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The knowledge that video games possess this power, that they allow us to adopt new identities and grant us new ways of seeing ourselves, is as old as Mario’s quest for his princess.

One central problem for artificial intelligence is how to get aboutness into computer programs – how to get semantics out of syntactics.

Visual experience is beyond merely having certain physical inputs in the forms of light waves, undergoing certain transformations in the brain and producing physical outputs such as speaking the sentence “There is something red.”

He needs to explain how he thinks a computational account can be provided of qualia; or he needs to abandon a qualia-based account of experience, in favour of some computational account; or he needs to abandon his conclusion that there is no objection in principle to a purely computational account of the mind.

The starting point for appreciating that there is a distinctive part of our psychology for morality is seeing how moral judgments differ from other kinds of opinions we have on how people ought to behave.

Moralization is a psychological state that can be turned on and off like a switch, and when it is on, a distinctive mind-set commandeers our thinking. This is the mind-set that makes us deem actions immoral (“killing is wrong”), rather than merely disagreeable (“I hate brussels sprouts”), unfashionable (“bell-bottoms are out”) or imprudent (“don’t scratch mosquito bites”).

The first hallmark of moralization is that the rules it invokes are felt to be universal

Many of these moralizations, like the assault on smoking, may be understood as practical tactics to reduce some recently identified harm. But whether an activity flips our mental switches to the “moral” setting isn’t just a matter of how much harm it does

We all know what it feels like when the moralization switch flips inside us — the righteous glow, the burning dudgeon, the drive to recruit others to the cause.

The human moral sense turns out to be an organ of considerable complexity, with quirks that reflect its evolutionary history and its neurobiological foundations.

At the same time, many behaviors have been amoralized, switched from moral failings to lifestyle choices. They include divorce, illegitimacy, being a working mother, marijuana use and homosexuality.

This wave of amoralization has led the cultural right to lament that morality itself is under assault, as we see in the group that anointed itself the Moral Majority. In fact there seems to be a Law of Conservation of Moralization, so that as old behaviors are taken out of the moralized column, new ones are added to it.

Much of our recent social history, including the culture wars between liberals and conservatives, consists of the moralization or amoralization of particular kinds of behavior.

People don’t generally engage in moral reasoning, Haidt argues, but moral rationalization: they begin with the conclusion, coughed up by an unconscious emotion, and then work backward to a plausible justification.

When psychologists say “most people” they usually mean “most of the two dozen sophomores who filled out a questionnaire for beer money.” But in this case it means most of the 200,000 people from a hundred countries who shared their intuitions on a Web-based experiment conducted by the psychologists Fiery Cushman and Liane Young and the biologist Marc Hauser. A difference between the acceptability of switch-pulling and man-heaving, and an inability to justify the choice, was found in respondents from Europe, Asia and North and South America; among men and women, blacks and whites, teenagers and octogenarians, Hindus, Muslims, Buddhists, Christians, Jews and atheists; people with elementary-school educations and people with Ph.D.’s.

Joshua Greene, a philosopher and cognitive neuroscientist, suggests that evolution equipped people with a revulsion to manhandling an innocent person. This instinct, he suggests, tends to overwhelm any utilitarian calculus that would tot up the lives saved and lost

the findings corroborate Greene’s theory that our nonutilitarian intuitions come from the victory of an emotional impulse over a cost-benefit analysis.

the heart palpitations, headaches, stomach troubles, numbness and weakness in her hands and feet — the most frustrating one is the tinnitus, a condition that can cause sufferers to hear phantom ringing, buzzing, whistling, chirping or other sounds.

“It makes it hard to concentrate, it makes it hard to hold conversations with others, it makes it almost impossible to lie down and go to sleep. It’s maddening, and you can’t fully understand it unless you experience it yourself.

the most common cause of chronic tinnitus is age

As the hair cells inside your inner ear become damaged over time, she said, they may no longer send sound waves to your brain, so your brain tries to recreate them on their own, which is what might cause the ringing.

But experts have long known that some viruses can temporarily cause hearing loss or ringing in the ears, too. When the body fights an infection, the overall inflammation from the virus can damage the nerves or hair cells in the ear, Dr. Cosetti said.

“I was so depressed and scared I’d never get better,” Ms. Suarez said. “I speak and talk for a living — how was I going to be able to have a conversation with a client or present in court if it constantly sounded like bells were exploding on my left side?”

Tinnitus has been linked to several mental health conditions, including anxiety and depression, and mostly in women. “It can be particularly challenging for many people initially because it’s something they have absolutely no control over,”

“For most people with tinnitus, the worst time is the first six to nine months after it begins,” Dr. Tyler said. “After that, most people adjust and learn to live with it, especially if they’re given the right treatments.”

If you are diagnosed with Covid-19 and you experience tinnitus that lasts for more than two days, tell your doctor right away.

If your tinnitus persists after you’ve recovered from the virus, make an appointment with an ear, nose and throat doctor, who can check for blockages in your ear

If no blockage exists, you might be sent to an audiologist to check your hearing.

“It’s always there and with me all the time — I can never escape it,” she said, adding that she has to take sedatives now to fall asleep. “I have days when I don’t know if I can handle this anymore. But I have to go on being hopeful.”

Biologists call this need “sleep pressure”: Stay up too late, build up sleep pressure. Feeling drowsy in the evenings? Of course you are—by being awake all day, you’ve been generating sleep pressure! But like “dark matter,” this is a name for something whose nature we do not yet understand.

The search for the hypnotoxin was not unsuccessful. There are a handful of substances clearly demonstrated to cause sleep—including a molecule called adenosine, which appears to build up in certain parts of the brains of waking rats, then drain away during slumber. Adenosine is particularly interesting because it is adenosine receptors that caffeine seems to work on.

For instance, if adenosine puts us under at the moment of transition from wakefulness to sleep, where does it come from? “Nobody knows,” remarks Michael Lazarus, a researcher at the institute who studies adenosine. Some people say it’s coming from neurons, some say it’s another class of brain cells. But there isn’t a consensus. At any rate, “this isn’t about storage,” says Yanagisawa. In other words, these substances themselves don’t seem to store information about sleep pressure. They are just a response to it.

A few years ago, the group discovered a mouse that just could not seem to get rid of its sleep pressure. Its EEGs suggested it lived a life of snoozy exhaustion, and mice that had been engineered to carry its mutation showed the same symptoms. “This mutant has more high-amplitude sleep waves than normal. It’s always sleep-deprived,” says Yanagisawa. The mutation was in a gene called SIK3. The longer the mutants stay awake, the more chemical tags the SIK3 protein accumulates. The researchers published their discovery of the SIK3 mutants, as well as another sleep mutant, in Nature in 2016.

"The science tells [us] when [we're] on the phone while driving, it is a high-risk activity -- very, very risky,"

Even hands-free phones appear to contribute to unsafe driving

What they found was that when children were on the cell phones, their attention to traffic -- the number of times a participant looked right or left -- went down 20 percent. The risk of getting hit by a car, or the number of close calls, went up 43 percent

Our reliance on our cell phones may actually be "training" some of us to believe it is vibrating when it is not. In the case of cell phones, people are rewarded when they pick up their calls and read their incoming text messages, which causes them to pick up their cell phones more and more frequently.

The sores and blisters that some experience from too much texting and typing have earned monikers such as "BlackBerry thumb." And while the sore thumbs may seem like a new phenomenon, medical experts say there is a rational explanation for this modern-day nuisance.

These sorts of injuries, known as repetitive strain injuries or a repetitive motion disorders, are sometimes minor. But they can also lead to serious medical problems.

According to statistics from the U.S. Centers for Disease Control and Prevention (http://www.cdc.gov/healthyyouth/noise/index.htm), about 12.5 percent of children and adolescents 6 and 19 years old and 17 percent of adults between 20 and 69 years of age have suffered permanent damage to their hearing from excessive exposure to noise. In total, this accounts for more than 30 million people.

Sounds louder than 85 decibels can damage hearing. Normal conversation is about 60 decibels, and stereo headphones out of our MP3-enabled devices often reach 100 decibels.

Physical warmth activates circuits in the brain associated with feelings of psychological warmth. The insular cortex, or insula, plays a critical role in this crossover between the outside world and our experience of it. This peach-sized region helps us to perceive whether a sensation is hot or cold, pleasurable or painful. It is activated when we crave chocolate, fall in love or get disgusted. The insula also guides us on social matters: whether to trust or feel guilty, to empathize or be embarrassed. People who meditate, according to some studies, have a thicker insula.

As it turns out, the insula's poetic merging of the physical and emotional helps to explain much of our unconscious behavior. People who are socially rejected—given the cold shoulder—get chills and crave warm food such as soup.

Warm springtime conditions are related to a better mood and expanded memory, but both take a plunge in the summer heat. Extreme temperatures make people hostile and aggressive, and violent crimes occur more often in the hotter months. Drivers honk more in heat waves. When you're hot and tired, you're more likely to interpret another person's neutral expression negatively.

our perception of reality still relies on sensory experience. Though we may wish for it to be otherwise, our minds cannot be separated from our bodies. And our bodies depend on the environment—what we encounter here on planet Earth

This process is referred to as cognitive dissonance — an unconscious defense system that many of us employ to protect our ego.

“Admitting we are wrong shows others that we are compassionate, empathetic, sympathetic, and good listeners. It also shows that we are capable of being objective about ourselves and that we not ‘perfect’ or always right.”

I was relieved -- we wouldn't have to make what felt like an impossible decision -- but then I kept reading. My father had noted that he did not want to be supported by a ventilator or hooked up to a feeding tube for any length of time. He had been connected to both for nearly two weeks.

There was grief on her face, but also curiosity. What had finally gotten to her younger son, the one who so rarely showed emotion during his father's hospitalization?

I called the hospital and approved the DNR. They told me his status was still dire. I called my dad's closest friends and started preparing them for the worst.

My father's lungs showed no signs of progress. The double pneumonia they diagnosed days before was worsening. His kidneys were failing. Dialysis was required but would put a strain on his blood pressure, which was already dangerously low. There was a special form of dialysis designed for delicate situations like this -- continuous veno-venous hemofiltration -- but it wasn't available at Lawrence

The morning after I searched for my father's health directive and drafted his obituary, I woke up and tried to turn on my laptop. It wouldn't start. When it eventually booted up, it asked if I wanted to restore an unsaved document. No, I thought, let's see what happens today.

It was the same doctor as yesterday, the one who asked about the DNR. "Look, your dad is on a ventilator. That's a form of life support. He's experiencing kidney failure and requires dialysis. His situation is still very acute. He was in good health before the Covid, but his kidney, heart, and lungs are 69 years old. It's tough for them to recover. But the numbers from today are undeniably better than yesterday. There's been an improvement at almost every level. Your dad is a tough guy."

One of my close friends, a nurse practitioner, would help me understand all the terminology and its implications. He was treating Covid patients at an ICU upstate. At the end of our calls I'd ask him how he was doing. "We ran out of gowns," he told me one day. "My ICU is out of ventilators -- we're diverting people to Albany," he said another time.

"There's a difference between good intentions and good outcomes," I explained to her. She would wave me away and pick up. Inevitably the call would bring her tears. I stewed on the porch. My brother, uncle and I would spend hours trying to ease her mind and pacify her anxiety. Any inquiry or outreach was like sticking a finger in the open wound of her anguish.

I called my friend, the nurse practitioner, and gave him the latest update. He seemed upset. "You OK, dude?" "A nurse from my hospital died," he explained.

The nurses and doctors who took care of my father -- first for four days at NewYork-Presbyterian Lawrence Hospital, then for nearly a month at NewYork-Presbyterian/Columbia -- were always empathetic, straightforward and willing to trust me with complicated details.

About a week after writing -- then refusing to recover -- my father's obituary, his condition was continuing to improve.

"He's only improving," I told her, "because of the life-saving care you guys have given him. The whole city is in awe of you. They should have a parade for you down the Canyon of Heroes."

Covid-19 was new and largely unstudied. Maybe one of these seemingly odd treatments would work.

"Yesterday was a stumble, but we're getting back on course," I emailed the group. "We always knew this recovery wasn't going to be a straight line. It's important to remain resilient and optimistic even when there are temporary setbacks."

"Oh Lou, I've been waiting for your call. I have such good news. They are planning to extubate him tomorrow. They are going to take your father off the ventilator!" She was practically screaming with excitement. I was speechless.

I had been withholding certain information from my family and friends during this whole ordeal. My dad had developed a blood clot two weeks into his hospitalization. Clots are extremely dangerous, of course, but it was small and in a relatively manageable location.

I called my brother and told him about the plan to get my father off the ventilator. Since there were a number of contingencies, we debated telling my mother. She was living and dying with every update.

My father's breathing was labored on the morning they were planning to extubate. They delayed the procedure a day. That next morning, April 16, a doctor called. I was in the shower and rushed out to answer my cell. He said they were doing the extubation within the hour. What do we want to do if the extubation fails?

"It went as well as we could have hoped for," the doctor said. "His vitals are stable and he's breathing well. He's resting now." She explained that my father was disoriented and it probably wasn't a great idea to speak with him that day. Whatever, I thought, I'll speak with him when he gets home. He had been on a ventilator for 28 days.

I called the doctor later in the day. She told me my dad seemed distressed. He was trying to speak, but his vocal cords were too swollen. "It's so frustrating," she told me. "I don't know what he wants to tell me."

"Each facility has their own Covid rules," she explained. "I'll send you over a list." On the list was the nursing home where my grandfather had died several years before. My father had visited him every day.

I called the step-down unit where he had been the past three days. They transferred me to his nurse. "He's doing better, love. We took him off the pressor and his blood pressure is in a good range. His heart rate is good. He's breathing fine. The doctors decided he didn't need to go back to the ICU. He's ok."

"I've repeatedly said that recovery isn't a straight line. ... Yesterday we managed the roller coaster ride as a family. My brother, uncle and I were with my mother the entire day. We never lost hope or confidence in my dad's medical care and ultimate recovery. If there's a light at the end of the tunnel, it's a blinking one. Right now, it shines again."

I drove back to my mom's house. I scanned the block for my brother's car. He had not arrived. I parked. I have to wait for him and then tell my mother, brother and uncle all at once, right? Should I call my wife first? Should I call my dad's best friend?

I called my wife. I called my dad's best friend. I called the guys he grew up with. I called his former colleagues. I began every conversation the same way, "This is that call." I listened to each of them yell and cry and ask if I was serious. Then I said I had to make another call.

I wrote about my father's career. How he got his law degree at night school and became a prosecutor at the city, state, and federal level. How he convicted mobsters, drug dealers, and those who abused power.

I wrote about my dad's volunteer work -- at the Special Olympics, at an organization he founded that helps police families with special needs, and at just about any Italian-American group that needed a lawyer. He was so proud of his Italian-American heritage. He loathed the mafioso caricatures and stereotypes found on TV -- he wrote countless op-eds attacking those -- but he revered the old-school virtues he associated with his Italian-American upbringing: loyalty, humility, hard work, dedication to family.

He was a Covid patient for 31 days. It was a painful experience, but ultimately unimportant. It doesn't matter how a man dies. It matters how he lives.

The advantage of having many different waves of data from the same people is that it enables researchers to speculate on whether changes in one characteristic cause changes in another. This can be done by asking whether changes at one time in one factor predict another more strongly than the reverse

irst, as we might expect, people’s personality characteristics and values are fairly stable. People’s responses to both the personality inventory and the values scale did not change much over time. However, the responses to the personality inventory changed less than the responses to the values survey.

Overall, some personality characteristics and some values are related. Agreeableness was correlated with the value of being prosocial (that is, wanting to engage in positive actions for society). Conscientiousness was correlated with conformity (which reflects that conscientious people tend to want to follow rules including societal rules). Extraversion was related to the value of enjoyment. Openness correlated with the value of self-direction. There were no strong correlations between neuroticism and any of the values.

In addition, personality traits appeared to influence a variety of measures of well-being. People high in agreeableness, conscientiousness, extraversion, and openness tended to show higher measures of well-being while being high in neuroticism was linked to decreased measures of well-being.

First, in an era in which key findings fail to replicate, this study solidifies the relationship between personality characteristics and values that have been observed before. It also demonstrates that both personality characteristics and values change slowly.

Second, this work suggests that changes in personality characteristics (which reflect people’s underlying motivation) have a bigger impact on values than changes in values have on people’s personality characteristics.

Third, this work suggests that both personality characteristics and values are related to people’s sense of well-being. However, personality characteristics seem to have a broad impact. Changes in personality can precede changes in well-being, but it appears that changes in well-being may actually have an impact on people’s values.

In 1972, using duct tape and spare parts in the basement on the campus of the University of California, Berkeley, Dr. Clauser and a graduate student, Stuart Freedman, who died in 2012, endeavored to perform Bell’s experiment to measure quantum entanglement. In a series of experiments, he fired thousands of light particles, or photons, in opposite directions to measure a property known as polarization, which could have only two values — up or down. The result for each detector was always a series of seemingly random ups and downs. But when the two detectors’ results were compared, the ups and downs matched in ways that neither “classical physics” nor Einstein’s laws could explain. Something weird was afoot in the universe. Entanglement seemed to be real.

in 2002, Dr. Clauser admitted that he himself had expected quantum mechanics to be wrong and Einstein to be right. “Obviously, we got the ‘wrong’ result. I had no choice but to report what we saw, you know, ‘Here’s the result.’ But it contradicts what I believed in my gut has to be true.” He added, “I hoped we would overthrow quantum mechanics. Everyone else thought, ‘John, you’re totally nuts.’”

the correlations only showed up after the measurements of the individual particles, when the physicists compared their results after the fact. Entanglement seemed real, but it could not be used to communicate information faster than the speed of light.

In 1982, Dr. Aspect and his team at the University of Paris tried to outfox Dr. Clauser’s loophole by switching the direction along which the photons’ polarizations were measured every 10 nanoseconds, while the photons were already in the air and too fast for them to communicate with each other. He too, was expecting Einstein to be right.

Quantum predictions held true, but there were still more possible loopholes in the Bell experiment that Dr. Clauser had identified

For example, the polarization directions in Dr. Aspect’s experiment had been changed in a regular and thus theoretically predictable fashion that could be sensed by the photons or detectors.

Anton Zeilinger

added even more randomness to the Bell experiment, using random number generators to change the direction of the polarization measurements while the entangled particles were in flight.

Once again, quantum mechanics beat Einstein by an overwhelming margin, closing the “locality” loophole.

as scientists have done more experiments with entangled particles, entanglement is accepted as one of main features of quantum mechanics and is being put to work in cryptology, quantum computing and an upcoming “quantum internet

One of its first successes in cryptology is messages sent using entangled pairs, which can send cryptographic keys in a secure manner — any eavesdropping will destroy the entanglement, alerting the receiver that something is wrong.

, with quantum mechanics, just because we can use it, doesn’t mean our ape brains understand it. The pioneering quantum physicist Niels Bohr once said that anyone who didn’t think quantum mechanics was outrageous hadn’t understood what was being said.

In his interview with A.I.P., Dr. Clauser said, “I confess even to this day that I still don’t understand quantum mechanics, and I’m not even sure I really know how to use it all that well. And a lot of this has to do with the fact that I still don’t understand it.”

“My first and biggest wish is that we had known early that Covid-19 was airborne,”

, “Once you’ve realized that, it informs an entirely different strategy for protection.” Masking, ventilation and air cleaning become key, as well as avoiding high-risk encounters with strangers, he says.

Instead of washing our produce and wearing hand-sewn cloth masks, we could have made sure to avoid superspreader events and worn more-effective N95 masks or their equivalent. “We could have made more of an effort to develop and distribute N95s to everyone,” says Dr. Volckens. “We could have had an Operation Warp Speed for masks.”

We didn’t realize how important clear, straight talk would be to maintaining public trust. If we had, we could have explained the biological nature of a virus and warned that Covid-19 would change in unpredictable ways.  

We didn’t know how difficult it would be to get the basic data needed to make good public-health and medical decisions. If we’d had the data, we could have more effectively allocated scarce resources

In the face of a pandemic, he says, the public needs an early basic and blunt lesson in virology

and mutates, and since we’ve never seen this particular virus before, we will need to take unprecedented actions and we will make mistakes, he says.

Since the public wasn’t prepared, “people weren’t able to pivot when the knowledge changed,”

By the time the vaccines became available, public trust had been eroded by myriad contradictory messages—about the usefulness of masks, the ways in which the virus could be spread, and whether the virus would have an end date.

, the absence of a single, trusted source of clear information meant that many people gave up on trying to stay current or dismissed the different points of advice as partisan and untrustworthy.

“The science is really important, but if you don’t get the trust and communication right, it can only take you so far,”

people didn’t know whether it was OK to visit elderly relatives or go to a dinner party.

Doctors didn’t know what medicines worked. Governors and mayors didn’t have the information they needed to know whether to require masks. School officials lacked the information needed to know whether it was safe to open schools.

Had we known that even a mild case of Covid-19 could result in long Covid and other serious chronic health problems, we might have calculated our own personal risk differently and taken more care.

just months before the outbreak of the pandemic, the Council of State and Territorial Epidemiologists released a white paper detailing the urgent need to modernize the nation’s public-health system still reliant on manual data collection methods—paper records, phone calls, spreadsheets and faxes.

While the U.K. and Israel were collecting and disseminating Covid case data promptly, in the U.S. the CDC couldn’t. It didn’t have a centralized health-data collection system like those countries did, but rather relied on voluntary reporting by underfunded state and local public-health systems and hospitals.

doctors and scientists say they had to depend on information from Israel, the U.K. and South Africa to understand the nature of new variants and the effectiveness of treatments and vaccines. They relied heavily on private data collection efforts such as a dashboard at Johns Hopkins University’s Coronavirus Resource Center that tallied cases, deaths and vaccine rates globally.

For much of the pandemic, doctors, epidemiologists, and state and local governments had no way to find out in real time how many people were contracting Covid-19, getting hospitalized and dying

To solve the data problem, Dr. Ranney says, we need to build a public-health system that can collect and disseminate data and acts like an electrical grid. The power company sees a storm coming and lines up repair crews.

If we’d known how damaging lockdowns would be to mental health, physical health and the economy, we could have taken a more strategic approach to closing businesses and keeping people at home.

t many doctors say they were crucial at the start of the pandemic to give doctors and hospitals a chance to figure out how to accommodate and treat the avalanche of very sick patients.

The measures reduced deaths, according to many studies—but at a steep cost.

The lockdowns didn’t have to be so harmful, some scientists say. They could have been more carefully tailored to protect the most vulnerable, such as those in nursing homes and retirement communities, and to minimize widespread disruption.

Lockdowns could, during Covid-19 surges, close places such as bars and restaurants where the virus is most likely to spread, while allowing other businesses to stay open with safety precautions like masking and ventilation in place.  

The key isn’t to have the lockdowns last a long time, but that they are deployed earlier,

If England’s March 23, 2020, lockdown had begun one week earlier, the measure would have nearly halved the estimated 48,600 deaths in the first wave of England’s pandemic

If the lockdown had begun a week later, deaths in the same period would have more than doubled

It is possible to avoid lockdowns altogether. Taiwan, South Korea and Hong Kong—all countries experienced at handling disease outbreaks such as SARS in 2003 and MERS—avoided lockdowns by widespread masking, tracking the spread of the virus through testing and contact tracing and quarantining infected individuals.

With good data, Dr. Ranney says, she could have better managed staffing and taken steps to alleviate the strain on doctors and nurses by arranging child care for them.

Early in the pandemic, public-health officials were clear: The people at increased risk for severe Covid-19 illness were older, immunocompromised, had chronic kidney disease, Type 2 diabetes or serious heart conditions

t had the unfortunate effect of giving a false sense of security to people who weren’t in those high-risk categories. Once case rates dropped, vaccines became available and fear of the virus wore off, many people let their guard down, ditching masks, spending time in crowded indoor places.

it has become clear that even people with mild cases of Covid-19 can develop long-term serious and debilitating diseases. Long Covid, whose symptoms include months of persistent fatigue, shortness of breath, muscle aches and brain fog, hasn’t been the virus’s only nasty surprise

In February 2022, a study found that, for at least a year, people who had Covid-19 had a substantially increased risk of heart disease—even people who were younger and had not been hospitalized

respiratory conditions.

Some scientists now suspect that Covid-19 might be capable of affecting nearly every organ system in the body. It may play a role in the activation of dormant viruses and latent autoimmune conditions people didn’t know they had

 A blood test, he says, would tell people if they are at higher risk of long Covid and whether they should have antivirals on hand to take right away should they contract Covid-19.

If the risks of long Covid had been known, would people have reacted differently, especially given the confusion over masks and lockdowns and variants? Perhaps. At the least, many people might not have assumed they were out of the woods just because they didn’t have any of the risk factors.