Statin therapy worsens insulin sensitivity and thus glucose regulation in women with PCOS. Women with PCOS are at increased risk for type II Diabetes. Statins interfere with glucose metabolism and thus will increase the effective risk for these women. This study was a randomized, prospective study.
Chiro-inositol increases the action of insulin in patients with the polycystic ovary syndrome, thereby improving ovulatory function and decreasing serum androgen concentrations, blood pressure, and plasma triglyceride concentrations.
women with PCOS, inflammatory cytokines TNF-alpha and CRP, associated with increasing androgen levels and with abdominal fat. Women with less fat had lower levels of TNF-alpha and CRP than their higher weight counterparts, though the inflammatory cytokines were still evident.
low grade, chronic inflammation associated with PCOS and common disease states associated with PCOS. It is known that high androgen levels in women causes inflammation.
It is well known that obesity increases CRP. However, in this meta-analysis, CRP elevation in women with PCOS was found to be independent from obesity and as they concluded: "...chronic low-grade inflammation that may underpin the pathogenesis of this disorder".
In women with PCOS, inflammation DIRECTLY stimulates androgen production from the ovaries. Inflammation is the driving force behind the high androgen levels in women with PCOS.
Only abstract available. Resveratrol found to reduce total Testosterone by 23% and DHEAS by 22% in women with PCOS; a decrease in insulin by 32% and improved insulin sensitivity was also noted.
high prevalence of thyroid antibodies, TPO, in women with PCOS. This does not prove cause and effect, merely an association. Both are inflammation driven.