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Nathan Goodyear

Inhibition of lipid peroxidation and pr... [Biochim Biophys Acta. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16236451

lipid peroxidation curcumin

shared by Nathan Goodyear on 03 Nov 13 - No Cached
  • Nathan Goodyear on 03 Nov 13
     
    Animal model finds that curcumin inhibits lipid peroxidation.
Nathan Goodyear

The adipose tissue metabolism: role of testosterone and dehydroepiandrosterone. - PubMe... - 0 views

www.ncbi.nlm.nih.gov/...10997611

Testosterone DHEA lipoprotein lipase adipose tissue hormones

shared by Nathan Goodyear on 17 Jun 15 - No Cached
  • T inhibits lipid uptake and lipoprotein-lipase (LDL) activity in adipocytes, and stimulates lipolysis
  • T inhibits differentiation of adipocyte precursor cells
  • DHEA stimulates resting metabolic rate (RMR) and lipid oxidation, and enhances glucose disposal, by increasing the expression of GLUT-1 and GLUT-4 on fat cell plasma membrane
  • ...2 more annotations...
  • The insulin-like effect of DHEA would be associated to a decrease of plasma insulin concentrations and, thus, to an increase of the molar ratio between lipolytic hormones and insulin
  • the fat-reducing effect of both T and DHEA seems to be more evident at the level of visceral adipose tissue
  • Nathan Goodyear on 17 Jun 15
     
    Testosterone inhibits lipid uptake into adipocytes.  Testosterone inhibits lipoprotein lipase.  Testosterone stimulated lipolysis.  Testosterone inhibits adipocyte differentiation of proginator cells. DHEAs effects are through different mechanisms.   Both have a preference for activity with visceral adipose tissue.
Nathan Goodyear

Cambridge Journals Online - Abstract - Effects of whey protein isolate on body composit... - 0 views

journals.cambridge.org/...displayAbstract

Whey protein elevated cholesterol insulin resistance diabetes

shared by Nathan Goodyear on 20 Jan 11 - No Cached
  • The present study demonstrated that supplementation with whey proteins improves fasting lipids and insulin levels in overweight and obese individuals.
  • Nathan Goodyear on 20 Jan 11
     
    Whey protein improves fasting lipids and insulin levels
Nathan Goodyear

Arch Intern Med -- Abstract: Effect of Different Antilipidemic Agents and Diets on Mort... - 0 views

archinte.ama-assn.org/...725

Omega-3 fish oil lipids cholesterol

shared by Nathan Goodyear on 15 Feb 11 - No Cached
  • Statins and n-3 fatty acids are the most favorable lipid-lowering interventions with reduced risks of overall and cardiac mortality.
  • Nathan Goodyear on 15 Feb 11
     
    Omega-3 most favorable lipid lowering agent
Nathan Goodyear

Effect of vitamin C on blood glucose, serum lipids... [Indian J Med Res. 2007] - PubMed... - 0 views

www.ncbi.nlm.nih.gov/...18160753

vitamin C blood glucose lipids cholesterol

shared by Nathan Goodyear on 09 Jul 11 - No Cached
  • Nathan Goodyear on 09 Jul 11
     
    1,000 mg Vitamin C improves Blood glucose and lipid levels in Type II DM. Also, known to improve HbA1c levels as well
Nathan Goodyear

Association of serum testosterone with lipid abnormalities in patients with angiographi... - 0 views

www.ncbi.nlm.nih.gov/...PMC3872686

Testosterone male men hormone hormones lipids HDL LDL cholesterol CAD coronary artery disease coronary heart disease

shared by Nathan Goodyear on 08 Jan 14 - No Cached
  • Nathan Goodyear on 08 Jan 14
     
    This study looked at Total serum Testosterone and lipid profiles in men with CAD.  What they found is that serum Total Testosterone is positively associated with HDL and negatively associated with LDL.
Nathan Goodyear

PPARγ and human metabolic disease - 0 views

www.ncbi.nlm.nih.gov/...PMC1386124

PPAR-gamma perioxisome proliferator-activated receptor disease PPAR

shared by Nathan Goodyear on 24 Jan 13 - No Cached
  • PPARα and PPARδ appear primarily to stimulate oxidative lipid metabolism
  • PPARγ is principally involved in the cellular assimilation of lipids via anabolic pathways
  • PPARs are members of the nuclear hormone receptor superfamily
  • ...7 more annotations...
  • Expression of PPARγ is highest in adipose tissue,
  • PPARγ also plays a key role in the entraining of adipose tissue lipid metabolism to nutritional state
  • Its expression is highest postprandially
  • its activation leads to upregulation of genes that mediate FA uptake and trapping
  • PPARγ may also promote futile cycling in adipocytes between triglyceride (TG) esterification and de-esterification
  • its high expression in macrophages, which are now known to infiltrate the dysfunctional adipose tissue of obese subjects
    • Nathan Goodyear
      Nathan Goodyear on 28 Aug 14
       
      PPAR gamma is associated with adipocyte differentiation and lipid storage.
  • Nathan Goodyear on 24 Jan 13
     
    review of PPAR gamma
  • Blu Electronic Cigarettes on 03 Sep 14
     
    very informative! Thanks for sharing!
Nathan Goodyear

http://www.eurjmedres.com/content/pdf/s40001-014-0056-6.pdf - 0 views

www.eurjmedres.com/...s40001-014-0056-6.pdf

Testosterone therapy treatment diet exercise low T low Testosterone low T Diabetes BMI weight HgbA1c hypertension blood pressure men male hormone hormones

shared by Nathan Goodyear on 27 Oct 14 - No Cached
  • Nathan Goodyear on 27 Oct 14
     
    Testosterone therapy in obese men with type II Diabetes and low T improved weight,  lipids, HgbA1c, and blood pressure.  There was more improvement with Leptin than with diet/exercise alone. What is very important is that the control group (diet, exercise, DM meds) had improvement in Testosterone levels, HgbA1c, lipids, BMI, and blood pressure; just not as strong as the treatment arm with Testosterone.
Nathan Goodyear

Penetration of Dihydroartemisinin into Cerebrospinal Fluid after Administration of Intr... - 0 views

www.ncbi.nlm.nih.gov/...PMC148951

dihydroartemisinin artesunate malaria

shared by Nathan Goodyear on 22 May 20 - No Cached
  • Nathan Goodyear on 22 May 20
     
    Artesunate has low lipid solubility and doesn't cross BBB well; but it's high lipid soluble metabolite dihydroartemisinin does.
Nathan Goodyear

Effect of systemic vitamin C on free fatty ac... [Diabetes Metab. 2004] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15671911

vitamin C lipid peroxidation antioxidant vitamin

shared by Nathan Goodyear on 05 Jun 13 - No Cached
  • Nathan Goodyear on 05 Jun 13
     
    Vitamin C shown to improve endothelial function, but not shown to decrease lipid peroxidation marker.
Nathan Goodyear

New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-relate... - 0 views

www.ncbi.nlm.nih.gov/...21442412

curcumin polyphenols obesity diabetes lipids inflammation leptin resistance adiponectin

shared by Nathan Goodyear on 05 Jun 16 - No Cached
  • Nathan Goodyear on 05 Jun 16
     
    Review article of Curcumin, a polyphenol, reduces insulin resistance, leptin resistance,  elevated glucose levels, elevated lipids, and inflammation in obesity and metabolic dysfunction.  Adiponectin levels were increased.
Nathan Goodyear

Multiple Sclerosis is not a Disease of the Immune System - 0 views

dl.dropbox.com/...MS_Not_an_Immune_Disease.pdf

MS multiple sclerosis inflammation inflammatory condition disease lipid metabolism autoimmune

shared by Nathan Goodyear on 03 Jan 12 - No Cached
  • Nathan Goodyear on 03 Jan 12
     
    good read on an alternate hypothesis of the pathophysiology of MS. THe author proposes that MS is an inflammatory induced dysfunction of lipid metabolism. This is in contrast to the current held dogma that MS is an autoimmune disease.
Nathan Goodyear

Pathway Central: PPAR Pathway - 0 views

www.sabiosciences.com/pathway.php

PPAR lipid metabolism

shared by Nathan Goodyear on 05 Jan 12 - No Cached
  • Nathan Goodyear on 05 Jan 12
     
    good description of the different types of PPAR's.  PPAR's are nuclear transcription factors that regulate lipid metabolism and mitochondrial function.
Nathan Goodyear

PPARs, Obesity, and Inflammation - 0 views

www.ncbi.nlm.nih.gov/...PMC1783744

PPARs PPAR obesity overweight weight-loss lipid metabolism

shared by Nathan Goodyear on 05 Jan 12 - No Cached
  • Nathan Goodyear on 05 Jan 12
     
    PPARs and how they regulate lipid metabolism.  PPARs play a critical role in obesity and inflammation
Nathan Goodyear

Obesity - Amelioration of Lipid Abnormalities by [alpha]-Lipoic acid Through Antioxidat... - 0 views

www.nature.com/...oby2011121a.html

ALA alpha-lipoic-acid lipoic acid obesity insulin oxidative stress damage inflammation inflammatory markers cytokine cytokines TNF-alpha IL-6 adiponectin IV intravenous oxidized LDL

shared by Nathan Goodyear on 01 Aug 12 - No Cached
  • Nathan Goodyear on 01 Aug 12
     
    alpha lipoic acid found to improve insulin sensitivity and reduce oxidative stress and inflammatory markers.  In this study, IV ALA was given daily for 2 weeks, and the result was reduced oxidized LDL and all other lipids, improved insulin sensitivity, reduced TNF-alpha, IL-6, and 8-iso-prostaglandin, and increased adiponectin.
Nathan Goodyear

Apolipoprotein E allele-dependent antioxidant activity in brains with Alzheimer's disease - 0 views

www.neurology.org/...2319.abstract

antioxidant alzheimer disease brains neurology brain TBARS oxidative stress lipid peroxidation

shared by Nathan Goodyear on 13 Jun 12 - No Cached
  • Nathan Goodyear on 13 Jun 12
     
    TBARS were found elevated in Alzheimer's individuals.  TBARS are the result of oxidative stress.  Thus TBARS can be used to evaluate lipid peroxidation (oxidative damage) in the brain.
Nathan Goodyear

The relationship between endogenous testost... [Eur J Endocrinol. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24394726

Testosterone total cholesterol cholesterol lipids triglycerides LDL HDL men male hormone hormones

shared by Nathan Goodyear on 17 Jan 14 - No Cached
  • Nathan Goodyear on 17 Jan 14
     
    Study finds Testosterone inversely associated with TC, TG, and LDL, but positively associated with HDL.  The evidence on Testosterone and lipids are mixed.  This study shows positive effects all the way around.
Nathan Goodyear

Effects of androgen supplementation of hormone... [Fertil Steril. 2001] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...11476766

Testosterone women female hormones hormone CVD cardiovascular disease health lipids

shared by Nathan Goodyear on 20 Mar 14 - No Cached
  • Nathan Goodyear on 20 Mar 14
     
    Testosterone therapy in post menopausal women appears to have adverse cardiovascular effects in women.  The negative effects were an increase in Pulsatility index and adverse change in lipid profiles.  This seemed to counter the positive effects by estrogen.  Others have proposed that combination E2 and T therapy hide the negative effects of testosterone on CV health in women.
Nathan Goodyear

SCD1 activity in muscle increases triglyceride PUFA content, exercise capacit... - 0 views

www.jlr.org/2636

lipids fat oxidation metabolism PUFA PPAR SCD

shared by Nathan Goodyear on 07 Oct 13 - No Cached
  • Nathan Goodyear on 07 Oct 13
     
    mice study suggests that increased linoleic acid increases lipid oxidation and increases metabolic rate and muscle performance.  The point is that some fat is good.  Too much Linoleic acid is pro-inflammatory which would promote adiposity.  The key is balance.
Nathan Goodyear

Colonization-Induced Host-Gut Microbial Metabolic Interaction - 0 views

mbio.asm.org/...e00271-10.full

gut flora gut microbiome gut microbiota CYP450 metabolism

shared by Nathan Goodyear on 06 May 15 - No Cached
  • he gut microbiota enhances the host’s metabolic capacity for processing nutrients and drugs and modulate the activities of multiple pathways in a variety of organ systems.
  • Acquisition of the gut microbiota was associated with rapid increase in body weight (4%) over the first 5 days of colonization
  • The colonization process stimulated glycogenesis in the liver prior to triggering increases in hepatic triglyceride synthesis
  • ...11 more annotations...
  • modifications of hepatic Cyp8b1 expression and the subsequent alteration of bile acid metabolites
  • Expression and activity of major drug-metabolizing enzymes (Cyp3a11 and Cyp2c29) were also significantly stimulated
  • The gut microbiota (GM) exhibits a relatively low level of diversity compared to those of most soil ecosystems and in humans it is comprised of usually no more than nine phyla of microorganisms, of which only two are dominant: the Firmicutes and the Bacteroidetes
  • colonization of a germfree gut was rapid and remarkably stable, establishing within only a week after first exposure
  • a study conducted on germfree rats by Nicholls et al. showed that 3 weeks were necessary to obtain a stabilization and “normalization”
  • the microbiota status affects the systemic metabolism of the host, modulating the metabolic fingerprint of topographically remote organs such as the liver and the kidney
  • Gut colonization induces a rapid weight gain associated with stimulation of hepatic glycogenesis and triglyceride synthesis
  • Gut colonization alters bile acid metabolite profiles via modulation of hepatic Cyp8b1 expression
  • Bile acids are well-known contributors to glucose and lipid metabolism in the liver
  • GM is known to alter bile metabolism
  • GM is also known to exert a strong influence on the metabolism of xenobiotics
  • Nathan Goodyear on 06 May 15
     
    The effects of gut microbiome are not confined to the gut.  They alter bile acid metabolism and thus lipid/glucose metabolism.  They alter CYP450 activity.  They effect metabolism.  They effect the metabolism, and thus effects, of other drugs. 
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