Skip to main content

Home/ Dr. Goodyear/ Group items tagged insulin-resistant

Rss Feed Group items tagged

Filter: All | Bookmarks | Topics Simple Middle
Nathan Goodyear

Metabolic Effects of Dietary Fiber Consumption and Prevention of Diabetes - 0 views

jn.nutrition.org/...439.long

soluble insoluble fiber dietary diet nutrition diabetes

shared by Nathan Goodyear on 22 Oct 13 - No Cached
  • DF are highly complex substances that can be described as any nondigestible carbohydrates and lignins not degraded in the upper gut
  • Commonly, DF are classified according to their solubility in water, even though grading according to viscosity, gel-forming capabilities, or fermentation rate by the gut microbiota might be physiologically more relevant
  • Main sources of soluble DF are fruits and vegetables
  • ...8 more annotations...
  • n increased intake of total DF was inversely associated with markers of insulin resistance in several studies
  • consumption of insoluble DF increased whole body glucose disposal independent of changes in body weight in both short-term and more prolonged studies
  • Short-chain fatty acids (SCFA) such as acetate, propionate, and butyrate are produced by bacterial fermentation of indigestible DF polysaccharides in the colon
  • increased production of SCFA is assumed to be beneficial by reducing hepatic glucose output and improving lipid homeostasis
  • a high DF diet (oligofructose) reduced gram-negative bacterial content and body weight, whereas a high fat diet increased the proportion of a gram-negative bacterial lipopolysaccharides (LPS) containing microbiota in humans
  • Prospective cohort studies indicate that diets high in insoluble cereal DF and whole grains might reduce diabetes risk
  • soluble DF (i.e., pectin, inulin, and β-glucans)
  • cereal DF (i.e., cellulose and hemicelluloses)
  • Nathan Goodyear on 22 Oct 13
     
    Good discussion of dietary fiber intake and Diabetes.  
Nathan Goodyear

Scopus - Document details - 0 views

www.scopus.com/...display.url

high protein diet Diabetes insulin resistance

shared by Nathan Goodyear on 22 Oct 13 - No Cached
  • Nathan Goodyear on 22 Oct 13
     
    High protein intake associated with increased type II Diabetes.  Many take in too much protein and actually need to increase fat and fiber rich carbs.
Nathan Goodyear

Effects of Weight Loss and Long-Term Weight Maintenance With Diets Varying in Protein a... - 0 views

circ.ahajournals.org/...2829.long

inflammation high protein diet obesity insulin resistance

shared by Nathan Goodyear on 21 Oct 13 - No Cached
  • Nathan Goodyear on 21 Oct 13
     
    High protein and high glycemic index intake are both associated with low grade inflammation.  An associated increase in cardiovascular risk was additionally found.
Nathan Goodyear

C-reactive protein, the metabolic syndrome, and pr... [Circulation. 2004] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...15262834

CRP metabolic syndrome cardiovascular disease

shared by Nathan Goodyear on 11 Feb 11 - No Cached
  • Elevated CRP levels are related to insulin resistance and the presence of the MetS, especially in women
  • both CRP and MetS are independent predictors of new CVD events.
  • Nathan Goodyear on 11 Feb 11
     
    elevated CRP helps predict metabolic syndrome and cardiovascular disease
Nathan Goodyear

Too much sugar may cause "brain decay" - Neurology - 0 views

www.neurology.org/...E9.full

sugar diabetes insulin resistance pre-diabetes dementia alzheimer's

shared by Nathan Goodyear on 01 Feb 11 - No Cached
  • Nathan Goodyear on 01 Feb 11
     
    pre-diabetes increases risk of neurodegenerative diseases ie. dementia, Alzheimers...
Nathan Goodyear

KoMCI.org - 0 views

www.komci.org/GSResult.php

D-chiro-inositol insulin signaling Diabetes resistance

shared by Nathan Goodyear on 13 May 11 - No Cached
  • Nathan Goodyear on 13 May 11
     
    D-chiro-inositol shown to be reduced in urinary testing in type 1 and 2 diabetics
Nathan Goodyear

Testosterone Replacement in Hypogonadal Men With Type 2 Diabetes and/or Metabolic Syndr... - 0 views

care.diabetesjournals.org/...828.abstract

testosterone replacement diabetes

shared by Nathan Goodyear on 31 Mar 11 - No Cached
  • CONCLUSIONS Over a 6-month period, transdermal TRT was associated with beneficial effects on insulin resistance, total and LDL-cholesterol, Lpa, and sexual health in hypogonadal men with type 2 diabetes and/or MetS.
  • Nathan Goodyear on 31 Mar 11
     
    Testosterone improves diabetes control in men
Nathan Goodyear

Nonalcoholic Fatty Liver Disease - 0 views

diabetes.diabetesjournals.org/...1844.short

nonalcoholic fatty liver disease metabolic syndrome

shared by Nathan Goodyear on 06 Apr 11 - No Cached
  • aracterized by clinical and laboratory data similar to those found in diabetes and obesity. NAF
  • We concluded that NAFLD, in the presence of normoglycemia and normal or moderately increased body weight, is ch
  • aracterized by clinical and laboratory data similar to those found in diabetes and obesity. NAF
  • ...1 more annotation...
  • LD may be considered an additional feature of the metabolic syndrome, with specific hepatic insulin resistance
  • Nathan Goodyear on 06 Apr 11
     
    Fatty Liver is component of Metabolic Syndrome
Nathan Goodyear

Testosterone deficiency and cardiovascular mortality Morgentaler A, - Asian J Androl - 0 views

www.ajandrology.com/preprintarticle.asp

testosterone low t low Testosterone CVD cardiovascular mortality therapy

shared by Nathan Goodyear on 01 Dec 14 - No Cached
  • overall mortality and CV mortality were inversely associated with serum T concentrations.
  • men with low serum T, defined as < 8.7 nmol l−1 (250 ng dl−1 ), demonstrated significantly greater all-cause mortality than men with higher serum T (hazard ratio [HR]: 2.24; 95% CI: 1.41-3.57), as well as greater CV mortality
  • lower T levels were significantly associated with the presence of any CV disease
  • ...19 more annotations...
  • more than 30 years of studies suggesting that low levels of T represent an increased risk for CV and overall mortality,
  • lower serum T concentrations also are associated with CV disease, including incident coronary artery disease [17],[18],[19] and atherosclerosis,
  • the actual rate of adverse events was only half as great in the T group (123 events in 1223 men at risk = 10.1%) as in the untreated group (1587 events in 7486 men = 21.2%)
  • The study by Vigen et al. [7] has already undergone two published corrections,
  • 29 medical societies have called for retraction of the article, asserting "gross data mismanagement and contamination," that rendered the study "no longer credible
  • Mortality in T-treated men was reduced by approximately half in treated men compared with untreated men, at 10.3% versus 20.7%, respectively
  • The mortality rate for men who received TTh was 3.4 deaths per 100 person-years, and 5.7 deaths per 100 person-years in untreated men
  • HR of 0.61 (95%CI: 0.42-0.88; P = 0.008), indicating a significant reduction in mortality with TTh
  • men in the highest prognostic MI risk quartile, treatment with TTh was associated with reduced risk
  • tripling in T prescriptions in the US over the last decade
  • a majority of observational studies have found that low endogenous serum T levels are associated with increased mortality.
  • Men who received TTh were able to exercise significantly longer without ischemia compared with men who received placebo
  • In men with congestive heart failure, those who received T demonstrated greater walking distance and other functional endpoints compared with those who received placebo
  • TTh has been shown uniformly and repeatedly to improve several known CV risk factors, including reduced fat mass, body fat percent, and waist circumference, and increased lean mass
  • improved glycemic control
  • reductions in insulin resistance.
  • the evidence strongly points to improved CV status with normal serum T or treatment with TTh in men with TD
  • analysis of health insurance claims data that reported a 36% increased rate of nonfatal MI in the 90d following receipt of a T prescription compared with the 12 prior months.
  • Comparison with men who received a prescription for a phosphodiesterase type 5 inhibitor (PDE5i) revealed no increased rate of MI following the prescription
  • Nathan Goodyear on 01 Dec 14
     
    Great review by Morgentaler of Testosterone and CVD.  He highlights the significant flaws in the JAMA and the NEJM articles of Testosterone therapy risks.  Morgentaler highlights the significant evidence that points to low T and increased risk of CVD. On contention I have, is Morgantaler seems to flip aside the massive uptick of Testosterone use in the US as compared to other countries.  The evidence definitely points to Testosterone therapy as being safe in those with low T, but there is definitely a problem of significant Testosterone doping that is taking place as well.
Nathan Goodyear

Fructose: A Key Factor in the Development of Metabolic Syndrome and Hypertension - 0 views

www.hindawi.com/...682673

fructose uric acid metabolic syndrome sugar

shared by Nathan Goodyear on 24 Aug 14 - No Cached
  • HFCS consists of fructose and glucose mixed in a variety of concentrations, but most commonly as 55% fructose and 45% glucose
  • In the United States, HFCS and sucrose are the major sources of fructose in the diet, and HFCS is a major ingredient in soft drinks, pastries, desserts, and various processed foods
  • fructose and glucose are metabolized in completely different ways and utilize different GLUT transporters
  • ...9 more annotations...
  • In the liver, fructose bypasses the two highly regulated steps of glycolysis, catalyzed by glucokinase/hexokinase and phosphofructokinase both of which are inhibited by increasing concentrations of their byproducts. Instead, fructose enters the pathway at a level that is not regulated and is metabolized to fructose-1-phosphate primarily by fructokinase or ketohexokinase
  • Fructokinase has no negative feedback system, and ATP is used for the phosphorylation process. As a result, continued fructose metabolism results in intracellular phosphate depletion, activation of AMP deaminase, and uric acid generation which is harmful at the cellular level
  • Uric acid, a byproduct of fructose degradation,
  • Uric acid inhibits endothelial NO both in vivo and in vitro, [15] and directly induces adipocyte dysfunction
  • Serum uric acid increases rapidly after ingestion of fructose, resulting in increases as high as 2 mg/dL within 1 hour
  • Uncontrolled fructose metabolism leads to postprandial hypertriglyceridemia, which increases visceral adipose deposition. Visceral adiposity contributes to hepatic triglyceride accumulation, protein kinase C activation, and hepatic insulin resistance by increasing the portal delivery of free fatty acids to the liver
  • Several reviews have concluded that intake of both fructose and HFCS by children and adults was associated with an increased risk of obesity and metabolic syndrome
  • Sucrose is a disaccharide that is comprised of fructose and glucose
  • Figure 2
  • Nathan Goodyear on 24 Aug 14
     
    great read and review of the role of fructose in metabolic syndrome.
Nathan Goodyear

Testosterone as Potential Effective Therapy in Treatment of Obesity in Men with Testost... - 0 views

www.ncbi.nlm.nih.gov/...PMC3296126

Testosterone low T low Testosterone men male hormone hormones obesity cardiovascular disease metabolic syndrome insulin resistance CVD Diabetes

shared by Nathan Goodyear on 23 Jan 15 - No Cached
  • Nathan Goodyear on 23 Jan 15
     
    Testosterone therapy in men with low T will improve lean body mass, some reduction in abdominal obesity, yet little effect in visceral obesity.
Nathan Goodyear

Fifty-two-week treatment with diet and exercise plus transdermal te... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19578132

low t low testosterone Testosterone diabetes metabolic syndrome insulin resistance adkiponectin CRP hsCRP men male hormone hormones diet nutrition exercise HgbA1c

shared by Nathan Goodyear on 02 Mar 15 - No Cached
  • Nathan Goodyear on 02 Mar 15
     
    This article finds that Testosterone transdermal therapy addition to Diet and exercise improved glycemic control and reversed Metabolic Syndrome in men with low T and type II Diabetes.  This article really highlights the proper approach to therapy: combined nutrition, exercise, and Testosterone therapy, when indicated, for men with Metabolic Syndrome and/or Diabetes.  A reduction in IR, adiponectin and hsCRP was observed.
Nathan Goodyear

Late-onset hypogonadism among old and middle-aged males with predia... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25657079

low T low Testosterone diabetes insulin resistance HgbA1c Testosterone men male hormone hormones pre-diabetes

shared by Nathan Goodyear on 02 Mar 15 - No Cached
  • Nathan Goodyear on 02 Mar 15
     
    Only abstract available here.  Study of Polish men found lowered Testosterone in men with pre diabetes.  The authors used the term "late onset hypogonadism" here.  An inverse association was found between calculated free Testosteorne and HgbA1c.  The authors conclusion says it all: routine screening of Testosterone in men with pre-diabetes is recommended.
Nathan Goodyear

Association of Mean Platelet Volume With Androgens and Insulin Resistance in Nonobese P... - 0 views

www.ncbi.nlm.nih.gov/...PMC4338650

MPV mean platelet volume androgens Testosterone DHEA women female hormone hormones PCOS CVD cardiovascular disease

shared by Nathan Goodyear on 10 Mar 15 - No Cached
  • Nathan Goodyear on 10 Mar 15
     
    Mean Platelet Volume (MPV) is associated with increased cardiovascular disease in some studies.  Hyperandrogenism is associated with increased CVD in women with PCOS. This study found that elevated androgen levels in non obese women with/without PCOS was associated with lower MPV values.  This stands in contrast to other studies. 
Nathan Goodyear

Growth hormone treatment of abdomina... [J Clin Endocrinol Metab. 1997] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9062473

GH growth hormone hormone hormones men male obesity metabolic syndrome metabolic syndrome insulin resistance cholesterol triglycerides blood pressure fat

shared by Nathan Goodyear on 03 Aug 14 - No Cached
  • Nathan Goodyear on 03 Aug 14
     
    Growth hormone treatment of abdominally obese men reduces abdominal fat mass, improves glucose and lipoprotein metabolism, and reduces diastolic blood pressure.
Nathan Goodyear

http://onlinelibrary.wiley.com/store/10.2164/jandrol.108.005751/asset/jandrol.108.00575... - 0 views

onlinelibrary.wiley.com/...jandrol.108.005751.pdf

low T low Testosterone low T Testosterone insulin resistance IR diabetes metabolic syndrome visceral fat obesity adiposity hypogonadism men male hormone hormones

shared by Nathan Goodyear on 14 Aug 14 - No Cached
  • Nathan Goodyear on 14 Aug 14
     
    Pubmed search finds low T associated IR, type II diabetes, Metabolic syndrome, and increased visceral fat in men.
Nathan Goodyear

Correlation between inflammatory markers a... [J Obstet Gynaecol. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25111421

TNF-alpha pregnancy IR insulin resistance GDM gestational diabetes hsCRP

shared by Nathan Goodyear on 13 Aug 14 - No Cached
  • Nathan Goodyear on 13 Aug 14
     
    Interesting, yet not surprising.  TNF-alpha has strong correlation with IR in pregnancy.  This follows metabolic endotoxemia pathophysiology.  I believe this could be used to assess risk for PIH...
Nathan Goodyear

Role of Oxidative Stress and the Microenvironment in Breast Cancer Development and Prog... - 0 views

www.ncbi.nlm.nih.gov/...PMC3950899

cancer oxidative stress warburg effect reverse warburg effect ROS

shared by Nathan Goodyear on 11 Nov 14 - No Cached
  • oxidative stress leads to HIF-1α accumulation
  • increased levels of hydrogen peroxide in exhaled breath condensate from patients with localized breast malignancy, associated with increased clinical severity
  • Oxidative stress generated by breast cancer cells activates HIF-1α and NFκB in fibroblasts, leading to autophagy and lysosomal degradation of Cav-1
  • ...18 more annotations...
  • Comparing mitochondrial metabolic activity revealed a difference between stroma and epithelial cells
  • metalloproteinases (MMP) such as MMP-2, MMP-3, and MMP-9 increase extracellular matrix turnover and are themselves activated by oxidative stress
  • Overexpression of NOX4 in normal breast epithelial cells results in cellular senescence, resistance to apoptosis, and tumorigenic transformation, as well as increased aggressiveness of breast cancer cells
  • Lowered expression of Cav-1 not only leads to myofibroblast conversion and inflammation but also seems to impact aerobic glycolysis, leading to secretion of high energy metabolites such as pyruvate and lactate that drive mitochondrial oxidative phosphorylation in cancer cells
  • Reverse Warburg Effect
  • secreted transforming growth factor β (TGFβ), insulin-like growth factor (IGF), platelet-derived growth factor (PDGF), fibroblast growth factor 2, and stromal-derived factor 1 (SDF1) are able to activate fibroblasts and increase cancer cell proliferation
  • oxidative stress has an important role in the initiation and preservation of breast cancer progression
  • cancer preventive role of healthy mitochondria
  • the cancer cells produce hydrogen peroxide and by driving the “Reverse Warburg Effect” initiate oxidative stress in fibroblasts. As a result of this process, fibroblasts exhibited reduced mitochondrial activity, increased glucose uptake, ROS, and metabolite production.
  • Oxidative stress results from an imbalance between unstable reactive species lacking one or more unpaired electrons (superoxide anion, hydrogen peroxide, hydroxyl radical, reactive nitrogen species) and antioxidants
  • cancer cells are able to induce drivers of oxidative stress, autophagy and mitophagy: HIF-1α and NFκB in surrounding stroma fibro-blasts
  • Studies show that loss of Cav-1 in adjacent breast cancer stroma fibroblasts can be prevented by treatment with N-acetyl cysteine, quercetin, or metformin
  • However, diets rich in antioxidants have fallen short in sufficiently preventing cancer
  • obstructing oxidative stress in the tumor microenvironment can lead to mitophagy and promote breast cancer shutdown is a promising discovery for the development of future therapeutic interventions.
  • It is widely held that HIF-1α function is dependent upon its location within the tumor microenvironment. It acts as a tumor promoter in CAFs and as a tumor suppressor in cancer cells
  • It was reported that overexpression of recombinant (SOD2) (Trimmer et al., 2011) or injection of SOD, catalase, or their pegylated counterparts can block recurrence and metastasis in mice
  • hydrogen peroxide is one of the main factors that can push fibroblasts and cancer cells into senescence
  • Recent studies show that in the breast cancer microenvironment, oxidative stress causes mitochondrial dysfunction
  • Nathan Goodyear on 11 Nov 14
     
    Really fascinating article on tumor signaling. The article points to a complex signaling between cancer cells and stromal fibroblasts that results in myofibroblast transformation that increases the microenvironment favorability of cancer. This article points to oxidative stress as the primary driving force.  
Nathan Goodyear

Homeostasis in Intestinal Epithelium Is Orchestrated by the Circadian Clock and Microbi... - 0 views

www.sciencedirect.com/...S0092867413004625

gut microbiota microflora flora intestinal epithelial cells metabolism TLRs MAMPs

shared by Nathan Goodyear on 20 Oct 14 - No Cached
  • a lack of microbiota results in a permanent ileal overproduction of corticosterone due to decreased expression of the D-box-binding E4BP4 repressor. This hypercorticosterolism generates systemic metabolic defects (hyperglycemia, insulin resistance, increased TG and FA)
  • Nathan Goodyear on 20 Oct 14
     
    to be read article on the communication between gut microbiota and intestinal epithelial cells and the resultant metabolic impact.
Nathan Goodyear

Increase in Glucose-6-Phosphate Dehydrogenase in Adipocytes Stimulates Oxidative Stress... - 0 views

diabetes.diabetesjournals.org/...2939

G6PD obesity insulin resistance adipocytes

shared by Nathan Goodyear on 10 Jan 19 - No Cached
  • Nathan Goodyear on 10 Jan 19
     
    G6PD as a marker of obesity and IR. G6PD is produced from adipocytes.
« First ‹ Previous 341 - 360 of 366 Next ›
Showing 20▼ items per page