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Nathan Goodyear

Adapted ECHO-7 virus Rigvir immunotherapy (oncolytic virotherapy) prolongs survival in ... - 0 views

www.ncbi.nlm.nih.gov/...PMC4560272

RIGVIR cancer oncolytic therapy immunotherapy cancer immunotherapy

shared by Nathan Goodyear on 16 Oct 18 - No Cached
  • Rigvir is a 2 ml frozen solution
  • ECHO-7 virus strain, Picornaviridae family, Enterovirus genus, Enteric Cytopathic Human Orphan (ECHO) type 7, group IV, positive-sense single-stranded RNA virus
  • a few side effects were reported, for example subfebrile temperature (37.5°C for a couple of days), pain in the tumour area, sleepiness and diarrhoea
  • ...12 more annotations...
  • In this retrospective study, however, there was no record of any untoward side effect from Rigvir treatment or its discontinuation
  • Early observations of tumour regressions after virus infections have been published starting from the late 19th century
  • The present results show that in substage IB, IIA, IIB and IIC melanoma patients, Rigvir administration after surgery significantly (P<0.05) prolongs survival compared with patients who were managed according to current published guidelines
  • no value higher than grade 2 was recorded in Rigvir-treated patients. This is in contrast to most other cancer therapies, where grades 3 and 4 are frequently observed
  • Administration of virus induces the formation of neutralising antibodies that might potentially influence the efficiency of Rigvir
  • In 94 healthy adult participants tested, the titres were found to be low (1 : 20 to 1 : 62) 39,40. When tested in 155 adult cancer patients who had not been treated with Rigvir, neutralising antibodies against ECHO-7 were detected in ∼50% of the patients
  • the presence of ECHO-7 antibodies was shown to increase with age in children and level off to a plateau of around 75% in adults
  • Rigvir is an immunomodulator that affects both the humoral, antibody-mediated, and the cellular immune systems
  • neutralising antibodies do not affect efficacy when local or regional administration is used
  • it reduces the viability of melanoma, as well as pulmonary, gastric, pancreatic, bone, and breast cancer cell cultures
  • It is oncolytic in melanoma and rectum cancer patients
  • shown to improve the 5-year survival in rectum cancer patients
  • Nathan Goodyear on 16 Oct 18
     
    RIGVIR shown to improve survival against standard therapy in stage IB, IIA, IIB, and IIC in malignant melanoma patients in retrospective study. Side effects are minimal. Neutralizing antibodies are an area to watch that likely effects individual outcome beyond that of the type of cancer
Nathan Goodyear

Comparisons of normal saline and lactated Ringer's resuscitation on hemodynamics, metab... - 0 views

www.ncbi.nlm.nih.gov/...PMC4029282

IV fluids lactated ringers normal saline LR NS

shared by Nathan Goodyear on 03 Jul 18 - No Cached
  • NS contains 154 mM Na+ and Cl-, with an average pH of 5.0 and osmolarity of 308 mOsm/L.
  • LR solution has an average pH of 6.5, is hypo-osmolar (272 mOsm/L), and has similar electrolytes (130 mM Na+, 109 mM Cl-, 28 mM lactate, etc.) to plasma
  • hyperchloremic acidosis
  • ...26 more annotations...
  • LR’s acid base balance is superior to that of NS’s
  • There were no significant differences between LR and NS groups in fibrinogen concentrations or platelet count
  • Total protein dropped
  • no significant differences in Hct (Table  1) or total protein between LR and NS groups
  • Bicarbonate HCO3- levels were decreased by hemorrhage but returned to pre-hemorrhage values by 3 h after LR resuscitation, whereas no return was observed with NS resuscitation
  • Na+ was increased after NS resuscitation
  • No changes in Na+ or K+ were observed
  • K+ did not change initially after NS resuscitation but was elevated at 6 h afterwards
  • Ca++ was similarly decreased
  • Cl- was elevated for 6 h after NS resuscitation, with no changes shown after LR resuscitation
  • PT was similarly prolonged by resuscitation with LR (from 11.2 ± 0.2 sec at baseline to 12.1 ± 0.2 sec at 6 h) and NS
  • Plasma aPTT was also similarly prolonged by resuscitation with LR (from 17.1 ± 0.5 sec baseline to 20.1 ± 1.2 sec at 6 h) or NS
  • NS resuscitation resulted in better oxygen delivery and oxygen delivery-to-oxygen demand ratio as an index of oxygen debt
  • NS had better tissue perfusion and oxygen metabolism than LR
  • LR resuscitation returned BE and bicarbonate to pre-hemorrhage levels within 3 h, but no return of BE or bicarbonate was observed for 6 hr with NS resuscitation
  • current blood bank guidelines state that LR should not be mixed with blood to prevent the risk of clot formation from calcium included in LR
  • LR resuscitation should not be given with blood through the same iv-line and crystalloids should be avoided in patients with blood transfusion
  • PT and aPTT were prolonged for 6 h after hemorrhage and resuscitation, suggesting a hypocoagulable states
  • potential thrombotic risk from LR resuscitation is unlikely.
  • we suspected that the blood pressure after NS resuscitation would be lower than that of LR due to its vasodilator effects
  • NS required a larger resuscitation volume and was associated with poor acid base status and elevated serum potassium in this model
  • NS required 50% more volume and was associated with a higher cardiac output and lower peripheral resistance, as compared to LR resuscitation
  • These differences are possibly due to the vasodilator effects from NS
  • an elevation of K+ was observed at 6 h post NS resuscitation, while no change of K+ was observed after LR resuscitation
  • The mechanism for the increase of K+ from NS is not fully known
  • NS is associated with vasodilator effects and the risks of metabolic acidosis and hyperkalemia
  • Nathan Goodyear on 03 Jul 18
     
    LR vs NS crystalloid.
Nathan Goodyear

Clinical review: Specific aspects of acute renal failure in cancer patients - 0 views

www.ncbi.nlm.nih.gov/...PMC1550893

cancer renal failure

shared by Nathan Goodyear on 13 Aug 18 - No Cached
  • uric acid crystal formation in the renal tubules secondary to hyperuricaemia
  • calcium phosphate deposition related to hyperphosphataemia
  • usually develops shortly after the initiation of cytotoxic chemotherapy
  • ...18 more annotations...
  • Non-recombinant urate oxidase (Uricozyme®)
  • recombinant urate oxidase (Rasburicase®)
  • urine alkalisation may induce calcium phosphate deposition
  • renal replacement therapy should be started on an emergency basis when hydration fails to produce a prompt metabolic improvement or when ARF develops
  • Up to 50% of patients with newly diagnosed multiple myeloma have renal failure and up to 10% require dialysis
  • renal ultrasonography remains the method of choice for investigating extra-renal obstruction
  • The relief of the obstruction, either by percutaneous nephrostomy or through a ureteral stent, is the cornerstone of treatment
  • TMA may be associated with the cancer itself, with cancer chemotherapy, or with allogeneic BMT
  • thrombotic microangiopathy (TMA)
  • it may be as high as 5%
  • Most of the cases occur in patients with solid tumours, the most common type being adenocarcinoma (stomach, breast and lung)
  • The pathophysiology of the TMA-malignancy association remains controversial, although many studies suggest an insult to the vascular endothelium
  • mitomycin C. Subsequently, TMA has been reported with many anti-cancer agents, including gemcita-bine, bleomycin, cisplatin, CCNU, cytosine arabinoside, daunorubicin, deoxycoformycin, 5-FU, azathioprine and interferon α
  • Plasma exchanges have been shown to improve prognosis in the general population of patients with TMA
  • Causative factors should be looked for and antihypertensive treatment given. Lastly, in the absence of guidelines, we believe that plasma exchange should be proposed in patients with severe cancer treatment-associated TMA
  • The most widely used protective measure is saline infusion to induce solute diuresis
  • During methotrexate infusion and elimination, fluids should be given to maintain a high urinary output and urinary alkalisation should be performed to keep the urinary pH above 7.5. Rescue with folinic acid (50 mg four times a day) should be started 24 hours after each high-dose metho-trexate infusion and serum methotrexate concentrations should be measured every day
  • cyclophosphamide and ifosfamide
  • Nathan Goodyear on 13 Aug 18
     
    cancer and renal failure
knackglobal

Knack Global is leading provider of revenue cycle management solutions to the health-ca... - 0 views

#healthcare #health #medicine #medical #hospital #healthy #healthylifestyle #wellness #healthyliving #digitalhealth #technology #medicalbilling #medicalcoding #medicalbillingandcoding #medicalbiller #healthcareadministration

shared by knackglobal on 26 Apr 19 - No Cached
  • knackglobal on 26 Apr 19
     
    Knack Global is the leading service provider into the U.S. Healthcare sector, we provide services in healthcare IT, enterprise IT and analytics
Nathan Goodyear

Gastroenteric tube feeding: Techniques, problems and solutions - 0 views

www.ncbi.nlm.nih.gov/...PMC4093701

gastrostomy tube G-tube G tube

shared by Nathan Goodyear on 13 Apr 20 - No Cached
  • Nathan Goodyear on 13 Apr 20
     
    Good review of G tube complications
medikaur

Dermal Fillers Treatment in London - 1 views

www.medikaur.com/dermal-fillers

Dermal Fillers Dermal Fillers London Fillers in London

shared by medikaur on 17 May 17 - No Cached
  • medikaur on 17 May 17
     
    Dermal fillers are one of the best long lasting solutions for lines and wrinkles. Find out more from Information. Call now on 0345 055 9106 for a.
digitalorainfo

Blog - Best Wordpress Developer / Digital Marketing Agency in Atlanta, GA - 0 views

www.webagencyatlanta.com/blog

Wordpress SEO Experts in Atlanta GA

shared by digitalorainfo on 21 May 20 - No Cached
  • digitalorainfo on 21 May 20
     
    We don't just build a boat, we make it sail too. Our team of expert developers is adept in both front-end and back-end programming and are delivering innovative web solutions everyday.
digitalorainfo

Blog - Ora Infotech - 0 views

orainfotech.com/blog

Android App and Web Development Company in USA

shared by digitalorainfo on 21 May 20 - No Cached
  • digitalorainfo on 21 May 20
     
    We don't just build a boat, we make it sail too. Our team of expert developers is adept in both front-end and back-end programming and are delivering innovative web solutions everyday.
indian-health

Chirurgie cardiaque en Inde Votre solution ultime au secret de vos problèmes ... - 0 views

french-health-trip-2-india.blogspot.com/...-cardiac-surgery-in-india.html

chirurgie cardiaque Inde Les meilleurs hôpitaux pour la chirurgie cardiaque en Inde Coût de la chirurgie cardiaque en Inde Chirurgie cardiaque low-cost Inde hôpitaux de chirurgie cardiaque en Inde les meilleurs chirurgiens cardiaques de l'Inde liste des m

shared by indian-health on 04 Jan 22 - No Cached
  • indian-health on 04 Jan 22
     
    En ces temps difficiles de pandémie, votre forme physique et votre sécurité sont la priorité absolue dans les hôpitaux indiens. La chirurgie cardiaque à faible coût Indi est actuellement moins chère que ses pays occidentaux comme les États-Unis et par conséquent le Royaume-Uni. Lire la suite https://french-health-trip-2-india.blogspot.com/2022/01/belgium-cardiac-surgery-in-india.html
forestgood

Ce Uzum: A Perfect Cleansing of Blood Vessels Find out how Ce Uzum can help clear bloc... - 0 views

UZUM est un produit tres efficace ; Uzum, le complément alimentaire révolutionnaire qui nettoie efficacement les vaisseaux sanguins Les problèmes de santé cardiovasculaire sont devenus de plus en...

heart disease men inflammation obesity

started by forestgood on 05 Aug 23 no follow-up yet
theawesomeskills

Cancer eBook - How To Stop Your Metastasized Cancer - 2 views

The solution below solved many peoples cancer problem and odds are it will give you a good chance to solve your cancer problem also. Should you choose to take the short journey below, you will di...

cancer hormones hormone Testosterone inflammation men disease obesity Male vitamin C

started by theawesomeskills on 20 Oct 22 no follow-up yet
indian-health

Chirurgie cardiaque Inde Votre solution ultime au secret de vos maladies cardiaques - 0 views

french-health-trip-2-india.blogspot.com/...logy-hospitals-in-chennai.html

Chirurgie cardiaque Inde Chirurgie cardiaque Meilleurs Cardiologues Liste des 10 meilleurs cardiologues Chennai Meilleurs hôpitaux de cardiologie à Chennai en Inde Meilleurs hôpitaux de cardiologie Les 12 meilleurs hôpitaux de cardiologie de Chennai Liste

shared by indian-health on 04 Aug 22 - No Cached
  • indian-health on 04 Aug 22
     
    Les meilleurs hôpitaux de cardiologie de Chennai en Inde proposent une chirurgie spécialisée de première classe pour toutes les maladies cardiaques. Ces hôpitaux effectuent environ 1600 opérations par an.
indian-health

Chirurgie cardiaque Inde Solution ultime à vos problèmes cardiaques - 0 views

french-health-trip-2-india.blogspot.com/...ium-cardiac-surgery-india.html

Chirurgie cardiaque en Inde meilleur cardiologue de bangalore le top 10 des cardiologues à bangalore Les 12 meilleurs cardiologues de Bangalore meilleur cardiologue à bangalore meilleur hôpital cardiaque de bangalore cardiologue bangalore

shared by indian-health on 13 May 22 - No Cached
  • indian-health on 13 May 22
     
    La chirurgie cardiaque en Inde est particulièrement attrayante pour les voyageurs internationaux car elle leur permet uniquement de réduire les prix, mais elle leur offre également l'avantage de subir les interventions chirurgicales par les meilleurs chirurgiens cardiaques du monde.
indiacardiacsurg

French Health Trip To India: Taux de réussite de la chirurgie Bentall Inde Vo... - 0 views

french-health-trip-2-india.blogspot.com/...urgery-success-rate-india.html

Taux de réussite de la chirurgie Bentall en Inde Chirurgie de Bentall

shared by indiacardiacsurg on 23 Mar 22 - No Cached
  • indiacardiacsurg on 23 Mar 22
     
    Le taux de réussite de la chirurgie de Bentall en Inde est très élevé, et ces chirurgiens ont renvoyé chez eux de nombreux patients heureux récupérés avec succès avec une totale satisfaction. Planifiez un rendez-vous, appelez-nous simplement au +91-9370586696 ou vous pouvez envoyer votre rapport médical à enquiry@indiacardiacsurgerysite.com
Nathan Goodyear

Stability of Magnesium Sulfate in 0.9% Sodium Chloride and Lactated Ringers solutions -... - 0 views

pubmed.ncbi.nlm.nih.gov/23989704

LR NS Magnesium

shared by Nathan Goodyear on 30 Jan 24 - No Cached
  • Nathan Goodyear on 30 Jan 24
     
    No incompatibility
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