European Journal of Clinical nutrition - Effect of maternal n-3 long-chain polyunsatura... - 0 views
www.nature.com/...ejcn2014158a.html
nutrition n-3 omega 3 omega-3 fish oil pregnancy childhood obesity
![](/images/link.gif)
-
It is estimated that approximately 30% of children and adolescents in the United States and about 15–30% of those in Europe can be classified as overweight or obese
-
An increasing body of evidence now suggests that the nutritional environment encountered in utero and the early postnatal life may elicit permanent alterations in adipose tissue structure or function and, thereby, programme the individual’s propensity to later obesity
-
The composition of fatty acids in the Western diets has shifted toward an increasing dominance of n-6 relative to n-3 LCPUFAs over the past decades.9,10 This shift is also reflected in the fatty acid composition of breast milk
- ...8 more annotations...
-
Evidence from animal studies suggests that the n-6 LCPUFA arachidonic acid promotes adipose tissue deposition, whereas the n-3 LCPUFAs eicosapentaenoic acid and docosahexaenoic acid seem to exert an opposite effect
-
Overall, no effect of supplementation was found on BMI in preschool (<5 years) and school-aged (6–12 years) children
-
Many studies have shown that even children <2 years with a high BMI are at increased risk of developing obesity later in life
-
Evidence from cell culture and animal studies suggests that early exposure to n-3 LCPUFAs has the potential to limit adipose tissue deposition mainly by attenuating the production of the arachidonic acid metabolite prostacyclin, which has been shown to enhance adipogenesis
-
In conclusion, there is currently no evidence to support that maternal n-3 LCPUFA supplementation during pregnancy and/or lactation exerts a favourable programming effect on adiposity status in childhood
-
our systematic review highlights that most of the trials reviewed were prone to methodological limitations
-
Literature review finds limited data (9 studies, only 6 RCTs) of omega-3 during pregnancy. no data was found that supported reduced obesity in children by mothers taking n-3 during pregnancy. no harm was found either. Data was sparse. Take home: not enough data, no harm to pregnancy, children, thus if indications are present for mother, then recommend n-3. At this point not studies have pointed to reduced obesity in children.