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Nathan Goodyear

Licorice reduces serum testosterone in heal... [Steroids. 2004 Oct-Nov] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15579328

PCOS polycystic ovarian syndrome polycystic ovary syndrome licorice licorice root extract Glycyrrhiza Testosterone women female hormones hormone herbal herbs natural therapy

shared by Nathan Goodyear on 10 Sep 14 - No Cached
  • Nathan Goodyear on 10 Sep 14
     
    Licorice root extract, also known as glycyrrhizic acid, found to quickly reduce endogenous Testosterone production in women.  The proposed mechanism is via inhibition of 17-hydroxysteroid dehydrogenase and 17-20 Lyase.  This is a good adjuvant in the treatment of PCOS.
Nathan Goodyear

http://biomedres.info/yahoo_site_admin/assets/docs/219-223-Gianfranco-Jan_14_2012.18155... - 0 views

biomedres.info/...ranco-Jan_14_2012.18155343.pdf

cancer alpha lipoic acid ALA hydroxycitrate

shared by Nathan Goodyear on 08 Sep 14 - No Cached
  • Nathan Goodyear on 08 Sep 14
     
    Study finds combination of Alpha lipoic acid and hydroxycitrate beneficial as adjuvant with chemotherapy.  Side effects were minimal.
Nathan Goodyear

Efficacy and Safety of Curcumin in Major Depre... [Phytother Res. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23832433

curcumin tumeric depression SSRI fluoxetine natural medicine natural alternative medicine complementary medicine

shared by Nathan Goodyear on 01 Dec 15 - No Cached
  • Nathan Goodyear on 01 Dec 15
     
    curcumin found to be statistically similar to fluoxetine in depression;  In combination there is an adjuvant effect to increase the efficacy.
Nathan Goodyear

Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice wi... - 0 views

www.cell.com/...S0165-6147(08)00252-6

inflammation curcumin NF-kappaB TNF-alpha IL-1 IL-6 disease

shared by Nathan Goodyear on 22 Mar 16 - No Cached
  • Nathan Goodyear on 22 Mar 16
     
    Just abstract available here.  Curcumin reduces NF-kappaB, Cox2 and 5 lipoxygenase and the cytokines TNF-alpha and IL-1 and IL-6.  This implicates curcumin as an adjuvant for all chronic diseases of aging that involve inflammation.
Nathan Goodyear

Evolving landscape of human epidermal growth factor receptor 2-positive breast cancer t... - 0 views

www.sciencedirect.com/...S0960977617300103

HER-2 breast cancer cancer herceptin Perjeta

shared by Nathan Goodyear on 06 Aug 18 - No Cached
  • 15%–20%
  • key mediator of cell growth, differentiation, and survival
  • of higher histological grade and are more likely to invade axillary lymph nodes
  • ...15 more annotations...
  • shortened survival and an increased risk of disease recurrence and metastasis
  • Currently, four HER2-directed agents are approved for the treatment of patients with HER2+ breast cancer: trastuzumab, pertuzumab, lapatinib, and ado-trastuzumab emtansine (T-DM1)
  • biosimilars
  • trastuzumab may provide greater benefit when administered concurrently with chemotherapy rather than after, and this has become the standard approach
  • concurrent use of anthracyclines (ie, doxorubicin or epirubicin) and trastuzumab is not recommended because of an increased risk for cardiac toxicity
    • Nathan Goodyear
      Nathan Goodyear on 06 Aug 18
       
      avoid herceptin in conjuction with antracyclines i.e. doxorubicin
  • Sequential doxorubicin plus cyclophosphamide followed by concomitant paclitaxel or docetaxel and trastuzumab is recommended for most patients
    • Nathan Goodyear
      Nathan Goodyear on 06 Aug 18
       
      top recommended regimen combination
  • Guidelines also recommend trastuzumab in combination with paclitaxel, docetaxel and carboplatin, or docetaxel and cyclophosphamide, particularly for patients with increased risk for cardiac toxicity or those with small (≤1 cm), node-negative HER2+ tumors
    • Nathan Goodyear
      Nathan Goodyear on 06 Aug 18
       
      good alternative in patients with increased risk of cardiac toxicity.
  • guidelines recommend up to 1 year of adjuvant trastuzumab
  • Neoadjuvant chemotherapy with trastuzumab is associated with higher rates of pathologic complete response (pCR) than chemotherapy alone or in combination with lapatinib
  • the combination of trastuzumab, lapatinib, and chemotherapy is not recommended because it failed to demonstrate noninferiority versus trastuzumab and chemotherapy in the adjuvant setting
  • recommend the combination of trastuzumab, pertuzumab, and chemotherapy as neoadjuvant treatment for patients with locally advanced HER2+ breast cancer and for some patients (node-positive or tumor ≥2 cm) with early-stage disease
  • neoadjuvant chemotherapy in combination with pertuzumab and trastuzumab reduced the risk of progression or death by 31% and recurrence or death by 40% versus trastuzumab alone
  • Concurrent chemotherapy and HER2-directed therapy improves survival outcomes over chemotherapy alon
  • dual inhibition of HER2 with trastuzumab and pertuzumab in combination with paclitaxel reduced the risk of death or progression by approximately 40% compared with concurrent trastuzumab and paclitaxel
  • the combination of trastuzumab, pertuzumab, and taxane chemotherapy is the preferred first-line regimen
  • Nathan Goodyear on 06 Aug 18
     
    HER-2 + breast cancer = appx 15-20% of all breast cancers and is a marker of worse prognosis and an indication for targeted immunotherapy blockade.
Nathan Goodyear

Ketogenic diets as an adjuvant cancer therapy: History and potential mechanism - 1 views

www.sciencedirect.com/...S2213231714000925

ketogenic diet cancer nutrition

shared by Nathan Goodyear on 03 Feb 16 - No Cached
  • Nathan Goodyear on 03 Feb 16
     
    review of science and mechanisms of ketogenic diet and cancer.
Nathan Goodyear

Ascorbic acid: Chemistry, biology and the treatment of cancer - 0 views

www.ncbi.nlm.nih.gov/...PMC3608474

IV vitamin C Intravenous vitamin C vitamin C vitamin C cancer treatment ascorbic acid

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Nathan Goodyear on 26 Aug 14
     
    IV vitamin C as an adjuvant in the treatment of cancer.
Nathan Goodyear

Adjuvant histamine in cancer immunotherapy, Seminars in Cancer Biology | 10.1006/scbi.2... - 0 views

www.deepdyve.com/...ancer-immunotherapy-6XEaCggcvx

histamine IL-2 NK NK cells immunotherapy cancer

shared by Nathan Goodyear on 12 May 18 - No Cached
  • Nathan Goodyear on 12 May 18
     
    histamine dihydrochloride augments IL-2 stimulation of NK and blocks the monocyte/macrophage inhibition of IL-2 stimulation of NK cells.
Nathan Goodyear

The association of vitamins C and K3 kills cancer cells mainly by autoschizis, a novel ... - 0 views

vitamin cancer vitamin C autoschizis IV vitamin C vitamin K3

shared by Nathan Goodyear on 24 Jul 19 - No Cached
  • Nathan Goodyear on 24 Jul 19
     
    Nice review of the adjuvant effects of vitamin C and vitamin K3 in the process of autoschizis of cancer cells.
Nathan Goodyear

Glucocorticoid receptor expression in 20 solid tumor types using immunohistochemistry a... - 0 views

www.ncbi.nlm.nih.gov/...PMC5345989

glucocorticoids cancer glucocorticoid receptors

shared by Nathan Goodyear on 12 Sep 23 - No Cached
  • Nathan Goodyear on 12 Sep 23
     
    Nice article describing solid tumors with high GC receptor expression. The authors point to GC antagonistic activity as an option for adjuvant therapy.
Nathan Goodyear

Body weight change in women receiving adjuvant chemotherapy for breast cancer: A French... - 0 views

www.sciencedirect.com/...S0261561409001678

chemotherapy weight weight gain cancer metabolism

shared by Nathan Goodyear on 14 Jun 16 - No Cached
  • Nathan Goodyear on 14 Jun 16
     
    Weight gain found in patients post-chemotherapy.  The authors of this study, abstract only, attribute the association to pre-diagnosis weight gain.  It is know that chemotherapy negatively effects metabolism.
Nathan Goodyear

Prophylactic and therapeutic effects of n-3 polyunsaturated fatty acids, capsaicin, and... - 0 views

www.jnutbio.com/...abstract

n-3 fish oil omega 3 capsaicin curcumin tumeric arthritis inflammation

shared by Nathan Goodyear on 13 Sep 13 - No Cached
  • Nathan Goodyear on 13 Sep 13
     
    Rat study, but it finds that n-3, capsaicin, and curcumin can not only decrease the inflammation associatied with arthritis, but it can delay it all together.
Nathan Goodyear

Altered Deoxyribonuclease Activity in Cancer Cells and its Role in Non Toxic Adjuvant C... - 0 views

ar.iiarjournals.org/...2727.full.pdf+html

autoschizis cancer IV vitamin C IV vitamin K3 vitamin C vitamin K3 vitamin C K K3

shared by Nathan Goodyear on 16 Oct 13 - No Cached
  • Nathan Goodyear on 16 Oct 13
     
    Combination of IV vitamin C and K3 in ratio of 100:1 shown to provide mechanism to induce cancer cell death through a process called autoschizis.
Nathan Goodyear

Reduced rates of metabolism and decreased physical activity in breast cancer patients r... - 0 views

ajcn.nutrition.org/...1495.short

chemotherapy BMR metabolism breast cancer cancer weight weight gain obesity

shared by Nathan Goodyear on 26 Aug 15 - No Cached
  • Nathan Goodyear on 26 Aug 15
     
    study suggests chemotherapy slows basic metabolic rate (BMR) in breast cancer treatment.
Nathan Goodyear

Curcumin inhibits VEGF-mediated angiogenesis in hu... [Gut. 2008] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...18596194

curcumin Cancer Inflammatory Bowel Disease

shared by Nathan Goodyear on 29 Mar 11 - No Cached
  • Moreover, curcumin inhibits microvascular endothelial cell angiogenesis through inhibition of COX-2 expression and PGE(2) production, suggesting that this natural product possesses antiangiogenic properties, which warrants further investigation as adjuvant treatment of IBD and cancer.
  • Nathan Goodyear on 29 Mar 11
     
    Curcumin reduces inflammation in IBD and Cancer
Nathan Goodyear

Transdermal Ketamine as an Adjuvant for Postoperative Analgesia After Abdominal Gynecol... - 1 views

www.anesthesia-analgesia.org/...1479

transdermal ketamine pain surgery

shared by Nathan Goodyear on 20 Oct 11 - No Cached
  • Nathan Goodyear on 20 Oct 11
     
    transdermal ketamine useful adjunct in post operative pain
Nathan Goodyear

Stuck at the bench: Potential natural neuroprotective compounds for concussion - 0 views

www.ncbi.nlm.nih.gov/...PMC3205506

concussions concussion natural therapies brain curcumin omega 3 resveratrol green tea EGCG EPA DHA vitamin E vitamin c vitamin D

shared by Nathan Goodyear on 20 Feb 16 - No Cached
  • Long-chain polyunsaturated fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are highly enriched in neuronal synaptosomal plasma membranes and vesicles
  • The predominant CNS polyunsaturated fatty acid is DHA
  • effective supplementation and/or increased ingestion of dietary sources rich in EPA and DHA, such as cold-water fish species and fish oil, may help improve a multitude of neuronal functions, including long-term potentiation and cognition.
  • ...45 more annotations...
  • multiple preclinical studies have suggested that DHA and/or EPA supplementation may have potential benefit through a multitude of diverse, but complementary mechanisms
  • pre-injury dietary supplementation with fish oil effectively reduces post-traumatic elevations in protein oxidation
  • The benefits of pre-traumatic DHA supplementation have not only been independently confirmed,[150] but DHA supplementation has been shown to significantly reduce the number of swollen, disconnected and injured axons when administered following traumatic brain injury.
  • DHA has provided neuroprotection in experimental models of both focal and diffuse traumatic brain injury
  • potential mechanisms of neuroprotection, in addition to DHA and EPA's well-established anti-oxidant and anti-inflammatory properties
  • Despite abundant laboratory evidence supporting its neuroprotective effects in experimental models, the role of dietary DHA and/or EPA supplementation in human neurological diseases remains uncertain
  • Several population-based, observational studies have suggested that increased dietary fish and/or omega-3 polyunsaturated fatty acid consumption may reduce risk for ischemic stroke in several populations
  • Randomized control trials have also demonstrated significant reductions in ischemic stroke recurrence,[217] relative risk for ischemic stroke,[2] and reduced incidence of both symptomatic vasospasm and mortality following subarachnoid hemorrhage
  • Clinical trials in Alzheimer's disease have also been largely ineffective
  • The clinical evidence thus far appears equivocal
  • curcumin has gained much attention from Western researchers for its potential therapeutic benefits in large part due to its potent anti-oxidant[128,194,236] and anti-inflammatory properties
  • Curcumin is highly lipophilic and crosses the blood-brain barrier enabling it to exert a multitude of different established neuroprotective effects
  • in the context of TBI, a series of preclinical studies have suggested that pre-traumatic and post-traumatic curcumin supplementation may bolster the brain's resilience to injury and serve as a valuable therapeutic option
  • Curcumin may confer significant neuroprotection because of its ability to act on multiple deleterious post-traumatic, molecular cascades
  • studies demonstrated that both pre- and post-traumatic curcumin administration resulted in a significant reduction of neuroinflammation via inhibition of the pro-inflammatory molecules interleukin 1β and nuclear factor kappa B (NFκB)
  • no human studies have been conducted with respect to the effects of curcumin administration on the treatment of TBI, subarachnoid or intracranial hemorrhage, epilepsy or stroke
  • studies have demonstrated that resveratrol treatment reduces brain edema and lesion volume, as well as improves neurobehavioral functional performance following TBI
  • green tea consumption or supplementation with its derivatives may bolster cognitive function acutely and may slow cognitive decline
  • At least one population based study, though, did demonstrate that increased green tea consumption was associated with a reduced risk for Parkinson's disease independent of total caffeine intake
  • a randomized, placebo-controlled trial demonstrated that administration of green tea extract and L-theanine, over 16 weeks of treatment, improved indices of memory and brain theta wave activity on electroencephalography, suggesting greater cognitive alertness
  • Other animal studies have also demonstrated that theanine, another important component of green tea extract, exerts a multitude of neuroprotective benefits in experimental models of ischemic stroke,[63,97] Alzheimer's disease,[109] and Parkinson's disease
  • Theanine, like EGCG, contains multiple mechanisms of neuroprotective action including protection from excitotoxic injury[97] and inhibition of inflammation
  • potent anti-oxidant EGCG which is capable of crossing the blood-nerve and blood-brain barrier,
  • Epigallocatechin-3-gallate also displays neuroprotective properties
  • More recent research has suggested that vitamin D supplementation and the prevention of vitamin D deficiency may serve valuable roles in the treatment of TBI and may represents an important and necessary neuroprotective adjuvant for post-TBI progesterone therapy
  • Progesterone is one of the few agents to demonstrate significant reductions in mortality following TBI in human patients in preliminary trials
  • in vitro and in vivo studies have suggested that vitamin D supplementation with progesterone administration may significantly enhance neuroprotection
  • Vitamin D deficiency may increase inflammatory damage and behavioral impairment following experimental injury and attenuate the protective effects of post-traumatic progesterone treatment.[37]
  • emerging evidence has suggested that daily intravenous administration of vitamin E following TBI significantly decreases mortality and improves patient outcomes
  • high dose vitamin C administration following injury stabilized or reduced peri-lesional edema and infarction in the majority of patients receiving post-injury treatment
  • it has been speculated that combined vitamin C and E therapy may potentiate CNS anti-oxidation and act synergistically with regards to neuroprotection
  • one prospective human study has found that combined intake of vitamin C and E displays significant treatment interaction and reduces the risk of stroke
  • Pycnogenol has demonstrated the ability to slow or reduce the pathological processes associated with Alzheimer's disease
  • Pcynogenol administration, in a clinical study of elderly patients, led to improved cognition and reductions in markers of lipid peroxidase
  • One other point of consideration is that in neurodegenerative disease states like Alzheimer's disease and Parkinson's disease, where there are high levels of reactive oxygen species generation, vitamin E can tend to become oxidized itself. For maximal effectiveness and to maintain its anti-oxidant capacity, vitamin E must be given in conjunction with other anti-oxidants like vitamin C or flavonoids
  • These various factors might account for the null effects of alpha-tocopherol supplementation in patients with MCI and Alzheimer's disease
  • preliminary results obtained in a pediatric population have suggested that post-traumatic oral creatine administration (0.4 g/kg) given within four hours of traumatic brain injury and then daily thereafter, may improve both acute and long-term outcomes
  • Acutely, post-traumatic creatine administration seemed to reduce duration of post-traumatic amnesia, length of time spent in the intensive care unit, and duration of intubation
  • At three and six months post-injury, subjects in the creatine treatment group demonstrated improvement on indices of self care, communication abilities, locomotion, sociability, personality or behavior and cognitive function when compared to untreated controls
  • patients in the creatine-treatment group were less likely to experience headaches, dizziness and fatigue over six months of follow-up
  • CNS creatine is derived from both its local biosynthesis from the essential amino acids methionine, glycine and arginine
  • Studies of patients with CNS creatine deficiency and/or murine models with genetic ablation of creatine kinase have consistently demonstrated significant neurological impairment in the absence of proper creatine, phosphocreatine, or creatine kinase function; thus highlighting its functional importance
  • chronic dosing may partially reverse neurological impairments in human CNS creatine deficiency syndromes
  • Several studies have suggested that creatine supplementation may also reduce oxidative DNA damage and brain glutamate levels in Huntington disease patients
  • Another study highlighted that creatine supplementation marginally improved indices of mood and reduced the need for increased dopaminergic therapy in patients with Parkinson's disease
  • Nathan Goodyear on 20 Feb 16
     
    great review of natural therapies in the treatment of concussions
Nathan Goodyear

Ozone Therapy as Adjuvant for Cancer Treatment: Is Further Research Warranted? - 0 views

www.hindawi.com/...7931849

lymphoma Hodgkin's lymphoma O3 ozone

shared by Nathan Goodyear on 04 Jun 19 - No Cached
  • Nathan Goodyear on 04 Jun 19
     
    To be read review of O3 in the treatment of Hodgkin's lymphoma.
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