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Nathan Goodyear

Elderly men over 65 years of age with late-onset hypogonadism benefit as much from test... - 0 views

  • The benefits of restoring serum testosterone in men with LOH were not significantly different between men older than 65 years of age and younger men. There were no indications that side effects were more severe in elderly men. The effects on prostate and urinary function and hematocrit were within safe margins.
  • obesity, but also impaired general health, are the more common causes of low testosterone in aging men
  • Severe LOH is associated with substantially higher risks of all-cause and cardiovascular mortality,
  • ...30 more annotations...
  • advanced age, obesity, a diagnosis of metabolic syndrome, and poor general health status were predictors of LOH
  • Diabetes mellitus was correlated with hypogonadism in most studies
  • coronary heart disease, hypertension, stroke, and peripheral arterial disease did not predict hypogonadism, they did correlate with the incidence of low testosterone
  • LOH can be defined by the presence of at least three sexual symptoms associated with a total testosterone level of less than 11 nmol/L (3.2 ng/mL) and a free testosterone level of less than 220 pmol/L (64 pg/mL)
    • Nathan Goodyear
       
      the European Male Aging study defined low T as total < 320 ng/dl and free < 64 pg/ml.  
  • Mean weight decreased
  • Waist circumference decreased
  • Total cholesterol decreased
  • Low-density lipoprotein decreased
  • Triglycerides decreased
  • High-density lipoprotein (HDL) increased
  • ratio of total cholesterol to HDL improved
  • Prostate volume increased
  • PSA increased
  • The benefits for men older than 65 years of age were compared with those of younger men, and the improvements in body weight, metabolic factors, psychological functioning, and sexual functioning were of the same magnitude in both age groups
  • weight loss was progressive over the 6-year period, effects of testosterone on lipids and on psychological and sexual functioning reached a plateau after approximately 3 years and these effects were sustained
  • Effects of testosterone on hematopoiesis, on the prostate, and on bladder function were not more severe in older men than in younger men
  • observe a mild increase in prostate volume and serum PSA over time, which is a normal finding in aging men. Maybe somewhat surprising, postvoiding residue and the IPSS did not deteriorate with aging but showed a degree of improvement
  • the severity of the metabolic syndrome is associated with the severity of lower urinary tract symptoms
  • The symptoms of the metabolic syndrome improve upon testosterone treatment and testosterone may thus have a favorable effect on lower urinary tract symptoms
  • it seems reasonable to conclude that the risks of testosterone administration to elderly men are not disproportionately higher in elderly men than in younger men.
  • Despite evidence to the contrary, physicians still harbor a wrongful association between testosterone and the development of prostate pathology (prostate cancer and benign prostate hyperplasia)
  • Not surprisingly, the incidence of prostate cancer was higher in older men; however, it was lower than expected in both groups
  • These observations suggest that the incidence of prostate cancer in patients receiving testosterone therapy, both in the younger and in the older group, was not greater than in the general population not receiving testosterone treatment
  • The historical fear that raising testosterone levels will result in more prostate cancer has been dispelled, particularly by the work of Abraham Morgentaler
  • Higher serum testosterone levels fail to show an increased risk of prostate cancer, and supraphysiological testosterone does not increase prostate volume or PSA in healthy men
  • This apparent paradox is explained by the "saturation model,"
  • Recent studies indicate no increased risk of prostate cancer among men with serum testosterone in the therapeutic range
  • In the present observational study, no cases of major adverse cardiovascular events occurred.
  • the benefits of testosterone therapy are fully achieved only by long-term treatment
  • To achieve maximal benefits, good patient adherence is a prerequisite
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    Study finds new difference in Testosterone benefits and/or side effects between men < 65 with low T and men > 65 with low T.
Nathan Goodyear

Fatigue and underperformance in athletes: the overtraining syndrome - 0 views

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    Over training syndrome: reason for athlete underperformance
Nathan Goodyear

Arch Intern Med -- Abstract: Human Chorionic Gonadotropin (HCG) Treatment of Obesity, F... - 0 views

  • hese results indicate that HCG has no effects on chemical and hormonal parameters measured and offers no advantage over calorie restriction in promoting weight loss.
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    HCG injections appear to have no effect on weight loss over those following 500 cal diets
Nathan Goodyear

Dopamine-based reward circuitry responsivity, genetics, and overeating. - PubMed - NCBI - 0 views

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    low dopamine Rc associated appears to increase addiction to sugar and its positive effect on these same receptors (and another that positively interacts with dopamine Rc's) and results in overeating and weight problems.
pharmacybiz

Community Pharmacies 22 Million Covid-19 Jabs In One Year - 0 views

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    Community pharmacies played a central role in the government's response to the Covid-19 pandemic, delivering more than 22 million jabs in the past 12 months. Besides delivering millions of jabs, latest figures from NHS England and NHS Improvement (NHSE&I) revealed a 50 per cent increase in the number of pharmacies delivering Covid boosters compared from October 2021 to January 2022. NHSE&I released the data on Friday (January 14) to thank community pharmacy teams for their work during the crisis time. Lauding the efforts made by community pharmacy teams during the pandemic, Pharmaceutical Services Negotiating Committee (PSNC) director of NHS Services Alastair Buxton said: "Just over a year ago we were fighting for Government recognition of the part community pharmacy could play in administering Covid vaccines, so a year later it is great to see the efforts of the pharmacy vaccination sites being praised by NHSE&I, with recognition of the significant role they have played in the overall programme.
Nathan Goodyear

ScienceDirect.com - Journal of Science and Medicine in Sport - Relationship between ser... - 0 views

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    The use of saliva found to be advantageous over that of serum and urine to assess cortisol.
Nathan Goodyear

JAMA Network | JAMA | Pharmaceutical Overdose Deaths, United States, 2010 - 1 views

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    2010 pharmaceutical overdose #'s.  Over 38.000.
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    i will be doing a lot of research on your articles. thank u. rita johnston
Nathan Goodyear

inhibition of estradiol synthesis attenuates renal injury in male streptozotocin-induce... - 0 views

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    Study finds that inhibition of aromatase activity in diabetic male rats provided renal protection. There has been debate about the effects of testosterone therapy on the renal system. However, I propose that aromatase activity and conversion to estrogen is the negative effects of Testosterone. Other than over dosing men. Though this is a rat study, this study does support the theory.
Smile Reef

Pediatric Dentist Teaching Children Oral Health - 0 views

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    Dr. Jensen and his staff at Smile Reef Pediatric Dentistry in Las Vegas had a great time visiting over 600 students at Goolsby Elementary School! Dr. Jensen led the students through a hands-on demonstration of proper hygiene and dental health.
Smile Reef

Pediatric Dentist in Las Vegas Teaching Kids To Brush And Floss - 0 views

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    Dr. Jensen and his staff at Smile Reef Pediatric Dentistry in Las Vegas had a great time visiting over 600 students at Goolsby Elementary School! Dr. Jensen led the students through a hands-on demonstration of proper hygiene and dental health.
market reports

Market Trends in Infection Control Market & Healthcare Facilities - 0 views

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    Future market trends in infection control market show the increased growth and demands for gamma, and e-beam sterilization services. These services are likely to take over the EtO sterilization process. This is the resultant of wide application area of both gamma and e-beam sterilization
Nathan Goodyear

1506 TESTOSTERONE REPLACEMENT THERAPY AND CANCER RISK - 0 views

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    Testosterone therapy found to not increase cancer risk in men.  This chart review, looked at 722 men over an average of 8.7 years to assess risk of cancer associated with testosterone therapy. This study was presented at the AUA in 2013.
Nathan Goodyear

Fatigue and underperformance in athletes: the overtraining syndrome - 0 views

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    Good review of the physiology behind over training syndrome.
Nathan Goodyear

Treatment of erectile dysfunction... [J Sex Marital Ther. 2003 May-Jun] - PubMed - NCBI - 0 views

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    l-Arginine with pycnogenol significantly improved ED over l-Arginine alone.
Nathan Goodyear

Effects of dietary coconut oil on the biochemical and... [Lipids. 2009] - PubMed - NCBI - 0 views

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    30 ml of coconut oil daily over 12 weeks reduced abdominal fat and improved HDL cholesterol.
Nathan Goodyear

The 20-Year Public Health Impact and Direct Cost of Testosterone Deficiency in U.S. Men... - 0 views

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    This study assumes a 13% low T prevalence.  Probably too low.  This will only grow.  Low T contributes to many disease states in men. This study showed a cost of 190-525$ billion in cost from these disease states over a 20 year time period.
Smile Reef

Pediatric Dentist Teaching Children Oral Health - 0 views

  •  
    Dr. Jensen and his staff at Smile Reef Pediatric Dentistry in Las Vegas had a great time visiting over 600 students at Goolsby Elementary School! Dr. Jensen led the students through a hands-on demonstration of proper hygiene and dental health.
wheelchairindia9

Karma Km 2500 - 0 views

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    Karma KM 2500 Small Wheel Wheelchair: Karma KM 2500 Small Wheel Wheelchair Specifications: Width 18" Front/Rear Wheels 6" to 14" Seat Width 47cm Seat Depth 40cm Overall Width 66cm Overall Collapsed Width 36cm Armrest Height 21cm Overall Length 90cm Seat Height 47cm Backrest Height 38cm Overall Height 86cm Weight 9.2 k.g. Karma KM 2500 Small Wheel Wheelchair Seat and Back: AEGIS Microbe Shield Approved by the FDA, EPA, EU, etc., bonded anti-microbial barrier upholstery protects from odor, staining and deterioration from bacteria, fungus and other microorganisms. It is a shield for your health. Karma KM 2500 Small Wheel Wheelchair Extended Armrest: By simulating the natural position of arms, the extended armrest design is ergonomic and creates bigger seating space. An Ultra lightweight wheelchair (9.2 kg) with a compact design for either attendant assisted or self propelling users. The use of aircraft-grade aluminium alloy and double cross brace provide this model with outstanding strength and durability. Karma Healthcare KM-2500 Premium Wheelchair is amazingly light and compact transit wheelchair which is ideal for outings and travelers. It folds down to take up virtually no space in the boot of a car and weighs just over 9.2 kg making it easy for anyone to lift into a vehicle. Backrest folds-down for easy transportation. Maximum user weight: 100 K.g. Aluminium frame. Fixed armrest/fixed footrest. Foldable frame via double cross bars. Comfortable & durable upholstery. Swing-away foot plates. Puncture proof tyres. Attendant cable brake. 14" flat-free rear wheels. Detachable and washable cushion. One Year Warranty. It folds down to take up virtually no space in the boot of a car. This amazingly light and compact transit wheelchair is ideal for outings and travelling. It comes with detachable and washable cushion. The wheel chair has attendant cable brake. It is made from aircraft-grade aluminium alloy fra
wheelchairindia9

Karma Km 2500 Wheelchair - 0 views

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    Karma KM 2500 Small Wheel Wheelchair: Karma KM 2500 Small Wheel Wheelchair Specifications: Width 18" Front/Rear Wheels 6" to 14" Seat Width 47cm Seat Depth 40cm Overall Width 66cm Overall Collapsed Width 36cm Armrest Height 21cm Overall Length 90cm Seat Height 47cm Backrest Height 38cm Overall Height 86cm Weight 9.2 k.g. Karma KM 2500 Small Wheel Wheelchair Seat and Back: AEGIS Microbe Shield Approved by the FDA, EPA, EU, etc., bonded anti-microbial barrier upholstery protects from odor, staining and deterioration from bacteria, fungus and other microorganisms. It is a shield for your health. Karma KM 2500 Small Wheel Wheelchair Extended Armrest: By simulating the natural position of arms, the extended armrest design is ergonomic and creates bigger seating space. An Ultra lightweight wheelchair (9.2 kg) with a compact design for either attendant assisted or self propelling users. The use of aircraft-grade aluminium alloy and double cross brace provide this model with outstanding strength and durability. Karma Healthcare KM-2500 Premium Wheelchair is amazingly light and compact transit wheelchair which is ideal for outings and travelers. It folds down to take up virtually no space in the boot of a car and weighs just over 9.2 kg making it easy for anyone to lift into a vehicle. Backrest folds-down for easy transportation. Maximum user weight: 100 K.g. Aluminium frame. Fixed armrest/fixed footrest. Foldable frame via double cross bars. Comfortable & durable upholstery. Swing-away foot plates. Puncture proof tyres. Attendant cable brake. 14" flat-free rear wheels. Detachable and washable cushion. One Year Warranty. It folds down to take up virtually no space in the boot of a car. This amazingly light and compact transit wheelchair is ideal for outings and travelling. It comes with detachable and washable cushion. The wheel chair has attendant cable brake. It is made from aircraft-grade aluminium alloy fra
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