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Caffeine: A User's Guide to Getting Optimally Wired - Developing Intelligence - 0 views

scienceblogs.com/...optimally-wired-a-caffeine-use

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shared by Innovation Blues on 10 Aug 12 - No Cached
  • Caffeine: A User’s Guide to Getting Optimally Wired
  • Caffeine is the most widely used stimulant in the world, but few use it to maximal advantage. Get optimally wired with these tips.
  • 1) Consume in small, frequent amounts. Between 20-200mg per hour may be an optimal dose for cognitive function. Caffeine crosses the blood-brain barrier quickly (owing to its lipid solubility) although it can take up to 45 minutes for full ingestion through the gastro-intestinal tract. Under normal conditions, this remains stable for around 1 hour before gradually clearing in the following 3-4 hours (depending on a variety of factors). A landmark 2004 study showed that small hourly doses of caffeine (.3mg per kg of body weight [approx 20 mg per hour; thanks digg!]) can support extended wakefulness, potentially by counteracting the homeostatic sleep pressure, which builds slowly across the day and acts preferentially on the prefrontal cortex (an area of the brain thought responsible for executive and “higher” cognitive functions).
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  • 2) Play to your cognitive strengths while wired. Caffeine may increase the speed with which you work, may decrease attentional lapses, and may even benefit recall – but is less likely to benefit more complex cognitive functions, and may even hurt others. Plan accordingly (and preferably prior to consuming caffeine!)
  • Recall from memory may be improved by caffeine (here and here), possibly due to enhancements in memory encoding rather than retrieval per se. Another study shows caffeine can actually impair estimates of “memory scanning” speed (in the Sternberg paradigm), so the failure of many studies to find recall-related effects of caffeine may reflect a speed-accuracy tradeoff at the time of retrieval.
  • 3) Play to caffeine’s strengths. Caffeine’s effects can be maximized or minimized depending on what else is in your system at the time. The beneficial effects of caffeine may be most pronounced in conjunction with sugar. For example, one factor analytic study has shown caffeine-glucose cocktails provide benefits to cognition not seen with either alone.
  • Withdrawal symptoms can onset within 12 to 24 hours of caffeine consumption and last between 2 and 9 days.
  • some studies show grapefruit juice might keep caffeine levels in the bloodstream high for longer, though others have found no such effect
  • Similarly, nicotine may speed the metabolism of caffeine.
  • 4) Know when to stop – and when to start again. Although you may not grow strongly tolerant to caffeine, you can become dependent on it and suffer withdrawal symptoms. Balance these concerns with the cognitive and health benefits associated with caffeine consumption – and appropriately timed resumption.
  • Long-term ingestion of large quantities of caffeine (by way of coffee) is associated with a variety of health benefits – not only cognitive enhancements but also reduction in risk for type 2 diabetes (c.f.), Alzheimer’s and Parkinson’s . These beneficial effects may be related to the neuroprotective role of adenosine.
  • Caffeine’s effects might be masked by green tea extract, Kava Kava or St. John’s Wort – all of which contain theanine and are associated with subjective feelings of relaxation – but other preliminary evidence indicates the opposite effect: theanine might actually potentiate the benefits of caffeine on some tasks (reported in longer format here).
  • In addition, there are well-established cognitive effects where recall is best when it matches the context of encoding – so if you’re caffeinated when you study for the test, you better be caffeinated when you take it.
  • 5) Finding good sources of caffeine Despite the huge variety of sources of caffeine – including caffeinated soap, candy, and of course chocolate – the optimal use of caffeine is likely to involve small, hourly doses along with some cardioprotective agent. Given the high solubility of caffeine, absorption time should not be an issue (but if for some reason it is, try gum). Otherwise, why not enjoy a cup of green tea (coffee-flavored, if you must), as the Chinese have for nearly 5000 years? It’s hard to come by a better longitudinal study than that.
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