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Nathan Goodyear

ScienceDirect.com - Food and Chemical Toxicology - Long term toxicity of a Roundup herb... - 0 views

www.sciencedirect.com/...S0278691512005637

GMO GMO foods genetically modified foods

shared by Nathan Goodyear on 21 Jan 13 - No Cached
  • Nathan Goodyear on 21 Jan 13
     
    First long-term study on GMO effects on rats. The majority of studies on GMO have been on animals with the end point at < 90 days.  This study followed the rats for 2 years.  Increased mammary tumors were found.  Is this definitive?  Of course not, but this is the first study to look at long term effects.
Nathan Goodyear

Testosterone Induces Dilation of Canine Coronary Conductance and Resistance Arteries In... - 0 views

circ.ahajournals.org/...2614.abstract

testosterone vasodilation androgen receptor AR androgen receptor antagonist blockade antagonist male men

shared by Nathan Goodyear on 14 May 13 - No Cached
  • Nathan Goodyear on 14 May 13
     
    another animal study, but blockade of androgen receptor, in this study, was not found to diminish the vasodilatory effect of testosterone.  This indicates that some of the vasoactive responses to testosterone are independent of AR and this has been shown in other studies ie. AR knockout mice.
Nathan Goodyear

Testosterone Relaxes Rabbit Coronary Arteries and Aorta - 0 views

circ.ahajournals.org/...1154.abstract

testosterone aromatase aromatase inhibition men male vasodilation

shared by Nathan Goodyear on 14 May 13 - No Cached
  • Nathan Goodyear on 14 May 13
     
    In this animal study, testosterone induces vasodilation via a non-classical genomic pathway.  Likely independent of androgen receptor.  Also, aromatase inhibition does not diminish the vasodilatory effect of testosterone.
Nathan Goodyear

Beyond the male sex hormone: deciphering the metabolic and vascular actions of testoste... - 0 views

joe.endocrinology-journals.org/...C1.full

AR androgen receptors androgen receptor testosterone androgen receptors Diabetes metabolic syndrome MetS CVD cardiovascular disease men hormone hormones male

shared by Nathan Goodyear on 08 May 13 - No Cached
  • androgen deprivation therapy results in unfavorable changes in body composition, insulin resistance, and dyslipidemia and predisposes men to develop atherosclerosis and an increased risk of cardiovascular mortality
  • The hypogonadal–obesity cycle hypothesis was originally proposed by Cohen in 1999 to explain the relationship between low testosterone levels and metabolic disease. It was based on the finding that obesity impairs testosterone levels by increasing the aromatization of testosterone to estradiol, while low testosterone levels promote increased fat deposition
  • adipocytokines contribute to low testosterone levels as well as to the processes underlying metabolic syndromes and type 2 diabetes
  • ...15 more annotations...
  • hypogonadal–obesity–adipocytokine hypothesis
  • The presence of estradiol and the adipocytokines TNF-α, IL6, and leptin (as a result of leptin resistance in obesity) inhibits the hypothalamic–pituitary–testicular axis response to decreasing androgen levels
  • An increasing number of studies have illustrated the potential for applying metabolomics to the field of androgen research
  • As early as the 1940s, the therapeutic use of testosterone was reported to improve angina pectoris in men with coronary artery disease
  • most of the epidemiological studies reported increased cardiovascular risk and mortality in men with low testosterone levels
  • long-term testosterone replacement appears to be a safe and effective means of treating hypogonadal elderly men
  • a recent interventional trial showed that testosterone treatment was associated with decreased mortality when compared with no testosterone treatment in an observational cohort of men with low testosterone levels
  • a number of short-term studies conducted support the notion that testosterone therapy reduces the cardiovascular risk
  • The majority of animal studies support the hypothesis that the actions of testosterone on vascular relaxation are both endothelium-dependent and -independent vasodilatory effects
  • Endothelial-dependent actions of testosterone increase the expression or activity of endothelial nitric oxide synthase and enhance nitric oxide production, which in turn activates cyclic guanosine monophosphate to induce vasorelaxation in smooth muscle cells
  • Endothelial-independent mechanisms of testosterone are believed to occur primarily via inhibition of voltage-operated Ca2+ channels and/or activation of K+ channels in smooth muscle cells
  • Testosterone may also inhibit intracellular Ca2+ influx via store-operated Ca2+ channels by blocking the response to prostaglandin F2α
  • testosterone has demonstrated anti-inflammatory effects to protect against atherogenesis in animal studies
  • both genomic AR activation to modulate gene transcription and non-genomic activation to modulate the rapid intracellular signaling pathways of ion channels may mediate testosterone effects on vascular function and inflammation.
  • Butenandt &amp; Ruzicka first showed how testosterone is synthesized and responsible for masculine characteristics in the early 1930s
  • Nathan Goodyear on 08 May 13
     
    Awesome review on the current understanding of Testosterone and Diabetes, metabolic syndrome, and CVD.  This article even goes into the literature on androgen receptors.
Nathan Goodyear

Treatment of Diabetes and Diabetic Complicati... [J Child Neurol. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23680948

diabetes ketogenic diet ketogenic diet nutrition

shared by Nathan Goodyear on 03 Jul 13 - No Cached
  • Nathan Goodyear on 03 Jul 13
     
    Only the abstract, but for Diabetics, a ketogenic diet needs to include high fat and low protein.  Especially the elimination of animal protein.  A transition to a high protein diet will reduce ketosis.  The switch to ketosis from glucose will be what improves glycemic control.  The primary increase in most ketogenic or "low carb" diets today is an increase in protein.
Nathan Goodyear

Dietary Fructose Activates Insulin Signaling and Inflammation in Adipose Tissue: Modula... - 0 views

www.ncbi.nlm.nih.gov/...27066503

fructose HFCS resveratrol insulin inflammation diet

shared by Nathan Goodyear on 12 Apr 16 - No Cached
  • Nathan Goodyear on 12 Apr 16
     
    Interesting animal study, dietary fructose intake increased insulin and inflammatory signaling.  The authors find that resveratrol had some blocking effect.
Nathan Goodyear

The effects of sex, estrous cycle, and social contact on cocaine and heroin self-admini... - 0 views

link.springer.com/...10.1007%2Fs00213-016-4368-9

hormones estrogen progesterone addiction women female hormones

shared by Nathan Goodyear on 28 Sep 16 - No Cached
  • Nathan Goodyear on 28 Sep 16
     
    hormones, estrogen and/or progesterone, may provide a solution to addiction in women says animal study.
Nathan Goodyear

Prolonged antibiotic treatment induces a diabetogenic intestinal microbiome that accele... - 0 views

www.ncbi.nlm.nih.gov/...26274050

diabetes type I diabetes gut gut bacteria gut flora gut health gut microbiome gut Microbiota diabetogenic microbiome probiotic antibiotics

shared by Nathan Goodyear on 17 Oct 16 - No Cached
  • Nathan Goodyear on 17 Oct 16
     
    Only abstract available here.  Animal study finds that gut bacteria induce diabetes and early antibiotic exposure accelerated this autoimmune activity.  This study also used VSL#3 to attempt to treat but no effect was evident.  
Nathan Goodyear

Ketone supplementation decreases tumor cell viability and prolongs survival of mice wit... - 0 views

onlinelibrary.wiley.com/...full

cancer ketogenic ketogenic diet ketones

shared by Nathan Goodyear on 16 Nov 16 - No Cached
  • Nathan Goodyear on 16 Nov 16
     
    animal study finds that high glycemic diets increase risk of cancer, hyperglycemia = poor prognosis in those diagnosed with cancer, blood glucose levels correlated to tumor growth, ketogenc diet lowers glucose, insulin, IGF=1, and ketones directly inhibit tumor growth!!  So what is the cancer community waiting for?
Nathan Goodyear

Diet-Microbiota Interactions Mediate Global Epigenetic Programming in Multiple Host Tis... - 0 views

www.cell.com/...S1097-2765(16)30670-0

epigenetics diet nutrition SCFA gut gut bacteria gut flora gut microbiome gut microbiota

shared by Nathan Goodyear on 28 Nov 16 - No Cached
  • SCFAs play a dual role both as substrates for metabolism and as signaling molecules
  • SCFAs can be either directly converted (acetate) or oxidized (propionate and butyrate) to acetyl-Co
  • Here we demonstrate that microbial colonization regulates global histone acetylation and methylation in multiple host tissues in a diet-dependent manner
  • ...1 more annotation...
  • complex functional interactions between diet, gut microbiota, and host health.
  • Nathan Goodyear on 28 Nov 16
     
    diet changes gut microbiota, which changes genetic expression--it is called epigenetics.  This is an animal study.
Nathan Goodyear

Selenomethionine and α-Tocopherol Do Not Inhibit Prostate Carcinogenesis in t... - 0 views

cancerpreventionresearch.aacrjournals.org/...371.long

prostate cancer prostate cancer estrogen estradiol male hormones

shared by Nathan Goodyear on 18 Nov 16 - No Cached
  • Nathan Goodyear on 18 Nov 16
     
    In this animal study, estradiol is added to Testosterone to increase prostate carcinogenesis.  Previous rat studies have shown that adding estradiol to Testosterone, which occurs naturally, increases prostate cancer risk.  
Nathan Goodyear

Effects of exogenous ketone supplementation on blood ketone, glucose, triglyceride, and... - 0 views

www.ncbi.nlm.nih.gov/...PMC4743170

ketones ketone bodies ketone salts BHB Beta-hydroxybutyrate MCT MCTs medium chain triglycerides

shared by Nathan Goodyear on 21 Nov 16 - No Cached
  • Nathan Goodyear on 21 Nov 16
     
    animal study finds increased BHB after ketone salt supplementation.  A resultant decrease in glucose was found.  The use of ketone salts was with concomitant MCT.  The effect was in 30-60 minutes and sustained, significantly for 8 hours.  Weight loss was also seen.  No change in cholesterol and triglycerides was seen.
Nathan Goodyear

Fasting is neuroprotective following traumatic brain injury - Davis - 2008 - Journal of... - 0 views

onlinelibrary.wiley.com/...abstract

ketones ketone bodies TBI brain mitochondria

shared by Nathan Goodyear on 21 Nov 16 - No Cached
  • Nathan Goodyear on 21 Nov 16
     
    short term fasting and ketosis provides neuroprotection and preserves mitochondria in animal TBI study.  This study found preventative effects of the ketones.
Nathan Goodyear

Dietary fiber and the short-chain fatty acid acetate promote resolution of neutrophilic... - 0 views

www.jleukbio.org/...275.abstract

SCFA fiber diet nutrition inflammation gout gut bacteria gut gut flora gut microbiome gut microbiota

shared by Nathan Goodyear on 09 Jan 17 - No Cached
  • Nathan Goodyear on 09 Jan 17
     
    new animal study finds that high fiber diet intake increases gut flora SCFA production that reduces inflammation in gout
Nathan Goodyear

Diabetes - 0 views

diabetes.diabetesjournals.org/...db16-0530

exercise ampk insulin muscle insulin sensitivity

shared by Nathan Goodyear on 10 Jan 17 - No Cached
  • Nathan Goodyear on 10 Jan 17
     
    exercise increases AMPK to improve insulin sensitivity and glucose uptake in new animal study.
Nathan Goodyear

Plasma ascorbic acid concentrations relate inversely to blood pressure in human subject... - 0 views

www.ncbi.nlm.nih.gov/...8424391

blood pressure hypertension vitamin c

shared by Nathan Goodyear on 16 Jan 17 - No Cached
  • Nathan Goodyear on 16 Jan 17
     
    only abstract available here.  Serum vitamin C levels significantly inversely associated with systolic and diastolic blood pressure.  Also of note, this was a human study, not animal.
Nathan Goodyear

Chronic antioxidant treatment improves arterial renovascular hypertension and oxidative... - 0 views

www.ncbi.nlm.nih.gov/...20186128

blood pressure hypertension vitamin C oxidative stress

shared by Nathan Goodyear on 16 Jan 17 - No Cached
  • Nathan Goodyear on 16 Jan 17
     
    animal study finds vitamin C improves hypertension via renovascular source and oxidative stress.  The dosage was 150 mg/kg/day.  This would be equivalent to 10,800 grams daily for a 72 human.  But what about a 200 lb male or female?  That would be 13,650 grams of vitamin C daily.
Nathan Goodyear

Effect of aqueous extract of Bulbine natalensis (Baker) stem on the sexual behaviour of... - 0 views

onlinelibrary.wiley.com/...abstract

Bulbine natalensis Baker stem ED libido natural therapies male hormones natural hormones

shared by Nathan Goodyear on 18 Jan 17 - No Cached
  • Nathan Goodyear on 18 Jan 17
     
    Bulbine natalensis (Baker) stem found to be useful in libido/ED at doses of 25-50 mg/kg in animal studies.
Nathan Goodyear

Anabolic and androgenic activities of Bulbine natalensis stem in male Wistar rats: Phar... - 0 views

www.tandfonline.com/...13880200903207094

Bulbine natalensis Baker stem natural hormones male hormones Testosterone natural therapies

shared by Nathan Goodyear on 18 Jan 17 - No Cached
  • Nathan Goodyear on 18 Jan 17
     
    Bulbine natalensis Baker stem found to increase Testosterone by up to 350% in animal studies in 2 weeks.  The dose with the optimum response was 25 and 50 mg/kg, with the most best effect at 50 mg/kg.  LH and FSH production was increase but exact mechanism not discussed.  Only abstract available here.
Nathan Goodyear

Effect of aqueous extract of Bulbine natalensis Baker stem on haematological and serum ... - 0 views

www.ncbi.nlm.nih.gov/...19382725

Bulbine natalensis Baker stem natural therapies

shared by Nathan Goodyear on 18 Jan 17 - No Cached
  • Nathan Goodyear on 18 Jan 17
     
    2 week animal study of Bulbine natalensis Baker stem found to decreased some wbc types.  In this short study, it also decreased HDL and increased cholesterol and triglycerides.
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