Skip to main content

Home/ Seasons Wellness/ Group items tagged stress

Rss Feed Group items tagged

Nathan Goodyear

The Androgen 5α-Dihydrotestosterone and Its Metabolite 5α-Androstan-3β, 17β-D... - 0 views

  • Sex steroid hormones are primarily responsible for sex difference in adult HPA function; androgens inhibit whereas estrogens enhance HPA axis activation after a stressor
  • the PVN contains relatively high levels of AR (Bingaman et al., 1994; Zhou et al., 1994) and ERβ (Alves et al., 1998; Hrabovszky et al., 1998; Somponpun and Sladek, 2003) but is essentially devoid of ERα
  • the nonaromatizable androgen DHT and the nonselective ER ligand E2 influence HPA reactivity by acting on neurons within or surrounding the PVN
  • ...9 more annotations...
  • inhibitory action of DHT is detectable at both the level of hormone secretion as well as PVN c-fos mRNA expression
  • the inhibition can be mimicked by the DHT metabolite 3β-diol and by the subtype selective ERβ agonist DPN
  • E2 acts to enhance HPA reactivity
  • the ability of the ER antagonist tamoxifen, but not the AR antagonist flutamide, to block the inhibitory actions of DHT, speaks to the intracellular mechanism by which this inhibitory signal might be transduced.
    • Nathan Goodyear
       
      that is because the interaction with the DHT metabolite is not with the AR, but with the ER-beta.
  • the DHT metabolite 3β-diol and the ERβ-subtype-selective agonist DPN suppressed ACTH, corticosterone, and c-fos mRNA responses to restraint stress in a manner similar to DHT
  • metabolism of DHT to 3β-diol and subsequent binding to ERβ can be inhibitory to HPA reactivity, and this is one possible mechanism for the action of DHT.
  • Our data also suggest that E2 enhances the reactivity of the HPA axis to stress by acting on or near neurons of the PVN
  • the actions of E2 appear to be through an ERα-dependent mechanism
  • these studies suggest that ERβ, within the male hypothalamus, acts to inhibit the HPA axis and that the inhibitory effects of DHT may be, at least in part, via its intracellular conversion to 3β-diol and subsequent binding to ERβ
  •  
    DHT metabolites: particularly 3beta-androstanediol inhibit HPA axis through ER-beta.
Nathan Goodyear

Chronic maternal stress inhibits the capacity to up-regulate placental 11beta-hydroxyst... - 0 views

  •  
    acute stress is associated with increased 11beta-HSD2 in pregnant rat model.
Nathan Goodyear

Estradiol, but not testosterone, heightens cortisol-mediated negative feedback on pulsa... - 0 views

  •  
    INteresting.  Estradiol enhances cortisol negative feedback on ACTH production in both men and women.
Nathan Goodyear

Does Cortisol Inhibit Pulsatile Luteinizing Hormone Secretion at the Hypothalamic or Pi... - 0 views

  •  
    Cortisol inhbits LH secretion at the level of the Pituitary.  The result is a decreased pulse amplitude as a result of decreased pituitary response to GNRH.
Nathan Goodyear

Acute Suppression of Circulating Testosterone Levels by Cortisol in Men: The Journal of... - 0 views

  •  
    Cortisol inhibits Testosterone production in men.
Nathan Goodyear

Hormones.gr - 0 views

  •  
    Nice review of the impact of exercise on cortisol and catecholeamines.
Nathan Goodyear

Effect of Tongkat Ali on stress hormones and psychological mood state in moderately str... - 0 views

  •  
    Tongkat Ali, commonly known as long jack, is found to reduce stress and increase Testosterone.  Stress is one of the common causes of low T in men.  It appears that long Jack functions as an adaptogen.
Nathan Goodyear

Effect of Magnolia officinalis and Phellodendron amurense (Relora®) on cortis... - 0 views

  •  
    Relora reduced the perception of stress as well as cortisol levels after 4 weeks.
Nathan Goodyear

Effect of Vitamin C on Male Fertility in Rats Subjected to Forced Swimming Stress - 0 views

  •  
    Vitamin C improved stress response and thus fertility in stress rat mode.
Nathan Goodyear

Using testosterone and cortisol as bioma... [J Strength Cond Res. 2014] - PubMed - NCBI - 0 views

  •  
    Study followed Total Testosterone:Cortisol ratios to monitor catabolic/anabolic states in basketball players.  The authors followed serum levels and monitored them 24-36 hours post game.  Those playing > 25 min/game had the lowest TT:C and highest cortisol indicating a catabolic state and making recovery critical.
Nathan Goodyear

Daily life stress and the cortisol awakening respon... [PLoS One. 2012] - PubMed - NCBI - 0 views

  •  
    Interesting: cortisol levels upon awakening associated with successful stress coping during the day. 
Nathan Goodyear

HerbalGram: Rhodiola rosea: A Phytomedicinal Overview - 0 views

  •  
    good review of rhodiola rosea--the historical and the physiologic effects discussed.
Nathan Goodyear

Life events are positively associated with luteinizin... [Stress. 2014] - PubMed - NCBI - 0 views

  •  
    Elevated Cortisol, life events as this study refers to, is associated with low Testosterone.  The authors found a positive association of cortisol with LH.  The result is elevated cortisol, low Testosterone, increased LH.
Nathan Goodyear

JISSN | Full text | Effect of Magnolia officinalis and Phellodendron amurense... - 0 views

  •  
    Relora found to reduce cortisol in short study.
Nathan Goodyear

Testosterone therapy affects Mexican American men differently - UNT Health Science Cent... - 0 views

  •  
    This is the public announcement of a article yet to be published.  The study, yet unread, points to increase damage to brain health in those caucasian men with oxidative stress.  This was not found in mexican-Americans.  Until I read this study, that is all I will say here.  
Nathan Goodyear

Peripheral oxidative stress in relapsing-remitting multiple sclerosis - 0 views

  •  
    Relapsing remitting MS patients found to have in increased 8OHdG, reduced glutathione, reduced glutathione to oxidized glutathione ratio, super oxidized disumutase, glutathione reductase, and global oxidative stress.  In contrast, decreased total antioxidant capacity, oxidized glutathione, glutathione perioxidase, and glutathione transferase were found in relapsing remitting MS patients.
Nathan Goodyear

Oxidative Stress, Testosterone, and Cognition among Caucasian and Mexican-American Men ... - 0 views

  •  
    Interesting study. This study points out the differences between individuals and groups i.e. Mexian-Americans and Caucasians in this study.  Men with low oxidative stress, Testosterone was associated with no cognitive dysfunction.  In contrast, with high oxidative stress, Testosterone therapy was associated with cognitive impairment in caucasians only.
Nathan Goodyear

Perinatal exposure to low-dose bisphenol A affects the neuroendocrine stress response i... - 0 views

  •  
    intra uterine exposure to BPA disrupts stress response in rat model.
Nathan Goodyear

Depression and cortisol responses to psychological stress: A meta-analysis - 0 views

  •  
    Depression found to have higher cortisol levels compared to non-depressed men and women.
Nathan Goodyear

The Androgen 5α-Dihydrotestosterone and Its Metabolite 5α-Androstan-3β, 17β-D... - 0 views

  •  
    Full article of previously posted abstract.  DHT metabolite 3beta-diol inhibits HPA stress response via ER beta.  
1 - 20 of 132 Next › Last »
Showing 20 items per page