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Wallis Tavern

A Magical Wedding Venue - 1 views

started by Wallis Tavern on 27 Jan 13 no follow-up yet
teremoso

To Maintain Body Fit, Used Fitness Equipment in Toronto - 2 views

While many of us are still experiencing economic challenges now, it's important to re-commit to health now more than ever. With Keystone Company raising premiums right and left, why not invest in t...

used fitness equipment toronto

started by teremoso on 21 May 12 no follow-up yet
Craftmatic Beds

The Perfect Bed for My Nana - 1 views

My grandnana always complain about waking up in the morning with muscle pains and backaches. She is already 86 years old and it pains me to hear that she is not having a good night sleep. So I deci...

craftmatic adjustable beds

started by Craftmatic Beds on 23 Nov 11 no follow-up yet
Nathan Goodyear

The orgasmic history of oxytocin: Love, lust, and labor - 0 views

www.ncbi.nlm.nih.gov/...PMC3183515

oxytocin hormone hormones

shared by Nathan Goodyear on 29 Jul 13 - No Cached
  • Nathan Goodyear on 29 Jul 13
     
    review of the history of knowledge on oxytocin.
felipp windsor

Restoring My Daughter's Shiny White Teeth - 1 views

I was surprised when I noticed that the teeth of my 13 year -old- daughter were discoloured. They were no longer that shiny and that white anymore. Maybe it was because of the food that she eats ev...

teeth whitening windsor

started by felipp windsor on 05 Dec 13 no follow-up yet
felipp windsor

Restoring My Daughter's Shiny White Teeth - 1 views

I was surprised when I noticed that the teeth of my 13 year -old- daughter were discoloured. They were no longer that shiny and that white anymore. Maybe it was because of the food that she eats ev...

teeth whitening windsor

started by felipp windsor on 31 Oct 13 no follow-up yet
wheelchairindia9

Standard Wheelchair - 0 views

www.wheelchairindia.com/...Standard-Wheelchair

Standard Wheelchair Gives Safety To User fixed or detachable armrests standard wheelchair sturdy and inexpensive available in limited sizes standard lightweight wheelchair comfort or to ease propulsion

shared by wheelchairindia9 on 11 May 15 - No Cached
  • wheelchairindia9 on 11 May 15
     
    Standard Manual Wheelchairs are the most commonly used type of wheelchair, if searching for a standard wheelchair with a durable frame and long-lasting support, take a look at standard wheelchairs. The Standard Wheelchair usually weighs over 35 lbs, have a seat width between 16 and 20 inches, and feature fixed or detachable armrests. Most are made with steel frames and can be an economical and consistent mobility choice. Almost all standard wheelchairs can support up to 250 lb. A standard wheelchair is designed to support longer trips, and to allow for self propulsion. These chairs almost always feature two, large, rear-mounted wheels that the user can set in motion by hand, so if need to be able to operate chair without aid from a loved one or caregiver, a standard wheelchair is an ideal option. Storage is a breeze with these units as well and every model we carry is foldable, allowing the user to fit his/her chair into a tighter spaces. Standard Wheelchairs, also known as Power Operated Vehicles (POVs), are a good choice if need assistance getting around home or apartment and don't have advanced seating or positioning needs. The right Standard Wheelchair will allow to get around home with ease and without getting tired. A Standard Wheelchair allows to go where it need, when it need, with little to no assistance. Numotion will work with it and clinicians to see if a Standard Wheelchair is the right choice. Features: Good for travel and in large outdoor spaces. Designed for mobility on the go. Easy control. Adjust for speed and comfort. Conveniently charged by simply plugging in.
Sonny Cher

Just the Thing to Enhance My Mood - 1 views

Just recently, I am going through a broken heart, all because of the only girl I ever loved for 5 years. The moment I decided to confess, I saw her with my best friend and knew that they are alread...

legal drugs

started by Sonny Cher on 23 May 11 no follow-up yet
High Syn

Safe and Legal Pot - 4 views

You can say that I love to party and get high occasionally. But, then again getting addicted to the real thing is a big NO NO. Gladly a friend of mine introduced me to Kronic. It is a brand of herb...

herbal highs

started by High Syn on 13 Jun 11 no follow-up yet
becomea paramedic

My Paramedic Dream Came True - 1 views

Two years ago, I pursued my dream of becoming a paramedic in the London Ambulance Service. I know it would be tough since there were many applicants vying for the few slots. But, I was undeterred i...

How To Become A Paramedic

started by becomea paramedic on 28 Oct 11 no follow-up yet
My Wellness

Studies Find Big Benefits in Marriage - 0 views

mywellness.in/does-marriage-elongate-life

emotional health love marriage relationships

shared by My Wellness on 31 Dec 14 - No Cached
  • My Wellness on 31 Dec 14
     
    One of the strongest and consistent benefits of marriage is better physical health and its consequence longer life,Marriage Increases the Quality of Life, Sexual fulfillment.
Nathan Goodyear

Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxid... - 0 views

www.ncbi.nlm.nih.gov/...PMC3180189

cancer reverse warburg effect warburg effect NF-kapppB HIF-1alpha Cav-1 H2O2

shared by Nathan Goodyear on 12 Nov 14 - No Cached
  • reducing oxidative stress with powerful antioxidants, is an important strategy for cancer prevention, as it would suppress one of the key early initiating steps where DNA damage and tumor-stroma metabolic-coupling begins. This would prevent cancer cells from acting as metabolic “parasites
  • Oxidative stress in cancer-associated fibroblasts triggers autophagy and mitophagy, resulting in compartmentalized cellular catabolism, loss of mitochondrial function, and the onset of aerobic glycolysis, in the tumor stroma. As such, cancer-associated fibroblasts produce high-energy nutrients (such as lactate and ketones) that fuel mitochondrial biogenesis and oxidative metabolism in cancer cells. We have termed this new energy-transfer mechanism the “reverse Warburg effect.
  • Then, oxidative stress, in cancer-associated fibroblasts, triggers the activation of two main transcription factors, NFκB and HIF-1α, leading to the onset of inflammation, autophagy, mitophagy and aerobic glycolysis in the tumor microenvironment
  • ...38 more annotations...
  • oxidative stress and ROS, produced in cancer-associated fibroblasts, has a “bystander effect” on adjacent cancer cells, leading to DNA damage, genomic instability and aneuploidy, which appears to be driving tumor-stroma co-evolution
  • tumor cells produce and secrete hydrogen peroxide, thereby “fertilizing” the tumor microenvironment and driving the “reverse Warburg effect.”
  • This type of stromal metabolism then produces high-energy nutrients (lactate, ketones and glutamine), as well as recycled chemical building blocks (nucleotides, amino acids, fatty acids), to literally “feed” cancer cells
  • loss of stromal caveolin (Cav-1) is sufficient to drive mitochondrial dysfunction with increased glucose uptake in fibroblasts, mimicking the glycolytic phenotype of cancer-associated fibroblasts.
  • oxidative stress initiated in tumor cells is transferred to cancer-associated fibroblasts.
  • Then, cancer-associated fibroblasts show quantitative reductions in mitochondrial activity and compensatory increases in glucose uptake, as well as high ROS production
  • These findings may explain the prognostic value of a loss of stromal Cav-1 as a marker of a “lethal” tumor microenvironment
  • aerobic glycolysis takes place in cancer-associated fibroblasts, rather than in tumor cells, as previously suspected.
  • our results may also explain the “field effect” in cancer biology,5 as hydrogen peroxide secreted by cancer cells, and the propagation of ROS production, from cancer cells to fibroblasts, would create an increasing “mutagenic field” of ROS production, due to the resulting DNA damage
  • Interruption of this process, by addition of catalase (an enzyme that detoxifies hydrogen peroxide) to the tissue culture media, blocks ROS activity in cancer cells and leads to apoptotic cell death in cancer cells
  • In this new paradigm, cancer cells induce oxidative stress in neighboring cancer-associated fibroblasts
  • cancer-associated fibroblasts have the largest increases in glucose uptake
  • cancer cells secrete hydrogen peroxide, which induces ROS production in cancer-associated fibroblasts
  • Then, oxidative stress in cancer-associated fibroblast leads to decreases in functional mitochondrial activity, and a corresponding increase in glucose uptake, to fuel aerobic glycolysis
  • cancer cells show significant increases in mitochondrial activity, and decreases in glucose uptake
  • fibroblasts and cancer cells in co-culture become metabolically coupled, resulting in the development of a “symbiotic” or “parasitic” relationship.
  • cancer-associated fibroblasts undergo aerobic glycolysis (producing lactate), while cancer cells use oxidative mitochondrial metabolism.
  • We have previously shown that oxidative stress in cancer-associated fibroblasts drives a loss of stromal Cav-1, due to its destruction via autophagy/lysosomal degradation
  • a loss of stromal Cav-1 is sufficient to induce further oxidative stress, DNA damage and autophagy, essentially mimicking pseudo-hypoxia and driving mitochondrial dysfunction
  • loss of stromal Cav-1 is a powerful biomarker for identifying breast cancer patients with early tumor recurrence, lymph-node metastasis, drug-resistance and poor clinical outcome
  • this type of metabolism (aerobic glycolysis and autophagy in the tumor stroma) is characteristic of a lethal tumor micro-environment, as it fuels anabolic growth in cancer cells, via the production of high-energy nutrients (such as lactate, ketones and glutamine) and other chemical building blocks
  • the upstream tumor-initiating event appears to be the secretion of hydrogen peroxide
  • one such enzymatically-active protein anti-oxidant that may be of therapeutic use is catalase, as it detoxifies hydrogen peroxide to water
  • numerous studies show that “catalase therapy” in pre-clinical animal models is indeed sufficient to almost completely block tumor recurrence and metastasis
  • by eliminating oxidative stress in cancer cells and the tumor microenvironment,55 we may be able to effectively cut off the tumor's fuel supply, by blocking stromal autophagy and aerobic glycolysis
  • breast cancer patients show systemic evidence of increased oxidative stress and a decreased anti-oxidant defense, which increases with aging and tumor progression.68–70 Chemotherapy and radiation therapy then promote further oxidative stress.69 Unfortunately, “sub-lethal” doses of oxidative stress during cancer therapy may contribute to tumor recurrence and metastasis, via the activation of myofibroblasts.
  • a loss of stromal Cav-1 is associated with the increased expression of gene profiles associated with normal aging, oxidative stress, DNA damage, HIF1/hypoxia, NFκB/inflammation, glycolysis and mitochondrial dysfunction
  • cancer-associated fibroblasts show the largest increases in glucose uptake, while cancer cells show corresponding decreases in glucose uptake, under identical co-culture conditions
  • Thus, increased PET glucose avidity may actually be a surrogate marker for a loss of stromal Cav-1 in human tumors, allowing the rapid detection of a lethal tumor microenvironment.
  • it appears that astrocytes are actually the cell type responsible for the glucose avidity.
  • In the brain, astrocytes are glycolytic and undergo aerobic glycolysis. Thus, astrocytes take up and metabolically process glucose to lactate.7
  • Then, lactate is secreted via a mono-carboxylate transporter, namely MCT4. As a consequence, neurons use lactate as their preferred energy substrate
  • both astrocytes and cancer-associated fibroblasts express MCT4 (which extrudes lactate) and MCT4 is upregulated by oxidative stress in stromal fibroblasts.34
  • In accordance with the idea that cancer-associated fibroblasts take up the bulk of glucose, PET glucose avidity is also now routinely used to measure the extent of fibrosis in a number of human diseases, including interstitial pulmonary fibrosis, postsurgical scars, keloids, arthritis and a variety of collagen-vascular diseases.
  • PET glucose avidity and elevated serum inflammatory markers both correlate with poor prognosis in breast cancers.
  • PET signal over-estimates the actual anatomical size of the tumor, consistent with the idea that PET glucose avidity is really measuring fibrosis and inflammation in the tumor microenvironment.
  • human breast and lung cancer patients can be positively identified by examining their exhaled breath for the presence of hydrogen peroxide.
  • tumor cell production of hydrogen peroxide drives NFκB-activation in adjacent normal cells in culture6 and during metastasis,103 directly implicating the use of antioxidants, NFκB-inhibitors and anti-inflammatory agents, in the treatment of aggressive human cancers.
  • Nathan Goodyear on 12 Nov 14
     
    Good description of the communication between cancer cells and fibroblasts.  This theory is termed the "reverse Warburg effect".
trungtamnamkhoa

Learn About Male Foreskin Disease - Men's Health Clinic - 1 views

menhealth.vn/...bao-quy-dau

hormone Testosterone Men Disease Male cancer health healthy

shared by trungtamnamkhoa on 25 Jun 19 - No Cached
  • trungtamnamkhoa on 25 Jun 19
     
    Long foreskin It was a situation in which he was always so shy when he opened his eyes even though he could easily go out easily, without pain, without tightening. Even when "greeting the flag" he kept hiding the ball under the glans or just poking out. Must have to wait for the hand of "big brother" to slide down to bear the road to see the world around. When you have a clear understanding of the above concepts, the men of the race race to wonder, "Why is the foreskin of my friend not narrowed but why are my and my brother's bad luck?". The doctor asked for the correct answer, partly because of his bad luck, from birth to growing up, the foreskin was like that, "keep loving and protecting the foreskin." But it is not uncommon for other reasons to make men suffer because of foreskin: First, we have to recall the untimely and improper foreskin effects of parents when children are young. It is these overly "anxious" actions of parents that have counterproductive and narrowed down the latter. There are some autoimmune diseases, making the foreskin a fibrous day, loss of elasticity, gradually worsening, called BXO (balanitisxerotica obliterans) - a narrowed glans. This can also be interpreted as a form of glans, which can even cause narrowing of the urinary tract to lead to urinary retention. Some cases of glans and foreskin have been repeatedly infected by microbiological agents (bacteria, viruses, fungi, etc.), which can be re-infected and non-stop treatment is also available. can lead to complications of fibrosis and secondary stenosis
communicationmem

Heart Patient Support - 0 views

heartpatientsupport.blogspot.com

Disease

shared by communicationmem on 31 Aug 19 - No Cached
  • communicationmem on 31 Aug 19
     
    My heart attack is a life changing event. I am always aware of this fact that when I am speaking to a loved one, it could be the last conversation that I have with them. My coronary arteriography present that I have three vessel diseases. Please support me for getting heart treatment.
trungtamnamkhoa

[BẬT MÍ]✅13 LOẠI THUỐC CƯỜNG DƯƠNG TỐT NHẤT 2020 ĐƯỢC QUÝ ÔNG TIN DÙNG✅ - 0 views

tolariz.com/thuoc-cuong-duong

cosmetic author heathy love something tolariz tolarizcom couple sex

shared by trungtamnamkhoa on 25 Feb 20 - No Cached
  • trungtamnamkhoa on 25 Feb 20
     
    Theo một số bằng chứng nghiên cứu cho thấy rằng rối loạn chức năng tình dục là phổ biến đối với cả nam và nữ, trong đó nam giới chiếm 31%. May mắn thay, hầu hết các trường hợp rối loạn chức năng sinh lý có thể điều trị được, vì vậy điều quan trọng là cần có sự hiểu biết rõ về vấn đề này để tìm được phương pháp cũng như các loại thuốc hỗ trợ cường dương phù hợp để đạt được hiệu quả đối với vấn đề bản thân nam giới gặp phải. Đối tượng sử dụng thuốc cường dương? Nam giới bị các vấn đề liên quan đến các bệnh lý như: Rối loạn xuất tinh, xuất tinh sớm, ức chế hoặc chậm xuất tinh, xuất tinh ngược, rối loạn cương dương (khó cương dương vật), giảm ham muốn tình dục,.. Tác dụng của thuốc cường dương đối với sinh lý phái mạnh Tùy vào vấn đề mà nam giới gặp phải, nam giới có thể chọn các sản phẩm phù hợp với mục đích hỗ trợ điều trị đối với mỗi cá nhân để đạt được nhu cầu bản thân mong muốn như: Cải thiện chức năng cương dương giúp đạt được hoặc duy trì sự cương cứng phù hợp cho giao hợp. Kiểm soát thời gian xuất tinh, dễ bị kích thích hoặc hưng phấn khi hoạt động tình dục. Hỗ trợ điều trị xuất tinh vắng mặt ,tình trạng trì hoãn mặc dù kích thích tình dục đầy đủ. Bài viết thuốc cường dương này được viết từ Mỹ Phẩm Tolariz: https://tolariz.com/thuoc-cuong-duong/
ivfconcep

How does surrogacy work - Complete Parents Guide to find a loving surrogate mother - 0 views

surrogacy in California surrogate mother cost surrogacy laws in colombia

shared by ivfconcep on 21 Nov 19 - No Cached
  • ivfconcep on 21 Nov 19
     
    It is true that Surrogate mothers are real angels for childless couples. But to know how does surrogacy work is important questions to be answered first.
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