series of screening questionnaires, physical examinations and CT scans to take pictures of the brain in order to evaluate TBI. However, experts agree these techniques aren’t perfect and there is no objective way to reliably evaluate TBI.
  • Aside from reducing health care costs, it can save people from unnecessary radiation that has been shown to increase the risk of cancer.
  • Despite the benefits, experts agree that physicians cannot rely entirely on this diagnostic test, stating it will only serve to supplement clinical judgment.
  • "The game-changing innovation of having a tool like this is that, as it becomes more widely used, I believe we will identify more people with TBI that’s more subtle, that could be life-altering."
ilanaprincilus06

'Social recession': how isolation can affect physical and mental health | Coronavirus |... - 0 views

www.theguardian.com/...cession-physical-mental-health

Covid-19 isolation social recession

shared by ilanaprincilus06 on 13 Jan 21 - No Cached
  • Long-term, isolation even increases the risk of premature death. It’s being called a “social recession”
  • “People who are more socially connected show less inflammation, conversely people who are more isolated and lonely show increased chronic inflammation.
  • “Loneliness increases earlier death by 26%, social isolation by 29% and living alone by 32%.”
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  • The risk of every cause of death – including heart disease, cancer, stroke, renal failure – increased from isolation.
  • One of the reasons people can suffer in social isolation is because personal relationships can help us cope with stress,
  • “For instance: the ongoing uncertainty of what’s going on right now in the world, your body’s response to that may differ. Depending on the extent to which you feel like you have the resources you need to cope with that. And that in large part may be dependent on whether or not you feel like you have others in your life you can rely on.
  • “We have evolved to be social creatures. For all the history of humanity, people have been in family structures, people have been in groups, we’re evolved to kind of crave and rely on that interaction with other human beings,”
  • “So when we don’t have that it’s a huge void in the way that we go about being human. This is something that has been kind of hard-wired into who we are as beings.”
  • people do at least have a wealth of options to stay connected. Texting, video calling or even the phone could potentially help avert the sense of isolation or loneliness, Khullar said.
pier-paolo

Opinion | The Paradox of Disclosure - The New York Times - 0 views

www.nytimes.com/...the-paradox-of-disclosure.html

shared by pier-paolo on 03 Nov 20 - No Cached
  • A POPULAR remedy for a conflict of interest is disclosure — informing the buyer (or the patient, etc.) of the potential bias of the seller (or the doctor, etc.)
  • disclosure: It often has the opposite of its intended effect, not only increasing bias in advisers but also making advisees more likely to follow biased advice.
  • But my research has found that people are still more likely to follow this advice because the disclosure creates increased pressure to follow the adviser’s recommendation.
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  • For example, surgeons are more likely to recommend surgery than non-surgeons. Radiation-oncologists recommend radiation more than other physicians. This is known as specialty bias.
  • patients with localized prostate cancer (a condition that has multiple effective treatment options) who heard their surgeon disclose his or her specialty bias were nearly three times more likely to have surgery than those patients who did not hear their surgeon reveal such a bias.
  • To be sure, physicians who disclose a financial conflict of interest or a specialty bias do not necessarily give poor advice.
  • When bias is unavoidable, as with specialty bias, options such as patient educational materials could alert patients to this problem without hearing it directly from the physician. Another solution could be multidisciplinary treatment consultations, in which patients meet multiple specialists at the same time.
  • Consumers should be aware of their reactions to disclosure and take time out to reconsider their options and seek second opinions. And advisers and policy makers must understand the potential unintended consequences when using disclosure as a solution to manage bias.
huffem4

Trump's "Chinese Virus" and What's at Stake in the Coronavirus's Name | The New Yorker - 1 views

www.newyorker.com/...hats-at-stake-in-a-viruss-name

COVID-19 knowledge racism

shared by huffem4 on 26 Mar 20 - No Cached
  • In another part of the study, the researchers determined that defining vaccination in terms of contamination—“the seasonal flu vaccine involves injecting people with the seasonal flu virus”—increased prejudice in subjects concerned about disease, whereas defining it in terms of protection—“the seasonal flu vaccine protects people from the seasonal flu virus”—had no such effect. Initiatives that minimize disease, the researchers concluded, might also end up minimizing discrimination.
  • It was only a matter of time before Donald Trump enlisted such language to serve his nativist agenda. Although COVID-19, the disease caused by the novel coronavirus, has killed more than twenty thousand people and affected countries around the world, Trump’s fixation on its origins in Wuhan, China, has encouraged a rash of anti-Asian bigotry in the United States.
  • This month, Trump has taken to referring to COVID-19 as the “Chinese virus,” presenting the label as a corrective to Beijing officials’ claims that the American military was the source of the outbreak.
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  • Much of the old nomenclature has turned out to be not only stigmatizing but inaccurate. The Ebola virus, for instance, gets its name from a river that sits about forty miles from Yambuku, the Congolese village where researchers first investigated the disease, in 1976.
  • Still, it’s hard not to see a similarity between the recent reports of harassment against Asian-Americans and the stigmatization that gay people suffered in the wake of the AIDS outbreak.
  • Evolutionary psychologists refer to a “behavioral immune system” that attunes humans to physical differences or unfamiliar behavior, even when it poses no risk.
  • Last week, an Asian-American journalist reported that a member of the President’s staff called COVID-19 the “kung flu” to her face.
  • This may seem like a trivial issue to some, but disease names really do matter to the people who are directly affected
  • no disease better illustrates the perils of disease naming than AIDS, which, in its early days, was sometimes called “gay cancer.”
knudsenlu

Study: Does Adult Neurogenesis Exist in Humans? - The Atlantic - 0 views

www.theatlantic.com/...555026

neuroscience neurogenesis psychology brain science research

shared by knudsenlu on 11 Mar 18 - No Cached
  • In 1928, Santiago Ramón y Cajal, the father of modern neuroscience, proclaimed that the brains of adult humans never make new neurons. “Once development was ended,” he wrote, “the founts of growth and regeneration ... dried up irrevocably. In the adult centers the nerve paths are something fixed, ended and immutable. Everything must die, nothing may be regenerated.”
  • For decades, scientists believed that neurogenesis—the creation of new neurons—whirs along nicely in the brains of embryos and infants, but grinds to a halt by adulthood. But from the 1980s onward, this dogma started to falter. Researchers showed that neurogenesis does occur in the brains of various adult animals, and eventually found signs of newly formed neurons in the adult human brain.
  • Finally, Gage and others say that several other lines of evidence suggest that adult neurogenesis in humans is real. For example, in 1998, he and his colleagues studied the brains of five cancer patients who had been injected with BrdU—a chemical that gets incorporated into newly created DNA. They found traces of this substance in the hippocampus, which they took as a sign that the cells there are dividing and creating new neurons.
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  • Greg Sutherland from the University of Sydney agrees. In 2016, he came to similar conclusions as Alvarez-Buylla’s team, using similar methods. “Depending on your inherent biases, two scientists can look at sparse events in the adult brain and come to different conclusions,” he says. “But when faced with the stark difference between infant and adult human brains, we can only conclude that [neurogenesis] is a vestigial process in the latter.”
  • Alvarez-Buylla agrees that there’s still plenty of work to do. Even if neurogenesis is a fiction in adult humans, it’s real in infants, and in other animals. If we really don’t make any new neurons as adults, how do we learn new things? And is there any way of restoring that lost ability to create new neurons in cases of stroke, Alzheimer’s, or other degenerative diseases? “Neurogenesis is precisely what we want to induce in cases of brain damage,” Alvarez-Buylla says. “If it isn’t there to begin with, how might you induce it?”
krystalxu

NIMH » Depression Basics - 0 views

www.nimh.nih.gov/...index.shtml

psychology brain science depression

shared by krystalxu on 03 Oct 17 - No Cached
  • Depression—also called “clinical depression” or a “depressive disorder”—is a mood disorder that causes distressing symptoms that affect how you feel, think, and handle daily activities, such as sleeping, eating, or working.
  • Two of the most common forms of depression
  • Major depression
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  • Perinatal Depression
  • Seasonal Affective Disorder (SAD):
  • Psychotic Depression:
  • Scientists at NIMH and across the country are studying the causes of depression. Research suggests that a combination of genetic, biological, environmental, and psychological factors play a role in depression.
  • Depression can occur along with other serious illnesses, such as diabetes, cancer, heart disease, and Parkinson’s disease. Depression can make these conditions worse and vice versa.
  • Depression affects different people in different ways.
  • The first step in getting the right treatment is to visit a health care provider or mental health professional, such as a psychiatrist or psychologist
  • Medications called antidepressants can work well to treat depression.
anniina03

People with at least two Northern Isles grandparents needed for genetics study - BBC News - 0 views

www.bbc.com/...-east-orkney-shetland-51135287

science research

shared by anniina03 on 19 Jan 20 - No Cached
  • People with at least two grandparents who were born in Orkney or Shetland are being sought for a genetics study aimed at improving health.The research aims to better understand the causes of conditions such as diabetes, stroke, heart disease and cancer, and in turn find treatments.Those taking part in the University of Edinburgh study-led Viking II project will complete an online questionnaire about their health and lifestyle.
  • The team believes the "unique genetic identity" of those with Northern Isles ancestry offers a "rare opportunity" to give a detailed picture on how genes are implicated in health
  • It is believed this information could be useful in terms of their future healthcare, including taking preventive actions to reduce the impact of health conditions.The study is being backed by the Medical Research Council.
katherineharron

Mindfulness: How it could help you be happier, healthier and more successful - CNN - 0 views

www.cnn.com/...index.html

shared by katherineharron on 19 Jan 20 - No Cached
  • "Change in humanity must start from individuals," the Dalai Lama told the mayors. "We created this violence, so we can reduce this violence."
  • Paying attention to the matters at hand may sound simple, but most Americans aren't doing it, studies show. Though the experts say there's a lot more research to be done, the number of scientific studies has grown exponentially over the past decade. They show that mindfulness is more than a passing fad; there's early evidence it can help your health.
  • n their 2010 study, they created a computer program that sent questions at random moments to people by iPhone. The program asked, "How are you feeling right now?" "What are you doing right now?" and "Are you thinking about something other than what you're currently doing?"
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  • Of the 2,250 adults who answered the pings, 46.9% were not thinking about the task they were doing at the moment. This was the case for 30% of their activities, with one exception: during sex. That, apparently, had
  • their full attention.
  • To remain mindful, the Dalai Lama said, he sleeps a lot: about nine hours a night. He also gets up at 3 a.m. to meditate. He has another session in the afternoon and one more right before bed.
  • Scientists had Buddhist monks meditate while being scanned by an MRI machine. While strapped to a board and put in the huge, noisy machine, the monks calmed their minds, reduced distractions and paid attention to life moment-by-moment.
  • The participants were then subjected to a stressful day-long training exercise. Both groups had similar spikes in blood pressure and breathing rates during the test, but when it was over, the mindfully trained Marines' heart rate and breathing recovered much faster, as did their nervous systems.
  • The data on stress reduction is pretty good," said Richard J. Davidson, founder of the Center for Healthy Minds at the University of Wisconsin-Madison. He has published hundreds of scientific papers about the impact of emotion on the brain and did some of the first MRIs of meditating Buddhist monks.
  • Several workplace studies found that employees who get mindfulness training become more productive and stable. They demonstrate more self-control and efficiency. Employees with mindfulness training also seem to pick up on things faster and can read group dynamics better.
  • Davidson suggests that the data are "much weaker and less convincing" as mindfulness relates to curing a specific disease.It can't cure cancer or chronic pain, but the practice can help manage some of the symptoms. For instance, if you have chronic lower back pain, mindfulness may be as helpful as medication at easing that pain.
Javier E

How Zeynep Tufekci Keeps Getting the Big Things Right - The New York Times - 0 views

www.nytimes.com/...ting-the-big-things-right.html

role model intellectual independent critical thinking psychology bias

shared by Javier E on 24 Aug 20 - No Cached
  • When the Centers for Disease Control and Prevention told Americans in January that they didn’t need to wear masks, Dr. S. Vincent Rajkumar, a professor at the Mayo Clinic and the editor of the Blood Cancer Journal, couldn’t believe his ears.
  • “Here I am, the editor of a journal in a high profile institution, yet I didn’t have the guts to speak out that it just doesn’t make sense,” Dr. Rajkumar told me. “Everybody should be wearing masks.”
  • Ms. Tufekci, an associate professor at the University of North Carolina’s School of Information and Library Science with no obvious qualifications in epidemiology, came out against the C.D.C. recommendation in a March 1 tweetstorm before expanding on her criticism in a March 17 Op-Ed article for The New York Times.
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  • The C.D.C. changed its tune in April, advising all Americans above the age of 2 to wear masks to slow the spread of the coronavirus. Michael Basso, a senior health scientist at the agency who had been pushing internally to recommend masks, told me Ms. Tufekci’s public criticism of the agency was the “tipping point.”
  • Ms. Tufekci, a 40-something who speaks a mile a minute with a light Turkish accent, has none of the trappings of the celebrity academic or the professional pundit. But long before she became perhaps the only good amateur epidemiologist, she had quietly made a habit of being right on the big things.
  • In 2011, she went against the current to say the case for Twitter as a driver of broad social movements had been oversimplified. In 2012, she warned news media outlets that their coverage of school shootings could inspire more. In 2013, she argued that Facebook could fuel ethnic cleansing. In 2017, she warned that YouTube’s recommendation algorithm could be used as a tool of radicalization.
  • And when it came to the pandemic, she sounded the alarm early while also fighting to keep parks and beaches open.
  • “I’ve just been struck by how right she has been,” said Julia Marcus, an infectious disease epidemiologist at Harvard Medical School.
  • She told me she chalks up her habits of mind in part to a childhood she wouldn’t wish on anyone.
  • Mr. Goff was enthusing about the campaign’s ability to send different messages to individual voters based on the digital data it had gathered about them. Ms. Tufekci quickly objected to the practice, saying that microtargeting would more likely be used to sow division.
  • An international point of view she picked up while bouncing as a child between Turkey and Belgium and then working in the United States.
  • Knowledge that spans subject areas and academic disciplines, which she happened onto as a computer programmer who got into sociology.
  • A habit of complex, systems-based thinking, which led her to a tough critique in The Atlantic of America’s news media in the run-up to the pandemic
  • it began, she says, with growing up in an unhappy home in Istanbul. She said her alcoholic mother was liable to toss her into the street in the early hours of the morning. She found some solace in science fiction — Ursula K. Le Guin was a favorite — and in the optimistic, early internet.
  • Perhaps because of a kind of egalitarian nerd ideology that has served her well, she never sought to meet the rebels’ charismatic leader, known as Subcomandante Marcos.
  • “I have a thing that fame and charisma screws with your head,” she said. “I’ve made an enormous effort throughout my life to preserve my thinking.”
  • While many American thinkers were wide-eyed about the revolutionary potential of social media, she developed a more complex view, one she expressed when she found herself sitting to the left of Teddy Goff, the digital director for President Obama’s re-election campaign, at a South by Southwest panel in Austin in 2012
  • “A bunch of things came together, which I’m happy I survived,” she said, sitting outside a brick house she rents for $2,300 a month in Chapel Hill, N.C., where she is raising her 11-year-old son as a single parent. “But the way they came together was not super happy, when it was happening.”
  • “At a time when everybody was being stupidly optimistic about the potential of the internet, she didn’t buy the hype,” he told me. “She was very prescient in seeing that there would be a deeper rot to the role of data-driven politics in our world.”
  • Many tech journalists, entranced by the internet-fueled movements sweeping the globe, were slow to spot the ways they might fail, or how social media could be used against them. Ms. Tufekci, though, had “seen movement after movement falter because of a lack of organizational depth and experience, of tools or culture for collective decision making, and strategic, long-term action,” she wrote in her 2017 book, “Twitter and Tear Gas.”
  • One of the things that makes Ms. Tufekci stand out in this gloomy moment is her lack of irony or world-weariness. She is not a prophet of doom, having hung on to an early-internet optimism
  • Ms. Tufekci has taught epidemiology as a way to introduce her students to globalization and to make a point about human nature: Politicians and the news media often expect looting and crime when disaster strikes, as they did when Hurricane Katrina hit New Orleans in 2005. But the reality on the ground has more to do with communal acts of generosity and kindness, she believes.
  • Her March column on masks was among the most influential The Times has published, although — or perhaps because —  it lacked the political edge that brings wide attention to an opinion piece.
  • “The real question is not whether Zuck is doing what I like or not,” she said. “The real question is why he’s getting to decide what hate speech is.”
  • She also suggested that we may get it wrong when we focus on individuals — on chief executives, on social media activists like her. The probable answer to a media environment that amplifies false reports and hate speech, she believes, is the return of functional governments, along with the birth of a new framework, however imperfect, that will hold the digital platforms responsible for what they host.
Javier E

The Cancel Culture Checklist - Persuasion - 0 views

www.persuasion.community/...e-cancel-culture-checklist-c63

psychology bias language social media cancel culture criticism

shared by Javier E on 28 Aug 20 - No Cached
  • a third of Americans say that they are personally worried about losing their jobs or missing out on career opportunities if they express their real political opinions.
  • Cancel culture now poses a real threat to intellectual freedom in the United States.
  • Americans in all walks of life have been publicly shamed, pressured into ritualistic apologies or summarily fired
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  • But critics of the critics of cancel culture make a powerful retort. Accusing others of canceling can, they claim, be a way to stigmatize legitimate criticism. As Hannah Giorgis writes in the Atlantic, “critical tweets are not censorship.”
  • So what, exactly, does a cancellation consist of? And how does it differ from the exercise of free speech and robust critical debate?
  • At a conceptual level, the difference is clear. Criticism marshals evidence and arguments in a rational effort to persuade.
  • Canceling, by contrast, seeks to organize and manipulate the social or media environment in order to isolate, deplatform or intimidate ideological opponents
  • its intent—or at least its predictable outcome—is to coerce conformity and reduce the scope for forms of criticism that are not sanctioned by the prevailing consensus of some local majority.
  • In practice, however, telling canceling apart from criticism can be difficult because both take the form of criticizing others.
  • The more signs you see, the more certain you can be that you are looking at a cancel campaign.
  • A better approach might therefore be diagnostic. Like the symptoms of cancer, the hallmarks of a cancellation are many. Though not all instances involve every single characteristic, they all involve some of its key attribute
  • Six warning signs make up my personal checklist for cancel culture.
  • Punitiveness
  • A critical culture seeks to correct rather than punish. In science, the penalty for being wrong is not that you lose your job or your friends. Normally, the only penalty is that you lose the argument
  • Canceling, by contrast, seeks to punish rather than correct—and often for a single misstep rather than a long track record of failure
  • Deplatforming
  • A critical culture tolerates dissent rather than silencing it. It understands that dissent can seem obnoxious, harmful, hateful and, yes, unsafe.
  • Canceling, by contrast, seeks to shut up and shout down its targets. Cancelers often define the mere act of disagreeing with them as a threat to their safety or even an act of violence
  • Organization
  • Critical culture relies on persuasion. The way to win an argument is to convince others that you are right.
  • By contrast, it’s common to see cancelers organize hundreds of petition-signers or thousands of social media users to dig up and prosecute an indictment.
  • Secondary Boycotts
  • With its commitments to exploring a wide range of ideas and correcting rather than coercing the errant, a critical culture sees no value in instilling a climate of fear
  • But instilling fear is what canceling is all about. By choosing targets unpredictably (almost anything can trigger a campaign), providing no safe harbors (even conformists can get hit), and implicitly threatening anyone who sides with those who are targeted, canceling sends the message: “you could be next.”
  • Moral Grandstanding
  • Precisely because speech can be hurtful, critical culture discourages extreme rhetoric. It encourages people to listen to each other, to use evidence and argumentation, to behave reasonably and to avoid personal attacks.
  • Cancel culture is much more invested in what philosophers Justin Tosi and Brandon Warmke call “moral grandstanding”: the display of moral outrage to impress one’s peer group, dominate others, or both
  • Truthiness
  • Concern for accuracy is the north star of a critical culture. Not everyone gets every fact right, nor do people always agree on what is true; and yet people in a critical culture try to present their own and others’ viewpoints honestly and accurately.
  • canceling is not about seeking truth or persuading others; it is a form of information warfare, in which truthiness suffices if it serves the cause.
  • Those are my six warning signs. If you spot one or two, you should fear that a canceling may be happening; if you see five or six, you can be sure.
  • Though our critics like to claim that those of us who worry about cancel culture just don’t like being criticized on the internet, cancel culture is all too real. And though it may at times bear a superficial resemblance to critical culture, the two are diametrically opposed—and not so very difficult to tell apart.
Javier E

How the leading coronavirus vaccines made it to the finish line - The Washington Post - 0 views

www.washingtonpost.com/...covid-vaccine-messenger-rna

vaccine R&D science profit innovation discovery research

shared by Javier E on 06 Dec 20 - No Cached
  • If, as expected in the next few weeks, regulators give those vaccines the green light, the technology and the precision approach to vaccine design could turn out to be the pandemic’s silver linings: scientific breakthroughs that could begin to change the trajectory of the virus this winter and also pave the way for highly effective vaccines and treatments for other diseases.
  • Vaccine development typically takes years, even decades. The progress of the last 11 months shifts the paradigm for what’s possible, creating a new model for vaccine development and a toolset for a world that will have to fight more never-before-seen viruses in years to come.
  • Long before the pandemic, Graham worked with colleagues there and in academia to create a particularly accurate 3-D version of the spiky proteins that protrude from the surface of coronaviruses — an innovation that was rejected for publication by scientific journals five times because reviewers questioned its relevance.
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  • Messenger RNA is a powerful, if fickle, component of life’s building blocks — a workhorse of the cell that is also truly just a messenger, unstable and prone to degrade.
  • . In 1990,
  • That same year, a team at the University of Wisconsin startled the scientific world with a paper that showed it was possible to inject a snippet of messenger RNA into mice and turn their muscle cells into factories, creating proteins on demand.
  • If custom-designed RNA snippets could be used to turn cells into bespoke protein factories, messenger RNA could become a powerful medical tool. It could encode fragments of virus to teach the immune system to defend against pathogens. It could also create whole proteins that are missing or damaged in people with devastating genetic diseases, such as cystic fibrosis.
  • In 2005, the pair discovered a way to modify RNA, chemically tweaking one of the letters of its code, so it didn’t trigger an inflammatory response. Deborah Fuller, a scientist who works on RNA and DNA vaccines at the University of Washington, said that work deserves a Nobel Prize.
  • messenger RNA posed a bigger challenge than other targets.“It’s tougher — it’s a much bigger molecule, it’s much more unstable,”
  • Unlike fields that were sparked by a single powerful insight, Sahin said that the recent success of messenger RNA vaccines is a story of countless improvements that turned an alluring biological idea into a beneficial technology.
  • “This is a field which benefited from hundreds of inventions,” said Sahin, who noted that when he started BioNTech in 2008, he cautioned investors that the technology would not yield a product for at least a decade. He kept his word: Until the coronavirus sped things along, BioNTech projected the launch of its first commercial project in 2023.
  • “It’s new to you,” Fuller said. “But for basic researchers, it’s been long enough. . . . Even before covid, everyone was talking: RNA, RNA, RNA.”
  • All vaccines are based on the same underlying idea: training the immune system to block a virus. Old-fashioned vaccines do this work by injecting dead or weakened viruses
  • ewer vaccines use distinctive bits of the virus, such as proteins on their surface, to teach the lesson. The latest genetic techniques, like messenger RNA, don’t take as long to develop because those virus bits don’t have to be generated in a lab. Instead, the vaccine delivers a genetic code that instructs cells to build those characteristic proteins themselves.
  • They wanted the immune system to learn to recognize the thumb tack spike, so McLellan tasked a scientist in his laboratory with identifying genetic mutations that could anchor the protein into the right configuration. It was a painstaking process for Nianshuang Wang, who now works at a biotechnology company, Regeneron Pharmaceuticals. After trying hundreds of genetic mutations, he found two that worked. Five journals rejected the finding, questioning its significance, before it was published in 2017.
  • That infection opened Graham’s eyes to an opportunity. HKU1 was merely a nuisance, as opposed to a deadly pneumonia; that meant it would be easier to work with in the lab, since researchers wouldn’t have to don layers of protective gear and work in a pressurized laboratory.
  • Severe acute respiratory syndrome had emerged in 2003. Middle East respiratory syndrome (MERS) broke out in 2012. It seemed clear to Graham and Jason McLellan, a structural biologist now at the University of Texas at Austin, that new coronaviruses were jumping into people on a 10-year-clock and it might be time to brace for the next one.
  • Last winter, when Graham heard rumblings of a new coronavirus in China, he brought the team back together. Once its genome was shared online by Chinese scientists, the laboratories in Texas and Maryland designed a vaccine, utilizing the stabilizing mutations and the knowledge they had gained from years of basic research — a weekend project thanks to the dividends of all that past work.
  • Graham needed a technology that could deliver it into the body — and had already been working with Moderna, using its messenger RNA technology to create a vaccine against a different bat virus, Nipah, as a dress rehearsal for a real pandemic. Moderna and NIH set the Nipah project aside and decided to go forward with a coronavirus vaccine.
  • On Jan. 13, Moderna’s Moore came into work and found her team already busy translating the stabilized spike protein into their platform. The company could start making the vaccine almost right away because of its experience manufacturing experimental cancer vaccines, which involves taking tumor samples and developing personalized vaccines in 45 days.
  • At BioNTech, Sahin said that even in the early design phases of its vaccine candidates, he incorporated the slight genetic changes designed in Graham’s lab that would make the spike look more like the real thing. At least two other companies would incorporate that same spike.
  • If all goes well with regulators, the coronavirus vaccines have the makings of a pharmaceutical industry fairy tale. The world faced an unparalleled threat, and companies leaped into the fight. Pfizer plowed $2 billion into the effort. Massive infusions of government cash helped remove the financial risks for Moderna.
  • But the world will also owe their existence to many scientists outside those companies, in government and academia who pursued ideas they thought were important even when the world doubted them
  • Some of those scientists will receive remuneration, since their inventions are licensed and integrated into the products that could save the world.
  • As executives become billionaires, many scientists think it is fair to earn money from their inventions that can help them do more important work. But McLellan’s laboratory at the University of Texas is proud to have licensed an even more potent version of their spike protein, royalty-free, to be incorporated into a vaccine for low and middle income countries.
  • “They’re using the technology that [Kariko] and I developed,” he said. “We feel like it’s our vaccine, and we are incredibly excited — at how well it’s going, and how it’s going to be used to get rid of this pandemic.”
  • “People hear about [vaccine progress] and think someone just thought about it that night. The amount of work — it’s really a beautiful story of fundamental basic research,” Fauci said. “It was chancy, in the sense that [the vaccine technology] was new. We were aware there would be pushback. The proof in the pudding is a spectacular success.”
  • The Vaccine Research Center, where Graham is deputy director, was the brainchild of Anthony S. Fauci, director of the National Institute of Allergy and Infectious Diseases. It was created in 1997 to bring together scientists and physicians from different disciplines to defeat diseases, with a heavy focus on HIV.
  • the pandemic wasn’t a sudden eureka moment — it was a catalyst that helped ignite lines of research that had been moving forward for years, far outside the spotlight of a global crisis.
Javier E

Don't Be Surprised About Facebook and Teen Girls. That's What Facebook Is. | Talking Po... - 0 views

talkingpointsmemo.com/...n-girls-thats-what-facebook-is

facebook instagram algorithm machine learning business model tobacco engagement addiction psychology brain science social media technology

shared by Javier E on 06 Oct 21 - No Cached
  • First, set aside all morality. Let’s say we have a 16 year old girl who’s been doing searches about average weights, whether boys care if a girl is overweight and maybe some diets. She’s also spent some time on a site called AmIFat.com. Now I set you this task. You’re on the other side of the Facebook screen and I want you to get her to click on as many things as possible and spend as much time clicking or reading as possible. Are you going to show her movie reviews? Funny cat videos? Homework tips? Of course, not.
  • If you’re really trying to grab her attention you’re going to show her content about really thin girls, how their thinness has gotten them the attention of boys who turn out to really love them, and more diets
  • We both know what you’d do if you were operating within the goals and structure of the experiment.
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  • This is what artificial intelligence and machine learning are. Facebook is a series of algorithms and goals aimed at maximizing engagement with Facebook. That’s why it’s worth hundreds of billions of dollars. It has a vast army of computer scientists and programmers whose job it is to make that machine more efficient.
  • the Facebook engine is designed to scope you out, take a psychographic profile of who you are and then use its data compiled from literally billions of humans to serve you content designed to maximize your engagement with Facebook.
  • Put in those terms, you barely have a chance.
  • Of course, Facebook can come in and say, this is damaging so we’re going to add some code that says don’t show this dieting/fat-shaming content but girls 18 and under. But the algorithms will find other vulnerabilities
  • So what to do? The decision of all the companies, if not all individuals, was just to lie. What else are you going to do? Say we’re closing down our multi-billion dollar company because our product shouldn’t exist?
  • why exactly are you creating a separate group of subroutines that yanks Facebook back when it does what it’s supposed to do particularly well? This, indeed, was how the internal dialog at Facebook developed, as described in the article I read. Basically, other executives said: Our business is engagement, why are we suggesting people log off for a while when they get particularly engaged?
  • what it makes me think about more is the conversations at Tobacco companies 40 or 50 years ago. At a certain point you realize: our product is bad. If used as intended it causes lung cancer, heart disease and various other ailments in a high proportion of the people who use the product. And our business model is based on the fact that the product is chemically addictive. Our product is getting people addicted to tobacco so that they no longer really have a choice over whether to buy it. And then a high proportion of them will die because we’ve succeeded.
  • . The algorithms can be taught to find and address an infinite numbers of behaviors. But really you’re asking the researchers and programmers to create an alternative set of instructions where Instagram (or Facebook, same difference) jumps in and does exactly the opposite of its core mission, which is to drive engagement
  • You can add filters and claim you’re not marketing to kids. But really you’re only ramping back the vast social harm marginally at best. That’s the product. It is what it is.
  • there is definitely an analogy inasmuch as what you’re talking about here aren’t some glitches in the Facebook system. These aren’t some weird unintended consequences that can be ironed out of the product. It’s also in most cases not bad actors within Facebook. It’s what the product is. The product is getting attention and engagement against which advertising is sold
  • How good is the machine learning? Well, trial and error with between 3 and 4 billion humans makes you pretty damn good. That’s the product. It is inherently destructive, though of course the bad outcomes aren’t distributed evenly throughout the human population.
  • The business model is to refine this engagement engine, getting more attention and engagement and selling ads against the engagement. Facebook gets that revenue and the digital roadkill created by the product gets absorbed by the society at large
  • Facebook is like a spectacularly profitable nuclear energy company which is so profitable because it doesn’t build any of the big safety domes and dumps all the radioactive waste into the local river.
  • in the various articles describing internal conversations at Facebook, the shrewder executives and researchers seem to get this. For the company if not every individual they seem to be following the tobacco companies’ lead.
  • Ed. Note: TPM Reader AS wrote in to say I was conflating Facebook and Instagram and sometimes referring to one or the other in a confusing way. This is a fair
  • I spoke of them as the same intentionally. In part I’m talking about Facebook’s corporate ownership. Both sites are owned and run by the same parent corporation and as we saw during yesterday’s outage they are deeply hardwired into each other.
  • the main reason I spoke of them in one breath is that they are fundamentally the same. AS points out that the issues with Instagram are distinct because Facebook has a much older demographic and Facebook is a predominantly visual medium. (Indeed, that’s why Facebook corporate is under such pressure to use Instagram to drive teen and young adult engagement.) But they are fundamentally the same: AI and machine learning to drive engagement. Same same. Just different permutations of the same dynamic.
Javier E

Opinion | What College Students Need Is a Taste of the Monk's Life - The New York Times - 0 views

www.nytimes.com/...ental-health-smart-phones.html

ultimate question cognitive resilience courses technology dependence purpose mission monastery distraction education learning knowledge

shared by Javier E on 26 May 23 - No Cached
  • When she registered last fall for the seminar known around campus as the monk class, she wasn’t sure what to expect.
  • “You give up technology, and you can’t talk for a month,” Ms. Rodriguez told me. “That’s all I’d heard. I didn’t know why.” What she found was a course that challenges students to rethink the purpose of education, especially at a time when machine learning is getting way more press than the human kind.
  • Each week, students would read about a different monastic tradition and adopt some of its practices. Later in the semester, they would observe a one-month vow of silence (except for discussions during Living Deliberately) and fast from technology, handing over their phones to him.
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  • Yes, he knew they had other classes, jobs and extracurriculars; they could make arrangements to do that work silently and without a computer.
  • The class eased into the vow of silence, first restricting speech to 100 words a day. Other rules began on Day 1: no jewelry or makeup in class. Men and women sat separately and wore different “habits”: white shirts for the men, women in black. (Nonbinary and transgender students sat with the gender of their choice.)
  • Dr. McDaniel discouraged them from sharing personal information; they should get to know one another only through ideas. “He gave us new names, based on our birth time and day, using a Thai birth chart,”
  • “We were practicing living a monastic life. We had to wake up at 5 a.m. and journal every 30 minutes.”
  • If you tried to cruise to a C, you missed the point: “I realized the only way for me to get the most out of this class was to experience it all,” she said. (She got Dr. McDaniel’s permission to break her vow of silence in order to talk to patients during her clinical rotation.)
  • Dr. McDaniel also teaches a course called Existential Despair. Students meet once a week from 5 p.m. to midnight in a building with comfy couches, turn over their phones and curl up to read an assigned novel (cover to cover) in one sitting — books like James Baldwin’s “Giovanni’s Room” and José Saramago’s “Blindness.” Then they stay up late discussing it.
  • The course is not about hope, overcoming things, heroic stories,” Dr. McDaniel said. Many of the books “start sad. In the middle they’re sad. They stay sad. I’m not concerned with their 20-year-old self. I’m worried about them at my age, dealing with breast cancer, their dad dying, their child being an addict, a career that never worked out — so when they’re dealing with the bigger things in life, they know they’re not alone.”
  • Both courses have long wait lists. Students are hungry for a low-tech, introspective experience —
  • Research suggests that underprivileged young people have far fewer opportunities to think for unbroken stretches of time, so they may need even more space in college to develop what social scientists call cognitive endurance.
  • Yet the most visible higher ed trends are moving in the other direction
  • Rather than ban phones and laptops from class, some professors are brainstorming ways to embrace students’ tech addictions with class Facebook and Instagram accounts, audience response apps — and perhaps even including the friends and relatives whom students text during class as virtual participants in class discussion.
  • Then there’s that other unwelcome classroom visitor: artificial intelligence.
  • stop worrying and love the bot by designing assignments that “help students develop their prompting skills” or “use ChatGPT to generate a first draft,” according to a tip sheet produced by the Center for Teaching and Learning at Washington University in St. Louis.
  • It’s not at all clear that we want a future dominated by A.I.’s amoral, Cheez Whiz version of human thought
  • It is abundantly clear that texting, tagging and chatbotting are making students miserable right now.
  • One recent national survey found that 60 percent of American college students reported the symptoms of at least one mental health problem and that 15 percent said they were considering suicide
  • A recent meta-analysis of 36 studies of college students’ mental health found a significant correlation between longer screen time and higher risk of anxiety and depression
  • And while social media can sometimes help suffering students connect with peers, research on teenagers and college students suggests that overall, the support of a virtual community cannot compensate for the vortex of gossip, bullying and Instagram posturing that is bound to rot any normal person’s self-esteem.
  • We need an intervention: maybe not a vow of silence but a bold move to put the screens, the pinging notifications and creepy humanoid A.I. chatbots in their proper place
  • it does mean selectively returning to the university’s roots in the monastic schools of medieval Europe and rekindling the old-fashioned quest for meaning.
  • Colleges should offer a radically low-tech first-year program for students who want to apply: a secular monastery within the modern university, with a curated set of courses that ban glowing rectangles of any kind from the classroom
  • Students could opt to live in dorms that restrict technology, too
  • I prophesy that universities that do this will be surprised by how much demand there is. I frequently talk to students who resent the distracting laptops all around them during class. They feel the tug of the “imaginary string attaching me to my phone, where I have to constantly check it,”
  • Many, if not most, students want the elusive experience of uninterrupted thought, the kind where a hash of half-baked notions slowly becomes an idea about the world.
  • Even if your goal is effective use of the latest chatbot, it behooves you to read books in hard copies and read enough of them to learn what an elegant paragraph sounds like. How else will students recognize when ChatGPT churns out decent prose instead of bureaucratic drivel?
  • Most important, students need head space to think about their ultimate values.
  • His course offers a chance to temporarily exchange those unconscious structures for a set of deliberate, countercultural ones.
  • here are the student learning outcomes universities should focus on: cognitive endurance and existential clarity.
  • Contemplation and marathon reading are not ends in themselves or mere vacations from real life but are among the best ways to figure out your own answer to the question of what a human being is for
  • When students finish, they can move right into their area of specialization and wire up their skulls with all the technology they want, armed with the habits and perspective to do so responsibly
  • it’s worth learning from the radicals. Dr. McDaniel, the religious studies professor at Penn, has a long history with different monastic traditions. He grew up in Philadelphia, educated by Hungarian Catholic monks. After college, he volunteered in Thailand and Laos and lived as a Buddhist monk.
  • e found that no amount of academic reading could help undergraduates truly understand why “people voluntarily take on celibacy, give up drinking and put themselves under authorities they don’t need to,” he told me. So for 20 years, he has helped students try it out — and question some of their assumptions about what it means to find themselves.
  • “On college campuses, these students think they’re all being individuals, going out and being wild,” he said. “But they’re in a playpen. I tell them, ‘You know you’ll be protected by campus police and lawyers. You have this entire apparatus set up for you. You think you’re being an individual, but look at your four friends: They all look exactly like you and sound like you. We exist in these very strict structures we like to pretend don’t exist.’”
  • Colleges could do all this in classes integrated with general education requirements: ideally, a sequence of great books seminars focused on classic texts from across different civilizations.
  • “For the last 1,500 years, Benedictines have had to deal with technology,” Placid Solari, the abbot there, told me. “For us, the question is: How do you use the tool so it supports and enhances your purpose or mission and you don’t get owned by it?”
  • for novices at his monastery, “part of the formation is discipline to learn how to control technology use.” After this initial time of limited phone and TV “to wean them away from overdependence on technology and its stimulation,” they get more access and mostly make their own choices.
  • Evan Lutz graduated this May from Belmont Abbey with a major in theology. He stressed the special Catholic context of Belmont’s resident monks; if you experiment with monastic practices without investigating the whole worldview, it can become a shallow kind of mindfulness tourism.
  • The monks at Belmont Abbey do more than model contemplation and focus. Their presence compels even non-Christians on campus to think seriously about vocation and the meaning of life. “Either what the monks are doing is valuable and based on something true, or it’s completely ridiculous,” Mr. Lutz said. “In both cases, there’s something striking there, and it asks people a question.”
  • Pondering ultimate questions and cultivating cognitive endurance should not be luxury goods.
  • David Peña-Guzmán, who teaches philosophy at San Francisco State University, read about Dr. McDaniel’s Existential Despair course and decided he wanted to create a similar one. He called it the Reading Experiment. A small group of humanities majors gathered once every two weeks for five and a half hours in a seminar room equipped with couches and a big round table. They read authors ranging from Jean-Paul Sartre to Frantz Fanon
  • “At the beginning of every class I’d ask students to turn off their phones and put them in ‘the Basket of Despair,’ which was a plastic bag,” he told me. “I had an extended chat with them about accessibility. The point is not to take away the phone for its own sake but to take away our primary sources of distraction. Students could keep the phone if they needed it. But all of them chose to part with their phones.”
  • Dr. Peña-Guzmán’s students are mostly working-class, first-generation college students. He encouraged them to be honest about their anxieties by sharing his own: “I said, ‘I’m a very slow reader, and it’s likely some or most of you will get further in the text than me because I’m E.S.L. and read quite slowly in English.’
  • For his students, the struggle to read long texts is “tied up with the assumption that reading can happen while multitasking and constantly interacting with technologies that are making demands on their attention, even at the level of a second,”
  • “These draw you out of the flow of reading. You get back to the reading, but you have to restart the sentence or even the paragraph. Often, because of these technological interventions into the reading experience, students almost experience reading backward — as constant regress, without any sense of progress. The more time they spend, the less progress they make.”
  • Dr. Peña-Guzmán dismissed the idea that a course like his is suitable only for students who don’t have to worry about holding down jobs or paying off student debt. “I’m worried by this assumption that certain experiences that are important for the development of personality, for a certain kind of humanistic and spiritual growth, should be reserved for the elite, especially when we know those experiences are also sources of cultural capital,
  • Courses like the Reading Experiment are practical, too, he added. “I can’t imagine a field that wouldn’t require some version of the skill of focused attention.”
  • The point is not to reject new technology but to help students retain the upper hand in their relationship with i
  • Ms. Rodriguez said that before she took Living Deliberately and Existential Despair, she didn’t distinguish technology from education. “I didn’t think education ever went without technology. I think that’s really weird now. You don’t need to adapt every piece of technology to be able to learn better or more,” she said. “It can form this dependency.”
  • The point of college is to help students become independent humans who can choose the gods they serve and the rules they follow rather than allow someone else to choose for them
  • The first step is dethroning the small silicon idol in their pocket — and making space for the uncomfortable silence and questions that follow
Javier E

For Chat-Based AI, We Are All Once Again Tech Companies' Guinea Pigs - WSJ - 0 views

www.wsj.com/...-are-tech-guinea-pigs-647d827b

ai chatbot generative experiment evaluation justification debate

shared by Javier E on 27 Feb 23 - No Cached
  • The companies touting new chat-based artificial-intelligence systems are running a massive experiment—and we are the test subjects.
  • In this experiment, Microsoft, MSFT -2.18% OpenAI and others are rolling out on the internet an alien intelligence that no one really understands, which has been granted the ability to influence our assessment of what’s true in the world. 
  • Companies have been cautious in the past about unleashing this technology on the world. In 2019, OpenAI decided not to release an earlier version of the underlying model that powers both ChatGPT and the new Bing because the company’s leaders deemed it too dangerous to do so, they said at the time.
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  • Microsoft leaders felt “enormous urgency” for it to be the company to bring this technology to market, because others around the world are working on similar tech but might not have the resources or inclination to build it as responsibly, says Sarah Bird, a leader on Microsoft’s responsible AI team.
  • One common starting point for such models is what is essentially a download or “scrape” of most of the internet. In the past, these language models were used to try to understand text, but the new generation of them, part of the revolution in “generative” AI, uses those same models to create texts by trying to guess, one word at a time, the most likely word to come next in any given sequence.
  • Wide-scale testing gives Microsoft and OpenAI a big competitive edge by enabling them to gather huge amounts of data about how people actually use such chatbots. Both the prompts users input into their systems, and the results their AIs spit out, can then be fed back into a complicated system—which includes human content moderators paid by the companies—to improve it.
  • , being first to market with a chat-based AI gives these companies a huge initial lead over companies that have been slower to release their own chat-based AIs, such as Google.
  • rarely has an experiment like Microsoft and OpenAI’s been rolled out so quickly, and at such a broad scale.
  • Among those who build and study these kinds of AIs, Mr. Altman’s case for experimenting on the global public has inspired responses ranging from raised eyebrows to condemnation.
  • The fact that we’re all guinea pigs in this experiment doesn’t mean it shouldn’t be conducted, says Nathan Lambert, a research scientist at the AI startup Huggingface.
  • “I would kind of be happier with Microsoft doing this experiment than a startup, because Microsoft will at least address these issues when the press cycle gets really bad,” says Dr. Lambert. “I think there are going to be a lot of harms from this kind of AI, and it’s better people know they are coming,” he adds.
  • Others, particularly those who study and advocate for the concept of “ethical AI” or “responsible AI,” argue that the global experiment Microsoft and OpenAI are conducting is downright dangerous
  • Celeste Kidd, a professor of psychology at University of California, Berkeley, studies how people acquire knowledge
  • Her research has shown that people learning about new things have a narrow window in which they form a lasting opinion. Seeing misinformation during this critical initial period of exposure to a new concept—such as the kind of misinformation that chat-based AIs can confidently dispense—can do lasting harm, she says.
  • Dr. Kidd likens OpenAI’s experimentation with AI to exposing the public to possibly dangerous chemicals. “Imagine you put something carcinogenic in the drinking water and you were like, ‘We’ll see if it’s carcinogenic.’ After, you can’t take it back—people have cancer now,”
  • Part of the challenge with AI chatbots is that they can sometimes simply make things up. Numerous examples of this tendency have been documented by users of both ChatGPT and OpenA
  • These models also tend to be riddled with biases that may not be immediately apparent to users. For example, they can express opinions gleaned from the internet as if they were verified facts
  • When millions are exposed to these biases across billions of interactions, this AI has the potential to refashion humanity’s views, at a global scale, says Dr. Kidd.
  • OpenAI has talked publicly about the problems with these systems, and how it is trying to address them. In a recent blog post, the company said that in the future, users might be able to select AIs whose “values” align with their own.
  • “We believe that AI should be a useful tool for individual people, and thus customizable by each user up to limits defined by society,” the post said.
  • Eliminating made-up information and bias from chat-based search engines is impossible given the current state of the technology, says Mark Riedl, a professor at Georgia Institute of Technology who studies artificial intelligence
  • He believes the release of these technologies to the public by Microsoft and OpenAI is premature. “We are putting out products that are still being actively researched at this moment,” he adds. 
  • in other areas of human endeavor—from new drugs and new modes of transportation to advertising and broadcast media—we have standards for what can and cannot be unleashed on the public. No such standards exist for AI, says Dr. Riedl.
  • To modify these AIs so that they produce outputs that humans find both useful and not-offensive, engineers often use a process called “reinforcement learning through human feedback.
  • that’s a fancy way of saying that humans provide input to the raw AI algorithm, often by simply saying which of its potential responses to a query are better—and also which are not acceptable at all.
  • Microsoft’s and OpenAI’s globe-spanning experiments on millions of people are yielding a fire hose of data for both companies. User-entered prompts and the AI-generated results are fed back through a network of paid human AI trainers to further fine-tune the models,
  • Huggingface’s Dr. Lambert says that any company, including his own, that doesn’t have this river of real-world usage data helping it improve its AI is at a huge disadvantage
  • In chatbots, in some autonomous-driving systems, in the unaccountable AIs that decide what we see on social media, and now, in the latest applications of AI, again and again we are the guinea pigs on which tech companies are testing new technology.
  • It may be the case that there is no other way to roll out this latest iteration of AI—which is already showing promise in some areas—at scale. But we should always be asking, at times like these: At what price?
Javier E

Synthetic Thinking | Jerome Groopman | The New York Review of Books - 0 views

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medicine political theory writing synthesis progress adaptation identity

shared by Javier E on 27 Apr 24 - No Cached
  • Did you hope to combine chemistry and political philosophy in some way in your medical career?
  • Chemistry requires synthetic thinking. You have to bring disparate pieces of knowledge together in order to look for a chemical structure. Political philosophy, to some degree, also involves disparate aspects of knowledge: economics, sociology, history, pure philosophy
  • I found that in medicine, you don’t have an answer when you start out. You’re looking for clues that are often distributed in different places: family history, as there might be a genetic predisposition; social history, because the person smoked or was exposed to a toxin; the physical examination, where you find that an organ might be disordered. Add to that the blood test, the CAT scan, all of it, but most importantly, the person, the psychology of the person you’re dealing with. It’s the same kind of synthetic process as political philosophy, but in a different dimension.
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  • Writing, especially the kind of writing that I do, brings together narrative, science, sometimes history, and an appreciation for the person who might be at the center of the narrative.
  • The greatest influence on me was Oliver Sacks, because he could capture people as people, and he always integrated serious science into his pieces.
  • The two subjects that were most prominent for him, as I once wrote for you, were identity and adaptation: Who is this person, despite their illness? How does that illness interface with their behavior and their decisions, how do people perceive them from the outside, and how do they try to find meaning and adapt to what looks like a disability, but sometimes—not always, but sometimes—gives them hidden strength?
  • I’ve gone from witnessing the depths of disability and death, like with AIDS: I saw some of the first people with AIDS in California, in 1982 or so. The average lifespan was six months. They were mostly young gay men, and it was devastating, the infections they got, the cancers they got. Now, with all the new drugs that have been developed, someone who gets HIV is projected to have a normal lifespan. From six months to fifty years: it’s miraculous
  • that’s part of what keeps you going: the belief that things can advance in a meaningful way.
  • Are there any major or interesting medical stories that the public doesn’t know enough about? 
  • The idea of genetic treatments. Often when people hear the words “genetics” or “DNA” or “RNA,” they shut down. The challenge is how to make it accessible.
  • There’s a wonderful line in the Talmud that says, “Whoever saves a single life saves the whole world.” There might be only a few hundred people in the whole country who have a particular genetic disorder. I
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