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Nathan Goodyear

Lipid-associated macrophages are induced by cancer-associated fibroblasts and mediate i... - 0 views

pubmed.ncbi.nlm.nih.gov/35862581

cancer CAF Tumor associate macrophages TME TAMs TAM breast cancer tumor microenvironment cancer associated fibroblasts

shared by Nathan Goodyear on 09 Aug 22 - No Cached
  • Nathan Goodyear on 09 Aug 22
     
    CAF manipulate TAMs recruited to TME to turn on the immune system-Cancer uses the immune system agains the immune system. Here, in TNBC.
Nathan Goodyear

Utilization of Pharmacological Ascorbate to Enhance Hydrogen Peroxide-Mediated Radiosen... - 0 views

www.ncbi.nlm.nih.gov/...PMC8509557

radiation fenton reaction High dose IV vitamin C vitamin C ascorbic acid high dose vitamin C H2O2 pharmacologic vitamin C

shared by Nathan Goodyear on 11 Aug 22 - No Cached
  • Nathan Goodyear on 11 Aug 22
     
    Conclusion: the data presented in this review show synergistically increased DNA damage with combination treatment of RT and P-AscH−, associated with H2O2 formation
Nathan Goodyear

Prooxidative inhibition against NF-κB-mediated inflammation by pharmacologica... - 0 views

www.sciencedirect.com/...S0891584922000181

vitamin C nuclear factor kappa B NF-KappaB v nuclear factor κB inflammation ascorbic acid NF-κB

shared by Nathan Goodyear on 16 Jul 22 - No Cached
  • Nathan Goodyear on 16 Jul 22
     
    The title tells it all.
Nathan Goodyear

Astaxanthin anticancer effects are mediated through multiple molecular mechanisms: A sy... - 0 views

www.sciencedirect.com/...S1043661819327367

Astaxanthin cancer

shared by Nathan Goodyear on 28 Feb 22 - No Cached
  • Nathan Goodyear on 28 Feb 22
     
    Astaxanthin has multiple anti-cancer effects.
Nathan Goodyear

Ascorbic Acid Chemosensitizes Colorectal Cancer Cells and Synergistically Inhibits Tumo... - 0 views

www.ncbi.nlm.nih.gov/...PMC6064950

cancer vitamin C ascorbic acid colorectal cancer

shared by Nathan Goodyear on 26 Mar 22 - No Cached
  • therapeutic potential has been supported by a large and consistent body of evidences from in vitro
  • Ascorbic acid might act as a way to deliver hydrogen peroxide (H2O2) to the tissues
  • pharmacological concentrations of AA were capable of inducing anti-proliferative, cytotoxic and genotoxic effects
  • ...12 more annotations...
  • chemosensitizing
  • pharmacological concentrations of AA can sensitize cancer cells to chemotherapy, enhancing its antineoplastic effect
  • synergistic effect with conventional chemotherapeutic drugs is a fact already reported, in various types of cancer, by numerous authors, namely in pancreatic (Espey et al., 2011), prostate (Gilloteaux et al., 2014), lung (Lee et al., 2017), breast (Kurbacher et al., 1996; Wu et al., 2017) and ovarian (Ma et al., 2014) cancers.
  • chemosensitizing effect of vitamin C has already been proven by several authors in various types of cancer
  • intravenous pharmacological concentrations, may not only potentiate the effects of conventional chemotherapy, but also improve the quality of life of cancer patients
  • AA reinforced the anti-proliferative activity of 5-FU
  • Combined treatment induced a reduction of 11.5% and 43% in cell viability compared with AA or Iri therapies, respectively, emphasizing the synergistic effect
  • cytotoxic effect occurred with treatment with Iri alone, but also this effect was further potentiated by the presence of AA.
  • association of AA with Oxa showed very promising results, considering that a synergistic effect was demonstrated, in almost all conditions
  • AA and Oxa seem to act synergistically by the activation of the intrinsic pathway of apoptosis, translated on the statistically significant increase of the ratio between BAX and BCL-2 proteins, which in turn is associated with a decrease of Δψm
    • Nathan Goodyear
      Nathan Goodyear on 26 Mar 22
       
      Apoptosis -> decrease in mitochondrial membrane potential
  • Previous results obtained by our group showed that AA mediates reactive oxygen species (ROS) formation capable of irreparably damaging DNA
  • oxidative role of AA may be a key factor on the synergistic anti-cancer mechanism
Nathan Goodyear

Temperature-dependent and time-dependent effects of hyperthermia mediated by dextran-co... - 0 views

www.ncbi.nlm.nih.gov/...PMC4346362

hyperthermia

shared by Nathan Goodyear on 18 Apr 23 - No Cached
  • Nathan Goodyear on 18 Apr 23
     
    effect of time and temperature on the viability of melanoma cell lines and expression of HSP 70 & 90 after brief exposure to hyperthermia. While hyperthermia has multiple mechanisms of action, this paper elucidates two essential benefits of high-dose hyperthermia. First, the study illustrates why high-dose hyperthermia treatments (45°C - 47°C) are so much more effective than the low-dose hyperthermia (39°C - 43°C) produced by commercially available heating devices.
Nathan Goodyear

Cannabinoids Inhibited Pancreatic Cancer via P-21 Activated Kinase 1 Mediated Pathway -... - 0 views

www.ncbi.nlm.nih.gov/...PMC7662796

pancreatic cancer CBD P-21 THC KRAS

shared by Nathan Goodyear on 30 Jan 24 - No Cached
  • Nathan Goodyear on 30 Jan 24
     
    THC:CBD target pancreatic cancer which expresses KRAS mutation appx 90% of time.
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