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Studies carried out with college students have found that brief episodes are common in young people, with a prevalence ranging from 30 to 70 percent. It can happen when you’re jet-lagged, hungover, or stressed. But for roughly 1 to 2 percent of the population, it becomes persistent, and distressing

Research suggests that areas of the brain that are key to emotional and physical sensations, such as the amygdala and the insula, appear to be less responsive in chronic depersonalization sufferers. You might become less empathetic; your pain threshold might increase. These numbing effects mean that it’s commonly conceived as a defense mechanism; Hunter calls it a “psychological trip switch” which can be triggered in times of stress.

Have you ever played that game when you repeat a word over and over again until it loses all meaning? It’s called semantic satiation. Like words, can a sense of self be broken down into arbitrary, socially-constructed components?

That question may be why the phenomenon has attracted a lot of interest from philosophers. In a sense, the experience presupposes certain notions of how the self is meant to feel. We think of a self as an essential thing—a soul or an ego that everyone has and is aware of—but scientists and philosophers have been telling us for a while now that the self isn’t quite as it seems

there is no center in the brain where the self is generated. “What we experience is a powerful depiction generated by our brains for our benefit,” he writes. Brains make sense of data that would otherwise be overwhelming. “Experiences are fragmented episodes unless they are woven together in a meaningful narrative,” he writes, with the self being the story that “pulls it all together.”

“The unity [of self that] we experience, which allows us legitimately to talk of ‘I,’ is a result of the Ego Trick—the remarkable way in which a complicated bundle of mental events, made possible by the brain, creates a singular self, without there being a singular thing underlying it,”

depersonalization is both a burden, a horrible burden—but it’s in some strange way a blessing, to reach some depths, some meaning which somehow comes only in the broken mirror,” Bezzubova says. “It’s a Dostoyevsky style illumination—where clarity cannot be distinguished from pain.”

for her, the experience is pleasant. “It’s helped me in my life,” she says. Over the past few years, she has learned to interpret her experiences in a Buddhist context, and she describes depersonalization as a “deconditioning” of sorts: “The significance I place on the world is all in my mind,”

“I believe I am on the path to enlightenment,” she says.

The crossover between dark mental states and Buddhist practices is being investigated

Mindfulness has become increasingly popular in the West over the past few years, but as Britton told The Atlantic, the practice in its original form isn’t just about relaxation: It’s about the often painstaking process of coming to terms with three specific insights of the Theravadin Buddhist tradition, which are anicca, or impermanence; dukkha, or dissatisfaction; and anatta, or not-self.

depersonalization must cause the patient distress and have an impact on her daily functioning for it to be classified as clinically significant. In this sense, it seems inappropriate to call Alice’s experiences pathological. “We have ways of measuring disorders, but you have to ask if it’s meaningful. It’s an open question,”

“I think calling it a loss of self is maybe a convenient shorthand for something that’s hard to capture,” he says. “I prefer to talk about experience—because that’s what’s important in psychiatry.”