Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer - 0 views
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The generic drug dichloroacetate is an orally available small molecule that, by inhibiting the pyruvate dehydrogenase kinase, increases the flux of pyruvate into the mitochondria, promoting glucose oxidation over glycolysis
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The most important reason for the poor performance of cancer drugs is the remarkable heterogeneity and adaptability of cancer cells. The molecular characteristics of histologically identical cancers are often dissimilar and molecular heterogeneity frequently exists within a single tumour.
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Because GO is far more efficient in generating ATP compared with GLY (producing 36 vs 2 ATP per glucose
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