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Just as the loss of a species decreases the richness of an ecosystem, the addition of new animals could achieve the opposite effect.

National Geographic Society hosted a larger conference to debate the scientific and ethical questions raised by the prospect of “de-extinction.

“De-extinction went from concept to potential reality right before our eyes,

less scientific, if more persuasive, argument was advanced by the ethicist Hank Greely and the law professor Jacob Sherkow, both of Stanford. De-extinction should be pursued, they argued in a paper published in Science, because it would be really

“This may be the biggest attraction and possibly the biggest benefit of de-extinction. It would surely be very cool to see a living woolly mammoth.”

They will replace chunks of band-tailed-pigeon DNA with synthesized chunks of passenger-pigeon DNA, until the cell’s genome matches their working passenger-pigeon genome.

Scientists predict that changes made by human beings to the composition of the atmosphere could kill off a quarter of the planet’s mammal species, a fifth of its reptiles and a sixth of its birds by 2050

This cloning method, called somatic cell nuclear transfer, can be used only on species for which we have cellular material.

There is a shortcut. The genome of a closely related species will have a high proportion of identical DNA, so it can serve as a blueprint, or “scaffold.”

By comparing the fragments of passenger-pigeon DNA with the genomes of similar species, researchers can assemble an approximation of an actual passenger-pigeon genome.

As with any translation, there may be errors of grammar, clumsy phrases and perhaps a few missing passages, but the book will be legible. It should, at least, tell a good story.

the genome will have to be inscribed into a living cell.

“We’ve framed it in terms of conservation,”

MAGE (Multiplex Automated Genome Engineering). MAGE is nicknamed the “evolution machine” because it can introduce the equivalent of millions of years of genetic mutations within minutes

Developmental and behavioral biologists would take over, just in time to answer some difficult questions. Chicks imitate their parents’ behavior. How do you raise a passenger pigeon without parents of its own species? And how do you train band-tailed pigeons to nurture the strange spawn that emerge from their eggs; chicks that, to them, might seem monstrous: an avian Rosemary’s Baby?

For endangered species with tiny populations, scientists would introduce genetic diversity to offset inbreeding.

They will try to alter the birds’ diets, migration habits and environment. The behavior of each subsequent generation will more closely resemble that of their genetic cousins.

For species threatened by contagion, an effort would be made to fortify their DNA with genes that make them disease-resistant

The scientific term for this type of genetic intervention is “facilitated adaptation.”

This optimistic, soft-focus fantasy of de-extinction, while thrilling to Ben Novak, is disturbing to many conservation biologists, who consider it a threat to their entire discipline and even to the environmental movement.

The first question posed by conservationists addresses the logic of bringing back an animal whose native habitat has disappeared. Why go through all the trouble just to have the animal go extinct all over again?

There is also anxiety about disease

“If you recreate a species genetically and release it, and that genotype is based on a bird from a 100-year-old environment, you probably will increase risk.”

“There’s always this fear that somehow, if we do it, we’re going to accidentally make something horrible, because only nature can really do it right. But nature is totally random. Nature makes monsters. Nature makes threats. Many of the things that are most threatening to us are a product of nature. Revive & Restore is not going to tip the balance in any way.”

De-extinction also poses a rhetorical threat to conservation biologists. The specter of extinction has been the conservation movement’s most powerful argument. What if extinction begins to be seen as a temporary inconvenience?

De-extinction suggests that we can technofix our way out of environmental issues generally, and that’s very, very bad.

How will we decide which species to resurrect?

Philip Seddon recently published a 10-point checklist to determine the suitability of any species for revival, taking into account causes of its extinction, possible threats it might face upon resurrection and man’s ability to destroy the species “in the event of unacceptable ecological or socioeconomic impacts.”

But the most visceral argument against de-extinction is animal cruelty.

“Is it fair to do this to these animals?” Shapiro asked. “Is ‘because we feel guilty’ a good-enough reason?” Stewart Brand made a utilitarian counterargument: “We’re going to go through some suffering, because you try a lot of times, and you get ones that don’t take. On the other hand, if you can bring bucardos back, then how many would get to live that would not have gotten to live?”

In “How to Permit Your Mammoth,” published in The Stanford Environmental Law Journal, Norman F. Carlin asks whether revived species should be protected by the Endangered Species Act or regulated as a genetically modified organism.

He concludes that revived species, “as products of human ingenuity,” should be eligible for patenting.

The term “de-extinction” is misleading. Passenger pigeons will not rise from the grave

Our understanding of the passenger pigeon’s behavior derives entirely from historical accounts.

There is no authoritative definition of “species.” The most widely accepted definition describes a group of organisms that can procreate with one another and produce fertile offspring, but there are many exceptions.

Theseus’ ship, therefore, “became a standing example among the philosophers . . . one side holding that the ship remained the same, and the other contending that it was not the same.”

What is coming will go well beyond the resurrection of extinct species. For millenniums, we have customized our environment, our vegetables and our animals, through breeding, fertilization and pollination. Synthetic biology offers far more sophisticated tools. The creation of novel organisms, like new animals, plants and bacteria, will transform human medicine, agriculture, energy production and much else.

This kind of modeling is already in use to study individual cellular processes like metabolism. But Dr. Covert said: “Where I think our work is different is that we explicitly include all of the genes and every known gene function. There’s no one else out there who has been able to include more than a handful of functions or more than, say, one-third of the genes.”

The simulation, which runs on a cluster of 128 computers, models the complete life span of the cell at the molecular level, charting the interactions of 28 categories of molecules — including DNA, RNA, proteins and small molecules known as metabolites, which are generated by cell processes.

They called the simulation an important advance in the new field of computational biology, which has recently yielded such achievements as the creation of a synthetic life form — an entire bacterial genome created by a team led by the genome pioneer J. Craig Venter. The scientists used it to take over an existing cell.

A decade ago, scientists developed simulations of metabolism that are now being used to study a wide array of cells, including bacteria, yeast and photosynthetic organisms. Other models exist for processes like protein synthesis.

“Right now, running a simulation for a single cell to divide only one time takes around 10 hours and generates half a gigabyte of data,” Dr. Covert wrote. “I find this fact completely fascinating, because I don’t know that anyone has ever asked how much data a living thing truly holds. We often think of the DNA as the storage medium, but clearly there is more to it than that.”

scientists chose an approach called object-oriented programming, which parallels the design of modern software systems. Software designers organize their programs in modules, which communicate with one another by passing data and instructions back and forth.

“The major modeling insight we had a few years ago was to break up the functionality of the cell into subgroups, which we could model individually, each with its own mathematics, and then to integrate these submodels together into a whole,”

At this point the idealist swooshes in: ladies and gentlemen, there is nothing but mind! There is no problem of interaction with matter because matter is mere illusion

idealism has its charms but taking it seriously requires an antipathy to matter bordering on the maniacal. Are we to suppose that material reality is just a dream, a baseless fantasy, and that the Big Bang was nothing but the cosmic spirit having a mental sneezing fit?

pan­psychism: even the lowliest of material things has a streak of sentience running through it, like veins in marble. Not just parcels of organic matter, such as lizards and worms, but also plants and bacteria and water molecules and even electrons. Everything has its primitive feelings and minute allotment of sensation.

The trouble with panpsychism is that there just isn't any evidence of the universal distribution of consciousness in the material world.

The dualist, by contrast, freely admits that consciousness exists, as well as matter, holding that reality falls into two giant spheres. There is the physical brain, on the one hand, and the conscious mind, on the other: the twain may meet at some point but they remain distinct entities.

The more we know of the brain, the less it looks like a device for creating consciousness: it's just a big collection of biological cells and a blur of electrical activity - all machine and no ghost.

mystery is quite pervasive, even in the hardest of sciences. Physics is a hotbed of mystery: space, time, matter and motion - none of it is free of mysterious elements. The puzzles of quantum theory are just a symptom of this widespread lack of understanding

The human intellect grasps the natural world obliquely and glancingly, using mathematics to construct abstract representations of concrete phenomena, but what the ultimate nature of things really is remains obscure and hidden. How everything fits together is particularly elusive, perhaps reflecting the disparate cognitive faculties we bring to bear on the world (the senses, introspection, mathematical description). We are far from obtaining a unified theory of all being and there is no guarantee that such a theory is accessible by finite human intelligence.

real naturalism begins with a proper perspective on our specifically human intelligence. Palaeoanthropologists have taught us that the human brain gradually evolved from ancestral brains, particularly in concert with practical toolmaking, centring on the anatomy of the human hand. This history shaped and constrained the form of intelligence now housed in our skulls (as the lifestyle of other species form their set of cognitive skills). What chance is there that an intelligence geared to making stone tools and grounded in the contingent peculiarities of the human hand can aspire to uncover all the mysteries of the universe? Can omniscience spring from an opposable thumb? It seems unlikely, so why presume that the mysteries of consciousness will be revealed to a thumb-shaped brain like ours?

The "mysterianism" I advocate is really nothing more than the acknowledgment that human intelligence is a local, contingent, temporal, practical and expendable feature of life on earth - an incremental adaptation based on earlier forms of intelligence that no one would reg

rd as faintly omniscient. The current state of the philosophy of mind, from my point of view, is just a reflection of one evolutionary time-slice of a particular bipedal species on a particular humid planet at this fleeting moment in cosmic history - as is everything else about the human animal. There is more ignorance in it than knowledge.

Way added that there might be other reasons why newborns should carry immunosuppressive cells

Baby formulas contain small amounts of arginine. Sidney Morris, a biochemist from the University of Pittsburgh, said that it may be important to avoid fortifying them with extra arginine, lest it swamps the arginase activity of CD71+ cells, releases the immune system, and causes problems for the developing infants’ guts.

“Whether the precise mechanism of immunosuppression is the same or different in each of these circumstances remains to be determined,” he said.

giving

he suffers from “auto-brewery syndrome”

“The problem arises when the yeast in our gut gets out of hand. Bacteria normally keep the yeast in check, but sometimes the yeast takes over.”

The team combines 1,200 scientists from 52 countries in disciplines ranging from geology and microbiology to chemistry and physics.

The results suggest 70% of Earth’s bacteria and archaea exist in the subsurface

“The strangest thing for me is that some organisms can exist for millennia. They are metabolically active but in stasis, with less energy than we thought possible of supporting life.”

Some microorganisms have been alive for thousands of years, barely moving except with shifts in the tectonic plates, earthquakes or eruption

these organisms are part of slow, persistent cycles on geological timescales.”

Underworld biospheres vary depending on geology and geography. Their combined size is estimated to be more than 2bn cubic kilometres, but this could be expanded further in the future

The researchers said their discoveries were made possible by two technical advances: drills that can penetrate far deeper below the Earth’s crust, and improvements in microscopes that allow life to be detected at increasingly minute levels.

The scientists have been trying to find a lower limit beyond which life cannot exist, but the deeper they dig the more life they find. There is a temperature maximum – currently 122C – but the researchers believe this record will be broken if they keep exploring and developing more sophisticated instruments.

Robert Hazen, a mineralogist at the Carnegie Institution for Science, said: “We must ask ourselves: if life on Earth can be this different from what experience has led us to expect, then what strangeness might await as we probe for life on other worlds?”

it’s unclear whether infectious virus can persist in blood or stool

the infection can spread through the mucous membranes, from the nose down to the rectum.

while the virus appears to zero in on the lungs, it may also be able to infect cells in the gastrointestinal system, experts say. This may be why some patients have symptoms like diarrhea or indigestion

“The virus will actually land on organs like the heart, the kidney, the liver, and may cause some direct damage to those organs,

some patients in China recovered but got sick again, apparently because they had damaged and vulnerable lung tissue that was subsequently attacked by bacteria in their body.

As the body’s immune system shifts into high gear to battle the infection, the resulting inflammation may cause those organs to malfunction, he said.

About 80 percent of people infected with the new coronavirus have relatively mild symptoms. But about 20 percent of people become more seriously ill and in about 2 percent of patients in China, which has had the most cases, the disease has been fatal.

the effects appear to depend on how robust or weakened a person’s immune system is. Older people or those with underlying health issues, like diabetes or another chronic illness, are more likely to develop severe symptoms

the course a patient’s coronavirus will take is not yet fully understood.

Some patients can remain stable for over a week and then suddenly develop pneumonia, Dr. Diaz said. Some patients seem to recover but then develop symptoms again.

more than half of 121 patients in China had normal CT scans early in their disease.

Coronavirus particles have spiked proteins sticking out from their surfaces, and these spikes hook onto cell membranes, allowing the virus’s genetic material to enter the human cell.

That genetic material proceeds to “hijack the metabolism of the cell and say, in effect, ‘Don’t do your usual job. Your job now is to help me multiply and make the virus,’

As copies of the virus multiply, they burst out and infect neighboring cells. The symptoms often start in the back of the throat with a sore throat and a dry cough.

The virus then “crawls progressively down the bronchial tubes,”

That can damage the alveoli or lung sacs and they have to work harder to carry out their function of supplying oxygen to the blood

The swelling and the impaired flow of oxygen can cause those areas in the lungs to fill with fluid, pus and dead cells. Pneumonia, an infection in the lung, can occur

Some people have so much trouble breathing they need to be put on a ventilator

One way alcohol may lead to cancer is because the body metabolizes it into acetaldehyde, which causes changes and mutations in DNA, Dr. Gapstur said. The formation of acetaldehyde starts when alcohol comes in contact with bacteria in the mouth, which may explain the link between alcohol and cancers of the throat, voice box and esophagus

These devices can measure a person’s temperature, heart rate, level of activity and other biometrics. With this information, researchers have been able to track and detect COVID-19 infections even before people notice they have any symptoms.

Wearables can detect symptoms of COVID-19 or other illnesses before symptoms are noticeable. While they have proved to be capable of detecting sickness early, the symptoms wearables detect are not unique to COVID-19.

So a logical way to look for new drugs to treat a specific disease is to study individual genes and proteins that are directly affected by that disease.

But this idea of mapping the protein interactions of diseases to look for novel drug targets doesn’t apply just to the coronavirus. We have now used this approach on other pathogens as well as other diseases including cancer, neurodegenerative and psychiatric disorders.

Studies with a popular laboratory model, the nematode Caenorhabditis elegans, have revealed a possible therapeutic avenue for a rare but deadly condition in which children are born without the ability to make molybdenum cofactor (Moco) on their own

Moco is essential for life

This suggests that such protein-Moco complexes could be used as a treatment for Moco deficiency in people.

C. elegans

The researchers found that the worms could take in Moco as a range of purified Moco-protein complexes. These included complexes with proteins from bacteria, bread mold, green algae and cow's milk. Ingesting these complexes saved the Moco-deficient worms.

"We do not want to overstate our findings, especially as they relate to patients, but we are extremely excited about the therapeutic and fundamental implications of this work."

All of your devices emit short wavelength light, known as blue light. A Harvard study claimed that exposure to blue light before bed decreases natural melatonin production, a hormone that regulates sleep. The brightness from your phone screen can interrupt your natural circadian rhythm, and cause for shorter REM cycles and overall restless sleep.

With a constant influx of information grabbing your attention, it can put pressure on you to have your phone on you at all times to stay informed. Researchers agreed, telling The Chicago Tribune that the possibility of missing something if you don’t keep your phone nearby can induce a feeling of stress and anxiety. 

Remember the blue light? The cornea and lens can’t filter it, so the light goes to the back of the eye, which can weaken vision over time.

Though social media can be fun entertainment, it can also open up the door for harmful comparison. Being able to keep up to date with someone else’s success (or pitfalls) invites the opportunity for you to compare your life to theirs. That can invoke a feeling of inadequacy and unhappiness, according to Psychology Today

In November 2020, the AI group DeepMind announced it had developed a program called AlphaFold that could rapidly predict this information using an algorithm. Since then, it has been crunching through the genetic codes of every organism that has had its genome sequenced, and predicting the structures of the hundreds of millions of proteins they collectively contain.

Last year, DeepMind published the protein structures for 20 species – including nearly all 20,000 proteins expressed by humans – on an open database. Now it has finished the job, and released predicted structures for more than 200m proteins.

“Essentially, you can think of it as covering the entire protein universe. It includes predictive structures for plants, bacteria, animals, and many other organisms, opening up huge new opportunities for AlphaFold to have an impact on important issues, such as sustainability, food insecurity, and neglected diseases,”

In May, researchers led by Prof Matthew Higgins at the University of Oxford announced they had used AlphaFold’s models to help determine the structure of a key malaria parasite protein, and work out where antibodies that could block transmission of the parasite were likely to bind.

“Previously, we’d been using a technique called protein crystallography to work out what this molecule looks like, but because it’s quite dynamic and moves around, we just couldn’t get to grips with it,” Higgins said. “When we took the AlphaFold models and combined them with this experimental evidence, suddenly it all made sense. This insight will now be used to design improved vaccines which induce the most potent transmission-blocking antibodies.”

AlphaFold’s models are also being used by scientists at the University of Portsmouth’s Centre for Enzyme Innovation, to identify enzymes from the natural world that could be tweaked to digest and recycle plastics. “It took us quite a long time to go through this massive database of structures, but opened this whole array of new three-dimensional shapes we’d never seen before that could actually break down plastics,” said Prof John McGeehan, who is leading the work. “There’s a complete paradigm shift. We can really accelerate where we go from here

“AlphaFold protein structure predictions are already being used in a myriad of ways. I expect that this latest update will trigger an avalanche of new and exciting discoveries in the months and years ahead, and this is all thanks to the fact that the data are available openly for all to use.”