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Nathan Goodyear

Green tea (-)-epigallocatechin-3-gallate reduces b... [Ann Nutr Metab. 2009] - PubMed r... - 0 views

  • green tea EGCG effectively reduces adipose tissue mass and ameliorates plasma lipid profiles in high-fat diet-induced obese mice.
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    Green tea extract and weight loss in obesity
Nathan Goodyear

Conjugated Linoleic Acid Supplementation for 8 Weeks Does Not Affect Body Composition, ... - 0 views

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    CLA not shown to be beneficial in short-term weight loss
Nathan Goodyear

The Effect of Testosterone Replacement on Endogenous Inflammatory Cytokines and Lipid P... - 0 views

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    Testosterone lowers inflammation and lowers total cholesterol
Nathan Goodyear

Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adipo... - 0 views

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    fructose intake increases obesity 
Nathan Goodyear

Curcumin Inhibits Adipogenesis in 3T3-L1 Adipocytes and Angiogenesis and Obesity in C57... - 0 views

  • Dietary polyphenols may suppress growth of adipose tissue through their antiangiogenic activity and by modulating adipocyte metabolism
  • curcumin, the major polyphenol in turmeric spice
  • curcumin suppression of angiogenesis in adipose tissue together with its effect on lipid metabolism in adipocytes may contribute to lower body fat and body weight gain
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  • Our findings suggest that dietary curcumin may have a potential benefit in preventing obesity
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    Curcumin useful in obesity
Nathan Goodyear

Consuming fructose-sweetened, not gluco - PubMed Mobile - 0 views

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    fructose and glucose are not one in the same.  Fructose increases cholesterol problems, reduces insulin sensitivity and increases fat
Nathan Goodyear

Nutrapharmacology of Tocotrienols for Metabol... [Curr Pharm Des. 2011] - PubMed - NCBI - 0 views

  • This review evaluates the effects of tocotrienols on the risk factors of metabolic syndrome using data from human, animal and in vitro studies. Tocotrienols improved lipid profiles and reduced atherosclerotic lesions, decreased blood glucose and glycated hemoglobin concentrations, normalized blood pressure, and inhibited adipogenesis.
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    Tocotrienols, vitamin E, shown to improve metabolic syndrome risk factors.
Nathan Goodyear

The relationship between sex hormones and lipi... [Int J Cardiol. 2005] - PubMed - NCBI - 0 views

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    High aromatase activity and estradiol production in men was found to be associated with elevated total cholesterol, LDL, TC:HDL, and triglycerides.  No association was found with Testosterone or SHBG.  The 111 men in this study had "stable CAD"
Nathan Goodyear

Sex hormones and high density lipoproteins i... [Atherosclerosis. 1979] - PubMed - NCBI - 0 views

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    Higher serum testosterone levels associated with higher HDL
Nathan Goodyear

Sex hormone-binding globulin is a major dete... [Atherosclerosis. 2005] - PubMed - NCBI - 0 views

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    SHBG positively associated with HDL and negatively associated with triglycerides.
Nathan Goodyear

Plasma testosterone, high density lipoprotein c... [Am J Cardiol. 1981] - PubMed - NCBI - 0 views

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    Free and total Testosterone in men found to be positively associated with HDL, but negatively associated with triglycerides and VLDL in this study.
Nathan Goodyear

Apolipoproteins versus lipids as indices of coronary risk and as targets for statin tre... - 0 views

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    apo B is a surrogate marker for LDL particle #.  However, it is an independent risk biomarker itself.
Nathan Goodyear

American College of Cardiology Foundation | Journal of the American College of Cardiolo... - 0 views

  • Lp(a) is a circulating lipoprotein composed of liver-derived apo(a) covalently bound to apoB, which is similar in lipid composition to apoB of LDL
  • multiple studies have shown that elevated Lp(a) levels are independently and linearly predictive of future CVD
  • higher levels were continuously related to risk of myocardial infarction.
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    good discussion of Lipoprotein(a) and its associated cardiovascular risk.
Nathan Goodyear

Apo B/Apo A-I Ratio is Statistically A Better Predictor of Cardiovascular Disease (CVD)... - 0 views

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    Apo B:apo A1 is a better predictor of cardiovascular risk than a traditional cholesterol panel is.
Nathan Goodyear

The Evaluation of Serum Levels of Testosterone in Type 2 Diabetic Men and Its Relation ... - 0 views

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    Small study of 2 men with type II diabetes finds fasting glucose levels negatively correlate with total and free Testosterone levels, HgbA1c negatively correlated with SHBG only, total cholesterol and LDL negatively correlated with SHBG and total testosterone.  The prevalence of type II diabetes was higher with low free Testosterone than total Testosterone, but both were statistically significant.
Nathan Goodyear

Lower low density lipid cholesterol levels are associated with Parkinson's disease - 0 views

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    Lower LDL levels associated with increased risk of Parkinson's disease.  LDL levels < 113 were associated with a 3.5 fold increase in Parkinson's disease compared to LDL of 138.
Nathan Goodyear

Effect of Dehydroepiandrosterone Replacement on Insulin Sensitivity and Lipids in Hypoa... - 0 views

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    Study finds 50 mg of DHEA improves insulin sensitivity in Hypoadrenal women.  The authors also found and increase in DHEAS, bioavailable T, androstenedione, and a reduced SHBG, insulin, and glucagon.
Nathan Goodyear

Lipid-Lowering Effects of Curcumin in Patients... [Phytother Res. 2014] - PubMed - NCBI - 0 views

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    Spice it up for cholesterol.  Study finds small, but significant, improvement in in HDL, LDL, and triglycerides with daily curcumin in those with metabolic syndrome.
Nathan Goodyear

Testosterone and benign prostatic hyperplasia Jarvis TR, Chughtai B, Kaplan SA, - Asian... - 0 views

  • The prevalence of hypogonadism (often defined as serum testosterone &lt; 300 ng dl−1 ) ranges from 6% [10] to as high as 38%
  • The process of BPH, however, continues as men age and despite the fact their serum testosterone decreases
  • Liu et al. [12] demonstrated that in a group of older males (mean age 59.8 years) that there was not a significant correlation of serum testosterone levels (total, free or bioavailable) with either prostate volume or International Prostate Symptom Score (IPSS)
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  • in eugonadal men, studies have demonstrated that the prostate can increase in volume by approximately 12%
  • There seems to be little doubt that the treatment with testosterone of a young hypogonadal male leads to significant growth of the prostate
  • Behre et al. [22] demonstrated increased prostate volume and prostate-specific antigen (PSA) levels in hypogonadal men
  • Most studies, however, have shown no effect of exogenous androgens on PSA or prostate volume for older hypogonadal males
  • They argue that the prostate is relatively insensitive to changes in androgen concentration at normal levels or in mild hypogonadism because the AR is saturated by androgens and therefore maximal androgen-AR binding is achieved. Conversely, the prostate is very sensitive to changes in androgen levels when testosterone is low
  • saturation model
  • visceral obesity (one of the most significant components of metabolic syndrome) is associated with prostate volume and influences prostate growth during TRT.
  • This hypothesis of inflammation induced LUTS is also argued to be a mechanism for improvement of LUTS with PDE5I
  • The concept, therefore, that treatment with TRT of hypogonadal males with metabolic syndrome might lead to improvement/stabilization of their LUTS, appears to be confirmed in recent work by Francomano et al.
  • There was also an improvement in components of the patient's metabolic syndrome (such as BMI, waist circumference, hemoglobin A1c [HbA1c], insulin sensitivity, and lipid profile) as well as inflammatory markers and C-reactive protein.
  • They concluded that TRT was safe in this group of men, and hypothesize that TRT mitigates the pro-inflammatory factors associated with metabolic syndrome.
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    Authors review the literature behind Testosterone and BPH.  The authors highlight the 4 proposed theories behind BPH: Testosterone, Estrogen, inflammation, and metabolic.   The conclusion is mixed: pointing out that no high level of evidence exists on either side of the debate of Testosterone and BPH.
Nathan Goodyear

N-Acetylcysteine for Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis o... - 0 views

  • compared effects of NAC with placebo or metformin in women with PCOS
  • NAC significantly improved rates of live births and spontaneous ovulation compared to placebo in women with PCOS
  • we found no evidence of effects of NAC on improving menstrual regularity, acne, hirsutism, BMI, fasting insulin, fasting glucose, or HOMA-IR
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  • NAC was not associated with greater benefits to metformin for improving pregnancy rate, spontaneous ovulations, and menstrual regularity
  • Metformin also improved the BMI, total testosterone, insulin level, and lipid levels compared to NAC
  • All the studies were of short duration (three months)
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    Data review finds NAC improves pregnancy rates and ovulation rates in women with PCOS against placebo.  Meta-analysis revealed limited studies on the topic.  When compared to metformin, there was no difference found.  Though, one wonders if attacking insulin resistance through proper diet and additional neutraceutical approach would negate that.  The reason?  NAC and metformin are working in different biochemical pathways.  The authors here seem to not realize this. It appears that they think NAC and metormin are both working in the same manner, but they don't.  The fact that there is still benefit found compared to placebo, despited the authors lack of understanding of what NAC is and does is a positive.
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