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Javier E

Reasons for COVID-19 Optimism on T-Cells and Herd Immunity - 0 views

  • It may well be the case that some amount of community protection kicks in below 60 percent exposure, and possibly quite a bit below that threshold, and that those who exhibit a cross-reactive T-cell immune response, while still susceptible to infection, may also have some meaningful amount of protection against severe disease.
  • early returns suggest that while the maximalist interpretation of each hypothesis is not very credible — herd immunity has probably not been reached in many places, and cross-reactive T-cell response almost certainly does not functionally immunize those who have it — more modest interpretations appear quite plausible.
  • Friston suggested that the truly susceptible portion of the population was certainly not 100 percent, as most modelers and conventional wisdom had it, but a much smaller share — surely below 50 percent, he said, and likely closer to about 20 percent. The analysis was ongoing, he said, but, “I suspect, once this has been done, it will look like the effective non-susceptible portion of the population will be about 80 percent. I think that’s what’s going to happen.”
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  • one of the leading modelers, Gabriela Gomes, suggested the entire area of research was being effectively blackballed out of fear it might encourage a relaxation of pandemic vigilance. “This is the very sad reason for the absence of more optimistic projections on the development of this pandemic in the scientific literature,” she wrote on Twitter. “Our analysis suggests that herd-immunity thresholds are being achieved despite strict social-distancing measures.”
  • Gomes suggested, herd immunity could happen with as little as one quarter of the population of a community exposed — or perhaps just 20 percent. “We just keep running the models, and it keeps coming back at less than 20 percent,” she told Hamblin. “It’s very striking.” Such findings, if they held up, would be very instructive, as Hamblin writes: “It would mean, for instance, that at 25 percent antibody prevalence, New York City could continue its careful reopening without fear of another major surge in cases.”
  • But for those hoping that 25 percent represents a true ceiling for pandemic spread in a given community, well, it almost certainly does not, considering that recent serological surveys have shown that perhaps 93 percent of the population of Iquitos, Peru, has contracted the disease; as have more than half of those living in Indian slums; and as many as 68 percent in particular neighborhoods of New York City
  • overshoot of that scale would seem unlikely if the “true” threshold were as low as 20 or 25 percent.
  • But, of course, that threshold may not be the same in all places, across all populations, and is surely affected, to some degree, by the social behavior taken to protect against the spread of the disease.
  • we probably err when we conceive of group immunity in simplistically binary terms. While herd immunity is a technical term referring to a particular threshold at which point the disease can no longer spread, some amount of community protection against that spread begins almost as soon as the first people are exposed, with each case reducing the number of unexposed and vulnerable potential cases in the community by one
  • you would not expect a disease to spread in a purely exponential way until the point of herd immunity, at which time the spread would suddenly stop. Instead, you would expect that growth to slow as more people in the community were exposed to the disease, with most of them emerging relatively quickly with some immune response. Add to that the effects of even modest, commonplace protections — intuitive social distancing, some amount of mask-wearing — and you could expect to get an infection curve that tapers off well shy of 60 percent exposure.
  • Looking at the data, we see that transmissions in many severely impacted states began to slow down in July, despite limited interventions. This is especially notable in states like Arizona, Florida, and Texas. While we believe that changes in human behavior and changes in policy (such as mask mandates and closing of bars/nightclubs) certainly contributed to the decrease in transmission, it seems unlikely that these were the primary drivers behind the decrease. We believe that many regions obtained a certain degree of temporary herd immunity after reaching 10-35 percent prevalence under the current conditions. We call this 10-35 percent threshold the effective herd immunity threshold.
  • Indeed, that is more or less what was recently found by Youyang Gu, to date the best modeler of pandemic spread in the U.S
  • he cautioned again that he did not mean to imply that the natural herd-immunity level was as low as 10 percent, or even 35 percent. Instead, he suggested it was a plateau determined in part by better collective understanding of the disease and what precautions to take
  • Gu estimates national prevalence as just below 20 percent (i.e., right in the middle of his range of effective herd immunity), it still counts, I think, as encouraging — even if people in hard-hit communities won’t truly breathe a sigh of relief until vaccines arrive.
  • If you can get real protection starting at 35 percent, it means that even a mediocre vaccine, administered much more haphazardly to a population with some meaningful share of vaccination skeptics, could still achieve community protection pretty quickly. And that is really significant — making both the total lack of national coordination on rollout and the likely “vaccine wars” much less consequential.
  • At least 20 percent of the public, and perhaps 50 percent, had some preexisting, cross-protective T-cell response to SARS-CoV-2, according to one much-discussed recent paper. An earlier paper had put the figure at between 40 and 60 percent. And a third had found an even higher prevalence: 81 percent.
  • The T-cell story is similarly encouraging in its big-picture implications without being necessarily paradigm-changing
  • These numbers suggest their own heterogeneity — that different populations, with different demographics, would likely exhibit different levels of cross-reactive T-cell immune response
  • The most optimistic interpretation of the data was given to me by Francois Balloux, a somewhat contrarian disease geneticist and the director of the University College of London’s Genetics Institute
  • According to him, a cross-reactive T-cell response wouldn’t prevent infection, but would probably mean a faster immune response, a shorter period of infection, and a “massively” reduced risk of severe illness — meaning, he guessed, that somewhere between a third and three-quarters of the population carried into the epidemic significant protection against its scariest outcomes
  • the distribution of this T-cell response could explain at least some, and perhaps quite a lot, of COVID-19’s age skew when it comes to disease severity and mortality, since the young are the most exposed to other coronaviruses, and the protection tapers as you get older and spend less time in environments, like schools, where these viruses spread so promiscuously.
  • Balloux told me he believed it was also possible that the heterogeneous distribution of T-cell protection also explains some amount of the apparent decline in disease severity over time within countries on different pandemic timelines — a phenomenon that is more conventionally attributed to infection spreading more among the young, better treatment, and more effective protection of the most vulnerable (especially the old).
  • Going back to Youyang Gu’s analysis, what he calls the “implied infection fatality rate” — essentially an estimated ratio based on his modeling of untested cases — has fallen for the country as a whole from about one percent in March to about 0.8 percent in mid-April, 0.6 percent in May, and down to about 0.25 percent today.
  • even as we have seemed to reach a second peak of coronavirus deaths, the rate of death from COVID-19 infection has continued to decline — total deaths have gone up, but much less than the number of cases
  • In other words, at the population level, the lethality of the disease in America has fallen by about three-quarters since its peak. This is, despite everything that is genuinely horrible about the pandemic and the American response to it, rather fantastic.
  • there may be some possible “mortality displacement,” whereby the most severe cases show up first, in the most susceptible people, leaving behind a relatively protected population whose experience overall would be more mild, and that T-cell response may play a significant role in determining that susceptibility.
  • That, again, is Balloux’s interpretation — the most expansive assessment of the T-cell data offered to me
  • The most conservative assessment came from Sarah Fortune, the chair of Harvard’s Department of Immunology
  • Fortune cautioned not to assume that cross-protection was playing a significant role in determining severity of illness in a given patient. Those with such a T-cell response, she told me, would likely see a faster onset of robust response, yes, but that may or may not yield a shorter period of infection and viral shedding
  • Most of the scientists, doctors, epidemiologists, and immunologists I spoke to fell between those two poles, suggesting the T-cell cross-immunity findings were significant without necessarily being determinative — that they may help explain some of the shape of pandemic spread through particular populations, but only some of the dynamics of that spread.
  • he told me he believed, in the absence of that data, that T-cell cross-immunity from exposure to previous coronaviruses “might explain different disease severity in different people,” and “could certainly be part of the explanation for the age skew, especially for why the very young fare so well.”
  • the headline finding was quite clear and explicitly stated: that preexisting T-cell response came primarily via the variety of T-cells called CD4 T-cells, and that this dynamic was consistent with the hypothesis that the mechanism was inherited from previous exposure to a few different “common cold” coronaviruses
  • “This potential preexisting cross-reactive T-cell immunity to SARS-CoV-2 has broad implications,” the authors wrote, “as it could explain aspects of differential COVID-19 clinical outcomes, influence epidemiological models of herd immunity, or affect the performance of COVID-19 candidate vaccines.”
  • “This is at present highly speculative,” they cautioned.
Javier E

Coronavirus Treatment: Hundreds of Scientists Scramble to Find One - The New York Times - 0 views

  • Working at a breakneck pace, a team of hundreds of scientists has identified 50 drugs that may be effective treatments for people infected with the coronavirus.
  • Many of the candidate drugs are already approved to treat diseases, such as cancer, that would seem to have nothing to do with Covid-19, the illness caused by the coronavirus.
  • If the research effort succeeds, it will be a significant scientific achievement: an antiviral identified in just months to treat a virus that no one knew existed until January.
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  • Dr. Krogan and his colleagues set about finding proteins in our cells that the coronavirus uses to grow. Normally, such a project might take two years. But the working group, which includes 22 laboratories, completed it in a few weeks.
  • In 2011, Dr. Krogan and his colleagues developed a way to find all the human proteins that viruses use to manipulate our cells — a “map,” as Dr. Krogan calls it. They created their first map for H.I.V.
  • That virus has 18 genes, each of which encodes a protein. The scientists eventually found that H.I.V. interacts, in one way or another, with 435 proteins in a human cell.
  • In February, the research group synthesized genes from the coronavirus and injected them into cells. They uncovered over 400 human proteins that the virus seems to rely on.
  • The flulike symptoms observed in infected people are the result of the coronavirus attacking cells in the respiratory tract.
  • The new map shows that the virus’s proteins travel throughout the human cell, engaging even with proteins that do not seem to have anything to do with making new viruses.
  • Kevan Shokat, a chemist at U.C.S.F., is poring through 20,000 drugs approved by the Food and Drug Administration for signs that they may interact with the proteins on the map created by Dr. Krogan’s lab.
  • If promising drugs are found, investigators plan to try them in an animal infected with the coronavirus — perhaps ferrets, because they’re known to get SARS, an illness closely related to Covid-19.
  • Even if some of these drugs are effective treatments, scientists will still need to make sure they are safe for treating Covid-19. It may turn out, for example, that the dose needed to clear the virus from the body might also lead to dangerous side effects.
  • In past studies on animals, remdesivir blocked a number of viruses. The drug works by preventing viruses from building new genes.
  • In February, a team of researchers found that remdesivir could eliminate the coronavirus from infected cells. Since then, five clinical trials have begun to see if the drug will be safe and effective against Covid-19 in people.
  • Other researchers have taken startling new approaches. On Saturday, Stanford University researchers reported using the gene-editing technology Crispr to destroy coronavirus genes in infected cells.
Javier E

Five months on, what scientists now know about the coronavirus | World news | The Guardian - 0 views

  • The Sars-CoV-2 virus almost certainly originated in bats, which have evolved fierce immune responses to viruses, researchers have discovered. These defences drive viruses to replicate faster so that they can get past bats’ immune defences. In turn, that transforms the bat into a reservoir of rapidly reproducing and highly transmissible viruses
  • “This virus probably jumped from a bat into another animal, and that other animal was probably near a human, maybe in a market,
  • Virus-ridden particles are inhaled by others and come into contact with cells lining the throat and larynx. These cells have large numbers of receptors – known as Ace-2 receptors – on their surfaces. (Cell receptors play a key role in passing chemicals into cells and in triggering signals between cells.
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  • “This virus has a surface protein that is primed to lock on that receptor and slip its RNA into the cell,”
  • Once inside, that RNA inserts itself into the cell’s own replication machinery and makes multiple copies of the virus. These burst out of the cell, and the infection spreads. Antibodies generated by the body’s immune system eventually target the virus and in most cases halt its progress.
  • “A Covid-19 infection is generally mild, and that really is the secret of the virus’s success,” adds Ball. “Many people don’t even notice they have got an infection and so go around their work, homes and supermarkets infecting others.”
  • the virus can cause severe problems. This happens when it moves down the respiratory tract and infects the lungs, which are even richer in cells with Ace-2 receptors. Many of these cells are destroyed, and lungs become congested with bits of broken cell. In these cases, patients will require treatment in intensive care.
  • Even worse, in some cases, a person’s immune system goes into overdrive, attracting cells to the lungs in order to attack the virus, resulting in inflammation
  • This process can run out of control, more immune cells pour in, and the inflammation gets worse. This is known as a cytokine storm.
  • Just why cytokine storms occur in some patients but not in the vast majority is unclear
  • Doctors examining patients recovering from a Covid-19 infection are finding fairly high levels of neutralising antibodies in their blood. These antibodies are made by the immune system, and they coat an invading virus at specific points, blocking its ability to break into cells.
  • Instead, most virologists believe that immunity against Covid-19 will last only a year or two. “That is in line with other coronaviruses that infect humans,
  • “It is clear that immune responses are being mounted against Covid-19 in infected people,” says virologist Mike Skinner of Imperial College London. “And the antibodies created by that response will provide protection against future infections – but we should note that it is unlikely this protection will be for life.”
  • “That means that even if most people do eventually become exposed to the virus, it is still likely to become endemic – which means we would see seasonal peaks of infection of this disease. We will have reached a steady state with regard to Covid-19.”
  • Skinner is doubtful. “We have got to consider this pandemic from the virus’s position,” he says. “It is spreading round the world very nicely. It is doing OK. Change brings it no benefit.”
  • In the end, it will be the development and roll-out of an effective vaccine that will free us from the threat of Covid-19,
  • the journal Nature reported that 78 vaccine projects had been launched round the globe – with a further 37 in development.
  • vaccines require large-scale safety and efficacy studies. Thousands of people would receive either the vaccine itself or a placebo to determine if the former were effective at preventing infection from the virus which they would have encountered naturally. That, inevitably, is a lengthy process.
  • some scientists have proposed a way to speed up the process – by deliberately exposing volunteers to the virus to determine a vaccine’s efficacy.
  • Volunteers would have to be young and healthy, he stresses: “Their health would also be closely monitored, and they would have access to intensive care and any available medicines.”
  • The result could be a vaccine that would save millions of lives by being ready for use in a much shorter time than one that went through standard phase three trials.
  • phase-three trials are still some way off, so we have time to consider the idea carefully.”
clairemann

How a Global Ecocide Law Could Hold Polluters to Account | Time - 0 views

  • When a Nigerian judge ruled in 2005 that Shell’s practice of gas flaring in the Niger Delta was a violation of citizens’ constitutional rights to life and dignity, Nnimmo Bassey, a local environmental activist, was thrilled.
  • “For the first time, a court of competence has boldly declared that Shell, Chevron and the other oil corporations have been engaged in illegal activities here for decades,” Bassey said on Nov. 14, 2005, the day the Federal High Court of Nigeria announced the ruling. “We expect this judgement to be respected and that for once the oil corporations will accept the truth and bring their sinful flaring activities to a halt.”
  • “Shell could ignore [the case] because it wasn’t in the international media but if it had gone to the ICC, it would have gotten global attention and shareholders would have known what the company was doing,” he says. “If we had had an ecocide law, things would have turned out differently.”
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  • Yet the judgement was not respected. A United Nations report published six years later found that Shell had not followed its own procedures regarding the maintenance of oilfield infrastructure. Today, Shell is still gas flaring in the Niger Delta.
  • The word “ecocide” is an umbrella term for all forms of environmental destruction from deforestation to greenhouse gas emissions.
  • Although there are questions about whether the ICC as an institution has the teeth to prosecute any crimes, Bassey and other activists believe the law will act as a powerful deterrent against future forms of environmental destruction. “We will not get different outcomes in cases of exploitation and marginalization unless we reimagine the laws that govern us,” Bassey says.
  • In December 2020, lawyers from around the world gathered to begin drafting a legal definition of ecocide.
  • The term ecocide first rose to the public consciousness in 1972, when Olof Palme, the premier of Sweden, used the term at a United Nations environmental conference in Stockholm to describe the environmental damage caused by the Vietnam War. At the conference, an ecocide convention was proposed but never came to pass.
  • “My recollection is that there was just no political support for it,” says Philippe Sands, who was involved in drafting the preamble of the Rome Statute in 1998 (and who would go on to co-chair the expert panel formed in 2020 to draft a legal definition of ecocide). Environmental destruction, Sands says, was not on the public’s consciousness.
  • Environmental advocates believe an ecocide law at the ICC would be groundbreaking. While some countries have national laws on environmental harm, there is no international criminal law that explicitly imposes penalties on individuals responsible for environmental destruction. If adopted, experts say there are three main areas where an ecocide law would make a difference.
  • The first is the symbolic impact of having the ICC elevate environmental destruction to the same level as genocidal crimes
  • The second area where this law could make a difference is by setting a legal precedent, creating a bandwagon effect where international law could prompt changes in national criminal laws, as countries look to signal their environmental commitment to others.
  • The third way an ecocide law could be useful is by prosecuting environmental crimes that fall outside of national jurisdictions.
lucieperloff

Why Riders Abandoning Buses and Trains is a Problem for Climate Change - The New York T... - 0 views

  • On the London Underground, Piccadilly Circus station is nearly vacant on a weekday morning, while the Delhi Metro is ferrying fewer than half of the riders it used to. In Rio, unpaid bus drivers have gone on strike. New York City subway traffic is just a third of what it was before the pandemic.
  • Public transit offers a relatively simple way for cities to lower their greenhouse gas emissions, not to mention a way to improve air quality, noise and congestion.
  • “It’s urgent to act.”
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  • transportation experts are scrambling to figure out how to better adapt public transit to the needs of riders as cities begin to emerge from the pandemic.
  • In India, a company that sells secondhand cars online saw sales swell in 2020 and its own value as a company jump to $1 billion, according to news reports. Elsewhere, bike sales have grown, suggesting that people are pedaling a bit more.
  • Both London and Paris sought to use lockdowns to expand bike lanes.
  • ridership was just over half of normal in the first two months of this year.
  • “only travel when absolutely necessary.”
  • The city transit agency, which had once projected a budget surplus for 2020, has instead been relying on government bailouts since the pandemic hit.
  • Most importantly, if transit systems continue to lose passenger fare revenues, they will not be able to make the investments necessary to be efficient, safe and attractive to commuters.
  • There’s even more distress in cities where people rely in large part on private bus companies.
  • Strikes by bus drivers have made bus travel even slower and more chaotic.
  • efficient bus system is critical for Rio to not only reduce its carbon emissions but also to clean its air. “It’s not just an environmental issue, but a public health issue,” Ms. Celidonio said.
  • “Those cities that were investing, they will get out stronger,”
cvanderloo

Long COVID: who is at risk? - 0 views

  • But some people have long-lasting symptoms after their infection – this has been dubbed “long COVID”.
  • In defining who is at risk from long COVID and the mechanisms involved, we may reveal suitable treatments to be tried – or whether steps taken early in the course of the illness might ameliorate it.
  • Indeed, early analysis of self-reported data submitted through the COVID Symptom Study app suggests that 13% of people who experience COVID-19 symptoms have them for more than 28 days, while 4% have symptoms after more than 56 days.
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  • Patients in this study had a mean age of 44 years, so were very much part of the young, working-age population. Only 18% had been hospitalised with COVID-19, meaning organ damage may occur even after a non-severe infection.
  • Another piece of early research (awaiting peer review) suggests that SARS-CoV-2 could also have a long-term impact on people’s organs.
  • Perhaps unsurprisingly, people with more severe disease initially – characterised by more than five symptoms – seem to be at increased risk of long COVID. Older age and being female also appear to be risk factors for having prolonged symptoms, as is having a higher body mass index.
  • Rather harder to explore is the symptom of fatigue. Another recent large-scale study has shown that this symptom is common after COVID-19 – occurring in more than half of cases – and appears unrelated to the severity of the early illness.
  • While men are at increased risk of severe infection, that women seem to be more affected by long COVID may reflect their different or changing hormone status.
  • Some symptoms of long COVID overlap with menopausal symptoms, and hormone replacement using medication may be one route to reducing the impact of symptoms.
  • What is clear, however, is that long-term symptoms after COVID-19 are common, and that research into the causes and treatments of long COVID will likely be needed long after the outbreak itself has subsided.
edencottone

Ron DeSantis' Florida boast rings hollow (opinion) - CNN - 0 views

  • New cases of Covid-19 in the United States have fallen in the last two months to about 55,000 a day.
  • These numbers are promising, but the ups and downs and ups tell an important lesson about keeping perspective in a pandemic. Today's promising numbers would have been horrific at this time last year and are hardly as good as they need to be.
  • No one knows this more than the country's governors. Since the Trump White House dumped the job of handling the pandemic almost entirely into their laps, they have had to respond on the fly.
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  • We are already seeing the first wave of "who won and who lost" sorts of stories pitting various governors' responses against each other in horse-race fashion, as if these were early polls for the 2024 presidential election.
  • Then reality stepped in. A surge of summer cases forced the imposition of some restrictions on Floridians, like local mask mandates imposed by mayors in some cities in South Florida.
  • Now DeSantis is claiming again to be a master of pandemic control, as Florida's beach-tourism-restaurant industry is said to be doing well. Never mind that the state's seven-day infection rate of 143.9 per 100,000 population places it 12th highest of the 50 states.
  • For example, as of March 22, over the last seven days, Florida has had the most Covid-19 cases in the country, according to data from the US Centers for Disease Control and Prevention (CDC), the 12th highest per capita case-rate, the fourth highest number of deaths, and the 17th highest death rate.
  • Once celebrated for his pandemic management, he is now getting poor marks on managing. He has not strutted or had roundtables of fan-doctors to sing his praise. But the fact is California's recent numbers are much better than those of Florida, coming in at about 47th in the country with a case-rate 46.8 per 100,000, according to the CDC's data, and fewer deaths as well.
  • Florida is ignoring the death toll and instead pushing the upbeat metrics the governor would like America to pay attention to: jobs are up! and schools are open! DeSantis stood up to the Covid-19 threat like John Wayne would have done!
  • Rather than wallow in reality, she chose to celebrate an active economy and the joys of hunting season (note: the South Dakota new-infection rate is climbing the charts once again and sits at 105 per 100,000 South Dakotans ).
  • These rate-the-governors perspectives ignore a basic fact: it is no time for trophies.
  • Worse, this obeisance to economic and social factors as measure of success creates a series of disturbing false equivalencies as they compare deaths against the economy.
  • Measuring Covid-19 management on anything other than the number of human lives lost is not only disgraceful, it will also almost certainly lead us to make all the wrong decisions once again and usher in yet another Covid-19 resurgence in the US.
Javier E

How Joe Biden's Digital Team Tamed the MAGA Internet - The New York Times - 1 views

  • it’s worth looking under the hood of the Biden digital strategy to see what future campaigns might learn from it.
  • while the internet alone didn’t get Mr. Biden elected, a few key decisions helped his chances.
  • 1. Lean On Influencers and Validators
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  • In the early days of his campaign, Mr. Biden’s team envisioned setting up its own digital media empire. It posted videos to his official YouTube channel, conducted virtual forums and even set up a podcast hosted by Mr. Biden, “Here’s the Deal.”
  • those efforts were marred by technical glitches and lukewarm receptions, and they never came close to rivaling the reach of Mr. Trump’s social media machine.
  • So the campaign pivoted to a different strategy, which involved expanding Mr. Biden’s reach by working with social media influencers and “validators,
  • Perhaps the campaign’s most unlikely validator was Fox News. Headlines from the outlet that reflected well on Mr. Biden were relatively rare, but the campaign’s tests showed that they were more persuasive to on-the-fence voters than headlines from other outlets
  • the “Rebel Alliance,” a jokey nod to Mr. Parscale’s “Death Star,” and it eventually grew to include the proprietors of pages like Occupy Democrats, Call to Activism, The Other 98 Percent and Being Liberal.
  • 2. Tune Out Twitter, and Focus on ‘Facebook Moms’
  • “The whole Biden campaign ethos was ‘Twitter isn’t real life,’” Mr. Flaherty said. “There are risks of running a campaign that is too hyper-aware of your own ideological corner.”
  • As it focused on Facebook, the Biden campaign paid extra attention to “Facebook moms” — women who spend a lot of time sharing cute and uplifting content
  • “Our goal was really to meet people where they were,”
  • 3. Build a Facebook Brain Trust
  • “When people saw a Fox News headline endorsing Joe Biden, it made them stop scrolling and think.”
  • Ultimately, he said, the campaign’s entire digital strategy — the Malarkey Factory, the TikTok creators and Facebook moms, the Fortnite signs and small-batch creators — was about trying to reach a kinder, gentler version of the internet that it still believed existed.
  • “I had the freedom to go for the jugular,” said Rafael Rivero, a co-founder of Occupy Democrats and Ridin’ With Biden, another big pro-Biden Facebook page.
  • “It was sort of a big, distributed message test,” Mr. Flaherty said of the Rebel Alliance. “If it was popping through Occupy or any of our other partners, we knew there was heat there.”
  • These left-wing pages gave the campaign a bigger Facebook audience than it could have reached on its own. But they also allowed Mr. Biden to keep most of his messaging positive, while still tapping into the anger and outrage many Democratic voters felt.
  • 4. Promote ‘Small-Batch Creators,’ Not Just Slick Commercials
  • the Biden campaign found that traditional political ads — professionally produced, slick-looking 30-second spots — were far less effective than impromptu, behind-the-scenes footage and ads that featured regular voters talking directly into their smartphones or webcams about why they were voting for Mr. Biden.
  • “The things that were realer, more grainy and cheaper to produce were more credible.”
  • In addition to hiring traditional Democratic ad firms, the campaign also teamed up with what it called “small-batch creators” — lesser-known producers and digital creators, some of whom had little experience making political ads
  • 5. Fight Misinformation, but Pick Your Battles
  • The campaign formed an in-house effort to combat these rumors, known as the “Malarkey Factory.” But it picked its battles carefully, using data from voter testing to guide its responses.
  • “The Hunter Biden conversation was many times larger than the Hillary Clinton email conversation, but it really didn’t stick, because people think Joe Biden’s a good guy,”
  • the campaign’s focus on empathy had informed how it treated misinformation: not as a cynical Trump ploy that was swallowed by credulous dupes, but as something that required listening to voters to understand their concerns and worries before fighting back
  • On the messaging app Signal, the page owners formed a group text that became a kind of rapid-response brain trust for the campaign.
  • “We made a decision early that we were going to be authentically Joe Biden online, even when people were saying that was a trap.”
jmfinizio

Transparent screens are the cool new tech trend - CNN - 0 views

  • you can also see right through them.
  • LG (LPL) unveiled a transparent TV with a screen you can see through when on or off.
  • While 8k TVs may be the next true big bump in screen resolution, many TV manufacturers use CES as a testing ground to tease new innovations.
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  • In August, Xiaomi started selling a 55-inch transparent TV with a mighty high $7,200 price tag.
  • Although transparent TVs seem like a cool-but-unnecessary technology, industry experts say they are something we could see more in public spaces soon.
  • "The major use case is going to be commercial for now,"
  • It's not unusual for companies to release technologies without a clear market for them
  • . Doing so is a way to gauge people's initial response and interest
  • LG's move to hide a transparent TV in a bed for its promotional video shows how the technology could find a home beyond public places
  • it can be placed like a space divider or against a large glass window, which will only look like glass when it is not in us
jmfinizio

Opinion: How to distribute Covid-19 vaccines fairly around the world - CNN - 0 views

  • how do we distribute vaccines safely and equitably to those most in need in our own countries and across the world
  • set back the United Nations' Sustainable Development Goals by an estimated 20 years.
  • to distribute 2 billion doses of a vaccine, as well as 245 million treatments and 500 million tests by the end of 2021.
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  • As of today, 189 economies have signed up or are supported by the facility, but more is needed.
  • "5-point plan to protect humanity against another pandemic like Covid-19,"
  • The more vaccine candidates we have, the more likely we are to end the pandemic quickly.
  • poorer countries will be left behind and all of us will be less safe.
  • killed over 2 million adults and children in a single year at its peak.
jmfinizio

Opinion: What Argentina's 'green handkerchief' movement is all about - CNN - 0 views

  • a majority of its Senate voted yes on a bill to legalize abortion up to 14 weeks into a pregnancy
  • President Alberto Fernández has pledged to sign the bill into law, which will make Argentina the largest nation in Latin America to legalize abortion
  • This victory comes after decades of feminist advocacy and a women's movement that has demanded its issues be understood as interconnected and overlapping.
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  • "It's also the notion that women are whole,
  • women's lives aren't segmented into political buckets.
  • The symbol of this movement has been the green handkerchief, and it has spread across Latin America to symbolize a commitment to women's rights.
  • women with fewer means -- often rural, indigenous, and poor women -- have fewer options,
  • All of those women, but most often the poor ones, risk being maimed or dying if an unsafe abortion goes wrong
  • unsafe abortion remains a leading cause of maternal mortality worldwide and women die from unsafe abortions in the highest numbers in nations where it is illegal or difficult to access
  • Legalizing abortion could have broad ripple effects from Brazil to Chile to Colombia and beyond
  • this shows "that we can overcome and resist and continue fighting and eventually succeed, even in the oddest of circumstances possible."
ilanaprincilus06

With Child Hunger Rising, A Federal Aid Program Has Stalled : NPR - 0 views

  • When schools shut down in the spring, that raised immediate worries about the nearly 30 million children who depend on school food.
  • According to a report from Feeding America, 1 in 4 households with children experienced food insecurity in 2020.
  • when families are having trouble stretching their food budget, the adults will go without food before allowing the children to go hungry. But in April, with shutdowns at their most acute, nearly 20 percent of mothers said their children themselves didn't have enough to eat.
  • ...7 more annotations...
  • School food programs have been working hard: offering groceries, pre-prepared meals and everything in between. But as we've reported, it often isn't enough.
  • Congress passed a law giving families the cash value of the meals they missed when schools were closed.
  • Families were eligible for $117 per child per month.
  • The potential value, estimates Bauer: $12 billion.
  • The U.S. Department of Agriculture didn't issue guidance to states on plans for how to do this for six weeks
  • So far, they have approved only the plans from Massachusetts, Indiana and Rhode Island. And they haven't yet touched the issue of how to give out the money to children under 6.
  • "The long and short of it is for the past three-plus months, states should have been able to distribute more than $100 of food benefits per child [per month]," she says. "And USDA is not making it easy for any state to roll out this program."
ilanaprincilus06

New York State Sues NYPD Over Its Handling Of 2020 Racial Justice Protests : NPR - 0 views

  • New York Attorney General Letitia James has filed a lawsuit against the New York City Police Department, citing "a pattern of using excessive force and making false arrests against New Yorkers during peaceful protests" that sought racial justice and other changes.
  • It's now seeking a court order "declaring that the policies and practices that the NYPD used during these protests were unlawful."
  • Along with the court order, the attorney general is asking for policy reforms and a monitor to oversee the NYPD's tactics and handling of future protests.
  • ...6 more annotations...
  • A video last May apparently showed police SUVs surging into a crowd that had surrounded them during a protest in Brooklyn.
  • n July, plainclothes officers were seen on video as they "aggressively detained a woman at a protest and hauled her away in an unmarked vehicle,"
  • inflicting significant physical and psychological harm and leading to great distrust in law enforcement."
  • "this longstanding pattern of brutal and illegal force ends. No one is above the law — not even the individuals charged with enforcing it."
  • "failed to prevent and address the pattern or practice of excessive force and false arrests by officers against peaceful protesters in violation of the First, Fourth, and Fourteenth Amendments of the United States Constitution"
  • says the NYPD made a practice out of "kettling" — corralling people by using physical force and obstructions — to arrest protesters rather than allowing crowds to disperse.
colemorris

Sports' path to return to normal may not be clear - The Washington Post - 0 views

  • “It was the mental part. You want to get it right; you want to be fair; you want to be smart. It just felt like there was broken glass all around. And it wasn’t a matter of if you’re going to step on it but how deep is the cut going to be.”
  • “It was the mental part. You want to get it right; you want to be fair; you want to be smart. It just felt like there was broken glass all around. And it wasn’t a matter of if you’re going to step on it but how deep is the cut going to be.”
    • colemorris
       
      it is very interesting to hear how even though he is not the one playing the sports and is the broadcaster/ analysist he is so heavily affected by this
  • will sports be fun again — will they serve as the harmless distraction and social balm that once sustained so many?
  • ...7 more annotations...
  • In the past, sports have served as a welcome distraction through pain or trauma. But no game could blot out what was unfolding in 2020. It all blended together, the planet’s problems disrupting the sports world, along with everything else.
  • Even when the games returned, television ratings were down almost across the board. Sports hadn’t been able to offer a respite for everyone.
    • colemorris
       
      covid really put the entire economy in shambles no matter what the business.
  • “Think about it: We took all the fundamental building blocks out of sports this year,” he said. “Anticipation, social gathering, water cooler talk, the ability to play — we took everything out.
  • Utah Jazz player Rudy Gobert tested positive in March and the NBA swiftly halted its season,
    • colemorris
       
      I remember this and in the press conference right before we found out he had it he was seen mocking the disease and touching everything around him purposely.
  • A majority of fans, 56 percent, said people shouldn’t play indoor sports, according to a Marist poll this month. And 49 percent said fans shouldn’t be allowed to attend the Super Bowl.
  • McManus points out that nearly one in five sports fans, 18 percent, said they should be allowed to attend games right now and another 36 percent said they should be allowed to attend with restrictions in place.
  • “Americans, in particular, have very, very short memories,”
    • colemorris
       
      true
mshilling1

Dominion Voting Systems Official Is In Hiding After Threats : NPR - 0 views

  • It's just the latest example of how people's lives are being upended and potentially ruined by the unprecedented flurry of disinformation this year.
  • As people experience their own individual Internet bubbles, it can be hard to recognize just how much misinformation exists and how the current information ecosystem compares with previous years.
  • NewsGuard, which vets news sources based on transparency and reliability standards, found recently that among the top 100 sources of news in the U.S., sources it deemed unreliable had four times as many interactions this year compared with 2019.
  • ...4 more annotations...
  • But election integrity advocates worry the disinformation won't truly begin to recede until political leaders such as Trump stop questioning the election's legitimacy.
  • Even in an election where almost all the voting was recorded on paper ballots and rigorous audits were done more than ever before, none of that helps if millions of people are working with an alternative set of facts,
  • Even if an election is run perfectly, it doesn't matter to a sizable portion of the public who believes it was unfair. No amount of transparency at the county and state level can really combat the sort of megaphone that Trump wields
  • "When we're in the realm of coupling disinformation from both foreign and domestic sources, and government and nongovernment sources, and none of it is really grounded in reality ... evidence doesn't help much,
anonymous

Trump's Twitter ban renews calls for tech law changes by many who don't get tech or the... - 1 views

  • There is no way Wednesday's events could have happened without the convenience and ease afforded to white supremacists — and almost everyone else — by the openness of the modern consumer internet.
  • It's ironic, then, that the insurrection unfolded on the heels of President Donald Trump's continual efforts to repeal Section 230 of the Communications Decency Act, which makes it difficult to sue online platforms over the content they host (or don't) — or how they moderate it (or don't).
  • Section 230 is, of course, the rare law that is disliked by Republicans and Democrats. Biden hates it, having said: "I think social media should be more socially conscious in terms of what is important in terms of our democracy. ... Everything should not be about whether they can make a buck."
  • ...8 more annotations...
  • It's one of the most consequential laws governing the internet, and it provided a crucial liability shield for technology companies for content they didn't themselves create, like comment threads.
  • and it has never even been updated to take into account any of the technological changes that have happened since.
  • What Rule 230 isn't (though it's often portrayed that way) is a bedrock for free speech protections: It's simply a rule that permits internet companies to moderate what other people put on their platforms — or not — without being on the hook legally for everything that happens to be there
  • There is an opportunity to use technology to protect people's ability to safely participate in democracy and enable a different America — the America we witnessed in Georgia on Tuesday — and a different world.
  • After Republicans lost the White House, the House and then the Senate, technology companies no longer feel pressure to cozy up to conservatives to keep their prerogatives.
  • But don't mistake the technology industry's lobbying points about free speech as being related to any real care for American democracy.
  • The major technology platforms enabling hate speech all have one thing in common with our 45th president: self-interest.
  • Freedom of speech is truly a value to cherish, but we cherish it through facilitating the expression of truth, not the unfettered right to spew lies and incite violence without consequence.
huffem4

Millennials and Gen Z Will Soon Dominate U.S. Elections - The Atlantic - 1 views

  • Gen Z, like a youthful cavalry, will start entering the electorate in large numbers this year, and will reinforce the change that Millennials began. These young Americans, born from 1997 to 2012, are even more racially diverse than Millennials. Forty-nine percent of Gen Z are people of color, versus 45 percent of Millennials, according to a recent analysis of census data
  • By contrast, more than 70 percent of Baby Boomers are white.
  • they are rebuking Trump and the Republicans in a way we haven’t seen since the 2008 presidential” race
  • ...2 more annotations...
  • Given that the younger generations align much more closely with Democratic ideological views on almost all policy questions, this shift underscores the stakes in the generational roulette Trump has played by defining the GOP so narrowly around the priorities and preferences of his core groups: older, nonurban, non-college-educated, and evangelical white people.
  • We see even people who self-identify as young Republicans disagree with Trump on almost every issue
huffem4

The Power of Positive Thinking: Too Much and Never Enough - The Bulwark - 1 views

  • Peale was exceptional for cutting the flock some spiritual slack, encouraging them to look for the sunny side and conquer their inferiority complexes. In his world, you can have the economic gains minus the guilt, which seems perfectly suited to the American sensibility.
  • The book sold millions of copies and was eventually translated into more than 40 languages, and Peale, from his pulpit at Marble Collegiate Church in Manhattan, became central to the spiritual life of the family of Fred Trump Sr., his wife, Mary, and the four Trump children, including the future president.
  • it was also well suited to justifying and exacerbating the pathologies of the Trump family and businesses
  • ...12 more annotations...
  • Mary Trump (the president’s niece who also happens to have a Ph.D. in psychology) paints a portrait of Fred Trump Sr. as a sociopath, utterly uninterested in entering into the moral, emotional, and psychological world of his family or its members. In keeping with Peale’s teaching, he would no more hear about his wife’s or children’s problems than he would accept a failed business deal
  • Fred would just say, “Everything’s great, right Toots?” refusing to acknowledge, much less accommodate, her illness. 
  • Fred Jr. was then further abused, repeatedly denied authority, second-guessed at every turn, and blamed for every problem, setback, and failure in a perverse tag-team between Fred Sr. and Donald. The abuse fed his alcoholism, which, in the family’s Peale-informed understanding, was not a disease requiring treatment but the result of Fred Jr.’s negative thinking
  • Peale wanted people to be hopeful, kind, and optimistic, and to become “people persons.” The Trump family heard the positive thinking, personal empowerment parts, which integrated easily with its win-at-all-cost ideology, but they, or at least Donald, missed the bits about seeking counsel from others and living a life of dependence upon God.
  • Fred Jr.’s deepening alcoholism only elicited increasing abuse from his father and brother seemingly under the theory that if they were hard enough on him he would turn around. Even in his final crisis, afflicted by fatal, alcohol-induced cardiac problems, no member of the family went with him to the hospital (Donald Trump went to a movie instead). Dying, it appears, is the result of late-stage negative thought.
  • The consistent element in each of these has been to deny negative realities and keep moving. The casinos, the airline, the football league, Trump Vodka, Trump Steaks, Trump University . . . all bear the same markings of hyper optimism and overpromise/underdeliver salesmanship
  • Trump’s just doing what he’s always done: conquering the challenge by blinding himself to it, just the way Reverend Peale taught him and his father insisted upon. 
  • My AEI colleague, Brad Wilcox, documented that men who identified as “evangelical” but infrequently attend church were more likely to engage in domestic violence than evangelicals who regularly attended church, mainline Protestants and those who never attend church. Wilcox believes this results from a kind of doctrinal cherry-picking—big on authority, sovereignty, and power but closed to other-directed teachings like altruism and self-sacrifice. Weak attachment to religious faith tends to put some of the worst behaviors on steroids.  
  • These are the problem-solving strategies that Donald Trump brought to his marriages, six corporate bankruptcies, presidential campaign, and now, what increasingly appears to be a failed presidency.
  • “prosperity gospel” (a belief popularized by televangelists that God intends Christians to be healthy and wealthy)
  • The purpose of these psychological and spiritual practices is to free individuals from self-doubt and feelings of inferiority and help them to become the people God truly intends them to be: happy, wealthy, popular, and professionally successful.
  • Now we have Trump COVID-19 and it’s following the same pattern. The virus is “very well under control” and “going to fade away.”
lucieperloff

Ancient Dog DNA Shows Early Spread Around the Globe - The New York Times - 0 views

  • pins their likely origin to a group of extinct wolves.
  • pins their likely origin to a group of extinct wolves.
    • lucieperloff
       
      extinct?
  • Now an international team of researchers has sequenced and analyzed an additional 27 genomes of ancient dogs.
    • lucieperloff
       
      Where did they find the new genomes?
  • ...9 more annotations...
  • that domestication probably began around 20,000 years ago.
  • much more diverse genetically than modern dogs.
  • All European dogs appear to have descended from one group of ancient European dogs, and the great modern diversity of dog shapes and sizes indicates an emphasis by breeders on certain very powerful genes.
    • lucieperloff
       
      European domesticated dogs came from ancient european dogs
  • Modern wolves, however, do show the incorporation of some dog DNA.
    • lucieperloff
       
      Wolf DNA is recessive?
  • The extraordinarily rich amount of information gathered from the 27 genomes provided many new perspectives on dog domestication and their association with humans.
  • even while they were sometimes breeding with wolves, no new wolf DNA entered their genomes.
  • Pigs can be a little wild but “if you’re a dog and you’ve got a little bit of wolf in you, that’s not a good thing and those things get knocked on the head very quickly or run away or disappear but they don’t get integrated into the dog population.”
    • lucieperloff
       
      Dogs with more wolf genes are less favorable - less common today
  • But then there was the sudden loss of diversity in dogs starting around 4,000 years ago.
  • The exact where and when of dog domestication remain unclear, and will never be pinned down to the kind of moment in time that dog owners like to imagine, but, in terms of a period of time and geographic area, Dr. Larson said, “We’re getting closer.”
    • lucieperloff
       
      No obvious answer to this question
lucieperloff

12 Ways People Say Their Anxiety Has Changed During 2020 | HuffPost Life - 0 views

  • This year has tested our collective mental health again and again — from fears over the coronavirus to the isolating effects of social distancing, the reckoning on racial injustice, financial struggles, natural disasters and a contentious presidential election just weeks away.
  • This year has tested our collective mental health again and again — from fears over the coronavirus to the isolating effects of social distancing, the reckoning on racial injustice, financial struggles, natural disasters and a contentious presidential election just weeks away.
    • lucieperloff
       
      So many more aspects in 2020 that have tested us than just the corona virus.
  • While many people with pre-existing anxiety report their symptoms have worsened in 2020, there’s also a subset who say they’ve been less anxious.
    • lucieperloff
       
      Different responses from everyone to this new trauma
  • ...11 more annotations...
  • It’s hard to break free from anxious thoughts when you’re consumed with the world falling apart with no end in sight.”
    • lucieperloff
       
      It's hard because no one knows (or knew) what was happening.
  • my anxiety always gave me this sinking feeling that something bad was going to happen.
  • But when the isolating isn’t by choice, and it’s to avoid a deadly disease, it can be the cause of panic-inducing thoughts that you can’t escape from.
    • lucieperloff
       
      Something that used to be a good thing created more anxiety
  • “Racial injustice doesn’t mix well with trauma, so I’ve had to do my mental illness a favor and log off of social media.
    • lucieperloff
       
      Social media can really increase all of the anxieties people feel
  • It’s as if the worry and anxiety is always at the back of my mind even when I sleep and as soon as I wake up, it overwhelms me immediately.
  • “As someone with anxiety, I already feel an unrealistic and heavy responsibility on how my actions and words affect others.
  • At first I was filled with panic, but now I’ve adjusted to this new normal.
    • lucieperloff
       
      The initially scary realities we were faced with have become routine
  • my anxiety started to stem from not knowing when this will end or when things can go back to feeling normal.
  • Now, I realize that the world can change in a second and that I have to learn to let certain things go. Who knows what is going to happen next.
  • “My mind immediately goes to the worst-case scenario and that’s when things start spiraling for me.
    • lucieperloff
       
      It's hard not to when this could easily be someone else's worse-case-scenario mindset
  • Today, after a few months, the COVID anxiety isn’t as strong as it was ― when, strangely, COVID is stronger than ever in my city
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