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Nathan Goodyear

Does Cortisol Inhibit Pulsatile Luteinizing Hormone Secretion at the Hypothalamic or Pituitary Level?: Endocrinology: Vol 145, No 2 - 0 views

press.endocrine.org/...en.2003-1114

cortisol stress LH pituitary hypothalamus GnRH hormone hormones

shared by Nathan Goodyear on 02 Apr 15 - No Cached
  • Nathan Goodyear on 02 Apr 15
     
    Cortisol inhbits LH secretion at the level of the Pituitary.  The result is a decreased pulse amplitude as a result of decreased pituitary response to GNRH.
Nathan Goodyear

Overtraining Syndrome - 0 views

www.ncbi.nlm.nih.gov/...PMC3435910

overtraining syndrome OTS exercise athletes cortisol adrenals Testosterone Testosterone:Cortisol hormones

shared by Nathan Goodyear on 29 Jan 16 - No Cached
  • Alterations in the HPA and hypothalamic-pituitary-gonadal axes with a resultant decrease in testosterone:cortisol ratios have been implicated in OTS. Proinflammatory cytokines are potent activators of the HPA system, which cause release of corticotropin-releasing hormone, adrenocorticotropic hormone, and cortisol. These cytokines suppress testosterone through central inhibition
  • Some have suggested that a decreased testosterone:cortisol ratio can be diagnostic of NFO and/or OTS. However, the ratio represents the physiologic strain of training rather than the athlete’s maladaption to that stress
  • Cortisol (catabolic and anti-inflammatory) is converted to inactive cortisone by 11β-HSD2
  • ...2 more annotations...
  • A prospective study found a clinically significant increase in overnight urinary cortisol:cortisone ratio during a high training load period in triathletes, who subsequently underperformed and reported fatigue
  • It is proposed that cytokines may inhibit 11β-HSD2 activity and result in relative increases in cortisol and, hence, catabolism
  • Nathan Goodyear on 29 Jan 16
     
    Overtraining syndrome described.
Nathan Goodyear

Gonadal hormone regulation of MAO and other enzymes in hypothalamic areas. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...6835476

progesterone MAO serotonin dopamine norepinephrine hormones

shared by Nathan Goodyear on 12 Jul 17 - No Cached
  • Nathan Goodyear on 12 Jul 17
     
    Progesterone increased MAO in prior estrogen treatment.  Without prior treatment, Progesterone did not increase MAO and decrease the monoamine neurotransmitters norepinephrine, serotonin, and dopamine.
Nathan Goodyear

An Overview of Melatonin and Breast Cancer | Natural Medicine Journal - 0 views

www.naturalmedicinejournal.com/...ew-melatonin-and-breast-cancer

melatonin cancer

shared by Nathan Goodyear on 31 May 18 - No Cached
  • Overall its effect on cancer cells is oncostatic at physiological levels, or cytotoxic at higher concentrations
  • direct antioxidant, antimitotic, antiestrogenic, prodifferentiating and antimetastatic effects have been well characterized
  • hypothalamic-pituitary axis (HPA) and immune system
  • ...2 more annotations...
  • On a cellular level, melatonin acts as a selective estrogen receptor modulator (SERM) through decreased expression of estrogen receptor alpha and reduction in the ability of estrogen-estrogen receptor alpha (ERα) complex to bind to the estrogen response element (ERE) on DNA
  • Melatonin also acts as a selective estrogen enzyme modulator (SEEM), reducing the activity of aromatase in cells
  • Nathan Goodyear on 31 May 18
     
    review of melatonins activity in cancer battle.
Nathan Goodyear

Chemotherapy-induced cachexia dysregulates hypothalamic and systemic lipoamines and is attenuated by cannabigerol - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/31035309

cachexia CBG

shared by Nathan Goodyear on 26 Dec 23 - No Cached
  • Nathan Goodyear on 26 Dec 23
     
    CBD as a treatment for cachexia
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