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Nathan Goodyear

Glucose tolerance status and risk of dementia in the community - 0 views

neurology.org/...1126.abstract

dementia Alzheimer's Alzheimer's disease OGTT post prandial glucose tolerance test glucose tolerance

shared by Nathan Goodyear on 11 Jun 12 - No Cached
  • Nathan Goodyear on 11 Jun 12
     
    elevated 2 hour post prandial OGTT associated with all-cause dementia, including Alzheimer's disease.  Interestingly, the association was not found with fasting glucose levels.
Nathan Goodyear

Alzheimer's disease--synergistic effects of ... [J Neural Transm. 1998] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9720973

AD AGE advanced glycation end products Alzheimer's disease neurofibrillary tangles Beta-amyloid protein microglia brain neurology oxidative stress alzheimer

shared by Nathan Goodyear on 11 Jun 12 - No Cached
  • AGEs are protein modifications that contribute to the formation of the histopathological and biochemical hallmarks of AD: amyloid plaques, neurofibrillary tangles and activated microglia
  • Nathan Goodyear on 11 Jun 12
     
    good review of understanding of how poor glucose control, oxidative stress result in AGE and Alzheimer's disease.
Nathan Goodyear

Advanced Glycation End Products in Alzheimer's Disease and Other Neurodegenerative Dise... - 0 views

www.ncbi.nlm.nih.gov/...PMC1853056

AGE advanced glycation end products AGE's neurodegenerative disease Alzheimer's disease alzheimer's Parkinson's parkinson's disease Parkinson's

shared by Nathan Goodyear on 11 Jun 12 - No Cached
  • Nathan Goodyear on 11 Jun 12
     
    AGE's, advanced glycation end products, play a role in development/progression of neurodegenerative diseases such as Alzheimer's, Parkinson's...
Nathan Goodyear

JAMA Network | Archives of Neurology | Reduced Risk of Alzheimer Disease in Users of An... - 0 views

archneur.jamanetwork.com/article.aspx

vitamin C vitamin E C E Alzheimer's disease Alzheimer's oxidative damage oxidative stress neurology antioxidant vitamin

shared by Nathan Goodyear on 13 Jun 12 - No Cached
  • Nathan Goodyear on 13 Jun 12
     
    Use of Vitamin C and Vitamin E associated with a 78% reduced prevalence of Alzheimer's disease.
Nathan Goodyear

Lymphocyte oxidative DNA damage and plasma antioxidants in Alzheimer Disease - 0 views

www.lycoredindia.com/...TI_18.pdf

oxidative damage oxidative stress 8-hydroxy-2-deoxyguanosine free radicals Alzheimer's Alzheimer's disease neurology brain

shared by Nathan Goodyear on 13 Jun 12 - No Cached
  • Nathan Goodyear on 13 Jun 12
     
    This study found an inverse association between elevated 8-hydroxy-2-deoxyguanosine and low antioxidants in individuals with Alzheimer's disease.
Nathan Goodyear

Dietary Antioxidants and Dementia in a Population-Based Case-Control Study among Older ... - 0 views

iospress.metapress.com/...h3215182vr7h5830

alzheimer's disease Alzheimers dementia antioxidants vitamin C beta-carotene

shared by Nathan Goodyear on 09 Sep 13 - No Cached
  • Nathan Goodyear on 09 Sep 13
     
    Study in people with Alzheimer's dementia, finds that those with dementia have lower levels of the antioxidants vitamin C and beta-carotene.
Nathan Goodyear

Progesterone enhances transthyretin expressio... [J Mol Neurosci. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20535645

progesterone Alzheimer's disease alzheimer's disease Alzheimers Transthyretin hormone hormones postmenopause women menopause

shared by Nathan Goodyear on 17 Mar 14 - No Cached
  • Nathan Goodyear on 17 Mar 14
     
    Postmenopausal cognitive decline is a common complaint.  Declining Estradiol and progesterone have been implicated, in part, to this cognitive decline.  This study finds that progesterone increases expression of Transthyretin, a protein that processes amyloid Beta protein.  This amyloid Beta protein is associated with damage found in Alzheimer's. 
Nathan Goodyear

Endogenous estrogen levels and Alzheimer's disease... [Neurology. 2000] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...10690972

estradiol estrogen alzheimer disease neurology Alzheimer's disease women hormone hormones

shared by Nathan Goodyear on 15 Jul 13 - No Cached
  • Nathan Goodyear on 15 Jul 13
     
    Women with the lower estradiol levels have an associated increased risk of Alzheimer's disease.  Inverse relationship found in women.
Nathan Goodyear

Effects of turmeric on Alzheimer's disease with behavioral and psychological symptoms o... - 0 views

www.ncbi.nlm.nih.gov/...PMC3665200

turmeric Alzheimer's disease alzheimer disease dementia curcumin

shared by Nathan Goodyear on 13 Aug 13 - No Cached
  • Nathan Goodyear on 13 Aug 13
     
    Small case study of 3 finds significant improvement in Alzheimer's with Turmeric.
Nathan Goodyear

The projected effect of risk factor reduction on Alzheimer's disease prevalence : The L... - 0 views

www.thelancet.com/...fulltext

alzheimer's disease brain

shared by Nathan Goodyear on 12 Nov 13 - No Cached
  • Nathan Goodyear on 12 Nov 13
     
    Study suggests that >50% of cases of Alzheimer's can be prevented through lifestyle change.  
Nathan Goodyear

http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.po... - 0 views

www.plosone.org/...fetchObject.action

alzheimer's disease Alzheimer's disease Alzheimers dementia huperzine A

shared by Nathan Goodyear on 30 Sep 14 - No Cached
  • Nathan Goodyear on 30 Sep 14
     
    Another meta-analysis, this time of 20 studies, finds benefit of huperzine A in the treatment of Alzheimer's disease.
Nathan Goodyear

Neuroprotective Sirtuin ratio reversed by ApoE4 - 0 views

www.pnas.org/...1314145110.abstract

ApoE4 alzheimer's disease Alzheimer's disease sirtuins SIRT1 resveratrol

shared by Nathan Goodyear on 23 Oct 13 - No Cached
  • Nathan Goodyear on 23 Oct 13
     
    ApoE4 allele is known to increase Alzheimer's disease by 10 fold.  One mechanism is through a lowering of SirT1 and an increase in the SirT1:SirT2 ratio.  This SirT1 is the target of resveratrol in red wine.
Nathan Goodyear

Efficacy of tablet huperzine-A on me... [Zhongguo Yao Li Xue Bao. 1995] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...8701750

Huperzine A Huperzine-A alzheimer's disease Alzheimer's disease memory cognition brain

shared by Nathan Goodyear on 06 Nov 13 - No Cached
  • Nathan Goodyear on 06 Nov 13
     
    8 week study finds Huperzine A improved memory, cognition, and behavior in those with Alzheimer's disease at 400 mcg.
Nathan Goodyear

Hypometabolism as a therapeutic target in Alzheimer's disease - 0 views

www.ncbi.nlm.nih.gov/...PMC2604900

cocconut oil brain Alzheimer's disease ketones

shared by Nathan Goodyear on 11 Nov 13 - No Cached
  • Nathan Goodyear on 11 Nov 13
     
    Medium chain fatty acids, such as cocconut oil, benefit brain with glucose hypometabolism problems such as in Alzheimer's disease.
Nathan Goodyear

Low Testosterone Level and Risk of Alzheimer's Disease in the Elderly Men: a Systematic... - 0 views

www.ncbi.nlm.nih.gov/...26154489

low T low Testosterone alzheimer's disease Testosterone men hormones hormone

shared by Nathan Goodyear on 21 Jul 15 - No Cached
  • Nathan Goodyear on 21 Jul 15
     
    Just abstract available here; low Testosterone in meta-analysis found to be associated with increased Alzheimer's disease risk in elderly men.
Nathan Goodyear

Mitochondria: a therapeutic target in neurodegener... [Biochim Biophys Acta. 2010] - Pu... - 0 views

www.ncbi.nlm.nih.gov/...19853657

mitochondria Alzheimer's Parkinson's Huntington's ALS neurodegenerative disease

shared by Nathan Goodyear on 07 Feb 11 - No Cached
  • mitochondrial dysfunction has a central role in the pathogenesis of Alzheimer's, Parkinson's and Huntington's diseases and amyotrophic lateral sclerosis
  • Nathan Goodyear on 07 Feb 11
     
    mitochondrial dysfunction has a central role in the pathogenesis of Alzheimer's, Parkinson's and Huntington's diseases and amyotrophic lateral sclerosis
Nathan Goodyear

Insulin resistance and Alzheimer's disease. [BMB Rep. 2009] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...19712582

alzheimer's disease insulin resistance neurodegenerative

shared by Nathan Goodyear on 20 Feb 11 - No Cached
  • there are dual mechanisms of brain insulin resistance leading to AD-type neurodegeneration: one mediated by endogenous, CNS factors; and the other, peripheral insulin resistance with excess cytotoxic ceramide production.
  • Nathan Goodyear on 20 Feb 11
     
    Insulin resistance has dual mechanism of contribution to Alzheimer's disease
Nathan Goodyear

Indoleamine 2,3 dioxygenase and quinolinic acid im... [Neuropathol Appl Neurobiol. 2005... - 0 views

www.ncbi.nlm.nih.gov/...16008823

indoleamine 2 3 Alzheimer's disease inflammation

shared by Nathan Goodyear on 20 Apr 11 - No Cached
  • kynurenine pathway is up-regulated in Alzheimer's disease (AD) brain
  • increases in the excitotoxin quinolinic acid (QUIN
  • indoleamine 2,3 dioxygenase (IDO) is abundant in AD compared with controls
  • ...1 more annotation...
  • QUIN may be involved in the complex and multifactorial cascade leading to neuro-degeneration in AD
  • Nathan Goodyear on 20 Apr 11
     
    immune system, inflammation, and brain come together to develop Alzheimer's disease
fnfdoc

Risk Factors For Alzheimer's | Health Blog - 0 views

www.fnfdoc.com/...risk-factors-alzheimers

Alzheimer Alzheimer's Dementia

shared by fnfdoc on 22 May 18 - No Cached
  • fnfdoc on 22 May 18
     
    Alzheimer's is a mental illness that mostly affects the elderly. It is characterized by dementia, cognitive impairment, and mood swings. The patient gradually fades into a state of perpetual darkness and lack of self-awareness. Here are some steps we can take to reduce our own risk.
  • fnfdoc on 22 May 18
     
    Scientists are trying to find ways to prevent Alzheimer's before it comes knocking at your doorstep. Extensive research is taking place even as you read this. Everyone hopes to put together the answer before it becomes a global issue. Here are a few risk factors that you can and can't avoid:
Nathan Goodyear

Alzheimer's Disease Clinical and Research Update for Health Care Practitioners - 0 views

www.ncbi.nlm.nih.gov/...PMC3776389

Alzheimer's disease cognition memory Alzheimers brain brain health alpha-GPC phosphatidyl serine Huperzine A choline

shared by Nathan Goodyear on 26 Sep 17 - No Cached
  • Alpha GPC, phosphatidylserine, Huperzine A, and choline show promise as nutraceutical agents for enhancing cognitive performance and slowing cognitive decline
  • Alpha GPC, also known as L-Alpha Glycerylphosphorylcholine, a naturally occurring form of choline, acts as a parasympathomimetic acetylcholine precursor and has shown promise in improving cognitive symptoms related to AD, vascular dementia, and multi-infarct dementia
  • Phosphatidylserine is a widely abundant anionic phospholipid in the human body and has been shown to improve age-related cognitive changes
  • ...2 more annotations...
  • Huperzine A (a natural cholinesterase inhibitor) has been linked to improved memory performance in elderly people with benign forgetfulness, as well as patients with AD and vascular dementia
  • Cholinesterase inhibitors have been shown to have neuroprotective properties in patients with mild [37] as well as moderate-to-advanced AD
  • Nathan Goodyear on 26 Sep 17
     
    good review of treatment for Alzheimer's, both prescription and natural.
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