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Nathan Goodyear

The Rankings - United Health Foundation - 0 views

www.americashealthrankings.org/LA

Louisiana Health united health foundation LA rankings

shared by Nathan Goodyear on 08 May 12 - No Cached
  • Nathan Goodyear on 08 May 12
     
    Louisiana Health rankings as determined by the United Health Foundation.  This 49 ranking is down from 47.  Only Mississippi ranks lower.  Yet, the LSBME is the most restrictive.  Go figure.
Nathan Goodyear

The Rankings - United Health Foundation - 0 views

www.americashealthrankings.org/TN

Tennessee health united health foundation rankings

shared by Nathan Goodyear on 08 May 12 - No Cached
  • Nathan Goodyear on 08 May 12
     
    Tennessee ranks 39 in Health as determined by the United Health Foundation.  I disagree with some of the defining terms in "health", but the point is well taken.
Nathan Goodyear

Minnesota a health haven for seniors, reports says; Mississippi not so much | McClatchy - 0 views

www.mcclatchydc.com/...-health-haven-for-seniors.html

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shared by Nathan Goodyear on 29 May 13 - No Cached
  • Nathan Goodyear on 29 May 13
     
    Fascinating ranking of states health of senior citizens.  Though I don't agree with all their inclusion criteria, this follows the obesity data from the CDC.  What is very interesting is that the most restrictive/obstructionist state medical boards exist in the states with the highest obesity rates and poorest health of its senior citizens exists.  Coincidence??  
arunaraayala

Forlan forever provides solutions: Jackichand Singh - Locality News - 0 views

www.localitynews.com/des-solutions-jackichand-singh

JACKICHAND SINGH MUMBAI CITY FC SPORTS NEWS

shared by arunaraayala on 26 Oct 16 - No Cached
  • arunaraayala on 26 Oct 16
     
    On October twenty, the Indian team achieved its best FIFA ranking (137) in over six years. The increase was propelled by India's 4-1 ending over higher hierarchal Puerto RICO Act. One among the scorers within the game was Mumbai town FC's Jackichand Singh
Nathan Goodyear

ATSDR - 2007 CERCLA Priority List of Hazardous Substances - 0 views

www.atsdr.cdc.gov/...07list.html

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shared by Nathan Goodyear on 16 Nov 10 - No Cached
  • Nathan Goodyear on 16 Nov 10
     
    Toxic ranking of hazardous substances
mothertobehyd

Mothertobe - Best Fertility Centre In Hyderabad - 0 views

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Best Fertility Centre In Hyderabad

shared by mothertobehyd on 30 Jul 19 - No Cached
  • mothertobehyd on 30 Jul 19
     
    Mothertobe fertility centre is one of the top ranked and best fertility centre in Hyderabad. Our center is one of the few centers in Hyderabad with a multidisciplinary team.
mothertobehyd

Mothertobe - Best Fertility Specialist In Hyderabad - 0 views

mothertobe.in/why-mothertobe

Best Fertility Specialist In Hyderabad

shared by mothertobehyd on 30 Jul 19 - No Cached
  • mothertobehyd on 30 Jul 19
     
    Mothertobe fertility clinic is one of the award-winning and top ranked fertility centre in Hyderabad. Find high quality and best fertility specialist in Hyderabad get quick Infertility treatment with higher success rate.
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shared by ashleyobama on 28 May 20 - No Cached
  • ashleyobama on 28 May 20
     
    Roids Meds is a reputable online pharmacy among all online pharmacies. We deliver prescription of anti-anxiety drugs pills, Nembutal, and pain killers to almost every part of the world at the cheapest prices. Buy cheap medication online, The quality of our medicines is not less than any medicine available at a top-ranked physical drugstore. We guarantee online medicine delivery and the quantity of our products. Buying your medications online can be a smart move.
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Careful Monitoring By Top 10 Pediatric Cardiac Surgeon in India Improve Long-Term Outc... - 0 views

www.briefingwire.com/...dia-improve-long-term-outcomes

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shared by indiacardiacsurg on 12 Jan 22 - No Cached
  • indiacardiacsurg on 12 Jan 22
     
    The low cost of pediatric cardiac surgery in India performed on the patients was ranked from 1 to 4 in growing complexity, with 43% being indexed at classes 3 or 4, and which include a few more complex than category 4. International Helpline Number : +91-9370586696 Email id: enquiry@indiacardiacsurgerysite.com
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shared by fitspresso on 27 Sep 23 - No Cached
  • fitspresso on 27 Sep 23
     
    LeanBiome™ (Official) | Get Save UpTo $540 Today Only! usleanbiome.com LeanBiome™ Hurry Up! Offer Expires in: 00 HOUR 29 MINUTE 59 SECOND LeanBiome Attention! Get Special 84% Discount Today Faster fat burning and weight loss Healthy cholesterol and sugar levels Higher energy levels Regular price: $129 Only for: 39$ What Is LeanBiome? LeanBiome Lean for Good is a weight loss dietary supplement derived from scientifically researched ingredients and comprehensively developed to help people achieve sustainable weight control. The formula comes in a capsule format that is easy to take and is made with natural ingredients from plants and other sources to achieve its goals. The main ingredient in LeanBiome is piperine, which has been found to affect the body's ability to absorb micronutrients and other compounds more effectively. LeanBiome is a dietary supplement that claims to help weight management. It contains 100% natural ingredients that support healthy weight loss. It does not interfere with any natural process making it safe for use. It ranks among the top weight loss supplements that claim to provide a permanent solution. LeanBiome is made by a company named Lean for Good. It is made with natural and research-backed ingredients that help you lose excess fat without hassles. It is sold in capsule form. The company assures the composition is GMO, gluten, and soy-free. As for manufacturing standards, you need not fret. The company makes the supplement in a facility certified by the FDA. How Does LeanBiome Work? The starting period of the LeanBiome program includes a detoxification process that effectively removes any accumulated ree radicals, toxins, fand oxidative stress. This cleansing enables improved blood circulation, setting the stage for the body to initiate its own fat-burning mechanisms. To enhance metabolic activity, introducing the lean bacteria contained in LeanBiome to your gut microbiome is a beneficial approach. This activation triggers r
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Sharper Focus, Safer Treatment: Gamma Knife Radiosurgery in the Heart of India - 0 views

www.briefingwire.com/...osurgery-in-the-heart-of-india

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shared by spineneuro on 27 Jan 24 - No Cached
  • spineneuro on 27 Jan 24
     
    The best gamma knife neurosurgeon in Delhi India ranks among the finest globally. Their skill and extensive experience in managing complex cases set them apart from their worldwide counterparts. Many of them have received education and training abroad.
Nathan Goodyear

America's Health Rankings and United Health Foundation - 0 views

www.americashealthrankings.org

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shared by Nathan Goodyear on 19 Apr 12 - Cached
  • Nathan Goodyear on 19 Apr 12
     
    very nice analysis of the statistics put together by United Health.  Give credit where it is due.  Good job United.
Nathan Goodyear

Normalization of testosterone level is associated with reduced incidence of myocardial ... - 0 views

eurheartj.oxfordjournals.org/...eurheartj.ehv346

low T low Testosterone men Testosterone mortality stroke MI CVD cardiovascular disease hormones male

shared by Nathan Goodyear on 11 Aug 15 - No Cached
  • Normalized-TRT group had significantly fewer deaths than no-TRT
  • Mortality was also significantly lower in the non-normalized-TRT group compared with those in no-TRT group
  • the normalized-TRT group was associated with significantly increased all-cause mortality-free survival (log-rank, P < 0.05) compared with the non-normalized-TRT or no-TRT groups
  • ...10 more annotations...
  • normalized-TRT group showed lower risk of MI than non-normalized-TRT (HR: 0.82, CI 0.71–0.95, P = 0.008) and no-TRT
  • normalized-TRT group had significantly lower stroke events compared with non-normalized-TRT (HR: 0.70, CI 0.51–0.96, P = 0.028) and no-TRT
  • study of men with low TT levels and without prior MI or stroke, normalization of TT levels using TRT is associated with lower all-cause mortality, fewer MIs, and ischaemic strokes
  • retrospective study
  • the first study to demonstrate that significant benefit is observed only if the dose is adequate to normalize the TT levels
  • Patients who failed to achieve the therapeutic range after TRT did not see a reduction in MI or stroke and had significantly less benefit on mortality
  • selected patients without any previous history of MI or stroke prior to initiation of TRT to reduce bias related to CV outcomes
  • currently only half of the men on TRT had been diagnosed with hypogonadism.
  • 25% of users did not have their T concentrations tested prior to initiating therapy, and 21% of those prescribed TRT did not have their levels tested at any time during treatment.
  • men without a history of previous MI or stroke who have low TT levels, TRT might be associated with decreased risks of MI, ischaemic stroke, and all-cause mortality in long-term follow-up
  • Nathan Goodyear on 11 Aug 15
     
    Testosterone therapy in men with low T found to reduce all cause mortality, stroke and MI.
Nathan Goodyear

Hypercalcemia of malignancy and new treatment options - 0 views

www.ncbi.nlm.nih.gov/...PMC4675637

hypercalcemia calcium cancer

shared by Nathan Goodyear on 11 Sep 18 - No Cached
  • Hypercalcemia of malignancy occurs as the result of direct bone metastasis and via humoral mechanisms such as parathyroid hormone-related protein (PTHrP) or 1,25-dihydroxyvitamin D mediated pathways
  • ectopic secretion of parathyroid hormone (PTH) has been implicated
  • Hypercalcemia due to osteolytic bone lesions is common in multiple myeloma, leukemia, and breast cancer
  • ...22 more annotations...
  • Humoral hypercalcemia is predominant in squamous cell, renal cell and ovarian cancers, and lymphomas are associated with 1,25-dihydroxyvitamin D mediated hypercalcemia
  • 20% of cases of hypercalcemia of malignancy and is frequently encountered in multiple myeloma, metastatic breast cancer, and to a lesser extent in leukemia and lymphoma
  • Physiologic bone turnover requires the complementary activity of osteoblasts – mesenchymal stem cell-derived bone-forming cells – and bone-resorbing cells of monocyte and macrophage lineage known as osteoclasts
  • In local osteolytic hypercalcemia, the RANKL/RANK interaction results in excessive osteoclast activation leading to enhanced bone resorption and thus hypercalcemia
  • In addition, osteoclast activation is also mediated by malignancy secreted cytokines, including interleukin-1, initially termed “osteoclast stimulating factor”
  • Macrophage inflammation protein 1-alpha (MIP 1-alpha)
  • hypercalcemia is through extra-renal 1,25-dihydroxyvitamin D (calcitriol) production
  • 1% of cases
  • increased production of 1,25-dihydroxyvitamin D occurs nearly exclusively in Hodgkin and non-Hodgkin lymphoma with case reports of the same in ovarian dysgerminoma
  • 1-α-hydroxylase in the kidney, a process regulated by PTH
  • in 1,25-dihydroxyvitamin D induced hypercalcemia, malignant cells likely recruit and induce adjacent macrophages to express 1-α-hydroxylase, converting endogenous calcidiol into calcitriol.31 Calcitriol then binds to receptors in the intestine leading to heightened enteric calcium reabsorption with resultant hypercalcemia
  • this mechanism of disease is best conceptualized as an absorptive form of hypercalcemia
  • Ectopic production of PTH by malignant cells has been described in a handful of cases involving cancer of the ovary and lung, as well as neuroendocrine tumors and sarcoma
  • primary hyperparathyroidism and malignancy comprising nearly 90% of cases of hypercalcemia
  • an initial panel consisting of PTH, PTHrP, phosphorus, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D should be obtained
  • Lymphoma, a hypercalcemia due to 1,25-dihydroxyvitamin D mediated pathways, is implied by elevations in 1,25-dihydroxyvitamin D without concomitant elevations in 25-hydroxyvitamin D. In such cases, PTH is low and PTHrP undetectable
  • Treatment of hypercalcemia of malignancy is aimed at lowering the serum calcium concentration by targeting the underlying disease, specifically by inhibiting bone resorption, increasing urinary calcium excretion, and to a lesser extent by decreasing intestinal calcium absorption
  • mildly symptomatic disease
  • marked symptoms
  • hydration with isotonic fluid (if admitted), avoidance of thiazide diuretics, and a low-calcium diet
  • denosumab
  • Denosumab is an RANKL antibody that inhibits osteoclast maturation, activation, and function
  • Nathan Goodyear on 11 Sep 18
     
    hypercalcemia in cancer and treatments.
Nathan Goodyear

In vivo loss-of-function screens identify KPNB1 as a new druggable oncogene in epitheli... - 0 views

www.pnas.org/E7301

Ivermectin cancer ovarian cancer oncogene oncogenes

shared by Nathan Goodyear on 20 Mar 18 - No Cached
  • we functionally validated a potent EOC oncogene, KPNB1, and showed its clinical relevance to human EOC
  • a well-established antiparasitic drug, ivermectin, has antitumor effects on EOC through its inhibition of KPNB1
  • EOC has high intertumor and intratumor heterogeneity at the molecular and epigenetic levels
  • ...22 more annotations...
  • the mortality rate of EOC has not been significantly changed for several decades
  • Sequencing revealed that almost all tumors (96%) had mutations in TP53, which serves as a major driver of this cancer
  • Low-prevalence but statistically significant mutations in nine other genes including NF1, BRCA1, BRCA2, RB1, and CDK12 were also identified, but the majority of genes were mutated at low frequency, making it difficult to distinguish between driver and passenger mutations
  • KPNB1 inhibition via any of three KPNB1 siRNAs or importazole treatment induced apoptosis in human EOC cell lines (Fig. 3 A–F and Fig. S4), and was accompanied by an increase in the expression levels of the proapoptotic proteins BAX and cleaved caspase-3
  • Stable overexpression of KPNB1 in SKOV3 and OVCAR3 (Fig. S6) significantly accelerated cell proliferation/survival (Fig. 5 A–C), confirming that KPNB1 functions as an oncogene in EOC
  • KPNB1 overexpression significantly decreased caspase-3/7 activity (Fig. 5D), in addition to the expression levels of cleaved caspase-3 and BAX proteins (Fig. 5E). KPNB1 overexpression also decreased p21 and p27 protein levels (Fig. 5E), as opposed to their increase by KPNB1 inhibition
  • KPNB1 functions as an antiapoptotic and proproliferative oncogene in EOC.
  • Patients with higher expression levels of KPNB1 showed earlier recurrence and worse prognosis than those with lower expression levels of KPNB1
  • KPNB1 acts as an oncogene in human EOC and represents a promising therapeutic target.
  • ivermectin treatment suppressed cell proliferation/viability in a dose-dependent manner (Fig. 7A), indicating that it exerts an antitumor effect on EOC
  • ivermectin also induced apoptosis
  • ivermectin increased the expression levels of BAX, and cleaved PARP, as well as p21 and p27
  • KPNB1 inhibition is responsible for the antitumor effect of ivermectin
  • we found that ivermectin synergistically reduced cell proliferation/viability in combination with paclitaxel in human EOC cells
  • Single treatment of ivermectin or paclitaxel reduced tumor growth in nude mice, but, notably, combination treatment of ivermectin and paclitaxel almost completely suppressed tumor growth
  • ERBB2, is amplified and overexpressed in many cancers, including breast (31), ovary (31), colon (32), bladder (33), non-small-cell lung (34), and gastric cancer (35), and is a poor prognostic factor in certain cancer types
  • KPNB1 was the second-highest-ranked gene identified in our screen
  • Increased KPNB1 protein levels have been reported in several cancers, including cervical cancer (42), hepatocellular carcinoma (43), and glioma (44), suggesting KPNB1’s oncogenic potential in these tumor types
  • our findings suggest that KPNB1 might serve as a master regulator of cell cycle by regulating several cell cycle-related proteins, including p21, p27, and APC/C family members
  • higher and/or more-frequent doses of ivermectin than currently approved for humans are well tolerated in humans
  • none of the mice in this study treated with the effective dosage of ivermectin for in vivo anticancer therapy showed severe adverse event
  • we found that the combination of ivermectin and paclitaxel produces a stronger antitumor effect on EOC cell lines than either drug alone
  • Nathan Goodyear on 20 Mar 18
     
    Ivermectin found to be pro-apoptotic for the epithelial ovarian cancer oncogene, KPNB1 in in Vivo study.  This effective anti-parasitic drug inhibits the KPNB1 oncogene.
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