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Nathan Goodyear

American College of Cardiology Foundation | Journal of the American College of Cardiolo... - 0 views

  • Although currently no drugs that specifically target mitochondrial biogenesis in HF are available, acceleration of this process through adenosine monophosphate–activated kinase (AMPK), endothelial nitric oxide synthase (eNOS), and other pathways may represent a promising therapeutic approach
  • Mitochondrial biogenesis can be enhanced therapeutically with the use of adenosine monophosphate kinase (AMPK) agonists, stimulants of nitric oxide/cyclic guanosine monophosphate (NO/cGMP) pathway (including phosphodiesteraes type 5 inhibitors), or resveratrol
  • metformin, a commonly used antidiabetic drug that activates AMPK signaling
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  • Recent evidence suggests that the eNOS/NO/cGMP pathway is an important activator of mitochondrial biogenesis
  • BH4 (tetrahydrobiopterin) supplementation can prevent eNOS uncoupling and was found to reduce left ventricular hypertrophy
  • folic acid is known to replenish reduced BH4 and has been shown to protect the heart through increased eNOS activity
  • Both folate deficiency and inhibition of BH4 synthesis were associated with reduced mitochondrial number and function
  • Resveratrol, a polyphenol compound responsible for the cardioprotective properties of red wine, was recently identified as a potent stimulator of mitochondrial biogenesis
  • epidemiological studies reveal a reduced risk of cardiovascular disease in premenopausal, but not post-menopausal, women compared with men
  • post-menopausal women
    • Nathan Goodyear
       
      I would hypothesis that a change in the predominance of ER expression is one of ER beta to ER alpha: creating a more pro-inflammatory signal.
  • The majority of ROS in the heart appear to come from uncoupling of mitochondrial electron transport chain at the level of complexes I and III
  • Because the majority of ROS in HF comes from mitochondria, these organelles are the primary target of oxidative damage.
  • cardioprotective therapies such as angiotensin-converting enzyme inhibitors and ATII receptor blockers were shown to possess antioxidant properties, although it is not known whether they target mitochondrial ROS directly or indirectly
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    great review of mitochondrial biogenesis, oxidative stress and heart failure.  
Nathan Goodyear

Clinical Effects of Korean Red Ginseng on Attention Deficit Hyperactivity Disorder in C... - 0 views

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    Panax ginseng may be helpful in ADD and ADHD, especially for focus/attention symptoms.
Nathan Goodyear

Effects of Korean Red Ginseng Extract on Behavior in Children with Symptoms of Inattent... - 0 views

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    Panax ginseng, or korean ginseng, maybe helpful in the treatment for attention and hyperactivity.
Nathan Goodyear

http://hyper.ahajournals.org/content/hypertensionaha/45/5/874.full.pdf - 0 views

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    study finds alcohol increases blood pressure in those without elevated blood pressure.
Nathan Goodyear

Sauna as a valuable clinical tool for cardiov... [Altern Med Rev. 2011] - PubMed - NCBI - 0 views

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    IR sauna shown to benefit many chronic health problems
Amelie warner

Red Robe Tea - 0 views

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    This is a very delicious tea which is introduced by our tea masters in Taiwan. Formosa Ruby... #Greentea http://bit.ly/1dEkd7C
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    This is a very delicious tea which is introduced by our tea masters in Taiwan. Formosa Ruby Tea has a rich... #haocha http://bit.ly/1dEkd7C
Nathan Goodyear

Transdermal testosterone replacement therapy in men - 0 views

  • a recent study has suggested that it may sometimes be inaccurate because of abnormal fluctuation of other circulating androgens
    • Nathan Goodyear
       
      The authors are referencing the increase in the suggestions to use other testing techniques i.e. saliva.
  • Testosterone therapy can inhibit hepcidin transcription and is associated with increased iron incorporation into red blood cells and increased erythropoietin concentrations
  • Transdermal TRT has a more favorable adverse effect profile when compared to buccal testosterone formulations
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  • Approximately 0.3% of testosterone is converted into estradiol by aromatase (CYP19A1)
  • the recommendation for injectable testosterone esters is to check the serum concentration midway between injections
  • it is recommended for serum testosterone to be evaluated 3 to 12 hours after application of the transdermal patch
  • testosterone concentrations should be checked 2–3 months after initiation of therapy and after adjusting the dose
  • a study from 1989 utilizing testosterone transdermally containing 5, 10, or 15 mg of testosterone showed that peak concentrations of testosterone were achieved 3 to 8 hours after scrotal application in hypogonadal men
  • It is used for many medications and has the advantage of high bioavailability, absence of hepatic first pass metabolism, increased therapeutic efficacy, and steadiness of plasma concentrations of the drug
  • evaluate serum testosterone at the end of the dosing interval for testosterone pellets
  • increased amount of fat leads to increased extragonadal aromatase activity, resulting in increased concentrations of estradiol. High circulating concentrations of estradiol down regulate the HPG axis and decrease the amount of circulating testosterone
  • Up to 80% of plasma estradiol originates from aromatization of testosterone and less than 20% of estradiol in the circulation is secreted by the testes
  • A PSA concentration, digital rectal examination, and hematocrit should be performed at baseline and at 3 months, 6 months, then yearly after TRT is initiated.
  • measure serum testosterone any time after the patient has been on treatment with gel for at least 1 week
  • If the hematocrit rises above 54%, treatment should be discontinued
  • elderly men having higher estradiol serum concentrations than postmenopausal women
blowfish9

Buy the latest models Me PRO Ultra online - Mepro-ipl.com - 0 views

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    Mepro-ipl have finally launched the latest model online of our Homedics Me PRO Ultra . Finally a machine for absolutely all skin tones and [ALL body ALL skin type] Permanent Infra-red Light [IPL] Laser Radio Frequency.
wheelchairindia9

Karma 8020 Wheelchair - 0 views

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    This wheelchair of choice for those who desire an extra wide, heavy-duty chair. Bariatric equipment is designed to be used in the care of large and heavy individuals. With childhood obesity levels also rising, the needs of heavier patients and those caring for them, have to be addressed. Wheelchairs that have been constructed for use by the heaviest individuals have built-in strengthening and bracing of the frame, to reduce the possibility of it twisting or buckling in use. The bariatric chairs are available in 20 and 22 inch widths with a red or blue frame. It comes with dual, reinforced steel cross braces for heavy duty support. The seat upholstery is reinforced for long life and comes with a back carry pouch for small items.The 12″ rear wheels are flat free, and the desk length arms are removable and reversible. Features bariatric chairs: Dual, reinforced steel cross braces. Supports individuals. Reinforced steel frame provides added support. Heavy duty, nylon reinforced upholstery with a back carry pouch. Removable, reversible desk length arms. Adjustable leg support. 12″ flat free rear wheels. Using a Karma KM-8020: wheelchairs require more strength to push by the caregiver and by the user, if the chair is self-propelled. In some cases, it may be wise for the caregiver to ask for assistance from another person in order to push the wheelchair safely. Because heavy duty wheelchairs are wider than standard wheelchairs, they require wider doorways and a larger turning radius. They are also heavier to lift into a vehicle and harder to push uphill. Features Can be used as standard self propelled wheelchair or a transport chair all in one. Quick release 24″ wheels can be removed to transition self propelled chair to a transport chair. All aluminum frame. Comes with two sets of aluminum wheel locks: one for use with wheelchair, one for use with transport chair. Fold down back with deluxe back release. Comes standard with swingaway footre
wheelchairindia9

Tricycle Manufacturers - 0 views

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    Tricycles make cycling accessible to all, whatever personal challenges. There are a wide range of disability cycles that suit people with a variety of learning and physical disabilities, as well as health issues. Tricycles have 3 wheels, which means that the rider does not need to be able to balance. This is particularly useful for people with learning disabilities, such as Dyspraxia, and those recovering from illnesses. Tricycles can be fitted with foot plates to make it easier for riders to rotate the pedals and they come in upright or recumbent (horizontal sitting position). For adults and children with balance issues, stabilisers can also be fitted to standard bikes, which makes them more like tricycles. Tricycles come in a variety of accessible styles for people of all abilities including many persons with spinal cord injury disabilities. Tricycles is a great upper body workout and can provide a great sense of freedom for persons with disabilities. While the high cost prevents many from enjoying Tricycles they are steadily growing in popularity. Tricycle Deluxe Double Hand Drive: Frame : Made by E.R.W. Tubes 38.0 mm-16 G. 25.4 mm & 22.22 mm- 18 G. Seat & Back: M S, C.R.C. Sheet. Seat Size 18"x 16" Wheel Size: Wheel Diameter 24"x 1 1/2" Tyre and Tube Standard Company. Parts: Standard Quality. Color: Black Painted. Brake: Front Wheel liver System Drive: Rear Wheel Right Side. Hand powered cycles work along the same principle as standard cycles. The pedals are replaced with handles that also steer, and riders use their arms to push the handles around to drive the chain and wheels. Most hand cycles have 3 wheels, although some have 4 wheels. 4-wheel cycles may have power assistance instead of the rider turning handles,or they may be built for going down hill, in which case gravity powers the bike. As with tricycles, hand cycles can have upright seats or low down recumbent seats. Specialist 'clip on' cycles are also available that can be attached
Nathan Goodyear

Polyphenols: food sources and bioavailability - 0 views

  • Fruit and beverages such as tea and red wine constitute the main sources of polyphenols
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    polyphenols
Nathan Goodyear

A Review of the Rationale for Additional Therapeutic Interventions to Attain Lower LDL-... - 0 views

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    review of a few natural therapies to manage cholesterol.
wheelchairindia9

KM 7501 Wheelchair - 0 views

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    Ergonomic Wheelchair often spend a lot of time leaning on armrests or a table exactly because they are not being supported with good posture in their chairs. This is a matter of seat angle and back angle, adjusting them according to body shape and degree of upper body balance. Poor seating makes slump, trying to get stable. The optimal posture is more upright, allowing spine to support. Ergonomic chairs are designed to confirm to a person's physical dimensions, allowing them to sit naturally and comfortably for long periods of time, while reducing the risk of pressure ulcers. Ergonomic system (Intelligent s-shaped ergonomic seating) provides efficient pressure relief by spreading weight over a greater area, at the same time provides stabilization and reduced sliding. With their lightweight frames and seats designed to reduce or prevent pressure points, ergonomic wheelchairs provide a comfortable option for mobility impaired users who have the upper body strength to propel themselves, or a caregiver strong enough to do so. Karma S Ergo 115 Wheelchair: This model features our S-Shape Seating System and is our number one best seller for many reasons. At a mere 11.3 kg in weight with detachable foot rest and many features such as removable machine washable and dry-able cushions treated by AEIGIS treated anti-microbial coated seating system. Karma S-Ergo 115 Wheelchair Features: Ergonomic Handrims & S-Shape Ergonomic Seating System Fixed armrest w/ wider concave armpads Swing In & Away Footrests Backrest Pouch attached to the upholstery 24" flat free polyurethane tires, high tread, flat free wheels Seat width: 16"x17" or 18"x17" or 20"x 17" Silver 1/4" Aegis Anti-Bacterial Upholstery, washable Folding backrest / folding seat for easy traveling "Tube-in Center" foot-plate, assures better side leg support High strength, starting weight at only 11.3 kg. (w/o footrests) 7×1" Polyurethane front casters Upholstery: Black breathable mesh bottom & t
wheelchairindia9

Ergonomic Lightweight Wheelchair - 0 views

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    Pediatric wheelchairs enable child or teen to participate in all types of daily activities. Pediatric wheelchairs are lightweight, portable, and convenient for use at school, day programs, doctor visits, and recreation with family and friends. Pediatric wheelchairs comes in wide range of sizes and vibrant colors for every lightweight wheelchair. A variety of positioning options are also available. Pediatric wheelchairs are manufactured with unsurpassed quality and style, specializing in compact-folding, lightweight wheelchairs for children of all ages - from toddlers to teens! Custom built to child's specific needs, mobility aids offer rehabilitative benefits for physical disabilities from Cerebral Palsy to Autism. Pediatric, or child wheelchairs, are mobile aids designed for and used by children. Children require the use of a wheelchair for many different reasons, some may have suffered head injuries, some have muscular dystrophy or cerebral palsy, some are amputees, and others only have an occasional use of their wheelchairs in lieu of a walking device or crutches. Certain types of pediatric wheelchairs are built to expand in size to accommodate increased bulk and weight by altering a cross balance on the bottom of the chair. The front frames for the legs can be lengthened as child's legs grow longer. For a pediatrician seeking to prescribe a Pediatric Wheelchair, must be sure that the patient has the proper upper body strength to use one. If the patient is too weak for self movement, the practitioner would be better to consider a powered wheelchair for mobility. While Pediatric Wheelchairs are smaller and can be just as manuverable as scooters, that depends upon the patient's own abilities in steering the chair. These are factors that the doctor must think about before recommending what type of wheelchair a patient should get. Pediatric Wheelchair with a body contouring S-Shaped seat frame and contoured armrests provides the user with all day comfort an
Nathan Goodyear

Polyphenols: antioxidants and beyond - 0 views

  • Polyphenols are the most abundant antioxidants in the diet.
  • main dietary sources are fruits and plant-derived beverages such as fruit juices, tea, coffee, and red wine. Vegetables, cereals, chocolate, and dry legumes also contribute to the total polyphenol intake
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    polyphenols
Nathan Goodyear

Mechanisms of Edema Formation After Intracerebral Hemorrhage: Effects of Extravasated R... - 0 views

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    How the brain swells after intracerebral hemorrhage
Nathan Goodyear

Resveratrol, an extract of red wine, inhibits lipopolysaccharide induced airw... - 0 views

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    resveratrol inhibits inflammation in in-vivo airway model, independent of NF-KB
Nathan Goodyear

Red alert for women's heart: the urgent need for more research and knowledge on cardiov... - 0 views

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    Vasomotor symptoms (hot flashes and night sweats) is associated with increased cardiovascular risk in women.
Nathan Goodyear

Transfusion of Blood and Blood Products: Indications and Complications - - American Fam... - 0 views

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    Good review of transfusion indications and complications
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