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Nathan Goodyear

Neuroendocrine disorders after... [J Neurol Neurosurg Psychiatry. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18559460

PTHP traumatic brain injury TBI neuroendocrine post-traumatic hypopituitarism brain injury neurology hormone hormones pituitary hypothalamus psychiatry

shared by Nathan Goodyear on 09 Jul 12 - No Cached
  • Nathan Goodyear on 09 Jul 12
     
    The majority of people with PTHP after TBI remain undiagnosed.  The current thought, is that 25% of those with TBI have at least one pituitary hormone deficiency.  It does not have to be total pituitary failure.  Deficiencies can be isolated.
Nathan Goodyear

Emory WHSC :: Press Releases - 0 views

whsc.emory.edu/press_releases2.cfm

progesterone bioidentical hormones BHRT natural brain injury TBI

shared by Nathan Goodyear on 18 Jan 12 - No Cached
  • Nathan Goodyear on 18 Jan 12
     
    progesterone shown to have promise as a treatment in those with traumatic brain injury
Nathan Goodyear

Improved outcomes from the administration of proge... [Crit Care. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18447940

progesterone TBI brain trauma injury bioidentical hormone hormones natural BHRT

shared by Nathan Goodyear on 19 Jan 12 - No Cached
  • Nathan Goodyear on 19 Jan 12
     
    progesterone shown to be neuroprotective in individuals with traumatic brain injuries.  In addition to improved neurologic function, there was a decreased mortality rate in the progesterone treated group compared to placebo.
Nathan Goodyear

Speech dysfunction due to trazodone-fluoxetine combination in traumatic brain injury, B... - 0 views

informahealthcare.com/...026990597123593

trazodone zoloft fluoxetine traumatic brain injury

shared by Nathan Goodyear on 03 Jan 12 - No Cached
  • Nathan Goodyear on 03 Jan 12
     
    common insomnia cocktail has powerful side effects
Nathan Goodyear

Traumatic brain injury: an overview of pathobiology with emphasis on military populations - 0 views

www.ncbi.nlm.nih.gov/...PMC2855235

TBI traumatic brain injury military soldiers

shared by Nathan Goodyear on 04 Feb 12 - No Cached
  • Nathan Goodyear on 04 Feb 12
     
    The pathobiology of a TBI in the military.
Nathan Goodyear

PsychiatryOnline | The Journal of Neuropsychiatry and Clinical Neurosciences | The Neur... - 0 views

neuro.psychiatryonline.org/article.aspx

TBI traumatic brain injury neuroendocrine hormone hormones

shared by Nathan Goodyear on 03 Feb 12 - No Cached
  • Nathan Goodyear on 03 Feb 12
     
    Understanding the neuroendocrine effects of TBI. This article discusses all hormonal effects as a result of TBI.
Nathan Goodyear

Hypothalamopituitary Dysfunction Following Traumatic Brain Injury and Aneurysmal Subara... - 0 views

jama.ama-assn.org/...1429.full

TBI traumatic brain injury pituitary HPA hormone hormones hypothalamic dysfunction

shared by Nathan Goodyear on 03 Feb 12 - No Cached
  • Nathan Goodyear on 03 Feb 12
     
    TBI results in altered pituitary function.  This study reviewed research articles published over a 7 year time (2000-2007).
Nathan Goodyear

Prevalence of Neuroendocrine Dysfunction in Patients Recovering from Traumatic Brain In... - 0 views

jcem.endojournals.org/...2752.full

TBI traumatic brain injury HGH pituitary cortisol thyroid hypothyroid hypothyroidism

shared by Nathan Goodyear on 03 Feb 12 - No Cached
  • Nathan Goodyear on 03 Feb 12
     
    TBI results in pituitary dysfunction.  The result in low cortisol, low thyroid, and low HGH.  Other hormones appeared to be unaffected
Nathan Goodyear

PsychiatryOnline | The Journal of Neuropsychiatry and Clinical Neurosciences | The Neur... - 0 views

neuro.psychiatryonline.org/article.aspx

TBI traumatic brain injury pituitary neuroendocrine deficits injury brain sex hormone HGH growth

shared by Nathan Goodyear on 03 Feb 12 - No Cached
  • Nathan Goodyear on 03 Feb 12
     
    TBI results in hormone disruption in 25-69% of those effected.  The major cause is a pituitary/neuro-endocrine effect.  This has been described since the early 20th century.
Nathan Goodyear

Immunoexcitotoxicity as a central mechanism in chronic traumatic encephalopathy--A unif... - 0 views

www.surgicalneurologyint.com/...rolInt21107-2574138_070901.pdf

immunoexcitotoxicity excitoxicity TBI traumatic brain injury chronic NFL players football soldiers combat

shared by Nathan Goodyear on 08 Feb 12 - No Cached
  • Nathan Goodyear on 08 Feb 12
     
    Article discusses the immunoexcitotoxic process involved in chronic TBI. This is likely to be the underlying process involved in NFL and other football players delayed neurological effects. A similar process has been see in combat veterans returning from the theatre.
Nathan Goodyear

Acta Pharmacologica Sinica - The neuroprotective effects of progesterone on traumatic b... - 0 views

www.nature.com/...aps2013160a.html

progesterone brain injury traumatic brain injury TBI hormone hormones head trauma

shared by Nathan Goodyear on 17 Mar 14 - No Cached
  • Nathan Goodyear on 17 Mar 14
     
    Good discussion and review of progesterone's role as neuroprotective in TBI.
Nathan Goodyear

Acute Glucocorticoid Deficiency and Diabetes Insipidus Are Common After Acute Traumatic... - 0 views

jcem.endojournals.org/...3229.abstract

traumatic brain injury brain injury HPA cortisol

shared by Nathan Goodyear on 21 Aug 13 - No Cached
  • Nathan Goodyear on 21 Aug 13
     
    High rate (78%) of those post TBI have low cortisol levels due to damaged HPA axis.  Low cortisol levels post TBI are associated with an increase mortality rate and increased long-term HPA disruption.
Nathan Goodyear

Absence of chronic traumatic encephalopat... [Front Hum Neurosci. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23745112

CTE concussions football neurology chronic traumatic encephalopathy encephalopathy

shared by Nathan Goodyear on 27 Oct 13 - No Cached
  • Nathan Goodyear on 27 Oct 13
     
    Study finds that not all football players with a history of multiple concussions and neurologic symptoms have CTE.
Nathan Goodyear

ω-3 Fatty Acid Supplementation as a Potential Therapeutic Aid for the Recover... - 0 views

advances.nutrition.org/...268.full

omega 3 DHA EPA fish oil TBI traumatic brain injury concussions concussion brain injury

shared by Nathan Goodyear on 30 Aug 15 - No Cached
  • There is a growing body of preclinical literature suggesting that ω-3 FAs, and DHA in particular, may play a therapeutic role in mTBI
  • the potential for ameliorating or possibly even preventing the complications associated with concussions
  • DHA is the predominant ω-3 FA present in the brain, and, consistent with this finding, DHA, and not EPA, has been demonstrated to be critical for brain development and cognitive function throughout life
  • ...7 more annotations...
  • the concentration of EPA in the brain is negligible (77–80), suggesting that EPA plays a limited role in mediating the beneficial effects of LCPUFA supplementation on mTBI pathology
  • the current state of the science regarding LCPUFA supplementation for the treatment of concussion is based primarily on animal models
  • there is evidence that the amount of DHA in brain tissue is decreased after mTBI (65, 66), suggesting an elevated need for DHA in mTBI recovery.
  • the well-established role of DHA in supporting the structure and function of the brain throughout the lifespan (26, 27, 46, 47, 53) provides encouragement that LCPUFAs may also prove beneficial in the context of concussion recovery.
  • no therapies are currently available to aid the recovery from this injury
  • Previously discussed reports outlining the use of ω-3 FAs in the recovery from severe TBIs (reviewed in Ref. 92) described the use of very-high doses of LCPUFAs (16.2 g/d EPA plus DHA) in the recovery of these patients
  • Within the context of mTBIs/concussions, translating a DHA intake used in several rat studies of mTBI recovery (40 mg ⋅ kg−1 ⋅ d−1 DHA) (57, 63, 64) using body surface area conversion methods (93) amounts to an estimated human intake of 387 mg/d DHA
  • Nathan Goodyear on 30 Aug 15
     
    nice review of the evidence of n-3, particularily DHA, in concussions and concussion recovery.
Nathan Goodyear

Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) - Nutrition and Traumatic Br... - 0 views

www.ncbi.nlm.nih.gov/...NBK209320

TBI traumatic brain injury brain injury omega 3 omega-3 DHA EPA fish oil brain

shared by Nathan Goodyear on 31 Aug 15 - No Cached
  • Nathan Goodyear on 31 Aug 15
     
    Evidence does support that n-3 reduces inflammation; yet limited evidence exists to provide direct evidence that n-3 protects against TBI.
Nathan Goodyear

PLOS ONE: Depletion of Brain Docosahexaenoic Acid Impairs Recovery from Traumatic Brain... - 0 views

journals.plos.org/...article

DHA TBI traumatic brain injury omega 3 brain injury brain omega-3

shared by Nathan Goodyear on 31 Aug 15 - No Cached
  • The polyunsaturated fatty acids linoleic (LA, 18:2n-6) and linolenic acid (LNA, 18:3n-3) are essential fatty acids that cannot be synthesized by the body.
  • LNA serves as the precursor for long chain omega-3 fatty acids such as docosahexaenoic acid (DHA) while LA is converted into long chain omega-6 fatty acids such as arachidonic acid (AA)
  • DHA and AA are abundantly found in the brain, where these are stored mainly in membrane phospholipids
  • ...10 more annotations...
  • DHA has been shown to increase neurite outgrowth and synaptogenesis, and promotes glutamatergic neurotransmission through increase in glutamate receptor subunit expression
  • DHA has been shown to be converted to anti-inflammatory, proresolving and neuroprotective mediators, such as resolvins [7] and protectins
  • AA is converted by cyclooxygenases into 2-series prostaglandins and 4-series leukotrienes, most of which exert pro-inflammatory effects
  • Supplementation of DHA exerts neuroprotective effects and has been reported to afford protection from diffuse axonal injury [11] and mixed brain injury [12] as well
  • severe depletion of membrane DHA in the brain renders mice significantly more susceptible to TBI and impairs recovery following the injury
  • Omega-3 fatty acids may serve as nutraceutical agents and precondition the brain to make it more resilient to injury
  • it can be suggested that enriching DHA in the brain may be prophylactic and protective against brain injury
  • severe DHA deficiency in the brain impairs functional recovery from TBI in terms of vestibulo-motor and cognitive deficits
  • DHA deficiency further elevates TBI-induced production of SBDPs
  • less neurons were found around the injury site of DHA deficient brain after TBI compared to the omega-3 fatty acid adequate group
  • Nathan Goodyear on 31 Aug 15
     
    mouse study finds prolonged recovery in DHA deficient mice compared to controls.
Nathan Goodyear

Docosahexaenoic Acid Reduces ER Stress and Abnormal Protein Accumulation and Improves N... - 0 views

www.jneurosci.org/...3743.short

TBI traumatic brain injury brain injury DHA omega 3 omega-3 brain

shared by Nathan Goodyear on 31 Aug 15 - No Cached
  • Nathan Goodyear on 31 Aug 15
     
    Animal study finds DHA aids recovery from TBI.
Nathan Goodyear

Depletion of Brain Docosahexaenoic Acid Impairs Recovery from Traumatic Brain Injury - 0 views

www.ncbi.nlm.nih.gov/...PMC3903526

DHA omega 3 omega-3 TBI traumatic brain injury brain

shared by Nathan Goodyear on 20 Feb 16 - No Cached
  • Nathan Goodyear on 20 Feb 16
     
    DHA plays important role in TBI risk and recovery.
Nathan Goodyear

Targeting Dopamine in Acute Traumatic Brain Injury - 0 views

www.ncbi.nlm.nih.gov/...PMC3269831

TBI traumatic brain injury dopamine brain brain injury concussion PCS post concussion syndrome

shared by Nathan Goodyear on 21 Feb 16 - No Cached
  • Nathan Goodyear on 21 Feb 16
     
    great read on the current understanding of dopamine in TBI--essentially an excitotoxic story.
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