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Damaged roads, lack of gear hinder Indonesia quake rescue - ABC News - 0 views

  • Damaged roads and bridges, power blackouts and lack of heavy equipment on Saturday hampered rescuers after a strong earthquake left at least 49 people dead and hundreds injured on Indonesia's Sulawesi island.
  • ollowing the magnitude 6.2 quake that struck early Friday,
  • Mamuju late Saturday, raising the death toll to 49. A total of 40 people were killed in Mamuju, while nine bodies were retrieved in neighboring Majene district.
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  • He said more than 200 people were receiving treatment at the Bhayangkara police hospital and several others in Mamuju alone. Another 630 were injured in Majene.
  • The quake set off landslides in three locations and blocked a main road connecting Mamuju to Majene. Power and phone lines were down in many areas.
  • A governor office building was almost flattened by the quake and a shopping mall was reduced to a crumpled hulk.
  • Two ships headed to the devastated areas from the nearby cities of Makassar and Balikpapan with rescuers and equipment, including excavators.
  • The pope was praying for “the repose of the deceased, the healing of the injured and the consolation of all who grieve.” Francis also offered encouragement to those continuing search and rescue effects, and he invoked “the divine blessings of strength and hope.”
  • Indonesia, home to more than 260 million people, is frequently hit by earthquakes, volcanic eruptions and tsunamis because of its location on the “Ring of Fire,” an arc of volcanoes and fault lines in the Pacific Basin.
ilanaprincilus06

Indonesian Boeing 737-500 With 62 On Board Goes Missing Minutes After Takeoff : NPR - 1 views

  • An Indonesian passenger plane carrying 62 people lost contact with air traffic controllers shortly after takeoff from the nation's capital of Jakarta on Saturday, according to state transportation officials.
  • About four minutes after takeoff, the plane lost more than 10,000 feet of altitude in less than a minute,
  • Sriwijaya Air is the third-largest airline in Indonesia, and since its launch in 2003 the carrier has never had a fatal crash involving a passenger.
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  • In October 2018, Indonesia witnessed one of the worst air tragedies in its history when Lion Air Flight 610 plunged into the Java Sea shortly after takeoff from Jakarta, killing all 189 people on board.
  • The accident was the first of two crashes involving Boeing's 737 Max jetliner — a different model Boeing than was in use for Sriwijaya Air Flight 182.
  • On Thursday, Boeing agreed to pay $2.5 billion to settle criminal charges that it repeatedly concealed and lied engineering problems that contributed to the 737 Max crashes.
Javier E

Wine-tasting: it's junk science | Life and style | The Observer - 0 views

  • google_ad_client = 'ca-guardian_js'; google_ad_channel = 'lifeandstyle'; google_max_num_ads = '3'; // Comments Click here to join the discussion. We can't load the discussion on guardian.co.uk because you don't have JavaScript enabled. if (!!window.postMessage) { jQuery.getScript('http://discussion.guardian.co.uk/embed.js') } else { jQuery('#d2-root').removeClass('hd').html( '' + 'Comments' + 'Click here to join the discussion.We can\'t load the ' + 'discussion on guardian.co.uk ' + 'because your web browser does not support all the features that we ' + 'need. If you cannot upgrade your browser to a newer version, you can ' + 'access the discussion ' + 'here.' ); } Wor
  • Hodgson approached the organisers of the California State Fair wine competition, the oldest contest of its kind in North America, and proposed an experiment for their annual June tasting sessions.Each panel of four judges would be presented with their usual "flight" of samples to sniff, sip and slurp. But some wines would be presented to the panel three times, poured from the same bottle each time. The results would be compiled and analysed to see whether wine testing really is scientific.
  • Results from the first four years of the experiment, published in the Journal of Wine Economics, showed a typical judge's scores varied by plus or minus four points over the three blind tastings. A wine deemed to be a good 90 would be rated as an acceptable 86 by the same judge minutes later and then an excellent 94.
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  • Hodgson's findings have stunned the wine industry. Over the years he has shown again and again that even trained, professional palates are terrible at judging wine."The results are disturbing," says Hodgson from the Fieldbrook Winery in Humboldt County, described by its owner as a rural paradise. "Only about 10% of judges are consistent and those judges who were consistent one year were ordinary the next year."Chance has a great deal to do with the awards that wines win."
  • French academic Frédéric Brochet tested the effect of labels in 2001. He presented the same Bordeaux superior wine to 57 volunteers a week apart and in two different bottles – one for a table wine, the other for a grand cru.The tasters were fooled.When tasting a supposedly superior wine, their language was more positive – describing it as complex, balanced, long and woody. When the same wine was presented as plonk, the critics were more likely to use negatives such as weak, light and flat.
  • In 2011 Professor Richard Wiseman, a psychologist (and former professional magician) at Hertfordshire University invited 578 people to comment on a range of red and white wines, varying from £3.49 for a claret to £30 for champagne, and tasted blind.People could tell the difference between wines under £5 and those above £10 only 53% of the time for whites and only 47% of the time for reds. Overall they would have been just as a successful flipping a coin to guess.
  • why are ordinary drinkers and the experts so poor at tasting blind? Part of the answer lies in the sheer complexity of wine.For a drink made by fermenting fruit juice, wine is a remarkably sophisticated chemical cocktail. Dr Bryce Rankine, an Australian wine scientist, identified 27 distinct organic acids in wine, 23 varieties of alcohol in addition to the common ethanol, more than 80 esters and aldehydes, 16 sugars, plus a long list of assorted vitamins and minerals that wouldn't look out of place on the ingredients list of a cereal pack. There are even harmless traces of lead and arsenic that come from the soil.
  • "People underestimate how clever the olfactory system is at detecting aromas and our brain is at interpreting them," says Hutchinson."The olfactory system has the complexity in terms of its protein receptors to detect all the different aromas, but the brain response isn't always up to it. But I'm a believer that everyone has the same equipment and it comes down to learning how to interpret it." Within eight tastings, most people can learn to detect and name a reasonable range of aromas in wine
  • People struggle with assessing wine because the brain's interpretation of aroma and bouquet is based on far more than the chemicals found in the drink. Temperature plays a big part. Volatiles in wine are more active when wine is warmer. Serve a New World chardonnay too cold and you'll only taste the overpowering oak. Serve a red too warm and the heady boozy qualities will be overpowering.
  • Colour affects our perceptions too. In 2001 Frédérick Brochet of the University of Bordeaux asked 54 wine experts to test two glasses of wine – one red, one white. Using the typical language of tasters, the panel described the red as "jammy' and commented on its crushed red fruit.The critics failed to spot that both wines were from the same bottle. The only difference was that one had been coloured red with a flavourless dye
  • Other environmental factors play a role. A judge's palate is affected by what she or he had earlier, the time of day, their tiredness, their health – even the weather.
  • Robert Hodgson is determined to improve the quality of judging. He has developed a test that will determine whether a judge's assessment of a blind-tasted glass in a medal competition is better than chance. The research will be presented at a conference in Cape Town this year. But the early findings are not promising."So far I've yet to find someone who passes," he says.
Ellie McGinnis

What You Get When 30 People Draw a World Map From Memory - Uri Friedman - The Atlantic - 1 views

  • Maps, as I've written before, are inherently subjective—no matter how detailed or scientific, they reflect our worldview and the age in which we're living, not to mention the difficulty of projecting a spherical globe onto a plane surface.
  • Now compound these challenges by asking 30 people to sketch a map of the world from memory.
  • The most interesting reaction to Ziebell's project has been overseas, where the warped, blobby maps seem to have reinforced stereotypes about geographically illiterate Americans (all but one of the participants, by Ziebell's reckoning, were from the U.S.). Under the headline, "Here's how American students view the world,"
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  • The Jakarta-based newspaper Kompas went into detail about the ways students had missed or misrepresented Indonesia.
ilanaprincilus06

Powerful earthquake in Indonesia's Sulawesi kills dozens, injures hundreds - CNN - 0 views

  • At least 42 people have died with hundreds more injured after a 6.2-magnitude earthquake hit Indonesia's Sulawesi island
  • In Majene, at least 637 were injured and 15,000 residents have been displaced
  • Thousands of residents fled their homes to seek safety following the quake, which could be felt strongly for five to seven seconds and damaged at least 300 houses in Majene
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  • The communications chief also said the quake had damaged four of Mamuju's largest hospitals.
  • Another difficulty was the lack of communication among rescue teams, as local telephone networks were down following the quake, he said, adding that there were eight locations where people were in urgent need of rescue.
  • The earthquake also triggered a power outage and caused three landslides along the main road connecting Majene and Mamuju.
Javier E

History News Network | History Gets Into Bed with Psychology, and It's a Happy Match - 0 views

  • The fact that many of our self-protective delusions are built into the way the brain works is no justification for not trying to override them. Knowing how dissonance works helps us identify our own inclinations to perpetuate errors -- and protect ourselves from those who can’t. Or won’t.Related LinksWhat Historians Can Learn from the Social Sciences and Sciences /* * * CONFIGURATION VARIABLES: EDIT BEFORE PASTING INTO YOUR WEBPAGE * * */ var disqus_shortname = 'hnndev'; // required: replace example with your forum shortname /* * * DON'T EDIT BELOW THIS LINE * * */ (function() { var dsq = document.createElement('script'); dsq.type = 'text/javascript'; dsq.async = true; dsq.src = '//' + disqus_shortname + '.disqus.com/embed.js'; (document.getElementsByTagName('head')[0] || document.getElementsByTagName('body')[0]).appendChild(dsq); })(); Please enable JavaScript to view the comments powered by Disqus. News Breaking News Historians DC Breaking News Historians DC ‘Scottsboro Boys’ pardoned in Alabama ‘November 22, 1963’ U-Boat discovered off the coast of Indonesia Vatican publicly unveils bone fragments said to belong to St. Peter Pictured: the 'real site' of the Hanging Gardens of Babylon Historian: Taiwan can use WWII legacy to improve standing with China 'I Take Long Walks': The Emotional Lives of Holocaust Scholars Chinese historian: Xi Jinping a master of "neo-authoritarianism" History Comes to Life With Tweets From Past Celtic Paths, Illuminated by a Sundial try{for(var lastpass_iter=0; lastpass_iter < document.forms.length; lastpass_iter++){ var lastpass_f = document.forms[lastpass_iter]; if(typeof(lastpass_f.lpsubmitorig2)=="undefined"){ lastpass_f.lpsubmitorig2 = lastpass_f.submit; lastpass_f.submit = function(){ var form=this; var customEvent = document.createEvent("Event"); customEvent.initEvent("lpCustomEvent", true, true); var d = document.getElementById("hiddenlpsubmitdiv"); for(var i = 0; i < document.forms.length; i++){ if(document.forms[i]==form){ d.innerText=i; } } d.dispatchEvent(customEvent); form.lpsubmitorig2(); } } }}catch(e){}
  • at last, history has gotten into bed with psychological science, and it’s a happy match. History gives us the data of, in Barbara Tuchman’s splendid words, our march of folly -- repeated examples of human beings unable and unwilling to learn from mistakes, let alone to admit them. Cognitive science shows us why
  • Our brains, which have allowed us to travel into outer space, have a whole bunch of design flaws, which is why we have so much breathtaking bumbling here on Earth.
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  • Of the many built-in biases in human thought, three have perhaps the greatest consequences for our own history and that of nations: the belief that we see things as they really are, rather than as we wish them to be; the belief that we are better, kinder, smarter, and more ethical than average; and the confirmation bias, which sees to it that we notice, remember, and accept information that confirms our beliefs -- and overlook, forget, and discount information that disconfirms our beliefs.
  • The great motivational theory that accommodates all of these biases is cognitive dissonance, developed by Leon Festinger in 1957 and further refined and transformed into a theory of self-justification by his student (and later my coauthor and friend) Elliot Aronson. The need to reduce dissonance is the key mechanism that underlies the reluctance to be wrong, to change our minds, to admit serious mistakes, and to be unwilling to accept unwelcome information
  • The greater the dissonance between who we are and the mistake we made or the cruelty we committed, the greater the need to justify the mistake, the crime, the villainy, instead of admitting and rectifying it
silveiragu

Economists tested 7 welfare programs to see if they made people lazy. They didn't. - Vox - 0 views

  • For as long as there have been government programs designed to help the poor, there have been critics insisting that helping the poor will keep them from working. But the evidence for this proposition has always been rather weak.
  • And a recent study from MIT and Harvard economists
  • found "no systematic evidence that cash transfer programs discourage work.
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  • he programs covered in the study have a pretty wide geographic spread. There are four in Latin America (two in Mexico, one each in Nicaragua and Honduras), two in Southeast Asia (Philippines and Indonesia), and one in Morocco
  • . The 95 percent confidence interval for how the programs affected the employment rate ranged from a 1.6 percentage point decline to a 0.9 point increase. There just isn't any change happening here
  • Some other studies find that cash encourages work
  • But it's worth being skeptical about welfare queen claims in rich countries as well.
  • There's a substantial body of evidence showing that the EITC encourages work
  • But even unrestricted cash programs aren't likely to have a major effect on work in rich countries
  • . A number of studies in the US in the 1970s examined "negative income tax" programs
  • The studies found very mild declines in work
  • A much better experiment in Canada, where an entire town got a guaranteed income by way of a negative income tax, found even milder reductions in wor
  • There's no doubt that poorly designed social programs can deter work. Aid to Families With Dependent Children, the pre–welfare reform welfare program, was found to decrease hours worked by 10 to 50 percen
  • Who would work under that condition
Javier E

Rewriting the War, Japanese Right Attacks a Newspaper - NYTimes.com - 1 views

  • Tabloids brand him a traitor for disseminating “Korean lies” that they say were part of a smear campaign aimed at settling old scores with Japan. Threats of violence, Mr. Uemura says, have cost him one university teaching job and could soon rob him of a second. Ultranationalists have even gone after his children, posting Internet messages urging people to drive his teenage daughter to suicide.
  • The threats are part of a broad, vitriolic assault by the right-wing news media and politicians here on The Asahi, which has long been the newspaper that Japanese conservatives love to hate. The battle is also the most recent salvo in a long-raging dispute over Japan’s culpability for its wartime behavior that has flared under Prime Minister Shinzo Abe’s right-leaning government.
  • “The War on The Asahi,” as commentators have called it, began in August when the newspaper bowed to public criticism and retracted at least a dozen articles published in the 1980s and early ’90s. Those articles cited a former soldier, Seiji Yoshida, who claimed to have helped abduct Korean women for the military brothels. Mr. Yoshida was discredited two decades ago, but the Japanese right pounced on The Asahi’s gesture and called for a boycott to drive the 135-year-old newspaper out of business.
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  • With elections this month, analysts say conservatives are trying to hobble the nation’s leading left-of-center newspaper. The Asahi has long supported greater atonement for Japan’s wartime militarism and has opposed Mr. Abe on other issues. But it is increasingly isolated as the nation’s liberal opposition remains in disarray after a crushing defeat at the polls two years ago.Continue reading the main story
  • Among the women who have come forward to say they were forced to have sex with soldiers are Chinese, Koreans and Filipinos, as well as Dutch women captured in Indonesia, then a Dutch colony.
  • The revisionists, however, have seized on the lack of evidence of abductions to deny that any women were held captive in sexual slavery and to argue that the comfort women were simply camp-following prostitutes out to make good money.
  • Many on the right have argued that Japan’s behavior was no worse than that of other World War II combatants, including the United States’ bombing of Japanese civilians.
  • Since August, The Asahi’s daily circulation has dropped by 230,797 to about seven million
  • Mr. Uemura said The Asahi had been too fearful to defend him, or even itself. In September, the newspaper’s top executives apologized on television and fired the chief editor.
  • Mr. Uemura did not attend, explaining that he was now reluctant to appear in public. “This is the right’s way of threatening other journalists into silence,” he said. “They don’t want to suffer the same fate that I have.”
Javier E

What Is Wrong with the West's Economies? by Edmund S. Phelps | The New York Review of B... - 1 views

  • What is wrong with the economies of the West—and with economics?
  • With little or no effective policy initiative giving a lift to the less advantaged, the jarring market forces of the past four decades—mainly the slowdowns in productivity that have spread over the West and, of course, globalization, which has moved much low-wage manufacturing to Asia—have proceeded, unopposed, to drag down both employment and wage rates at the low end. The setback has cost the less advantaged not only a loss of income but also a loss of what economists call inclusion—access to jobs offering work and pay that provide self-respect.
  • The classical idea of political economy has been to let wage rates sink to whatever level the market takes them, and then provide everyone with the “safety net” of a “negative income tax,” unemployment insurance, and free food, shelter, clothing, and medical care
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  • This failing in the West’s economies is also a failing of economics
  • many people have long felt the desire to do something with their lives besides consuming goods and having leisure. They desire to participate in a community in which they can interact and develop.
  • Our prevailing political economy is blind to the very concept of inclusion; it does not map out any remedy for the deficiency
  • injustice of another sort. Workers in decent jobs view the economy as unjust if they or their children have virtually no chance of climbing to a higher rung in the socioeconomic ladder
  • “Money is like blood. You need it to live but it isn’t the point of life.”4
  • justice is not everything that people need from their economy. They need an economy that is good as well as just. And for some decades, the Western economies have fallen short of any conception of a “good economy”—an economy offering a “good life,” or a life of “richness,” as some humanists call it
  • The good life as it is popularly conceived typically involves acquiring mastery in one’s work, thus gaining for oneself better terms—or means to rewards, whether material, like wealth, or nonmaterial—an experience we may call “prospering.”
  • As humanists and philosophers have conceived it, the good life involves using one’s imagination, exercising one’s creativity, taking fascinating journeys into the unknown, and acting on the world—an experience I call “flourishing.”
  • prospering and flourishing became prevalent in the nineteenth century when, in Europe and America, economies emerged with the dynamism to generate their own innovation.
  • What is the mechanism of the slowdown in productivity
  • prospering
  • In nineteenth-century Britain and America, and later Germany and France, a culture of exploration, experimentation, and ultimately innovation grew out of the individualism of the Renaissance, the vitalism of the Baroque era, and the expressionism of the Romantic period.
  • What made innovating so powerful in these economies was that it was not limited to elites. It permeated society from the less advantaged parts of the population on up.
  • High-enough wages, low-enough unemployment, and wide-enough access to engaging work are necessary for a “good-enough” economy—though far from sufficient. The material possibilities of the economy must be adequate for the nonmaterial possibilities to be widespread—the satisfactions of prospering and of flourishing through adventurous, creative, and even imaginative work.
  • today’s standard economics. This economics, despite its sophistication in some respects, makes no room for economies in which people are imagining new products and using their creativity to build them. What is most fundamentally “wrong with economics” is that it takes such an economy to be the norm—to be “as good as it gets.”
  • ince around 1970, or earlier in some cases, most of the continental Western European economies have come to resemble more completely the mechanical model of standard economics. Most companies are highly efficient. Households, apart from the very low-paid or unemployed, have gone on saving
  • In most of Western Europe, economic dynamism is now at lows not seen, I would judge, since the advent of dynamism in the nineteenth century. Imagining and creating new products has almost disappeared from the continent
  • The bleak levels of both unemployment and job satisfaction in Europe are testimony to its dreary economies.
  • a recent survey of household attitudes found that, in “happiness,” the median scores in Spain (54), France (51), Italy (48), and Greece (37) are all below those in the upper half of the nations labeled “emerging”—Mexico (79), Venezuela (74), Brazil (73), Argentina (66), Vietnam (64), Colombia (64), China (59), Indonesia (58), Chile (58), and Malaysia (56)
  • The US economy is not much better. Two economists, Stanley Fischer and Assar Lindbeck, wrote of a “Great Productivity Slowdown,” which they saw as beginning in the late 1960s.11 The slowdown in the growth of capital and labor combined—what is called “total factor productivity”—is star
  • though the injustices in the West’s economies are egregious, they ought not to be seen as a major cause of the productivity slowdowns and globalization. (For one thing, a slowdown of productivity started in the US in the mid-1960s and the sharp loss of manufacturing jobs to poorer countries occurred much later—from the late 1970s to the early 1990s.) Deeper causes must be at work.
  • The plausible explanation of the syndrome in America—the productivity slowdown and the decline of job satisfaction, among other things—is a critical loss of indigenous innovation in the established industries like traditional manufacturing and services that was not nearly offset by the innovation that flowered in a few new industries
  • hat then caused this narrowing of innovation? No single explanation is persuasive. Yet two classes of explanations have the ring of truth. One points to suppression of innovation by vested interests
  • some professions, such as those in education and medicine, have instituted regulation and licensing to curb experimentation and change, thus dampening innovation
  • established corporations—their owners and stakeholders—and entire industries, using their lobbyists, have obtained regulations and patents that make it harder for new firms to gain entry into the market and to compete with incumbents.
  • The second explanation points to a new repression of potential innovators by families and schools. As the corporatist values of control, solidarity, and protection are invoked to prohibit innovation, traditional values of conservatism and materialism are often invoked to inhibit a young person from undertaking an innovation.
  • ow might Western nations gain—or regain—widespread prospering and flourishing? Taking concrete actions will not help much without fresh thinking: people must first grasp that standard economics is not a guide to flourishing—it is a tool only for efficiency.
  • Widespread flourishing in a nation requires an economy energized by its own homegrown innovation from the grassroots on up. For such innovation a nation must possess the dynamism to imagine and create the new—economic freedoms are not sufficient. And dynamism needs to be nourished with strong human values.
  • a reform of education stands out. The problem here is not a perceived mismatch between skills taught and skills in demand
  • The problem is that young people are not taught to see the economy as a place where participants may imagine new things, where entrepreneurs may want to build them and investors may venture to back some of them. It is essential to educate young people to this image of the economy.
  • It will also be essential that high schools and colleges expose students to the human values expressed in the masterpieces of Western literature, so that young people will want to seek economies offering imaginative and creative careers. Education systems must put students in touch with the humanities in order to fuel the human desire to conceive the new and perchance to achieve innovations
  • This reorientation of general education will have to be supported by a similar reorientation of economic education.
Javier E

The Disease Detective - The New York Times - 1 views

  • What’s startling is how many mystery infections still exist today.
  • More than a third of acute respiratory illnesses are idiopathic; the same is true for up to 40 percent of gastrointestinal disorders and more than half the cases of encephalitis (swelling of the brain).
  • Up to 20 percent of cancers and a substantial portion of autoimmune diseases, including multiple sclerosis and rheumatoid arthritis, are thought to have viral triggers, but a vast majority of those have yet to be identified.
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  • Globally, the numbers can be even worse, and the stakes often higher. “Say a person comes into the hospital in Sierra Leone with a fever and flulike symptoms,” DeRisi says. “After a few days, or a week, they die. What caused that illness? Most of the time, we never find out. Because if the cause isn’t something that we can culture and test for” — like hepatitis, or strep throat — “it basically just stays a mystery.”
  • It would be better, DeRisi says, to watch for rare cases of mystery illnesses in people, which often exist well before a pathogen gains traction and is able to spread.
  • Based on a retrospective analysis of blood samples, scientists now know that H.I.V. emerged nearly a dozen times over a century, starting in the 1920s, before it went global.
  • Zika was a relatively harmless illness before a single mutation, in 2013, gave the virus the ability to enter and damage brain cells.
  • The beauty of this approach” — running blood samples from people hospitalized all over the world through his system, known as IDseq — “is that it works even for things that we’ve never seen before, or things that we might think we’ve seen but which are actually something new.”
  • In this scenario, an undiscovered or completely new virus won’t trigger a match but will instead be flagged. (Even in those cases, the mystery pathogen will usually belong to a known virus family: coronaviruses, for instance, or filoviruses that cause hemorrhagic fevers like Ebola and Marburg.)
  • And because different types of bacteria require specific conditions in order to grow, you also need some idea of what you’re looking for in order to find it.
  • The same is true of genomic sequencing, which relies on “primers” designed to match different combinations of nucleotides (the building blocks of DNA and RNA).
  • Even looking at a slide under a microscope requires staining, which makes organisms easier to see — but the stains used to identify bacteria and parasites, for instance, aren’t the same.
  • The practice that DeRisi helped pioneer to skirt this problem is known as metagenomic sequencing
  • Unlike ordinary genomic sequencing, which tries to spell out the purified DNA of a single, known organism, metagenomic sequencing can be applied to a messy sample of just about anything — blood, mud, seawater, snot — which will often contain dozens or hundreds of different organisms, all unknown, and each with its own DNA. In order to read all the fragmented genetic material, metagenomic sequencing uses sophisticated software to stitch the pieces together by matching overlapping segments.
  • The assembled genomes are then compared against a vast database of all known genomic sequences — maintained by the government-run National Center for Biotechnology Information — making it possible for researchers to identify everything in the mix
  • Traditionally, the way that scientists have identified organisms in a sample is to culture them: Isolate a particular bacterium (or virus or parasite or fungus); grow it in a petri dish; and then examine the result under a microscope, or use genomic sequencing, to understand just what it is. But because less than 2 percent of bacteria — and even fewer viruses — can be grown in a lab, the process often reveals only a tiny fraction of what’s actually there. It’s a bit like planting 100 different kinds of seeds that you found in an old jar. One or two of those will germinate and produce a plant, but there’s no way to know what the rest might have grown into.
  • Such studies have revealed just how vast the microbial world is, and how little we know about it
  • “The selling point for researchers is: ‘Look, this technology lets you investigate what’s happening in your clinic, whether it’s kids with meningitis or something else,’” DeRisi said. “We’re not telling you what to do with it. But it’s also true that if we have enough people using this, spread out all around the world, then it does become a global network for detecting emerging pandemics
  • Metagenomic sequencing is especially good at what scientists call “environmental sampling”: identifying, say, every type of bacteria present in the gut microbiome, or in a teaspoon of seawater.
  • After the Biohub opened in 2016, one of DeRisi’s goals was to turn metagenomics from a rarefied technology used by a handful of elite universities into something that researchers around the world could benefit from
  • metagenomics requires enormous amounts of computing power, putting it out of reach of all but the most well-funded research labs. The tool DeRisi created, IDseq, made it possible for researchers anywhere in the world to process samples through the use of a small, off-the-shelf sequencer, much like the one DeRisi had shown me in his lab, and then upload the results to the cloud for analysis.
  • he’s the first to make the process so accessible, even in countries where lab supplies and training are scarce. DeRisi and his team tested the chemicals used to prepare DNA for sequencing and determined that using as little as half the recommended amount often worked fine. They also 3-D print some of the labs’ tools and replacement parts, and offer ongoing training and tech support
  • The metagenomic analysis itself — normally the most expensive part of the process — is provided free.
  • But DeRisi’s main innovation has been in streamlining and simplifying the extraordinarily complex computational side of metagenomics
  • IDseq is also fast, capable of doing analyses in hours that would take other systems weeks.
  • “What IDseq really did was to marry wet-lab work — accumulating samples, processing them, running them through a sequencer — with the bioinformatic analysis,”
  • “Without that, what happens in a lot of places is that the researcher will be like, ‘OK, I collected the samples!’ But because they can’t analyze them, the samples end up in the freezer. The information just gets stuck there.”
  • Meningitis itself isn’t a disease, just a description meaning that the tissues around the brain and spinal cord have become inflamed. In the United States, bacterial infections can cause meningitis, as can enteroviruses, mumps and herpes simplex. But a high proportion of cases have, as doctors say, no known etiology: No one knows why the patient’s brain and spinal tissues are swelling.
  • When Saha and her team ran the mystery meningitis samples through IDseq, though, the result was surprising. Rather than revealing a bacterial cause, as expected, a third of the samples showed signs of the chikungunya virus — specifically, a neuroinvasive strain that was thought to be extremely rare. “At first we thought, It cannot be true!” Saha recalls. “But the moment Joe and I realized it was chikungunya, I went back and looked at the other 200 samples that we had collected around the same time. And we found the virus in some of those samples as well.”
  • Until recently, chikungunya was a comparatively rare disease, present mostly in parts of Central and East Africa. “Then it just exploded through the Caribbean and Africa and across Southeast Asia into India and Bangladesh,” DeRisi told me. In 2011, there were zero cases of chikungunya reported in Latin America. By 2014, there were a million.
  • Chikungunya is a mosquito-borne virus, but when DeRisi and Saha looked at the results from IDseq, they also saw something else: a primate tetraparvovirus. Primate tetraparvoviruses are almost unknown in humans, and have been found only in certain regions. Even now, DeRisi is careful to note, it’s not clear what effect the virus has on people. “Maybe it’s dangerous, maybe it isn’t,” DeRisi says. “But I’ll tell you what: It’s now on my radar.
  • it reveals a landscape of potentially dangerous viruses that we would otherwise never find out about. “What we’ve been missing is that there’s an entire universe of pathogens out there that are causing disease in humans,” Imam notes, “ones that we often don’t even know exist.”
  • “The plan was, Let’s let researchers around the world propose studies, and we’ll choose 10 of them to start,” DeRisi recalls. “We thought we’d get, like, a couple dozen proposals, and instead we got 350.”
  • One study found more than 1,000 different kinds of viruses in a tiny amount of human stool; another found a million in a couple of pounds of marine sediment. And most were organisms that nobody had seen before.
  • “When you draw blood from someone who has a fever in Ghana, you really don’t know very much about what would normally be in their blood without fever — let alone about other kinds of contaminants in the environment. So how do you interpret the relevance of all the things you’re seeing?”
  • Such criticisms have led some to say that metagenomics simply isn’t suited to the infrastructure of developing countries. Along with the problem of contamination, many labs struggle to get the chemical reagents needed for sequencing, either because of the cost or because of shipping and customs holdups
  • we’re less likely to be caught off-guard. “With Ebola, there’s always an issue: Where’s the virus hiding before it breaks out?” DeRisi explains. “But also, once we start sampling people who are hospitalized more widely — meaning not just people in Northern California or Boston, but in Uganda, and Sierra Leone, and Indonesia — the chance of disastrous surprises will go down. We’ll start seeing what’s hidden.”
cvanderloo

Lava Flows Again As Indonesian Volcano Erupts : NPR - 1 views

  • Indonesian officials are monitoring the country's most active volcano after it erupted again Saturday morning, launching hot ash clouds high into the air, and sending lava spewing down the side of the mountain.
  • No injuries were reported, but local officials are cautioning of more activity to come.
  • "it is concluded that the volcanic activity of Mount Merapi is still quite high in the form of effusive eruptions,"
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  • Mining companies have been advised to temporarily suspend work in the river that originates at Mount Merapi, and tourism companies have been asked to temporarily stay away from "areas of potential danger and crater openings" up to 3 miles away.
  • The last major eruption of Mount Merapi, in 2010, killed over 300 people.
Javier E

Dengue Mosquitoes Can Be Tamed by a Common Microbe - The Atlantic - 0 views

  • Dengue fever is caused by a virus that infects an estimated 390 million people every year, and kills about 25,000; the World Health Organization has described it as one of the top 10 threats to global health.
  • It spreads through the bites of mosquitoes, particularly the species Aedes aegypti. Utarini and her colleagues have spent the past decade turning these insects from highways of dengue into cul-de-sacs. They’ve loaded the mosquitoes with a bacterium called Wolbachia, which prevents them from being infected by dengue viruses. Wolbachia spreads very quickly: If a small number of carrier mosquitoes are released into a neighborhood, almost all of the local insects should be dengue-free within a few months
  • Aedes aegypti was once a forest insect confined to sub-Saharan Africa, where it drank blood from a wide variety of animals. But at some point, one lineage evolved into an urban creature that prefers towns over forests, and humans over other animals.
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  • The World Mosquito Program (WMP), a nonprofit that pioneered this technique, had run small pilot studies in Australia that suggested it could work. Utarini, who co-leads WMP Yogyakarta, has now shown conclusively that it does.
  • Carried around the world aboard slave ships, Aedes aegypti has thrived. It is now arguably the most effective human-hunter on the planet, its senses acutely attuned to the carbon dioxide in our breath, the warmth of our bodies, and the odors of our skin.
  • Wolbachia was first discovered in 1924, in a different species of mosquito. At first, it seemed so unremarkable that scientists ignored it for decades. But starting in the 1980s, they realized that it has an extraordinary knack for spreading. It passes down mainly from insect mothers to their children, and it uses many tricks to ensure that infected individuals are better at reproducing than uninfected ones. To date, it exists in at least 40 percent of all insect species, making it one of the most successful microbes on the planet.
  • The team divided a large portion of the city into 24 zones and released Wolbachia-infected mosquitoes in half of them. Almost 10,000 volunteers helped distribute egg-filled containers to local backyards. Within a year, about 95 percent of the Aedes mosquitoes in the 12 release zones harbored Wolbachia.
  • The team found that just 2.3 percent of feverish people who lived in the Wolbachia release zones had dengue, compared with 9.4 percent in the control areas. Wolbachia also seemed to work against all four dengue serotypes, and reduced the number of dengue hospitalizations by 86 percent.
  • Even then, these already remarkable numbers are likely to be underestimates. The mosquitoes moved around, carrying Wolbachia into the 12 control zones where no mosquitoes were released. And people also move: They might live in a Wolbachia release zone but be bitten and infected with dengue elsewhere. Both of these factors would have worked against the trial, weakening its results
  • The Wolbachia method does have a few limitations. The bacterium takes months to establish itself, so it can’t be “deployed to contain an outbreak today,” Vazquez-Prokopec told me. As the Yogyakarta trial showed, it works only when Wolbachia reaches a prevalence of at least 80 percent, which requires a lot of work and strong community support
  • The method has other benefits too. It is self-amplifying and self-perpetuating: If enough Wolbachia-infected mosquitoes are released initially, the bacterium should naturally come to dominate the local population, and stay that way. Unlike insecticides, Wolbachia isn’t toxic, it doesn’t kill beneficial insects (or even mosquitoes), and it doesn’t need to be reapplied, which makes it very cost-effective.
  • An analysis by Brady’s team showed that it actually saves money by preventing infections
  • Wolbachia also seems to work against the other diseases that Aedes aegypti carries, including Zika and yellow fever. It could transform this mosquito from one of the most dangerous species to humans into just another biting nuisance.
tongoscar

Singapore's climate change plan needs more ambition | ASEAN Today - 0 views

  • Each person in Singapore produces more greenhouse gas emissions than their counterpart in Indonesia, China or the United Kingdom. The city-state may be responsible for just 0.11% of total global emissions, but Singapore ranks 27th out of 142 countries in terms of per capita emissions.
  • In 2015, Singapore pledged to reduce its emission intensity, the amount of greenhouse gas emissions for every dollar of gross domestic product (GDP), by 36% from 2005 levels come 2030. The city-state also committed to stabilising and capping its greenhouse gas emissions by 2030. &nbsp;
  • Countries are expected to update their climate pledges by the end of this year but do not necessarily have to submit completely new ones.
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  • Singapore’s climate pledge in 2015 was deemed a “stretch target” that would not be easily met, as efforts towards sustainable development in the country were still in their nascent stages.
  • Singapore has installed large-scale floating solar panels in its reservoirs and coastal shorelines. Efforts are also being made towards making 80% of the buildings in the country green by 2030. Come 2040, only 10% of rush-hour commutes in Singapore will be made via private transportation.
  • Protecting Singapore against climate change will be costly. Up to S$100 billion will be poured into measures to cope with rising sea levels caused by climate change. Prevention is better than cure. Singapore, and countries around the world, must identify their vulnerabilities and undertake the actions required to defend their long-term national interests. But these measures should not become a substitute for ambitious efforts to reduce emissions and prevent temperatures from rising wherever possible.
anniina03

Coronavirus: Why some countries wear face masks and others don't - BBC News - 0 views

  • Since the start of the coronavirus outbreak some places have fully embraced wearing face masks, and anyone caught without one risks becoming a social pariah.But in many other parts of the world, from the UK and the US to Sydney and Singapore, it's still perfectly acceptable to walk around bare-faced.
  • the official advice from the World Health Organization has been clear. Only two types of people should wear masks: those who are sick and show symptoms, and those who are caring for people who are suspected to have the coronavirus.
  • a mask is not seen as reliable protection, given that current research shows the virus is spread by droplets and contact with contaminated surfaces. So it could protect you, but only in certain situations such as when you're in close quarters with others where someone infected might sneeze or cough near your face.
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  • Removing a mask requires special attention to avoid hand contamination, and it could also breed a false sense of security.
  • in some parts of Asia everyone now wears a mask by default - it is seen as safer and more considerate.
  • In mainland China, Hong Kong, Japan, Thailand and Taiwan, the broad assumption is that anyone could be a carrier of the virus, even healthy people. So in the spirit of solidarity, you need to protect others from yourself.
  • In East Asia, many people are used to wearing masks when they are sick or when it's hayfever season, because it's considered impolite to be sneezing or coughing openly.
  • The 2003 Sars virus outbreak, which affected several countries in the region, also drove home the importance of wearing masks, particularly in Hong Kong, where many died as a result of the virus.So one key difference between these societies and Western ones, is that they have experienced contagion before - and the memories are still fresh and painful.
  • Some argue that ubiquitous mask wearing, as a very visual reminder of the dangers of the virus, could actually act as a "behavioural nudge" to you and others for overall better personal hygiene.
  • But there are downsides of course. Some places such as Japan, Indonesia and Thailand are facing shortages at the moment, and South Korea has had to ration out masks.
  • There is the fear that people may end up re-using masks - which is unhygienic - use masks sold on the black market, or wear homemade masks, which could be of inferior quality and essentially useless.
  • People who do not wear masks in these places have also been stigmatised, to the point that they are shunned and blocked from shops and buildings.
  • In countries where mask wearing is not the norm, such as the West, those who do wear masks have been shunned or even attacked. It hasn't helped that many of these mask wearers are Asians.
Javier E

Covid Study Finds 18 Million Deaths, Three Times Official Tally - Bloomberg - 0 views

  • “At the global level, this is quite the biggest mortality shock since the Spanish flu,” s
  • Covid drove a 17% jump in deaths worldwide, he said in an interview. The flu pandemic that began in 1918 killed at least 50 million people.&nbsp;
  • The evidence suggests the mortality surge is a direct result of Covid-19, the researchers said. But some deaths may also have occurred indirectly, they said, caused by a lack of access to health care and other essential services during the pandemic, or from behavioral shifts that led to suicide or drug abuse.&nbsp;
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  • Because of its large population, India alone accounted for an estimated 22% -- or 4.1 million -- of the global deaths. The U.S. and Russia were the next highest with 1.1 million each, followed by Mexico, Brazil and Indonesia.
  • In the end, the scientists estimated there was an excess of 120 deaths for every 100,000 people around the world. The study found 21 countries had estimated mortality rates higher than 300 per 100,000, led by Bolivia and Bulgaria
  • Places with the lowest estimated excess mortality rate were Iceland, Australia, Singapore and New Zealand.
  • Mask-wearing, physical distancing and other public health measures led to a decline in other communicable diseases, which reduced mortality in some countries
  • the prevalence of obesity and older age in a population were two of the biggest determinants of excess mortality, Murray said.&nbsp;
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