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Nathan Goodyear

The Anti-aromatase Effect of Progesterone and of its Natural Metabolites 20α- and 5α-Dihydroprogesterone in the MCF-7aro Breast Cancer Cell Line - 0 views

ar.iiarjournals.org/...2129.short

hormones progesterone progesterone metabolites breast cancer cancer 4-pregnenes 20alpha-HSO aromatase

shared by Nathan Goodyear on 07 Oct 16 - No Cached
  • Nathan Goodyear on 07 Oct 16
     
    The progesterone metabolite, 20alpha-dihydroprogesterone, is found to have anti-aromatase activity.  20alphaDHP via the enzyme 20alpha-HSO is a 4-pregnene.
Nathan Goodyear

Progesterone metabolites in breast cancer - 0 views

erc.endocrinology-journals.org/...717.long

progesterone metabolism metabolites breast cancer hormones progesterone metabolites

shared by Nathan Goodyear on 12 Jun 14 - No Cached
  • In breast tumor tissue and tumorigenic cell lines, 5α-reductase activity and mRNA expression are significantly higher, whereas 3α- and 20α-HSO activities and mRNA expression are significantly lower than in normal breast tissue and nontumorigenic cells
  • Studies using various breast cell lines have shown that 5αP and 3αHP have opposing actions in terms of cell proliferation and adhesion; 5αP stimulates cell proliferation (through increased mitosis and decreased apoptosis) and cell detachment, whereas 3αHP suppresses cell proliferation (through decreased mitosis and increased apoptosis) and detachment
  • the paracrine/ autocrine functions of 5αP are cancer-promoting and those of 3αHP are cancer-inhibiting
  • Nathan Goodyear on 12 Jun 14
     
    Awesome article on progesterone metabolism in breast cancer.  The author, weibe, describes 2 categories of progesterone metabolites in breast tissue: 5alpha-pregnanes and 4-pregnenes.  The author describes 3 primary enzymes that control the balance between these 2 metabolites--5alpha reductase, 3alpha-HSO, and 20alpha-HSO.  The resultant balance of 5alpha-dihydroprogesterone and 3alpha-dihydroprogesterone helps to determine the cancer potential of breast tissue.
Nathan Goodyear

Activity and expression of progesterone metabolizing 5α-reductase, 20α-hydroxysteroid oxidoreductase and 3α(β)-hydroxysteroid oxidoreductases in tumorigenic (MCF-7, MDA-MB-231, T-47D) and nontumorigenic (MCF-10A) human breast cancer cells | BMC Cancer | F - 0 views

bmccancer.biomedcentral.com/...1471-2407-3-9

hormones progesterone progesterone metabolites cancer breast cancer 5alpha reductase 5alpha-pregnane 4-pregnene

shared by Nathan Goodyear on 07 Oct 16 - No Cached
  • Nathan Goodyear on 07 Oct 16
     
    cell culture study finds that increased 5alpha reductase activity and resultant 5alpha-pregnanes are associated with breast cancer cell lines.  This is in contrast to the 4-pregnenes.  In fact, decreased 4-pregnenes are found in the same breast cancer cell lines; this suggests decreased 20alpha-HSO and 3alpha-HSO activity.
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