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Nathan Goodyear

Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms Associ... - 0 views

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    Great review of the mechanisms of adaptogens on stress management
Nathan Goodyear

Molecular Psychiatry - Estrogen-dependent association of HDAC4 with fear in female mice... - 0 views

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    New study suggests estrogen may protect a woman's brain at times of stress.
Nathan Goodyear

Glutathione in multiple sclerosis: More than just an antioxidant? - 0 views

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    good read on glutathione in MS.  Glutathione is depleted in MS.  
Nathan Goodyear

Inflammation and cortisol response in coronary artery disease: Annals of Medicine: Vol ... - 0 views

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    Inflammation disrupts HPA axis.  This is no surprise as we Know that inflammation can disrupt Testosterone in men and progesterone production in women.  This study suggests that this HPA axis disruption contributes to CAD.
Nathan Goodyear

Posttraumatic Stress Disorder: Does the Gut Microbiome Hold the Key? - 0 views

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    Gut microbiome diversity is different in stressed mice and calm mice in animal study.  Authors propose intricate connection between gut:brain and possible evaluation and therapy in PTSD.
Nathan Goodyear

Growing Up Or Growing Old? Cellular Aging Linked With Testosterone Reactivity To Stress... - 0 views

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    Study finds no correlation between Testosterone and buccal Telomere length in children.  Correlation is found with stress.
Nathan Goodyear

The Androgen 5α-Dihydrotestosterone and Its Metabolite 5α-Androstan-3β, 17β-D... - 0 views

  • Sex steroid hormones are primarily responsible for sex difference in adult HPA function; androgens inhibit whereas estrogens enhance HPA axis activation after a stressor
  • the PVN contains relatively high levels of AR (Bingaman et al., 1994; Zhou et al., 1994) and ERβ (Alves et al., 1998; Hrabovszky et al., 1998; Somponpun and Sladek, 2003) but is essentially devoid of ERα
  • the nonaromatizable androgen DHT and the nonselective ER ligand E2 influence HPA reactivity by acting on neurons within or surrounding the PVN
  • ...9 more annotations...
  • inhibitory action of DHT is detectable at both the level of hormone secretion as well as PVN c-fos mRNA expression
  • the inhibition can be mimicked by the DHT metabolite 3β-diol and by the subtype selective ERβ agonist DPN
  • E2 acts to enhance HPA reactivity
  • the ability of the ER antagonist tamoxifen, but not the AR antagonist flutamide, to block the inhibitory actions of DHT, speaks to the intracellular mechanism by which this inhibitory signal might be transduced.
    • Nathan Goodyear
       
      that is because the interaction with the DHT metabolite is not with the AR, but with the ER-beta.
  • the DHT metabolite 3β-diol and the ERβ-subtype-selective agonist DPN suppressed ACTH, corticosterone, and c-fos mRNA responses to restraint stress in a manner similar to DHT
  • metabolism of DHT to 3β-diol and subsequent binding to ERβ can be inhibitory to HPA reactivity, and this is one possible mechanism for the action of DHT.
  • Our data also suggest that E2 enhances the reactivity of the HPA axis to stress by acting on or near neurons of the PVN
  • the actions of E2 appear to be through an ERα-dependent mechanism
  • these studies suggest that ERβ, within the male hypothalamus, acts to inhibit the HPA axis and that the inhibitory effects of DHT may be, at least in part, via its intracellular conversion to 3β-diol and subsequent binding to ERβ
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    DHT metabolites: particularly 3beta-androstanediol inhibit HPA axis through ER-beta.
Nathan Goodyear

Chronic maternal stress inhibits the capacity to up-regulate placental 11beta-hydroxyst... - 0 views

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    acute stress is associated with increased 11beta-HSD2 in pregnant rat model.
Nathan Goodyear

Estradiol, but not testosterone, heightens cortisol-mediated negative feedback on pulsa... - 0 views

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    INteresting.  Estradiol enhances cortisol negative feedback on ACTH production in both men and women.
Nathan Goodyear

Does Cortisol Inhibit Pulsatile Luteinizing Hormone Secretion at the Hypothalamic or Pi... - 0 views

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    Cortisol inhbits LH secretion at the level of the Pituitary.  The result is a decreased pulse amplitude as a result of decreased pituitary response to GNRH.
Nathan Goodyear

Acute Suppression of Circulating Testosterone Levels by Cortisol in Men: The Journal of... - 0 views

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    Cortisol inhibits Testosterone production in men.
Nathan Goodyear

Hormones.gr - 0 views

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    Nice review of the impact of exercise on cortisol and catecholeamines.
Nathan Goodyear

Effect of Tongkat Ali on stress hormones and psychological mood state in moderately str... - 0 views

  • At the age of 60, testosterone levels are typically only 40-50% of youthful levels and may be lower
  • Eurycoma contains a group of small peptides referred to as “eurypeptides” that are known to have effects in improving energy status and sex drive in studies of rodents
  • The effects of tongkat ali in restoring normal testosterone levels appears to be less due to actually “stimulating” testosterone synthesis, but rather by increasing the release rate of “free” testosterone from its binding hormone, sex-hormone-binding-globulin (SHBG)
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  • The current study found that daily supplementation with tongkat ali root extract (200 mg/day) improves stress hormone profile (lower cortisol; higher testosterone) and certain mood state parameters (lower tension, anger, and confusion)
  • tongkat ali supplementation (100 mg/day) improved lean body mass, 1-RM strength, and arm circumference to a significantly greater degree compared to a placebo group.
  • In a recent 12-week trial [] of Eurycoma longifolia supplementation (300 mg/day), men (30–55 years of age) showed significant improved compared to placebo in the Physical Functioning domain of the SF-36 quality of life survey
  • sexual libido was increased by 11%
  • In men with low testosterone levels (average age 51 years), one month of daily supplementation with tongkat ali extract (200 mg/day) resulted in a significant improvement in serum testosterone levels and quality-of-life parameters
  • rise in cortisol and drop in testosterone is an early signal of “overtraining”
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    Tongkat Ali, commonly known as long jack, is found to reduce stress and increase Testosterone.  Stress is one of the common causes of low T in men.  It appears that long Jack functions as an adaptogen.
Nathan Goodyear

Effect of Magnolia officinalis and Phellodendron amurense (Relora®) on cortis... - 0 views

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    Relora reduced the perception of stress as well as cortisol levels after 4 weeks.
Nathan Goodyear

Effect of Vitamin C on Male Fertility in Rats Subjected to Forced Swimming Stress - 0 views

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    Vitamin C improved stress response and thus fertility in stress rat mode.
Nathan Goodyear

Using testosterone and cortisol as bioma... [J Strength Cond Res. 2014] - PubMed - NCBI - 0 views

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    Study followed Total Testosterone:Cortisol ratios to monitor catabolic/anabolic states in basketball players.  The authors followed serum levels and monitored them 24-36 hours post game.  Those playing > 25 min/game had the lowest TT:C and highest cortisol indicating a catabolic state and making recovery critical.
Nathan Goodyear

Daily life stress and the cortisol awakening respon... [PLoS One. 2012] - PubMed - NCBI - 0 views

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    Interesting: cortisol levels upon awakening associated with successful stress coping during the day. 
Nathan Goodyear

HerbalGram: Rhodiola rosea: A Phytomedicinal Overview - 0 views

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    good review of rhodiola rosea--the historical and the physiologic effects discussed.
Nathan Goodyear

Life events are positively associated with luteinizin... [Stress. 2014] - PubMed - NCBI - 0 views

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    Elevated Cortisol, life events as this study refers to, is associated with low Testosterone.  The authors found a positive association of cortisol with LH.  The result is elevated cortisol, low Testosterone, increased LH.
Nathan Goodyear

JISSN | Full text | Effect of Magnolia officinalis and Phellodendron amurense... - 0 views

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    Relora found to reduce cortisol in short study.
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