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Nathan Goodyear

Peroxisome Proliferator-activated Receptor α Activation Modulates Cellular Redox Status, Represses Nuclear Factor-κB Signaling, and Reduces Inflammatory Cytokine Production in Aging - 0 views

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    DHEA inhibits NF-kappaB stimulated TNF-alpha production through regulation of PPAR-alpha.
Nathan Goodyear

Dehydroepiandrosterone Supplementation in Elderly Men: A Meta-Analysis Study of Placebo-Controlled Trials - 0 views

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    Meta-analysis finds DHEA beneficial in men.  The main outcome this study looked at was weight loss and/or body composition (i.e. muscle, fat...).
Nathan Goodyear

Dehydroepiandrosterone exerts antiglucocorticoid action on human preadipocyte proliferation, differentiation, and glucose uptake | Endocrinology and Metabolism - 0 views

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    Animal study, finds that DHEA inhibited 11beta-HSD type I and thus improved glucose uptake and adipocyte proliferation.  This effect occurred peripherally.
Nathan Goodyear

Low circulating androgens and mortality risk in heart ... [Heart. 2010] - PubMed - NCBI - 0 views

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    low androgens, DHEA and free Testosterone, associated with increased poor prognosis in men with heart failure
Nathan Goodyear

Endogenous Sex Hormones and Glucose Tolerance Status in Postmenopausal Women - 0 views

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    Increase in free Testosterone, DHEA, and Estradiol in postmenopause women associated with increase in insulin resistance.
Nathan Goodyear

Dehydroepiandrosterone supplementati... [J Clin Endocrinol Metab. 2013] - PubMed - NCBI - 0 views

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    meta-analysis finds reduction in fat mass from DHEA in elderly men.  The authors propose that it is due to the conversion to other hormones.  
Nathan Goodyear

Dehydroepiandrosterone, its metab... [J Steroid Biochem Mol Biol. 2014] - PubMed - NCBI - 0 views

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    abstract only, but the article is a good review of DHEA metabolism
Nathan Goodyear

Association of serum androgen concentrations with... [Aging Male. 2014] - PubMed - NCBI - 0 views

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    Men with heart failure have lower Total Testosterone, free Testosterone, DHEAS levels and increased SHBG when compared to those without.
Nathan Goodyear

Adrenal secretion during major depression in 8- to... [Psychol Med. 1996] - PubMed result - 0 views

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    salvia testing of cortisol and DHEA in children
Nathan Goodyear

A double-blind, placebo-controlled, clinical trial... [Lupus. 1999] - PubMed result - 0 views

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    DHEA beneficial in mild/moderate SLE
Nathan Goodyear

Effects of prasterone on corticosteroid requiremen... [Arthritis Rheum. 2002] - PubMed result - 0 views

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    DHEA reduces dosage of prednisone compared to placebo
Nathan Goodyear

Stress Sensitivity in Metastatic Breast Cancer: Analysis of Hypothalamic-Pituitary-Adrenal Axis Function - 0 views

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    salivary cortisol and DHEA used to evaluate hypothalamic-pituitary changes in cancer survivors to predict survival
Nathan Goodyear

Salivary cortisol and dehydroepiandrosterone sulph... [Eur J Cancer Clin Oncol. 1983] - PubMed result - 0 views

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    Salivary cortisol and DHEA levels in postmenopausal women with primary breast cancer.
Nathan Goodyear

Dexamethasone in resting and exercising men. II. Effects on adrenocortical hormones - Journal of Applied Physiology - 0 views

  • The consistent results obtained from the two matrices allow us to consider salivary assays as a useful tool for steroid abuse detection.
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    saliva testing for cortisol, DHEA, androstenedione
Nathan Goodyear

Day-to-day differences in cortisol levels and mola... [Yonsei Med J. 2010] - PubMed result - 0 views

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    salivary cortisol and DHEA levels change. This reflects the day to day, week to week stressors.
Nathan Goodyear

Salivary sex hormone measurement in a national, po... [J Gerontol B Psychol Sci Soc Sci. 2009] - PubMed result - 0 views

  • These data demonstrate a high cooperation rate with in-home salivary specimen collection from older adults and good validity of sex hormone measurements
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    salivary estradiol, progesterone, DHEA, and testosterone validated in study of 3,005 men and women
Nathan Goodyear

http://press.endocrine.org/doi/pdf/10.1210/jc.2014-1725 - 0 views

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    New study finds "modest" association between Testosterone, DHEA, and FSH with libido, masturbation, and climax in women.  The author describes them as "subtle".  The association was not statistically significant.  The study found a great association with relationships than with Testosterone. This study points out the complexity that is libido in women.  It also casts doubt on the massive Testosterone push in women with little documented data.
Nathan Goodyear

Chemoprevention of precursors to colon cancer by dehydroepiandroste... - PubMed - NCBI - 0 views

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    Animal study suggests DHEA is preventative in colon cancer.
Nathan Goodyear

Inhibition of 1,2-dimethylhydrazine-induced colon tumorigenesis in Balb/c mice by dehydroepiandrosterone - 0 views

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    Only abstract available here.  DHEA, in mouse model, finds reduced malignant lesions in colon.
Nathan Goodyear

Differential Effects of Dehydroepiandrosterone and Testosterone in Prostate and Colon Cancer Cell Apoptosis: The Role of Nerve Growth Factor (NGF) Receptors. - ResearchGate - 0 views

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    Study finds Testosterone induces apoptosis via deactivation of NGF.  Testosterone counters the proliferation of DHEA, via NGF activation.  Without evaluation of aromatase activity, this study is incomplete.
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