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Award Categories - Pharmacy Business Awards 2023 - 0 views

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    Pharmacy Business will be hosting their annual awards event in the pharmacy calendar with a glittering ceremony to celebrate the very best of community pharmacy. The 23rd edition of the Pharmacy Business Awards will be on Wednesday 4 October 2023 in central London. The awards attract the biggest names in pharmacy, with heads of pharmacy organisations, CEOs of leading manufacturers and wholesalers, health officials and government ministers in attendance. We look forward to bringing together the shining lights of community pharmacy, who show the nation the unique services they continue to provide. All entries must be made on the official online entry form. Please select from the award categories by expanding the drop-down boxes below then click 'Enter now' by selecting the category you would like to enter. You can enter three categories. To complete your entry, agree to the terms and conditions then click the 'COMPLETE' button at the bottom of the page. All submissions must be made by Monday 7th July 2023. Please note only submitted entries will proceed to the judging stage. Nomination date 7th july 2023
umar111

Colour Me Black Perfume - 0 views

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    If you're looking for a new fragrance that can transform your personality, then you must try Colour Me Black perfume. This captivating fragrance has been designed to evoke a sense of sensuality and confidence, and is perfect for those who want to make a bold statement. With its unique blend of exotic and alluring notes, Colour Me Black is a perfume that is sure to turn heads. The Fragrance of Colour me Black Perfume Original Colour Me Black perfume is a seductive fragrance that combines rich and spicy notes to create an alluring aroma. The top notes of this fragrance are made up of bergamot, lavender, and pineapple, which provide a fresh and invigorating scent. The heart notes include jasmine, geranium, and nutmeg, which add a spicy and exotic twist to the fragrance. The base notes of Colour Me Black are made up of cedarwood, musk, and amber, which provide a warm and sensual finish.
wheelchairindia9

Karma Km 2500 Wheelchair - 0 views

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    Karma KM 2500 Small Wheel Wheelchair: Karma KM 2500 Small Wheel Wheelchair Specifications: Width 18" Front/Rear Wheels 6" to 14" Seat Width 47cm Seat Depth 40cm Overall Width 66cm Overall Collapsed Width 36cm Armrest Height 21cm Overall Length 90cm Seat Height 47cm Backrest Height 38cm Overall Height 86cm Weight 9.2 k.g. Karma KM 2500 Small Wheel Wheelchair Seat and Back: AEGIS Microbe Shield Approved by the FDA, EPA, EU, etc., bonded anti-microbial barrier upholstery protects from odor, staining and deterioration from bacteria, fungus and other microorganisms. It is a shield for your health. Karma KM 2500 Small Wheel Wheelchair Extended Armrest: By simulating the natural position of arms, the extended armrest design is ergonomic and creates bigger seating space. An Ultra lightweight wheelchair (9.2 kg) with a compact design for either attendant assisted or self propelling users. The use of aircraft-grade aluminium alloy and double cross brace provide this model with outstanding strength and durability. Karma Healthcare KM-2500 Premium Wheelchair is amazingly light and compact transit wheelchair which is ideal for outings and travelers. It folds down to take up virtually no space in the boot of a car and weighs just over 9.2 kg making it easy for anyone to lift into a vehicle. Backrest folds-down for easy transportation. Maximum user weight: 100 K.g. Aluminium frame. Fixed armrest/fixed footrest. Foldable frame via double cross bars. Comfortable & durable upholstery. Swing-away foot plates. Puncture proof tyres. Attendant cable brake. 14" flat-free rear wheels. Detachable and washable cushion. One Year Warranty. It folds down to take up virtually no space in the boot of a car. This amazingly light and compact transit wheelchair is ideal for outings and travelling. It comes with detachable and washable cushion. The wheel chair has attendant cable brake. It is made from aircraft-grade aluminium alloy fra
Nathan Goodyear

Heading in soccer - 0 views

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    Increased risk associated with headers in soccer. Only about 50% respondent rate in the questionnaires though.
Nathan Goodyear

Mild Traumatic Brain Injury in UK Military Personnel Returni... : The Journal of Head T... - 0 views

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    Prevalence of mild Traumatic Brain Injury was found to be 9.5% in returning US soldiers.  This was associated with PTSD and Etoh abuse.
Nathan Goodyear

Progesterone neuroprotection in trauma... [Front Neuroendocrinol. 2009] - PubMed - NCBI - 0 views

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    Progesterone has a neuroprotective and promyelinating effects in the nervous system.  Progesterone increases BDNF.  Progesterone increases proliferation and differentiation of oligodendrocyte progenitor cells which will increase myelin production.
Nathan Goodyear

Acta Pharmacologica Sinica - The neuroprotective effects of progesterone on traumatic b... - 0 views

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    Good discussion and review of progesterone's role as neuroprotective in TBI.
Nathan Goodyear

Insulin and Sympathoexcitation: It Is Not All in Your Head - 0 views

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    Insulin has a stimulatory effect on the sympathetic system resulting in elevated B/P.  There is a movement by some to put every diabetic on insulin early.  This is seriously flawed and will only contribute to further complications.
wheelchairindia9

Folding Wheelchair - 0 views

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    Lightweight, compact-folding wheelchairs for children, teenagers, and young adults let go anywhere, while still ensuring proper positioning and support. Going to school, appointments and even on vacation is possible with the convenient, lightweight design. Just fold it up and put it in trunk. Foldable Wheelchair by features a powder coat steel frame with durable nylon upholstery and padded armrests. Composite mag wheels with maintenance-free bearings and composite handrims make for a smooth ride. As with anything with moveable parts, the folding wheelchair is not as durable as the rigid frame wheelchair. Therefore maintenance is required more frequently to keep all parts in good working order. Before purchasing a wheelchair, consider all activity level. If traveling often, and need a highly-portable option, a folding lightweight wheelchair may be. Lightweight wheelchairs provide convenience and comfort to the user and caregiver alike and are often built using materials like aluminum and titanium alloy, while foldable wheelchairs allow for easy storage and transport. Merge the two styles, and got a great mobility aid that isn't a pain to lug around. Folding wheelchairs also have removable foot rests which allow for easy folding. Most frames are made from aluminum or titanium and are heavier than the rigid frame. wheelchair is designed to fit the body of the user, while the primary design of the folding wheelchair is to fold. Folding wheelchairs are generally more "boxy" while rigid wheelchairs conform to the shape of the body. This means it can hold the users body in place by tapering the frame and seat. The folding wheelchair cannot be tapered or it would not close completely. Features: Powder coat steel frame. Durable nylon upholstery. Composite mag wheels with maintenance-free bearings. Composite footplates. Padded armrests. Composite handrims. Maximum weight capacity.
Nathan Goodyear

Tumor cytokinetic response to total parenteral nutrition in patients with head and neck... - 0 views

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    Study to look at IV nutrition to see if it promotes tumor growth; actually shows it slows tumor growth
Sonny Cher

Getting High Legally! - 1 views

After getting out of rehab, I still cannot shake off my need to get high. However, I vowed not to resort to illegal drugs again. After consulting a friend about it, he introduced legal drugs and ma...

Kronic

started by Sonny Cher on 27 May 11 no follow-up yet
Nathan Goodyear

Hypopituitarism After Multiple Concussions: A Retrospective Case Study in an Adolescent... - 0 views

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    multiple concussions result in hypopituitarism in 14 year old young man.
Nathan Goodyear

JAMA Network | JAMA Otolaryngology-Head & Neck Surgery | Prevalence of Thyroi... - 0 views

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    study finds active Meniere's disease is associated with hypothyroidism.
Nathan Goodyear

Prevalence of chronic hypopituitarism after blast concussion -- Wilkinson et al. 27 (1)... - 1 views

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    One of the first studies to look at PCS found that 42% of soldiers produced abnormally low hormone production following TBI one year after the injury.  This study highlights the potential pituitary dysfunction that can result from TBI.
Nathan Goodyear

Nivolumab for previously treated unresectable metastatic anal cancer (NCI9673): a multi... - 0 views

  • Patients received a median of six doses of nivolumab
  • four of the first 12 patients had partial responses
  • Nine (24% [95% CI 15–33]) of 37 patients achieved a response (seven partial responses and two complete responses
  • ...16 more annotations...
  • no treatment-related deaths
  • the most common adverse events were anaemia (26 [70%]), fatigue (25 [68%]), and rash
  • hypothyroidism
  • hypothyroidism
  • nivolumab-related autoimmune hypothyroidism, which resolved after a short course of corticosteroids
  • No grade 3 or 4 adverse events occurred
  • Nivolumab resulted in objective responses in 24% of patients with metastatic SCCA
  • Historically, doublet chemotherapy with cisplatin and fluorouracil has been the most common treatment for patients with metastatic SCCA
  • our results suggest that immune checkpoint blockade agents might extend overall survival beyond currently available therapies, especially if provided early in the disease treatment course
  • the dose of nivolumab we used differs from the 2016 recommendation of a fixed 240 mg every 2 weeks
  • 25% of patients develop distant metastases
  • most patients with localised SCCA are cured by chemoradiation
  • More than 90% of cases of SCCA are linked to prior infection with human papillomavirus (HPV)
  • Within tumour cells, HPV oncoproteins are immunogenic and can trigger an anti-tumour host immune response by recruitment of tumour-infiltrating lymphocytes
  • Tumour cells express PD-L1 and, on binding its inhibitory receptor PD-1 on the surface of T cells, downregulate T-cell activation and thwart the local anti-tumour immune response
  • Nivolumab is a humanised monoclonal antibody against PD-1 that disrupts this interaction, enabling T-cell cytotoxicity. It has activity as a monotherapy in advanced solid cancers, such as head and neck cancer, melanoma, non-small-cell lung cancer, and renal cell carcinoma
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    study finds nivolumab helpful in some patients with surgically unresectable or metastatic anal cancer.  The dose used was 3 mg/kg every 2 weeks. 
Nathan Goodyear

Neuroimaging of sport concussion: persistent alterations in brain structure and functio... - 0 views

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    New study suggest brain healing lags far behind in concussion recovery.
Nathan Goodyear

Promising role for Gc-MAF in cancer immunotherapy: from bench to bedside - 0 views

  • MAF precursor activity has also been lost or reduced after Gc-globulin treatment in some cancer cell lines
  • This appears to result from the deglycosylated ɑ-N-acetylgalactosaminidase (nagalase) secreted from cancerous cells
  • Nagalase has been detected in many cancer patients, but not in healthy individuals
  • ...31 more annotations...
  • Studies have shown that the production of nagalase has a mutual relationship with Gc-MAF level and immunosuppression
  • It has been demonstrated that serum levels of nagalase are good prognosticators of some types of cancer
  • The nagalase level in serum correlates with tumor burden and it has been shown that Gc-MAF therapy progresses, nagalase activity decreases
  • It has been shown that Gc-MAF can inhibit the angiogenesis induced by pro-inflammatory prostaglandin E1
  • The effect of Gc-MAF on chemotaxis or activation of tumoricidal macrophages is likely the main mechanism against angiogenesis.
  • Administration of Gc-MAF stimulates immune-cell progenitors for extensive mitogenesis, activates macrophages and produces antibodies. “This indicates that Gc-MAF is a powerful adjuvant for immunization.”
  • Cancer cell lines do not develop into tumor genes in mouse models after Gc-MAF-primed immunization (29-31) and the effect of Gc-MAF has been approved for macrophage stimulation for angiogenesis, proliferation, migration and metastatic inhibition on tumors induced by MCF-7 human breast cancer cell line
  • The protocol included: "a high dose of second-generation Gc-MAF (0.5 ml) administered twice a week intramuscularly for a total of 21 injections.”
  • Yamamoto et al. showed that the administration of Gc-MAF to 16 patients with prostate cancer led to improvements in all patients without recurrence
  • Inui et al. reported that a 74-year-old man diagnosed with prostate cancer with multiple bone metastases was in complete remission nine months after initiation of GcMAF therapy simultaneously with hyper T/NK cell, high-dose vitamin C and alpha lipoic acid therapy
  • It has also been approved for non-neoplastic diseases such as autism (41), multiple sclerosis (42, 43), chronic fatigue syndrome (CFS) (40), juvenile osteoporosis (44) and systemic lupus erythematous (45).
  • Gc-MAF has been verified for use in colon, thyroid (38), lung (39), liver, thymus (36), pancreatic (40), bladder and ovarian cancer and tongue squamous carcinoma
  • Prostate, breast, colon, liver, stomach, lung (including mesothelioma), kidney, bladder, uterus, ovarian, head/neck and brain cancers, fibrosarcomas and melanomas are the types of cancer tested thus far
  • weekly administration of 100 ng Gc-MAF to cancer at different stages and types showed curative effects at different follow-up times
  • this treatment has been suggested for non-anemic patients
  • Studies have shown that weekly administration of 100 ng Gc-MAF to cancer patients had curative effects on a variety of cancers
  • Because the half-life of the activated macrophages is approximately one week, it must be administered weekly
  • In vivo weekly intramuscular administration of Gc-MAF (100 ng) for 16-22 weeks was used to treat patients with breast cancer
  • individuals harboring different VDR genotypes had different responses to Gc-MAF and that some genotypes were more responsive than others
  • Administration of Gc-MAF for cancer patients exclusively activates macrophages as an important cell in adaptive immunity
  • Gc-MAF supports humoral immunity by producing, developing and releasing large quantities of antibodies against cancer. Clinical evidence from a human model of breast cancer patients supports this hypothesis
  • There is also evidence that confirms the tumoricidal role of Gc-MAF via Fc-receptor mediation
  • It is likely that the best therapeutic responses will be observed when the nutritional and inflammatory aspects are taken together with stimulation of the immune system
  • it should be noted that no harmful side effects of Gc-MAF treatment have been reported, even when it was successfully administered to autistic children
  • The natural activation mechanism of macrophages by Gc-MAF is so natural and it should not have any side effects on humans or animal models even in cell culture
  • Besides the Gc-MAF efficacy on macrophage activity, it can be a potential anti-angiogenic agent (28) and an inhibitor of the migration of cancerous cells in the absence of macrophages (47).
  • Activating or modifying natural killer cells, dendritic cells, DC, CTL, INF and IL-2 have all been recommended for cancer immunotherapy
  • It has been reported that nagalase cannot deglycosylate Gc-MAF as it has specificity for Gc globulin alone
  • inflammation-derived macrophage activation with the participation of B and T lymphocytes is the main mechanism
  • macrophages highly-activated by the addition of Gc-MAF can show tumoricidal activity
  • Previous clinical investigations have confirmed the efficacy of Gc-MAF. In addition to activating existing macrophages, Gc-MAF is a potent mitogenic factor that can stimulate the myeloid progenitor cells to increase systemic macrophage cell counts by 40-fold in four days
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    great review on Gc-MAF in cancer.  An increase in nagalase blocks Gc-protein to Gc-MAF activity leaving the host immune system compromised.
trungtamnamkhoa

Pharma Injectable Sust 250mg of the faculty Men's Health - 1 views

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    Pharma Sust 250mg injections treat hypogonadism disorders in men, after the illness, impotence due to lack of hormones, menstrual symptoms in men such as reducing sexual pleasure and physiological activities. Side effects: The drug can cause erectile dysfunction, signs of excessive sexual stimulation, reduced sperm count, decreased volume of ejaculation, water & salt retention. In pre-puberty boys: develop sex early, increase the frequency of erectile dysfunction, enlargement of the penis, and early growth of bone heads.
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