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Nathan Goodyear

SpringerLink - Diabetologia, Volume 42, Number 2 - 0 views

www.springerlink.com/...l50vrq37getytvjw

fatty acids saturated fats glucose insulin

shared by Nathan Goodyear on 27 May 11 - No Cached
  • Nathan Goodyear on 27 May 11
     
    The type of fat you eat can increase the insulin response to glucose.  For example, saturated fats + glucose  promote a larger insulin response than does glucose alone.
Nathan Goodyear

The Effect of Abdominal Exercise on Abdominal Fat. [J Strength Cond Res. 2011] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...21804427

abdominal fat exercse

shared by Nathan Goodyear on 20 Aug 11 - No Cached
  • Six weeks of abdominal exercise training alone was not sufficient to reduce abdominal subcutaneous fat and other measures of body composition
  • Nathan Goodyear on 20 Aug 11
     
    Abdominal exercise doesn't decrease abdominal fat in 6 week study.
Nathan Goodyear

Dietary l-Arginine Supplementation Reduces White Fat Gain and Enhances Skeletal Muscle and Brown Fat Masses in Diet-Induced Obese Rats - 0 views

jn.nutrition.org/...230.abstract

l-Arginine fat muscle weight loss overweight obesity

shared by Nathan Goodyear on 11 Jul 11 - No Cached
  • Nathan Goodyear on 11 Jul 11
     
    L-Arginine shifts from fat building to muscle building
Nathan Goodyear

Effect of Testosterone Treatment on Glucose Metabolism in men With Type 2 Diabetes: A Randomized Controlled Trial - 0 views

care.diabetesjournals.org/...dc13-2845.abstract

diabetes type II diabetes low T Testosterone glucose insulin metabolism men male hormone hormones HOMA-IR fat mass lean

shared by Nathan Goodyear on 15 May 14 - No Cached
  • Nathan Goodyear on 15 May 14
     
    Study finds no improvement with glucose control in diabetics.  This study looked at moderately controlled diabetes. Studies have previously shown that poorly controlled diabetes definitely benefits more than those with more mild glucose control problems.  Additionally, the Testosterone levels in this study would not have met the definition of low T by other studies.  So, the question is did these men need T?  Second, did the authors design the study long enough to see changes in the insulin sensitivity and glucose control?  Abstract only available and thus I don't have access to that information.  Third, and this might support the 2nd point, increased lean mass and decreased fat mass was found.  This points to positive metabolic change.  Would this have, given more time, resulted in improved glucose control? No change in visceral adiposity was seen.  This finding, also, is not new.  Testosterone therapy does not improve visceral adiposity.  Though, increasing fat adiposity, low Testosterone, and associated increase in systemic inflammatory cytokine production results in visceral adiposity, Testosterone therapy does reverse the visceral adiposity.  
Nathan Goodyear

The effect of a low-fat, plant-based lifestyle intervention (CHIP) on serum HDL levels and the implications for metabolic syndrome status - a cohort study - 0 views

www.ncbi.nlm.nih.gov/...PMC3849684

diet nutrition metabolic syndrome metabolism plant-based low fat diet low-fat HDL

shared by Nathan Goodyear on 16 Aug 14 - No Cached
  • Nathan Goodyear on 16 Aug 14
     
    Study finds a decrease in metabolic syndrome parameters with a low-fat, plant-based diet.  Also of note, HDL decreased.
Nathan Goodyear

http://press.endocrine.org/doi/pdf/10.1210/jc.2014-2934 - 0 views

press.endocrine.org/...jc.2014-2934

androgens hormone hormones cardiovascular disease CVD cardiovascular disease Testosterone DHEA dehydroepiandrosterone men women adipose tissue fat mass SHBG

shared by Nathan Goodyear on 02 Feb 15 - No Cached
  • Nathan Goodyear on 02 Feb 15
     
    Again, what is the evidence on androgens in women.  The majority of data is points to negative metabolic effects.  This study looked at men and women and found inverse relationships between Testosterone and DHEA in the sexes.  In women, higher bioavailable Testosterone and DHEA was associated with visceral and subcutaneous fat in women, where as the opposite is true in men.  In both men and women, higher SHBG was associated with lower fat.
Nathan Goodyear

Testosterone Deficiency in Young Men: Marked Alterations in Whole Body Protein Kinetics, Strength, and Adiposity: The Journal of Clinical Endocrinology & Metabolism: Vol 83, No 6 - 0 views

press.endocrine.org/...jcem.83.6.4892

low T low Testosterone muscle muscle mass strength fat obesity adipose tissue metabolism hormone hormones men male

shared by Nathan Goodyear on 06 Mar 15 - No Cached
  • Nathan Goodyear on 06 Mar 15
     
    low T in men, small study, found to decrease muscle growth, decreased strength as a result, decrease in fat oxidation/breakdown and increase in fat stores.  Low T turns the muscle:fat ratio in men upside down--the result is a metabolic derailment.
Nathan Goodyear

The role of dietary fat in peripheral thyroid hor... [Metabolism. 1980] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...7421583

diet fat carbohydrates T3 reverse T3 metabolism HF high fat

shared by Nathan Goodyear on 16 Aug 14 - No Cached
  • Nathan Goodyear on 16 Aug 14
     
    High fat diet in this small animal study finds an increase in reverse T3 and a decrease in T3.  Higher carbohydrate diet provided no significant change.
Nathan Goodyear

Press-pulse: a novel therapeutic strategy for the metabolic management of cancer | Nutrition & Metabolism | Full Text - 0 views

nutritionandmetabolism.biomedcentral.com/...s12986-017-0178-2

ketogenic diet ketogenic press-pulse hyperbaric oxygen therapy HBOTnutrition diet cancer HBOT IVC IV vitamin C DCA dichloracetic acid cancer therapy cancer treatment alternative cancer treatment

shared by Nathan Goodyear on 09 Jul 17 - No Cached
mamdouh_hfz liked it
  • A “press” disturbance was considered a chronic environmental stress on all organisms in an ecological community
  • “pulse” disturbances were considered acute events that disrupted biological communities to produce high mortality
  • Neoplasia involving dysregulated cell growth is the biological endpoint of the disease
  • ...84 more annotations...
  • Data from the American Cancer Society show that the rate of increase in cancer deaths/year (3.4%) was two-fold greater than the rate of increase in new cases/year (1.7%) from 2013 to 2017
  • cancer is predicted to overtake heart disease as the leading cause of death in Western societies
  • cancer can also be recognized as a metabolic disease.
  • glucose is first split into two molecules of pyruvate through the Embden–Meyerhof–Parnas glycolytic pathway in the cytosol
  • Aerobic fermentation, on the other hand, involves the production of lactic acid under normoxic conditions
  • persistent lactic acid production in the presence of adequate oxygen is indicative of abnormal respiration
  • Otto Warburg first proposed that all cancers arise from damage to cellular respiration
  • The Crabtree effect is an artifact of the in vitro environment and involves the glucose-induced suppression of respiration with a corresponding elevation of lactic acid production even under hyperoxic (pO2 = 120–160 mmHg) conditions associated with cell culture
  • the Warburg theory of insufficient aerobic respiration remains as the most credible explanation for the origin of tumor cells [2, 37, 51, 52, 53, 54, 55, 56, 57].
  • The main points of Warburg’s theory are; 1) insufficient respiration is the predisposing initiator of tumorigenesis and ultimately cancer, 2) energy through glycolysis gradually compensates for insufficient energy through respiration, 3) cancer cells continue to produce lactic acid in the presence of oxygen, and 4) respiratory insufficiency eventually becomes irreversible
  • Efraim Racker coined the term “Warburg effect”, which refers to the aerobic glycolysis that occurs in cancer cells
  • Warburg clearly demonstrated that aerobic fermentation (aerobic glycolysis) is an effect, and not the cause, of insufficient respiration
  • all tumor cells that have been examined to date contain abnormalities in the content or composition of cardiolipin
  • The evidence supporting Warburg’s original theory comes from a broad range of cancers and is now overwhelming
  • respiratory insufficiency, arising from any number mitochondrial defects, can contribute to the fermentation metabolism seen in tumor cells.
  • data from the nuclear and mitochondrial transfer experiments suggest that oncogene changes are effects, rather than causes, of tumorigenesis
  • Normal mitochondria can suppress tumorigenesis, whereas abnormal mitochondria can enhance tumorigenesis
  • In addition to glucose, cancer cells also rely heavily on glutamine for growth and survival
  • Glutamine is anapleurotic and can be rapidly metabolized to glutamate and then to α-ketoglutarate for entry into the TCA cycle
  • Glucose and glutamine act synergistically for driving rapid tumor cell growth
  • Glutamine metabolism can produce ATP from the TCA cycle under aerobic conditions
  • Amino acid fermentation can generate energy through TCA cycle substrate level phosphorylation under hypoxic conditions
  • Hif-1α stabilization enhances aerobic fermentation
  • targeting glucose and glutamine will deprive the microenvironment of fermentable fuels
  • Although Warburg’s hypothesis on the origin of cancer has created confusion and controversy [37, 38, 39, 40], his hypothesis has never been disproved
  • Warburg referred to the phenomenon of enhanced glycolysis in cancer cells as “aerobic fermentation” to highlight the abnormal production of lactic acid in the presence of oxygen
  • Emerging evidence indicates that macrophages, or their fusion hybridization with neoplastic stem cells, are the origin of metastatic cancer cells
  • Radiation therapy can enhance fusion hybridization that could increase risk for invasive and metastatic tumor cells
  • Kamphorst et al. in showing that pancreatic ductal adenocarcinoma cells could obtain glutamine under nutrient poor conditions through lysosomal digestion of extracellular proteins
  • It will therefore become necessary to also target lysosomal digestion, under reduced glucose and glutamine conditions, to effectively manage those invasive and metastatic cancers that express cannibalism and phagocytosis.
  • Previous studies in yeast and mammalian cells show that disruption of aerobic respiration can cause mutations (loss of heterozygosity, chromosome instability, and epigenetic modifications etc.) in the nuclear genome
  • The somatic mutations and genomic instability seen in tumor cells thus arise from a protracted reliance on fermentation energy metabolism and a disruption of redox balance through excess oxidative stress.
  • According to the mitochondrial metabolic theory of cancer, the large genomic heterogeneity seen in tumor cells arises as a consequence, rather than as a cause, of mitochondrial dysfunction
  • A therapeutic strategy targeting the metabolic abnormality common to most tumor cells should therefore be more effective in managing cancer than would a strategy targeting genetic mutations that vary widely between tumors of the same histological grade and even within the same tumor
  • Tumor cells are more fit than normal cells to survive in the hypoxic niche of the tumor microenvironment
  • Hypoxic adaptation of tumor cells allows for them to avoid apoptosis due to their metabolic reprograming following a gradual loss of respiratory function
  • The high rates of tumor cell glycolysis and glutaminolysis will also make them resistant to apoptosis, ROS, and chemotherapy drugs
  • Despite having high levels of ROS, glutamate-derived from glutamine contributes to glutathione production that can protect tumor cells from ROS
    • Nathan Goodyear
      Nathan Goodyear on 08 Feb 18
       
      reason to eliminate glutamine in cancer patients and even GSH with cancer patients
  • It is clear that adaptability to environmental stress is greater in normal cells than in tumor cells, as normal cells can transition from the metabolism of glucose to the metabolism of ketone bodies when glucose becomes limiting
  • Mitochondrial respiratory chain defects will prevent tumor cells from using ketone bodies for energy
  • glycolysis-dependent tumor cells are less adaptable to metabolic stress than are the normal cells. This vulnerability can be exploited for targeting tumor cell energy metabolism
  • In contrast to dietary energy reduction, radiation and toxic drugs can damage the microenvironment and transform normal cells into tumor cells while also creating tumor cells that become highly resistant to drugs and radiation
  • Drug-resistant tumor cells arise in large part from the damage to respiration in bystander pre-cancerous cells
  • Because energy generated through substrate level phosphorylation is greater in tumor cells than in normal cells, tumor cells are more dependent than normal cells on the availability of fermentable fuels (glucose and glutamine)
  • Ketone bodies and fats are non-fermentable fuels
  • Although some tumor cells might appear to oxidize ketone bodies by the presence of ketolytic enzymes [181], it is not clear if ketone bodies and fats can provide sufficient energy for cell viability in the absence of glucose and glutamine
  • Apoptosis under energy stress is greater in tumor cells than in normal cells
  • A calorie restricted ketogenic diet or dietary energy reduction creates chronic metabolic stress in the body
  • . This energy stress acts as a press disturbance
  • Drugs that target availability of glucose and glutamine would act as pulse disturbances
  • Hyperbaric oxygen therapy can also be considered another pulse disturbance
  • The KD can more effectively reduce glucose and elevate blood ketone bodies than can CR alone making the KD potentially more therapeutic against tumors than CR
  • Campbell showed that tumor growth in rats is greater under high protein (>20%) than under low protein content (<10%) in the diet
  • Protein amino acids can be metabolized to glucose through the Cori cycle
  • The fats in KDs used clinically also contain more medium chain triglycerides
  • Calorie restriction, fasting, and restricted KDs are anti-angiogenic, anti-inflammatory, and pro-apoptotic and thus can target and eliminate tumor cells through multiple mechanisms
  • Ketogenic diets can also spare muscle protein, enhance immunity, and delay cancer cachexia, which is a major problem in managing metastatic cancer
  • GKI values of 1.0 or below are considered therapeutic
  • The GKI can therefore serve as a biomarker to assess the therapeutic efficacy of various diets in a broad range of cancers.
  • It is important to remember that insulin drives glycolysis through stimulation of the pyruvate dehydrogenase complex
  • The water-soluble ketone bodies (D-β-hydroxybutyrate and acetoacetate) are produced largely in the liver from adipocyte-derived fatty acids and ketogenic dietary fat. Ketone bodies bypass glycolysis and directly enter the mitochondria for metabolism to acetyl-CoA
  • Due to mitochondrial defects, tumor cells cannot exploit the therapeutic benefits of burning ketone bodies as normal cells would
  • Therapeutic ketosis with racemic ketone esters can also make it feasible to safely sustain hypoglycemia for inducing metabolic stress on cancer cells
    • Nathan Goodyear
      Nathan Goodyear on 08 Feb 18
       
      Ketones are much more than energy adaptabilit, but actually are therapeutic.
  • ketone bodies can inhibit histone deacetylases (HDAC) [229]. HDAC inhibitors play a role in targeting the cancer epigenome
  • Therapeutic ketosis reduces circulating inflammatory markers, and ketones directly inhibit the NLRP3 inflammasome, an important pro-inflammatory pathway linked to carcinogenesis and an important target for cancer treatment response
  • Chronic psychological stress is known to promote tumorigenesis through elevations of blood glucose, glucocorticoids, catecholamines, and insulin-like growth factor (IGF-1)
  • In addition to calorie-restricted ketogenic diets, psychological stress management involving exercise, yoga, music etc. also act as press disturbances that can help reduce fatigue, depression, and anxiety in cancer patients and in animal models
  • Ketone supplementation has also been shown to reduce anxiety behavior in animal models
  • This physiological state also enhances the efficacy of chemotherapy and radiation therapy, while reducing the side effects
  • lower dosages of chemotherapeutic drugs can be used when administered together with calorie restriction or restricted ketogenic diets (KD-R)
  • Besides 2-DG, a range of other glycolysis inhibitors might also produce similar therapeutic effects when combined with the KD-R including 3-bromopyruvate, oxaloacetate, and lonidamine
    • Nathan Goodyear
      Nathan Goodyear on 08 Feb 18
       
      oxaloacetate is a glycolytic inhibitor, as is doxycycline, and IVC.
  • A synergistic interaction of the KD diet plus radiation was seen
  • It is important to recognize, however, that the radiotherapy used in glioma patients can damage the respiration of normal cells and increase availability of glutamine in the microenvironment, which can increase risk of tumor recurrence especially when used together with the steroid drug dexamethasone
  • Poff and colleagues demonstrated that hyperbaric oxygen therapy (HBOT) enhanced the ability of the KD to reduce tumor growth and metastasis
  • HBOT also increases oxidative stress and membrane lipid peroxidation of GBM cells in vitro
  • The effects of the KD and HBOT can be enhanced with administration of exogenous ketones, which further suppressed tumor growth and metastasis
  • Besides HBOT, intravenous vitamin C and dichloroacetate (DCA) can also be used with the KD to selectively increase oxidative stress in tumor cells
  • Recent evidence also shows that ketone supplementation may enhance or preserve overall physical and mental health
  • Some tumors use glucose as a prime fuel for growth, whereas other tumors use glutamine as a prime fuel [102, 186, 262, 263, 264]. Glutamine-dependent tumors are generally less detectable than glucose-dependent under FDG-PET imaging, but could be detected under glutamine-based PET imaging
  • GBM and use glutamine as a major fuel
  • Many of the current treatments used for cancer management are based on the view that cancer is a genetic disease
  • Emerging evidence indicates that cancer is a mitochondrial metabolic disease that depends on availability of fermentable fuels for tumor cell growth and survival
  • Glucose and glutamine are the most abundant fermentable fuels present in the circulation and in the tumor microenvironment
  • Low-carbohydrate, high fat-ketogenic diets coupled with glycolysis inhibitors will reduce metabolic flux through the glycolytic and pentose phosphate pathways needed for synthesis of ATP, lipids, glutathione, and nucleotides
  • Nathan Goodyear on 09 Jul 17
     
    Cancer is a mitochondrial disease? So says the well published Dr Seyfried. Glucose and glutamine drive cancer growth.
Nathan Goodyear

Effect of Distinct Lifestyle Interventions on Mobilization of Fat Storage Pools: The CENTRAL MRI Randomized Controlled Trial | Circulation - 0 views

circ.ahajournals.org/...CIRCULATIONAHA.117.030501

Mediterranean diet diet nutrition lifestyle obesity lifestyle intervention weight loss

shared by Nathan Goodyear on 19 Dec 17 - No Cached
  • Nathan Goodyear on 19 Dec 17
     
    low carb mediterranean nutrition out performs low fat diet; but both are not served by following weight number.  MRI shows that fat mobilization of the superior low carb mediterranean nutrition plan is not adequately reflected in weight measurement. 
Nathan Goodyear

Postnatal diet remodels hepatic DNA methylation in metabolic pathways established by a maternal high-fat diet | Epigenomics - 0 views

www.futuremedicine.com/...epi-2017-0066

epigenetics nutrition disease methylation diet DNA

shared by Nathan Goodyear on 23 Oct 17 - No Cached
  • Nathan Goodyear on 23 Oct 17
     
    Only abstract available here.  Maternal nutrition, high fat diet in this study, altered genetic expression of offspring to increase future disease risk.  This study would have been better served if they had differentiated fats i.e. PUFA, MUFA, SF, TF....
Nathan Goodyear

Inflammation in Response to Glucose Ingestion Is Independent of Excess Abdominal Adiposity in Normal-Weight Women with Polycystic Ovary Syndrome - 0 views

jcem.endojournals.org/...4071.abstract

PCOS polycystic ovarian syndrome inflammation TNF-alpha CRP women androgens testosterone

shared by Nathan Goodyear on 09 Nov 12 - No Cached
  • Nathan Goodyear on 09 Nov 12
     
    women with PCOS, inflammatory cytokines TNF-alpha and CRP, associated with increasing androgen levels and with abdominal fat.  Women with less fat had lower levels of TNF-alpha and CRP than their higher weight counterparts, though the inflammatory cytokines were still evident.
Nathan Goodyear

JAMA Network | JAMA Internal Medicine | Fat Intake After Diagnosis and Risk of Lethal Prostate Cancer and All-Cause MortalityFat Intake After Lethal Prostate Cancer - 0 views

archinte.jamanetwork.com/article.aspx

fat vegetable cancer prostate carbs carbohydrates diet

shared by Nathan Goodyear on 11 Jun 13 - No Cached
  • Nathan Goodyear on 11 Jun 13
     
    Carb reduction and increase in vegetable fat appears to be associated with reduction in prostate cancer spread and all-cause mortality
Nathan Goodyear

JAMA Network | JAMA | Association of All-Cause Mortality With Overweight and Obesity Using Standard Body Mass Index CategoriesA Systematic Review and Meta-analysisAll-Cause Mortality Using BMI Categories - 0 views

jama.jamanetwork.com/article.aspx

obese obesity overweight mortality

shared by Nathan Goodyear on 02 Jan 13 - No Cached
  • Nathan Goodyear on 02 Jan 13
     
    Don't get to excited about this article.  It is just a meta-analysis.  Second, they looked at BMI and BMI is a notoriously bad estimater of muscle mass versus fat content.  I am the perfect example, my BMI has me as obese, yet my measured fat % is 16%.   My read on this, is most of the individuals that are "overweight" are actually at a health weight with a higher muscle mass percentage not picked up with the BMI measurement.
Nathan Goodyear

An Open-Label Pilot Study to Assess the Efficacy and Safety of Virgin Coconut Oil in Reducing Visceral Adiposity - 0 views

www.ncbi.nlm.nih.gov/...PMC3226242

coconut oil coconut weight loss overweight obesity

shared by Nathan Goodyear on 22 Jan 13 - No Cached
  • Nathan Goodyear on 22 Jan 13
     
    short 4 week pilot study of coconut oil aids abdominal weight loss shows.  Must take the right fat to lose fat.
Nathan Goodyear

Genetic Analysis of 16 NMR-Lipoprotein Fractions in H... [Lipids. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23192668

SNPs single nucleotide polymorphisms genes genetics lipid metabolism metabolism weight overweight obesity

shared by Nathan Goodyear on 24 Jan 13 - No Cached
  • Nathan Goodyear on 24 Jan 13
     
    genetic SNPs play a role in lipid/fat metabolism. A person's weight problem may be, in part, a genetic problem of fat metabolism.
Nathan Goodyear

Effect of meal fat content on salivary testosterone and cortisol levels in healthy female volunteers - 0 views

www.endocrine-abstracts.org/...ea0010p75.htm

Testosterone nutrition diet fat low T low Testosterone hormones saliva salivary hormones

shared by Nathan Goodyear on 19 Sep 16 - No Cached
  • Nathan Goodyear on 19 Sep 16
     
    higher fat diet found to increase cortisol and Testosterone levels post meal in health women.  The effect was first seen early after lunch (30 minutes).
Nathan Goodyear

Altered Preconception Fatty Acid Intake Is Associated with Improved Pregnancy Rates in Overweight and Obese Women Undertaking in Vitro Fertilisation - 0 views

www.ncbi.nlm.nih.gov/...PMC4728624

obesity overweight infertility IVF nutrition pregnancy omega-6 omega-3 omega 3 omg

shared by Nathan Goodyear on 17 Oct 16 - No Cached
  • Nathan Goodyear on 17 Oct 16
     
    Health fat intake associated with improved fertility in overweight and obese women undergoing IVF.  Higher intake of polyunsaturated fats were associated with improved fertile rates: specifically omega 6 and Linoleum acid.  Only a trend was seen with omega 3's.
hadiyasafdar

Cosmetic Surgeons on United Arab Emirates: Things you should know about tummy tuck surgery - 0 views

dubaicosmeticsurgeryclinics.blogspot.com/...uld-know-about-tummy-tuck.html

#tummytuckdubai #tummytucksharjah #abdominoplastydubai #abdominoplastysharjah #tummytucksurgerydubai #tummytucktreatmentdubai #liposuctionDubai

shared by hadiyasafdar on 10 Jan 17 - No Cached
  • hadiyasafdar on 10 Jan 17
     
    If you are suffering from any serious medical condition, you may not qualify for a tummy tuck treatment. You should delay the surgery if you are pregnant. If you have excessive fat deposits but minimal skin, you are not an ideal candidate for a tummy tuck surgery. You can opt for liposuction in Dubai for fat removal.
hadiyasafdar

All You Need to Know About Fat Transfer in Dubai - 0 views

dubaicosmeticsurgeryclinics.blogspot.com/...o-know-about-fat-transfer.html

#FatInjectionDubai #ButtockLiftDubai #FatInjectionTreatmentDubai #ButtockLiftsurgeryDubai

shared by hadiyasafdar on 13 Jan 17 - No Cached
  • hadiyasafdar on 13 Jan 17
     
    * What is fat injection Dubai? * What buttock lift in Dubai can do for you? * The results of the respective treatments * Benefits of the respective treatments
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