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Nathan Goodyear

Free triiodothyronine: a novel predictor of postoperative atrial fibrillation -- Cerillo et al. 24 (4): 487 -- European Journal of Cardio-Thoracic Surgery - 0 views

ejcts.ctsnetjournals.org/...487

triiodothyronine free T3 atrial fibrillation CABG cardiovascular disease

shared by Nathan Goodyear on 01 Feb 11 - No Cached
  • Nathan Goodyear on 01 Feb 11
     
    Conclusions: Low basal fT3 concentration can reliably predict the occurrence of postoperative Atrial Fibrillation in Coronary-bypass patients
Nathan Goodyear

Subclinical thyroid dysfunctions are independent risk factors for mortality in a 7.5-year follow-up: the Japanese-Brazilian thyroid study -- Sgarbi et al. 162 (3): 569 -- European Journal of Endocrinology - 0 views

www.eje-online.org/...569

subclinical thyroid dysfunctions

shared by Nathan Goodyear on 24 Mar 11 - No Cached
  • subclinical hyperthyroidism is an independent risk factor for all-cause and cardiovascular mortality, while subclinical hypothyroidism is associated with all-cause mortality
  • Nathan Goodyear on 24 Mar 11
     
    sub-clinical hypothyroidism and sub-clinical hyperthyroidism associated with increased mortality
Nathan Goodyear

Decreased serum TSH levels are not associated with mortality in the adult northeast German population -- Ittermann et al. 162 (3): 579 -- European Journal of Endocrinology - 0 views

www.eje-online.org/...579

tsh

shared by Nathan Goodyear on 24 Mar 11 - No Cached
  • Nathan Goodyear on 24 Mar 11
     
    decreased TSH not associated with increased mortality in German study
Nathan Goodyear

Metabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: a double-blind trial - EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES - 0 views

www.europeanreview.org/articolo.php

PCOS myo-inositol

shared by Nathan Goodyear on 24 May 11 - No Cached
  • Treatment of PCOS patients with Myo-inositol provided a decreasing of circulating insulin and serum total testosterone as well as an improvement in metabolic factors.
  • Nathan Goodyear on 24 May 11
     
    Myo-inositol shown to improve insulin resistance and lower testosterone levels in women with PCOS
Nathan Goodyear

ENA - European Nutraceutical Association - 0 views

www.enaonline.org/index.php

antioxidant therapy antioxidants cancer treatment

shared by Nathan Goodyear on 12 Sep 11 - No Cached
  • Nathan Goodyear on 12 Sep 11
     
    antioxidant therapy during traditional cancer treatment proves to be beneficial adjunctive therapy
Nathan Goodyear

European Journal of Clinical Nutrition - Abstract of article: Effect of vitamin C on common cold: randomized controlled trial - 0 views

www.nature.com/...1602261a.html

Vitamin C common cold flu immune enhancing effect nutrition

shared by Nathan Goodyear on 05 Oct 11 - No Cached
  • Nathan Goodyear on 05 Oct 11
     
    vitamin C shown to reduce the # of colds over a 5 year period.  Showing a long-term immune enhancing effect of vitamin C
Nathan Goodyear

Alpha-lipoic acid improves vascular endothelial function in patients with type 2 diabetes: a placebo-controlled randomized trial - Heinisch - 2009 - European Journal of Clinical Investigation - Wiley Online Library - 0 views

onlinelibrary.wiley.com/...full

alpha lipoic acid IV therapy

shared by Nathan Goodyear on 05 Apr 11 - No Cached
  • Nathan Goodyear on 05 Apr 11
     
    IV alpha lipoic acid improves vascular function
Nathan Goodyear

Access : Effect of three consecutive meals on the physicochemical properties of HDL and LDL in individuals with the metabolic syndrome and patients with type 2 diabetes : European Journal of Clinical Nutrition - 0 views

www.nature.com/...ejcn2011114a.html

HDL access LDL metabolic syndrome diabetes nutrition

shared by Nathan Goodyear on 11 Jul 11 - No Cached
  • Nathan Goodyear on 11 Jul 11
     
    repetitive post-meal reveals elevated lipids promote an atherogenic change in HDL and LDL
Nathan Goodyear

SpringerLink - European Journal of Nutrition, Online First™ - 0 views

www.springerlink.com/...k46070w7p83g1181

vitamins minerals supplements mortality

shared by Nathan Goodyear on 14 Oct 11 - No Cached
  • Nathan Goodyear on 14 Oct 11
     
    vitamins/minerals shown to reduce all-cause mortality.  this study also warns of "sick-user effect" that is on of the many flaws in the recently released, flawed Iowa Health Study
Nathan Goodyear

The Relationships between Sex Hormones and Sexual Function in Middle-Aged and Older European Men - 0 views

jcem.endojournals.org/...E1577.abstract

testosterone T low estradiol sexual function men

shared by Nathan Goodyear on 31 Oct 11 - No Cached
  • Nathan Goodyear on 31 Oct 11
     
    Testosterone, estradiol and sexual function in men
Nathan Goodyear

Endogenous androgens and risk of epithelial invasive ovarian cancer by tumor characteristics in the European Prospective Investigation into Cancer and Nutrition - Ose - International Journal of Cancer - Wiley Online Library - 0 views

onlinelibrary.wiley.com/...FD615B31CBA2A30EB588D93.f01t03

ovarian cancer SHBG androgens women female

shared by Nathan Goodyear on 04 Jun 14 - No Cached
  • Nathan Goodyear on 04 Jun 14
     
    prospective study finds that increasing endogenous androgens is associated with low grade epithelial ovarian cancer and inversely associated with high-grade.
Nathan Goodyear

Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes | European Heart Journal - 0 views

eurheartj.oxfordjournals.org/...998

endurance athletes training heart health injury

shared by Nathan Goodyear on 09 Jan 15 - No Cached
  • In a cohort of well-trained athletes, we demonstrated that intense endurance exercise causes an acute reduction in RV function that increases with race duration and correlates with increases in biomarkers of myocardial injury
  • no relationship between LV function and biomarker levels
  • focal gadolinium enhancement and increased RV remodelling were more prevalent in those athletes with a longer history of competitive sport, suggesting that repetitive ultra-endurance exercise may lead to more extensive RV change and possible myocardial fibrosis
  • ...22 more annotations...
  • he cardiac impact of both acute and cumulative exercise is greatest on the RV.
  • Greater reductions in RV function occurred in those athletes competing for a longer duration, suggesting that the heart has a finite capacity to maintain the increased work demands of exercise
  • cardiac injury is greatest in the least trained
  • Previous investigators have documented reductions in RV function in less trained subjects over the marathon distance
  • We enrolled elite and subelite athletes and found a significant association between fitness (VO2max) and the reduction in post-race RVEF
  • Even after many years of detraining, cardiac dilation may not completely regress in elite athletes
  • The focus on well-trained athletes may be of particular relevance, given that they perform exercise of highest intensity and duration most frequently, and, thus, may be at a greater risk of cumulative injury.
  • The lack of correlation between increases in troponin and changes in LV function seen in this study has been previously interpreted as evidence that post-exercise elevations in cardiac biomarkers are benign.
  • a significant correlation between changes in RVEF and post-race biomarker levels and this relationship was even stronger in the athletes who completed the race of longest duration, the ultra-triathlon
  • The correlations with RVEF, but not LVEF, provide further evidence of the differential effects of intense exercise on RV and LV function
  • BNP release during intense exercise is associated with greater relative increases in RV systolic pressures, but not LV pressures
  • BNP may provide a measure of both acute RV load and the resultant fatigue which occurs when this load is sustained
  • It has been demonstrated that ventricular load increases with exercise intensity and is greater for the RV than the LV,29 thus potentially explaining why the RV is more susceptible to fatigue after prolonged exercise.
  • This study demonstrates, for the first time, an association between endurance exercise of increasing duration and structural, functional, and biochemical markers of cardiac dysfunction in highly trained athletes
  • Functional abnormalities were confined to the RV and were largely reversible 1 week following the event
  • there remained a significant minority of athletes in whom there was evidence of myocardial fibrosis in the interventricular septum
  • RV abnormalities may be acquired through cumulative bouts of intense exercise and provides direction for prospective investigations aimed at elucidating whether extreme exercise may promote arrhythmias in some athletes.
  • the acute injury and chronic remodelling of the myocardium both disproportionately affect the RV and it remains possible that the two are linked.
  • focal DGE was confined to the interventricular septum and commonly at the site of RV attachment
  • emerging evidence that intense endurance exercise may be associated with an excess in arrhythmic disorders, the mechanisms for which remain unexplained
  • RVEF (and not LVEF) was reduced in athletes with complex ventricular arrhythmias when compared with healthy athletes and non-athletes without arrhythmias
  • it is premature to conclude that these changes may represent a proarrhythmic substrate
  • Nathan Goodyear on 09 Jan 15
     
    Study finds endurance racing results in reduce Right ventricle ejection fraction even in elite athletes.  This post-race RVEF reduction is associated with VO2max.
Nathan Goodyear

European Journal of Clinical Nutrition - Effect of maternal n-3 long-chain polyunsaturated fatty acid supplementation during pregnancy and/or lactation on adiposity in childhood: a systematic review and meta-analysis of randomized controlled trials - 0 views

www.nature.com/...ejcn2014158a.html

nutrition n-3 omega 3 omega-3 fish oil pregnancy childhood obesity

shared by Nathan Goodyear on 22 Dec 14 - No Cached
  • It is estimated that approximately 30% of children and adolescents in the United States and about 15–30% of those in Europe can be classified as overweight or obese
  • An increasing body of evidence now suggests that the nutritional environment encountered in utero and the early postnatal life may elicit permanent alterations in adipose tissue structure or function and, thereby, programme the individual’s propensity to later obesity
  • The composition of fatty acids in the Western diets has shifted toward an increasing dominance of n-6 relative to n-3 LCPUFAs over the past decades.9,10 This shift is also reflected in the fatty acid composition of breast milk
  • ...8 more annotations...
  • Evidence from animal studies suggests that the n-6 LCPUFA arachidonic acid promotes adipose tissue deposition, whereas the n-3 LCPUFAs eicosapentaenoic acid and docosahexaenoic acid seem to exert an opposite effect
  • Overall, no effect of supplementation was found on BMI in preschool (<5 years) and school-aged (6–12 years) children
  • increased adiposity, once established in childhood, tends to track into adulthood
  • Many studies have shown that even children <2 years with a high BMI are at increased risk of developing obesity later in life
  • The acquisition of fat cells early in life appears to be an irreversible process
  • Evidence from cell culture and animal studies suggests that early exposure to n-3 LCPUFAs has the potential to limit adipose tissue deposition mainly by attenuating the production of the arachidonic acid metabolite prostacyclin, which has been shown to enhance adipogenesis
  • In conclusion, there is currently no evidence to support that maternal n-3 LCPUFA supplementation during pregnancy and/or lactation exerts a favourable programming effect on adiposity status in childhood
  • our systematic review highlights that most of the trials reviewed were prone to methodological limitations
  • Nathan Goodyear on 22 Dec 14
     
    Literature review finds limited data (9 studies, only 6 RCTs) of omega-3 during pregnancy.  No data was found that supported reduced obesity in children by mothers taking n-3 during pregnancy.  No harm was found either.  Data was sparse.   Take home: not enough data, no harm to pregnancy, children, thus if indications are present for mother, then recommend n-3.  At this point not studies have pointed to reduced obesity in children.
Nathan Goodyear

Hypothalamic-Pituitary-Testicular Axis Disruptions in Older Men Are Differentially Linked to Age and Modifiable Risk Factors: The European Male Aging Study: The Journal of Clinical Endocrinology & Metabolism: Vol 93, No 7 - 0 views

press.endocrine.org/...jc.2007-1972

low T low Testosterone low T Testosterone aging LH hormone hormones men male SHBG

shared by Nathan Goodyear on 03 Sep 14 - No Cached
  • 0.4–2% annual decline
  • the age trend in free T was more substantial (−1.3% per annum)
  • The core hormonal pattern with increasing age is suggestive of incipient primary testicular dysfunction with maintained total T and progressively blunted free T associated with higher LH.
  • ...16 more annotations...
  • Obesity was associated with progressively lower total and free T independent of the simultaneous decrease in SHBG.
  • our data highlight the fact that LH was unchanged or even lower in older men in the face of lower T in obesity, suggesting that there may be a failure at the hypothalamic-pituitary level.
  • a change in BMI from nonobese to obese may be equivalent to a 15 yr fall in T.
  • This pattern supports the hypothesis that different underlying mechanisms influence the functions of the HPT axis: age predominantly affects testicular function, whereas obesity impairs hypothalamic/pituitary function.
  • the effects of aging on testicular function can be moderated by increased LH compensation for many decades
  • obesity impairs hypothalamic/pituitary function independent of age, arguably an adaptive response for which there should be no compensatory mechanism.
  • the concurrent but opposite (and separate) effects of obesity and age on SHBG
  • SHBG was negatively associated with increasing strata of obesity
  • Obesity is associated with insulin resistance (28), and the increased circulating insulin inhibits hepatic SHBG synthesis
  • the SHBG increase with age may be related to relative IGF-I deficiency (27), although this has not been directly proven.
  • Obesity is associated with peripheral and central insulin resistance (30) and proinflammatory cytokine production (TNFα and IL-6) from adipocytes (31) and central nervous system endocannibinoid release (32), all of which are potential candidates for abrogating hypothalamic endocrine and downstream reproductive axis functions.
    • Nathan Goodyear
      Nathan Goodyear on 03 Sep 14
       
      The HPA axis effect may be the result of inflammation.
  • The relationship between obesity and T can be bidirectional: low T may be the cause rather than consequence of obesity
  • chronic alcohol abuse is known to suppress LH (40), our data showed no significant association among the three hormones or SHBG and alcohol intake.
  • increase in total T in smokers occurs through a primary increase in SHBG with a compensatory rise in LH
  • the effects of obesity (BMI or waist circumference) was by far the most important determinant of variance in total T, whereas age per se was important for SHBG, LH, and free T with comorbidity and smoking being comparatively minor contributors
  • It is noteworthy that these predisposing lifestyle and health factors are modifiable. This implies that the apparent age-related decline in T may constitute a barometer of health and thus be potentially preventable and/or reversible.
  • Nathan Goodyear on 03 Sep 14
     
    Age induced decline in Testosterone is more associated with a decline in leydig cell function and thus elevated LH will be associated.  In contrast, obesity is more of a HPA axis disruption and thus LH may be normal to low.  The pulse amplitude is decrease.  No change in pulse frequency is noted.   With obesity, a decline in TT and fT was independent of SHBG. Aging is associated with a greater decrease in fT versus TT.
Nathan Goodyear

Associations between Sex Steroids and the Development of Metabolic Syndrome: a Longitudinal Study in European Men: The Journal of Clinical Endocrinology & Metabolism: Vol 0, No 0 - 0 views

press.endocrine.org/...jc.2014-4184

low T low Testosterone SHBG metabolic syndrome men male hormone hormones

shared by Nathan Goodyear on 02 Feb 15 - No Cached
  • Nathan Goodyear on 02 Feb 15
     
    Men with lower Testosterone levels are associated with increased odds (72%) of Metabolic Syndrome.  This was independent from SHBG and BMI.
Nathan Goodyear

Red alert for women's heart: the urgent need for more research and knowledge on cardiovascular disease in women | European Heart Journal - 0 views

eurheartj.oxfordjournals.org/...1362

hot flashes night sweats vasomotor symptoms cardiovascular disease CVD women female menopause symptoms heart health

shared by Nathan Goodyear on 11 Mar 15 - No Cached
  • Nathan Goodyear on 11 Mar 15
     
    Vasomotor symptoms (hot flashes and night sweats) is associated with increased cardiovascular risk in women.
Nathan Goodyear

BMC Endocrine Disorders | Full text | The prevalence of metabolic syndrome and metabolically healthy obesity in Europe: a collaborative analysis of ten large cohort studies - 0 views

www.biomedcentral.com/...9

metabolic syndrome metabolic syndrome obesity health europe Europeans

shared by Nathan Goodyear on 02 Aug 14 - No Cached
  • Nathan Goodyear on 02 Aug 14
     
    metabolic syndrome incidence in Europe far below that of the US.  One of the primary driving forces of MetS is obesity.
Nathan Goodyear

Characteristics of Secondary, Primary, and Compensated Hypogonadism in Aging Men: Evidence from the European Male Ageing Study: The Journal of Clinical Endocrinology & Metabolism: Vol 95, No 4 - 0 views

press.endocrine.org/...jc.2009-1796

low T low Testosterone hypogonadism aging obesity men male hormone hormones

shared by Nathan Goodyear on 30 Mar 15 - No Cached
  • Circulating testosterone (T) in men declines progressively by 0.4–2% per year from the third decade onward
  • late-onset hypogonadism (LOH) (6, 7), whereas others have used various terms including andropause, male menopause, and androgen deficiency syndrome of the aging male.
    • Nathan Goodyear
      Nathan Goodyear on 30 Mar 15
       
      all names for Low T--interesting
  • Secondary hypogonadism is associated with obesity (and potentially reversible) independently of age
  • ...2 more annotations...
  • primary hypogonadism (probably the genuine form of LOH) is strongly associated with age
  • Compensated hypogonadism represents a distinct clinical entity that warrants continued monitoring to prevent or preempt further deterioration
  • Nathan Goodyear on 30 Mar 15
     
    Study divides low T into primary (age), secondary (weight), and compensated hypogonadism (elevated LH with normal T)
Nathan Goodyear

Heart failure improvement from a supplement containing copper | European Heart Journal - 0 views

eurheartj.oxfordjournals.org/...117.1

heart failure copper cardiovascular disease cardiovascular disease

shared by Nathan Goodyear on 22 Dec 15 - No Cached
  • Nathan Goodyear on 22 Dec 15
     
    heart failure improved with copper supplementation.
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