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Love and lust have distinct but interlocking brain signatures: People often think of love and lust as polar opposites-love exalted as the binder of two souls, lust the transient devil on our shoulders, disturbing and disruptive. Now neuroscientists are discovering that lust and love work together more closely than we think. Indeed, the strongest relationships have elements of both. (rest of article not provided free) In Brief Brain imaging is revealing the distinct but interlocking patterns of neural activation associated with lust and love. Lust is most likely grounded in the concrete sensations of the given moment. Love is a more abstract gloss on our experiences with another person. Imaging is also helping to decipher the disorders of lust, including anorgasmia. Dozens of discrete regions across the brain fire at the point of orgasm-suggesting many different ways to develop anorgasmia.