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Nathan Goodyear

Lower sexual interest in postpartum women: relati... [Horm Behav. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23085496

oxytocin libido hormone hormones intranasal

shared by Nathan Goodyear on 29 Jul 13 - No Cached
  • Nathan Goodyear on 29 Jul 13
     
    The right amygdala appears to play a role in the postpartum decline in libido in women.  This study found no difference with intranasal oxytocin spray.
Nathan Goodyear

[Oxytocin and male sexual function]. [Zhonghua Nan Ke Xue. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21735659

oxytocin hormone hormones sex

shared by Nathan Goodyear on 29 Jul 13 - No Cached
  • Nathan Goodyear on 29 Jul 13
     
    Article is published in Chinese, so abstract is only available.  Oxytocin has antagonistic effects peripherally versus centrally.  But, oxytocin appears to play role in ejaculation, detumescence and refractory phase in men.
Nathan Goodyear

Low Testosterone Associated With Obesity and the Metabolic Syndrome Contributes to Sexu... - 0 views

care.diabetesjournals.org/...1669.full

low testosterone obesity metabolic syndrome cardiovascular disease diabetes CVD men male hormone hormones

shared by Nathan Goodyear on 28 Aug 13 - No Cached
  • Nathan Goodyear on 28 Aug 13
     
    Low T associated with metabolic syndrome, CVD, type 2 Diabetes in men.
Nathan Goodyear

Gonadal Steroids and Body Composition, Strength, and Sexual Function in Men - NEJM - 0 views

www.nejm.org/...NEJMoa1206168

Testosterone Estradiol goserelin men male hormone hormones

shared by Nathan Goodyear on 27 Sep 13 - No Cached
  • Nathan Goodyear on 27 Sep 13
     
    This study confirms what we know about Testosterone, but this study finds that Estradiol aids libido and fat loss.  The conclusion on Estradiol I believe to be extremely premature.  First, it flies in the face of all the accumulative data on estradiol, second, what normal physiology is being replicated with goserelin???  Goserelin has been shown to decrease Prolactin which can effect libido also.  What about the potential there?  The men included in the study were described as "healthy".  So, you are taking "healthy" normal funcitoning men, throwing in a monkey wrench and looking at the effects of your monkey wrench.  Sorry, not physiologic.  In all my practice, I have seen one man with low Estradiol levels.  There is no reference to the hormone levels in the men preceding the suppression with goserelin.  This is a study that lacks application.
Nathan Goodyear

Testosterone Levels and Sexual Function Disorders ... [J Sex Med. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24286389

testosterone women depression antidepressants

shared by Nathan Goodyear on 02 Dec 13 - No Cached
  • Nathan Goodyear on 02 Dec 13
     
    Interesting finding in this study. They looked at Total Testosterone and bioavailable Testosterone and found that antidepressant therapy increased both values post treatment.  This is counter to what has been readably seen in men--with a decline.  The abstract here does not point disclose the actual Testosterone numbers.  I wonder if the well known disruption of the CYP enzymes by antidepressants slowed clearance and increased Testosterone levels.  This study did not look at other hormones or inflammatory cytokines.  Very tunneled vision study.  Nothing can be drawn from this study.
Nathan Goodyear

Review of health risks of low testosterone and testosterone administration - 0 views

www.ncbi.nlm.nih.gov/...PMC4391003

low Testosterone low T Testosterone men male hormone hormones health

shared by Nathan Goodyear on 28 Apr 15 - No Cached
  • Hypogonadism may be defined either as serum concentration of T (either total T, bioavailable T or free T) or as low T plus symptoms of hypogonadism
  • The Baltimore Longitudinal Study on Aging reported the incidence of total serum T < 325 ng/dL to be 20% for men in their 60s, 30% for men in their 70s and 50% for men over 80
  • The Massachusetts Aging Male Study reported that 12.3% of men aged 40 to 70 had a total serum T of < 200 ng/dL with 3 or more symptoms of hypogonadism
  • ...19 more annotations...
  • The Boston Area Community Health Study reported that 5.6% of men aged 30 to 70 were hypogonadal, as defined by total serum T < 300 ng/dL; or, free serum T < 5 ng/dL plus 3 or more symptoms of hypogonadism
  • In a health screening project among 819 men in Taiwan, the prevalence of hypogonadism (total serum T < 300 ng/dL) ranged from 16.5% for men in their 40s, 23.0% for men in their 50s, 28.9% for men in their 60s, and 37.2% for men older than 70 years of age
  • The prevalence of hypogonadism among men in Taiwan is higher than the prevalence reported in the Massachusetts Male Aging Study
  • CAG repeat sequence, within the androgen receptor (AR). Rajender et al[12] reviewed over 30 studies on the AR trinucleotide repeat and infertility
  • suggestion that CAG repeat length may determine androgen responsiveness, this issue is not clearly settled
  • reported prevalence of low T in older men range from 5.6% to 50%
  • Those in the hypogonadal group (n = 4269) had direct health care costs, that exceeded the eugonadal group (n = 4269) by an average of $7100 over the course of the observation window
  • higher economic burden and presence of co-morbidities for hypogonadism
  • minor to moderate improvements in lean mass and muscle strength
  • increased bone mineral density
  • modest enhancement in sexual function
  • reduced adiposity
  • lessening of depressive symptoms
  • Meta-analyses of clinical TRT trials as of 2010 have identified three major adverse events resulting from TRT: (1) polycythemia; (2) an increase in prostate-related events; and (3) and a slight reduction in serum high-density lipoprotein (HDL) cholesterol
  • polycythemia (> 3.5-fold increase in risk
  • TRT produced a 40% prostate enlargement in older hypogonadal male Veterans over 12 mo
  • no published analysis has reported measurable increases in prostate cancer risk or Gleason score in men undergoing TRT, or in hypogonadal men with a history of prostate cancer undergoing TRT
  • the prostate which highly expresses the type II 5α-reductase enzyme. Inhibition of this enzyme via finasteride (a type II 5α-reductase inhibitor) or dutasteride (a dual type I and II 5α-reductase inhibitor) reduces circulating DHT 50%-75% and > 90%, respectively[47], and reduces prostate mass[48] and prostate cancer risk
  • Normally estradiol partially regulates testosterone levels, at the hypothalamus, blunting LH and FSH release from the pituitary. As a selective estrogen receptor modulator, CC interrupts this pathway, and consequently there is a greater stimulation for the production of testosterone in Leydig cells
    • Nathan Goodyear
      Nathan Goodyear on 28 Apr 15
       
      this would only apply if E1 and/or E2 levels were elevated, which the authors make no mention of.
  • Nathan Goodyear on 28 Apr 15
     
    to be read
Nathan Goodyear

Association Between Viral Hepatitis and Erectile Dysfunction: A Population-Based Case-C... - 0 views

onlinelibrary.wiley.com/...4B3F25DEF6C04C3FE9AA4A6.f03t02

low T low Testosterone Testosterone men male hormone hormones ED libido hepatitis Hepatitis C

shared by Nathan Goodyear on 22 Apr 15 - No Cached
  • Nathan Goodyear on 22 Apr 15
     
    Low Testosterone, low libido, and ED associated with prior hepatitis B and hepatitis C.  
Nathan Goodyear

Sexual dysfunction in males with chronic hepatitis C and antiviral therapy: interferon-... - 0 views

joe.endocrinology-journals.org/...345.long

hepatitis Hepatitis C HCV interferon low T low testosterone deficiency men male hormone hormones depression

shared by Nathan Goodyear on 22 Apr 15 - No Cached
  • Nathan Goodyear on 22 Apr 15
     
    Study of men with hepatitis C and interferon therapy found decrease in free and total Testosterone levels in men.  The study results suggest a non-HPA effect, which suggests more of a peripheral effect at the level of the TEsticles.
Nathan Goodyear

Differences in Hematopoietic Stem Cells Contribute to Sexually Dimorphic Inflammatory R... - 0 views

www.jbc.org/13250

obesity inflammation

shared by Nathan Goodyear on 01 Jun 15 - No Cached
  • Nathan Goodyear on 01 Jun 15
     
    Study of mice finds increased inflammatory response (increased macrophage response in adipose tissue) in male mice vs female mice.
Nathan Goodyear

Female social and sexual interest across the menst... [BMC Womens Health. 2010] - PubMe... - 0 views

www.ncbi.nlm.nih.gov/...20507626

saliva salivary testing

shared by Nathan Goodyear on 17 Nov 10 - No Cached
  • Nathan Goodyear on 17 Nov 10
     
    Saliva testing no longer questioned
Nathan Goodyear

A long-term, prospective study of the physiologic and behavioral effects of hormone rep... - 0 views

www.andrologyjournal.org/...297

low T testosterone ED erectile dysfunction

shared by Nathan Goodyear on 02 Mar 11 - No Cached
  • hese data support the hypothesis that androgen treatment increases nocturnal and spontaneous erections, and sexual interest, and has some capacity to improve mood.
  • Nathan Goodyear on 02 Mar 11
     
    testosteron in low Testosterone men improves symptoms
Nathan Goodyear

The Effect of Statin Therapy on Testosterone Levels in Subjects Consulting for Erectile... - 0 views

onlinelibrary.wiley.com/...full

Statins ED low Testosterone T

shared by Nathan Goodyear on 01 Jun 11 - No Cached
  • Nathan Goodyear on 01 Jun 11
     
    Statin therapy linked to ED through low Testosterone
Nathan Goodyear

Testosterone Replacement in Hypogonadal Men With Type 2 Diabetes and/or Metabolic Syndr... - 0 views

care.diabetesjournals.org/...828.abstract

testosterone replacement diabetes

shared by Nathan Goodyear on 31 Mar 11 - No Cached
  • CONCLUSIONS Over a 6-month period, transdermal TRT was associated with beneficial effects on insulin resistance, total and LDL-cholesterol, Lpa, and sexual health in hypogonadal men with type 2 diabetes and/or MetS.
  • Nathan Goodyear on 31 Mar 11
     
    Testosterone improves diabetes control in men
Nathan Goodyear

Exposure to Bisphenol A Prenatally or in Adulthood Promotes TH2 Cytokine Production Ass... - 0 views

www.ncbi.nlm.nih.gov/...PMC2290985

BPA plastics endocrine disruptor immune T reg cells

shared by Nathan Goodyear on 01 Jul 11 - No Cached
  • BPA promotes the development of TH2 cells in adulthood and both TH1 and TH2 cells in prenatal stages by reducing the number of regulatory T cells.
  • Bisphenol A (BPA), an estrogenic endocrine-disrupting chemical (EDC
  • BPA is one of the most widespread EDCs.
  • ...12 more annotations...
  • BPA antagonizes the actions of thyroid hormone
  • Prenatal exposure to BPA has been shown to alter a variety of reproductive endocrine parameters, such as testosterone and luteinizing hormone levels
  • arly onset of sexual maturation of female mice
  • imbalanced T-helper (TH)1/TH2 immune responses have been demonstrated on exposure to BPA
  • indicating that BPA exerted its effects by reducing the number of Treg cells.
  • Exposure to BPA by subcutaneous injection in adulthood significantly promoted antigen-stimulated production of IL-4, IL-10, and IL-13 in TH2-skewed
  • BPA can leak from the placenta and accumulate in the fetus
  • We showed that prenatal exposure to BPA increased the production of a TH1 cytokine, IFN-γ, and a TH2 cytokine, IL-4, after the offspring developed, suggesting that prenatal exposure to BPA can induce persistent immunologic effects lasting into adulthood.
  • These results are consistent with a previous report that fetal exposure to BPA augmented TH1 and TH2 immune responses
  • our results clearly demonstrate that the production of TH2 cytokines is promoted by BPA in adult mice and in offspring during developmental exposure.
  • The decrease of Treg cells would predispose to immune dysfunction in aged individuals, explaining their higher risk of immune-mediated diseases, cancer, and infections.
  • BPA might cause these diseases. Thus, avoiding exposure to or promoting the excretion of BPA and other EDCs would help in preventing diseases and adverse health effects.
  • Nathan Goodyear on 01 Jul 11
     
    BPA as endocrine disruptor and as immune disruptor
Nathan Goodyear

Sexual dimorphism in cortisol secretion starts after age 10 in healthy children: urinar... - 0 views

ajpendo.physiology.org/...E970

cortisol metabolites metabolism hormone hormones

shared by Nathan Goodyear on 23 May 14 - No Cached
  • Nathan Goodyear on 23 May 14
     
    good discussion of cortisol metabolite excretion in children.
Nathan Goodyear

Endocrine screening for sexual dysfunction using free... [J Urol. 1996] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...8683690

free Testosterone free Total total Testosterone Testosterone low T ED men male hormone hormones

shared by Nathan Goodyear on 24 Jul 14 - No Cached
  • Nathan Goodyear on 24 Jul 14
     
    free Testosterone proves more useful than serum Total Testosterone, symptom questionnaire and testicular atrophy in the diagnosis of hypogonadism in men with ED.
Nathan Goodyear

International Journal of Impotence Research - Obesity, low testosterone levels and erec... - 0 views

www.nature.com/...ijir200842a.html

low T low Testosterone men male hormone hormones ED erectile dysfunction Testosterone diabetes metabolic syndrome obesity

shared by Nathan Goodyear on 27 Jan 15 - No Cached
  • Studies have shown that ED may be an early biomarker of general endothelial dysfunction, atherosclerosis and CVD
  • testosterone treatment of hypogonadal young and older men improves sexual function, increases lean mass and decreases fat mass
  • In men with low serum testosterone (for example, <8 or 230 nmol l−1) with obesity, metabolic syndrome and diabetes mellitus, treatment with testosterone is warranted
  • ...12 more annotations...
  • In obese middle-aged men, testosterone treatment reduced visceral adipocity, insulin resistance, serum cholesterol and glucose levels
  • testosterone replacement has a favorable impact on body mass, insulin secretion and sensitivity, lipid profile and blood pressure in hypogonadal men with the metabolic syndrome as well as type 2 diabetes mellitus
  • Testosterone significantly inhibits lipoprotein lipase activity, which reduces triglycerides uptake into adipocytes in the abdominal adipose tissue
  • testosterone treatment decreased endogenous inflammatory cytokines (tumor necrosis factor-α and IL-1β) and lipids (total cholesterol) and increased IL-10 in hypogonadal men
  • Testosterone treatment reduced leptin and adiponectin levels in hypogonadal type 2 diabetic men after 3 months of testosterone replacement
  • available data clearly show a relationship between obesity, low testosterone levels and ED
  • Obesity adversely affects endothelial function and lowers serum testosterone levels through the development of insulin resistance and metabolic syndrome
  • Metabolic disturbances as well as production of cytokines and adipokines by inflamed fat cells may be causal factors in the development of ED
  • The onset of ED and the associated risk of CVD may be delayed through lifestyle modifications that affect obesity, such as diet and exercise
  • Very low testosterone levels contribute to the development of ED in obesity, metabolic syndrome and type 2 diabetes mellitus
  • Obesity is associated with low total testosterone levels that can be explained at least partially by lower sex hormone-binding globulin (SHBG) in obese men
  • epidemiological studies have shown a negative correlation between BMI and total testosterone and to a lesser extent with free and bioavailable (biologically active) testosterone levels
  • Nathan Goodyear on 27 Jan 15
     
    Obesity is associated with low Testosterone and ED in men.
Nathan Goodyear

Low Testosterone Has a Similar Prevalence among Men with Sexual Dys... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25580982

low Testosterone low T ED Peyronie's disease Testosterone men male hormone hormones

shared by Nathan Goodyear on 27 Jan 15 - No Cached
  • Nathan Goodyear on 27 Jan 15
     
    low Testosterone prevalence found to be no different between men with ED or Peyronie's disease.
Nathan Goodyear

Testosterone Deficiency, Cardiac Health, and Older Men - 0 views

www.ncbi.nlm.nih.gov/...PMC4000629

low T low Testosterone hypogonadism men male hormone hormones Testosterone therapy disease diabetes metabolic syndrome osteoporosis HIV infertility opiates

shared by Nathan Goodyear on 27 Jan 15 - No Cached
  • 2.1 standard deviations in total testosterone was associated with a 25% increase in mortality
  • Erectile dysfunction is an established marker for future cardiovascular risk and the major presenting symptom leading to a diagnosis of low testosterone
  • There is a considerable body of evidence that low testosterone is associated with increased cardiovascular and cancer mortality
  • ...1 more annotation...
  • There is considerable evidence of modest cardiac and metabolic benefits that are shown to reduce cardiovascular risk plus sexual, mood, and quality of life changes associated with restoring testosterone levels
  • Nathan Goodyear on 27 Jan 15
     
    low Testosterone is associated with increased mortality in men and Testosterone therapy in men with low T is associated with a reduction in mortality in men.
Nathan Goodyear

Quality of life, self-esteem, fatigue, and sexual function in young men after cancer - ... - 0 views

onlinelibrary.wiley.com/...abstract

low T low Testosterone cancer quality of life fatigue men male hormone hormones

shared by Nathan Goodyear on 19 Nov 14 - No Cached
  • Nathan Goodyear on 19 Nov 14
     
    Low Testosterone is common among male cancer survivors after therapy.  Many studies point to low T at the time of diagnosis as a prognostic biomarker.  The low T impairs QOL in this men.
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