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Nathan Goodyear

Association between sex hormone-binding glob... [Sao Paulo Med J. 2014] - PubMed - NCBI - 0 views

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    low levels of SHBG associated with increasing incidence of metabolic syndrome in men ages 40-70.
Nathan Goodyear

Hypogonadism and Metabolic Syndrome in Nigerian Male Patients With Both Type 2 Diabetes... - 0 views

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    Asian study finds Testosterone is inversely associated with increased central obesity, increased dyslipidemia, and metabolic syndrome in me with new diagnosis of type II diabetes and hypertension.  Men with metabolic syndrome, type II diabetes, and CVD must have appropriate hormone evaluation.
Nathan Goodyear

[Evaluation of relationships between pla... [Pol Merkur Lekarski. 2014] - PubMed - NCBI - 0 views

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    Men with Metabolic Syndrome have lower Total Testosterone values.  Symptoms correlated with age: older men associated with increased symptoms.  This study only found lot T at 6.5%.  The authors in this study have come up with a new box--andropenia.  I don't know what the heck that is and how that helps clients.  If symptoms are present and if levels are on the decline, then symptomatic hypogonadism is present.  I know the logic seems simple, but it appears hard to follow in the science.  I don't see this any different then type II diabetes.  At 126 you have diabetes, but at 125, we don't know what to do with you but see us next year and you will have diabetes and we will know what to do because you are in the box of diabetes.
Nathan Goodyear

Glucose and Insulin Components of the Metabolic Syndrome Are Associated with Hyperandro... - 0 views

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    Increasing Free androgen index is associated with worsening metabolic syndrome parameters in women.  Paticularily increasing insulin and poor glucose control was found.
Nathan Goodyear

Metabolic syndrome, circulating RBP4, testosterone, and SHBG predict weight regain at 6... - 0 views

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    Interesting study finds that men with low serum Total Testosterone, elevated RBP4 and low SHBG at baseline predict weight regain.  Thus Testosterone should be used as a biomarker of failure in weight loss and if low, Testosterone therapy should be employed to improved metabolic function.  Other parameters, such as leptin, adiponectin, prolactin, progesterone...were not predictive.
Nathan Goodyear

[Plasma testosterone, obesity, metabolic syndrome and diabetes]. - Abstract - Europe Pu... - 0 views

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    Androgen deprivation therapy leads to insulin resistance, metabolic syndrome, and type II diabetes in men. Testosterone therapy in men with IR, obesity, metabolic syndrome, and type II Diabetes will result in improved cardiovascular risk.  
Nathan Goodyear

Low testosterone levels are associated with metabolic syndrome, in elderly men: the rol... - 0 views

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    Low Serum Testosterone inversely associated metabolic syndrome in men.  This study was conducted in the Ikaria islands.  No association was found with women and Testosterone.  In men, Testosterone was inversely associated with waist circumference, hs-CRP, insulin, and HDL.
Nathan Goodyear

Fifteen years of experience with intramuscular testosterone undecanoate for substitutio... - 0 views

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    Abstract presented finds that Testosterone IM undecanoate significantly reduced metabolic syndrome parameters in men.  This study looked at men with secondary hypogonadism and late onset.  The ages were from 15-72.  The full is not available as of this post.  The study only looked at serum T.  This limits the usefulness of this test.  According to this abstract, no evaluation of SHBG was performed.  Though not significant, PSA and prostate volume increased.
Nathan Goodyear

Metabolic syndrome as a prognostic factor for breast cancer recurrences - Pasanisi - 20... - 0 views

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    Women with metabolic syndrome have increased recurrence of breast cancer after initial therapy.  Likewise, Increasing Testosterone was associated with increasing risk of metabolic syndrome.  This is the opposite of men.  One wonders what this massive doping of Testosterone that is underway is doing to women?  Are we merely feeding disease?
Nathan Goodyear

Metabolic syndrome and risk for ED: a meta-a... [Int J Impot Res. 2014] - PubMed - NCBI - 0 views

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    Metabolic syndrome associated with increased risk of ED in men in meta-analysis.  This points to ED as a metabolic condition.
Nathan Goodyear

Endogenous sex hormones, metabolic syndrome... [Curr Cardiol Rep. 2014] - PubMed - NCBI - 1 views

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    Abstract ahead of print.  Low Testosterone in men is associated with increased risk of metabolic syndrome and type II Diabetes.  Just the opposite is the case in women: elevated Testosterone in women is associated with increasing metabolic syndrome and diabetes risk. Low  SHBG is associated with increased risk in both.
Nathan Goodyear

Nature Clinical Practice Endocrinology & Metabolism | Testosterone and ill-health in ag... - 0 views

  • Levels of total and bioavailable testosterone and SHBG were reported to be inversely correlated with the prevalence of the metabolic syndrome in men aged 40–80 years
  • as were total testosterone and SHBG in men aged 65–96 years
  • and in a cross-sectional analysis of a large cohort of non-diabetic men aged 70–89 years
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  • In longitudinal studies, decreased levels of total testosterone and SHBG predicted an increased incidence of metabolic syndrome in nonobese men
  • Free testosterone level is not associated with the prevalence of metabolic syndrome in middle-aged and older men
  • Levels of free, bioavailable and total testosterone are lower in men with T2DM than in age-matched controls,34, 35 and decreased total testosterone level predicts incident T2DM in middle-aged men.
  • men with T2DM commonly have low total or free testosterone levels
  • Total, bioavailable and free testosterone levels are inversely correlated with fasting insulin level and insulin resistance in middle-aged men without T2DM
  • total testosterone is positively correlated with insulin sensitivity in men with normal or impaired glucose tolerance or T2DM
  • low SHBG level is more strongly associated with metabolic syndrome than low total testosterone in aging men
  • the recognized association between low SHBG level and insulin resistance
  • Low levels of SHBG are also associated with smaller, denser LDL-cholesterol molecules in nondiabetic men,58 and were found to predict increased cardiovascular disease mortality in one study of older men
  • Low levels of SHBG might reflect obesity, insulin resistance and overall poor health
  • Compared with those who have normal testosterone levels, men aged 40 years or more with total testosterone levels <9.8 nmol/l or elevated LH level have greater CIMT
  • In men aged 73–94 years, total testosterone was inversely correlated with CIMT
  • a prospective analysis of men aged 73–91 years, progression of CIMT was not related to total testosterone level, but it was inversely related to free testosterone level
  • A study of men aged 55 years or more found that those with total and bioavailable testosterone levels in the highest tertile had a lower risk of severe aortic atherosclerosis (detected by radiography as abdominal aortic calcification) than those with the lowest testosterone levels.
  • a large study of men aged 69–80 years, those with total or free testosterone in the lowest quartile had increased odds of lower-extremity peripheral arterial disease
  • the possibility of reverse causation has to be considered, as systemic illness can result in decreased testosterone levels
  • previous case–control studies and longitudinal studies have failed to identify low testosterone levels as strong predictors of clinically significant coronary disease
  • Reviews of trials on testosterone therapy in men with either low or low-to-normal testosterone levels have not shown consistent beneficial effects either on lipid profiles or on actual cardiovascular events.24, 54, 55 These trials, however, have not been designed or powered to detect treatment-related differences in cardiovascular outcome
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    Declining Testosterone or low Testosterone is clearly associated with poor health in men.  

    Very nice review of the association between low Testosterone and metabolic dysfunction.  Low T is associated with increased metabolic syndrome, Diabetes, weight gain, insulin resistance...
Nathan Goodyear

Androgen Deprivation Therapy, Insulin Resistance, and Cardiovascular Mortality: An Inco... - 0 views

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    Androgen deprivation therapy is associated with increased diabetes, metabolic syndrome, insulin resistance, and cardiovascular mortality.  The longer the duration of therapy, the more the progression of metabolic dysfunction.  This process seems similar to chemotherapy i.e. secondary cancer due to chemotherapy.  The treatment of one disease, prostate cancer in this case, leads to an increase in the risk of the #1 killer in men--logic seems severely flawed there.
Nathan Goodyear

Inverse Association of Testosterone and the Metabolic Syndrome in Men Is Consistent acr... - 0 views

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    Total Testosterone and SHBG inversely associated with Metabolic Syndrome.
Nathan Goodyear

Aging, Androgens, and the Metabolic Syndrome in a Longitudinal Study of Aging: The Jour... - 0 views

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    Study finds Total Testosterone and SHBG inversely associated with Metabolic Syndrome.  Free Testosterone and BMI were positively associated with MetS.
Nathan Goodyear

Higher Serum Testosterone Concentration in Older Women is Associated with Insulin Resis... - 0 views

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    This study found that increasing Testosterone, as determined by serum, is associated with increased CVD, insulin resistance, and metabolic syndrome in postmenopausal women.  I believe that this massive Testosterone doping campaign that we are seeing in men and women is following the same patter seen with premarin and provera. 
Nathan Goodyear

Black women with polycystic ovary syndrome (PCOS) have increased risk for metabolic syn... - 0 views

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    The medical field continues to be amazed that people are different. More, that different people groups are different.  This study found that black women with PCOS have an elevated risk of metabolic syndrome when compared to white women with PCOS.  Body weight was a variable that was controlled for.  This was a retrospective study.
Nathan Goodyear

Gut Microbiota, Low-grade Inflammation, and Metabolic Syndrome. - ResearchGate - 0 views

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    Gut dysbiosis can be the cause of chronic inflammation that results in metabolic syndrome.  This can be, in part, precipitated by delivery, breast feeding, and diet.
Nathan Goodyear

Metabolic syndrome in men with low testosterone le... [J Sex Med. 2013] - PubMed - NCBI - 0 views

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    Metabolic syndrome and Low T definitely run together.  Whether one causes the other or merely associations, they reflect the risk of the other.  It is known that increasing MetS parameters drives the Testosterone lower.  In this study, they found ED, obesity, PVD, and Etoh intake associated with increased incidence of MetS.  ED and obesity are both associated with low T.
Nathan Goodyear

Hormonal Modulation in Aging Patients with Erectile Dysfunction and Metabolic Syndrome - 0 views

  • Hypogonadism and MetS are strongly associated [12, 13, 16], having even been demonstrated that with the increasing number of MetS parameters there is a proportional raise in the incidence of hypogonadism
  • increasing number of MetS components is inversely associated with T levels
  • the presence of MetS did not prove to be a significant determinant of hypogonadism, as it did not lead to a decline in T levels, in MetS patients with already established hypogonadism, the increasing number of MetS features was associated with further decline in T
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  • In the setting of MetS, hypertriglyceridemia and increased WC have been reported as the most important determinants of hypogonadism
  • recent literature consistently associates obesity not only with higher risk of hypogonadism [4, 6, 27] but also with lower T levels
  • Visceral adiposity has been particularly related with reduction of T and SHBG levels (independent of other metabolic disorders)
  • WC was one of the MetS parameters with the greatest influence in T levels decrease, presenting itself as a strong risk factor for hypogonadism development
  • MetS-related T decline was not accompanied by an increase in pituitary LH levels, suggesting impairment in gonadotropin secretion
  • The molecules behind this smoothing compensatory effect of GnRH/LH are still unknown, but estrogens and insulin, as well as leptin, TNF-α, and other adipokines, were proposed candidates
  • fat stores undertake an increase aromatization of androgens, therefore raising estrogen levels [9, 15], which in turn decrease LH secretion
  • our data contradicts the concept that estradiol exerts a negative feedback on hypothalamic GnRH secretion
  • taking into account that high estradiol levels have already been described as the only abnormality in a subset of patients with ED, the hypothesis that the later might not only be caused by androgen deficiency is becoming increasingly evident
  • it has been reported that the chronic exposure to phosphodiesterase type 5 inhibitors (PDE5i), widely used for the treatment of ED, may influence serum estradiol levels
  • thyroid disorders (specially hyperthyroidism) have been related to ED and hypogonadism, and so must be considered in a sexual-dysfunction setting
  • It is clear from the current literature that collecting a more thorough hormonal panel might be a wise approach to further uncover hormonal relations
    • Nathan Goodyear
       
      outstanding point.  This hits to the point that Low T is the effect not the cause.
  • We concluded that in ED patients with hypogonadism and MetS, the attenuated response of HPG axis (normal or low LH levels) might not always be due to an underlying adiposity-dependent estrogen-raising effect.
  • our findings indicate that ED, aging, and estradiol might have a stronger connection than what is currently described in the literature.
  • this study underlines the importance of the collection of a full hormonal panel in ED men
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    low T strongly associated with metabolic syndrome in men.
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