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Nathan Goodyear

Clustering of metabolic and cardiovascular risk f... [Metabolism. 2014] - PubMed - NCBI - 0 views

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    When you look at PCOS in women, it is really just the early manifestation of Metabolic Syndrome.  PCOS no longer needs to be viewed through the prism of hormones and/or infertility but the means through which disease will walk.
Nathan Goodyear

Carotid artery intima-media thickness and erec... [Med Sci Monit. 2014] - PubMed - NCBI - 0 views

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    The full pdf is available for free download.  ED should be used as a marker for cardiovascular disease.  This study, though small, of turkey men found low T to be a prominent feature of MetS.
Nathan Goodyear

Association of sympathovagal imbalance with cardi... [Endocr Res. 2014] - PubMed - NCBI - 0 views

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    Interesting study looked PCOS and the sympathetic vagal system and cardiovascular disease risk. They found that those with PCOS were found to have sympathovagal imbalance and decreased HRV.  Low HRV has been clearly associated with increased cardiovascular disease.  They also found insulin resistance and dyslipidemia to be associated with sympthovagal imbalance and cardiovascular risk as well.
Nathan Goodyear

Testosterone Dose-Response Relationships with Cardiovascular Risk Markers in Androgen-D... - 0 views

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    Study finds no worsening in cardiovascular biomarkers in women on Testosterone.  The women in this study were chose due to low Testosterone.  Testosterone was given IM at 4 different doses.  This is in contrast to other studies that have looked at endogenous Testosterone level.  Studies have shown increasing endogenous T levels in women is associated with increased CVD.  Studies on exogenous are lacking.  This points to limited risk associated with CVD and T therapy in women.  

    One caveat.  Two of the authors of this study have ties to the maker of the Testosterone enanthate used in this study.  Why is this important?  Prior studies have shown significant decrease in adverse event reporting in those funded by pharma--bias.
Nathan Goodyear

Testosterone therapy not associated with myocardial infarction, stroke | Endocrinology - 0 views

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    Retrospective study finds no increase in new MI and/or stroke in men with Testosterone therapy.  There are some men that Testosterone therapy is cardioprotective and some that are not.
Nathan Goodyear

A reverse J-shaped association of leisure time physical activity with prognosis in pati... - 0 views

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    Increased risk of cardiovascular events and all-cause mortality is highest in the least active population in those with coronary heart disease.  However, those with the highest, strenuous physical activity were also at increased risk--though less than the inactive group.
Nathan Goodyear

Cardiovascular Diabetology | Full text | Improvement of the diabetic foot upon testoste... - 0 views

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    Case report of 3 cases finds improvement in diabetic foot complications, including neuropathy, in men treated with Testosterone.  This makes sense as the Testosterone will improve insulin function, improve HgbA1c and reduce inflammation in these men.
Nathan Goodyear

Testosterone and the Cardiovascular System: A Comprehensive Review of the Clinical Lite... - 0 views

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    Some startling statistics in this 2013 review on Testosterone in men.  Studies reflect an inverse relationship between Testosterone and CAD severity.  That is, the lower the Testosterone levels, the increase in severity of CAD. This same association was also found with CHF.  Low Testosterone is common in those with CAD, CHF, type II diabetes, increased IMT in carotids and aorta, and obesity when compared to "healthy" individuals.  Testosterone therapy in those with CAD found benefits: prolongation of ST segment depression, coronary vasodilation, improved exercise capacity in those with CHF, shift to type I muscle fibers, shorten the QTc interval.  Testosterone therapy has been shown to improve insulin resistance, improve HgbA1c and decrease waist circumference and fat loss in obese individuals.  Otherwise, a good review of the association between a declining Testosterone and cardiovascular disease.
Nathan Goodyear

Toxic Effects of Mercury on the Cardiovascular and Central Nervous Systems - 0 views

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    Good review of the toxic effects of Hg on the CNS and cardiovascular system.
Nathan Goodyear

Sex steroids and cardiovascular disease - 0 views

  • T circulates bound with high affinity to sex hormone binding globulin (SHBG) and with lower affinity to albumin, with a small fraction unbound or free
  • Levels of SHBG are higher in older men, therefore levels of free T decline more steeply than total T as men's age increases
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    Previously posted article.  The journal changed the URL
Nathan Goodyear

Late-Onset Hypogonadism and Mortality in Aging Men: The Journal of Clinical Endocrinolo... - 0 views

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    severe hypogonadism was associated with a 5 fold increase risk of cardiovascular mortality and all cause mortality in men ages 40-79 in European study.
Nathan Goodyear

Subclinical Hypothyroidism, Weight Change, and Body Composition in the Elderly: The Car... - 0 views

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    Study found no significant effect of subclinical hypothyroidism on weight in the elderly.  However, higher free T4 levels were associated with lower baseline weight and weight loss in women. TSH and free T3 were not. associated.
Nathan Goodyear

Testosterone, aging and s... [Curr Opin Endocrinol Diabetes Obes. 2014] - PubMed - NCBI - 0 views

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    Another review study.  Low Testosterone is associated with increased CVD in men.  However, some studies have suggested an increase in CVD with men using exogenous Testosterone therapy.  Is Testosterone the cause of CVD in men?  Likely, low T is a
Nathan Goodyear

Testosterone and cardiova... [Curr Opin Endocrinol Diabetes Obes. 2014] - PubMed - NCBI - 0 views

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    Review of recent articles suggest increased risk of cardiovascular disease in men. The issue at hand is the cause is not being treated and thus the Testosterone is fuel on the metabolic fire and the doping dose that most men receive.
Nathan Goodyear

http://eurheartj.oxfordjournals.org/content/34/48/3691.full.pdf#page=1&view=FitH - 0 views

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    A large body of evidence exists to associate low vitamin D with cardiovascular disease.  However, this review finds no causal relationship.  Is vitamin D an indicator of poor health?  Or is it the cause of poor health.  Yet to be determined.  Is vitamin D safe? Yes.
Nathan Goodyear

[Low testosterone lev... [Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2013] - PubMed - NCBI - 0 views

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    Testosterone, like all other hormones, appears to have a "U" shape therapeutic curve in women.  This cohort study found increased atherosclerosis, as determined by IMT and usb, in women with low serum Total Testosterone.
Nathan Goodyear

Serum sex hormone-binding globulin and test... [Eur J Endocrinol. 2014] - PubMed - NCBI - 0 views

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    SHBG positively associated with lower CVD risk profile, CRP, blood pressure, TC, triglycerides..., in young men.  This was found independent of Testosterone.  This is similar to a lot of the research on Metabolic Syndrome as well.
Nathan Goodyear

CARDIOVASCULAR DISEASE IN TRANSSEXUAL PERSO... [Eur J Endocrinol. 2014] - PubMed - NCBI - 0 views

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    The point of this study post is not the focus on the sex change, but that estrogen dosing in men is associated with increased CVD. This is known from the other literature.
Nathan Goodyear

Testosterone, Dihydrotestosterone and Incident Cardiovascular Disease and Mortality in ... - 0 views

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    Abstract published ahead of print finds that DHT and calculated free DHT was associated with CVD and all-cause mortality.  This cohort found that Total Testosterone and calculated free Testosterone were not.  
Nathan Goodyear

High-dose testosterone is associated with atherosc... [Maturitas. 2007] - PubMed - NCBI - 0 views

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    One of the rare long-term studies of Testosterone in women.  This study was a respective study of high dose Testosterone.  The authors found an increase in atherosclerosis in the aorta versus non-HRT.
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