The PICO framework is used in evidence-based practice and especially in evidence-based medicine to formulate a clinical or healthcare related question
In a systematic review, the PICO framework is also used to develop literature search strategies to ensure the comprehensive and bias-free searches
The Cochrane Handbook for Systematic Reviews of Interventions mentioned using the PICO framework as a model for developing a review question, thus ensuresthat the relevant components of the question are well defined
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